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Acta Pharmaceutica Sinica B 2024年第2期14卷 893-896页

作者： Mingwei Fu Min Ge Wanxiang Yang Chunchen Hu Xiaowei Li Yuanjiang Wang Shaohua Gou Pharmaceutical research Center and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Jiangsu Province Hi-Tech Key Laboratory for biomedical research Southeast UniversityNanjing 211189China Zenji research Laboratories Nanjing 211189China

To the Editor:Kinase cell division cycle 7(CDC7),a cell division cycle protein,takes a vital role in mediating DNA ***7 complexes in the nucleus can phosphorylate the minichromosome maintenance complex(MCM)family members that bind to *** addition,CDC7 kinase,as a molecular switch regulating DNA replication,can mediate DNA damage signaling pathways to stimulate cell cycle termination as well as DNA *** have shown that CDC7 is overexpressed in many types of cancer cells,and its overexpression was related to poor patient survival,tumor grade,genetic instability,aneuploidy and so ***,CDC7 is a promising target for antitumor therapy.

关键词： Cell division cycle 7 DNA replication CDC7 inhibitor Anti-tumor

The utilization of chitosan/Bletilla striata hydrogels to elevate anti-adhesion,anti-inflammatory and pro-angiogenesis properties of polypropylene mesh in abdominal wall repair

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Regenerative Biomaterials 2024年第4期3卷 111-124页

作者： Yuntao Di Lu Wang Wei He Shuyan Liu Yuqi He Jie Liao Ruihong Zhang Lan Yin Zhiwei Xu Xiaoming Li Department of Neurosurgery The Fourth Central Hospital of Baoding CityBaoding 072350China research Center for biomedical Engineering Medical Innovation&Research DivisionChinese PLA General HospitalKey Laboratory of Biomedical Engineering and Translational MedicineMinistry of Industry and Information TechnologyBeijing 100853China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China College of Lab Medicine Hebei North UniversityZhangjiakou 075000China Key Laboratory of Advanced Materials of Ministry of Education Tsinghua UniversityBeijing 100084China

Polypropylene(PP)mesh is commonly used in abdominal wall repair due to its ability to reduce the risk of organ damage,infections and other ***,the PP mesh often leads to adhesion formation and does not promote functional tissue *** this study,we synthesized one kind of aldehyde Bletilla striata polysaccharide(BSPA)modified chitosan(CS)hydrogel based on Schiff base *** hydrogel exhibited a porous network structure,a highly hydrophilic surface and good *** wrapped the PP mesh inside the hydrogel and evaluated the performance of the resulting composites in a bilateral 1×1.5cm abdominal wall defect model in *** results of gross observation,histological staining and immunohistochemical staining demonstrated the positive impact of the CS hydrogel on anti-adhesion and wound healing ***,the addition of BSPA to the CS hydrogel further improved the performance of the composites in vivo,promoting wound healing by enhancing collagen deposition and capillary *** study suggested that the BSPA-modified CS hydrogel significantly promoted the anti-adhesion,anti-inflammatory and pro-angiogenesis properties of PP meshes during the healing ***,this work offers a novel approach to the design of abdominal wall repair patches.

关键词： abdominal wall wound healing hydrogel Bletilla striata anti-adhesion

Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

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Communications in Theoretical Physics 2024年第4期76卷 167-175页

作者： Xingyu Qi Zilong Guo Shimin Le Hu Chen research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China Center of biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

Force spectrum measurements with constant loading rates are widely used in single-molecule manipulation experiments to study the mechanical stability and force response of ***-dependent transition rates can be obtained from the transition force distribution,but it is limited to the force range with non-zero force *** constant loading rate control can be realized with magnetic tweezers,the loading rate range is limited due to the slow movement of permanent ***-linear exponential and exponential squared force loading functions are more feasible in magnetic tweezers,while there is no theoretical result available for these two kinds of non-linear force loading *** this study,we solved the unfolding process of a protein following Bell's model under nonlinear exponential and exponential squared force loading functions,which offer a broader range of unfolding force distribution compared to the traditional constant loading rate ***,we derived two force loading functions,which can produce uniform unfolding force *** research contributes fundamental equations for the analysis of experimental data obtained through single-molecule manipulation under nonlinear force loading controls,paving the way for the use of nonlinear force control in magnetic tweezer experiments.

关键词： single-molecule manipulation magnetic tweezers force loading transition rates force distribution

Oncostatin M:a love-hate relationship in neuroinflammation

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Neural Regeneration research 2024年第12期19卷 2571-2572页

作者： Doryssa Hermans Niels Hellings Bieke Broux University MS Center Campus DiepenbeekDiepenbeekBelgium Neuro-Immune Connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium

Oncostatin M and multiple sclerosis:Every 5minutes,someone in the world is diagnosed with multiple sclerosis(MS),a chronic inflammatory and degenerative disease of the central nervous system(CNS).MS appears in unpredictable episodes of symptoms,which are highly patient-dependent,but often include visual impairment,muscle weakness/spasms,fatigue,cognitive difficulties,and *** sexual dysfunction.

关键词： visual bladder someone

Biomaterial design for regenerating aged bone:materiobiological advances and paradigmatic shifts

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National Science Review 2024年第5期11卷 405-419页

作者：戴凯耿振张文超魏雪王靖聂广军刘昌胜 Engineering research Center for biomedical Materials of the Ministry of Education East China University of Science and Technology State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Frontiers Science Center for Materiobiology and Dynamic Chemistry East China University of Science and Technology Key Laboratory for Ultrafine Materials of the Ministry of Education East China University of Science and Technology Institute of Translational Medicine Shanghai University National Center for Translational Medicine(Shanghai) SHU Branch Shanghai University CAS Key Laboratory for biomedical Effects of Nanomaterials &Nanosafety CAS Centre for Excellence in Nanoscience National Centre for Nanoscience and Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment,blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of ‘healthy aging'.

关键词： materiobiology biomaterial design aging bone regeneration artificial intelligence

Erratum to“Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer”

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research 2024年第3期6卷 797-798页

作者： Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur research Center for biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China

In the research Article “Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer,” the authors made an error in Fig. 6A. In Fig. 6A, the image of “pre” in the “Free Cy5-siRNA” group was misused. When incorporating the final images in Fig. 6A, another image of “24 h” in the “Free Cy5-siRNA” group was inadvertently chosen as the “Pre” image, so they appear to be remarkably similar. After the error was discovered, the authors repeated the experiments that concluded that this error did not affect the results, discussion, or conclusion of this paper. Figure 6A has now been corrected in the PDF and HTML (full text).

关键词： Internal Cancer Breast

Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan Fen Neoh Tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee Biotechnology research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia centre of Excellence for research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

WavEnhancer: Unifying Wavelet and Transformer for Image Enhancement

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Journal of Computer Science & Technology 2024年第2期39卷 336-345页

作者：李梓诺陈绪行郭淑娜王书强潘治文 Department of Computer and Information Science University of MacaoMacao 999078China research Center for biomedical Information Technology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Image enhancement is a widely used technique in digital image processing that aims to improve image aesthetics and visual quality. However, traditional methods of enhancement based on pixel-level or global-level modifications have limited effectiveness. Recently, as learning-based techniques gain popularity, various studies are now focusing on utilizing networks for image enhancement. However, these techniques often fail to optimize image frequency domains. This study addresses this gap by introducing a transformer-based model for improving images in the wavelet domain. The proposed model refines various frequency bands of an image and prioritizes local details and high-level features. Consequently, the proposed technique produces superior enhancement results. The proposed model’s performance was assessed through comprehensive benchmark evaluations, and the results suggest it outperforms the state-of-the-art techniques.

关键词： transformer wavelet transform image enhancement

Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales Armando Rojas biomedical research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

Line-scanning microscopy with laterally symmetric imaging using simultaneous cross-line illumination

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Photonics research 2024年第7期12卷 1513-1521页

作者： DAN SHEN YAFENG LI MENG WANG YUTONG HAN BOLIN LU HUI GONG QINGMING LUO JING YUAN Britton Chance Center for biomedical Photonics and MoE Key Laboratory for biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics JITRI Institute for BrainsmaticsSuzhou 215123China School of biomedical Engineering Hainan UniversityHaikou 570228China

Using an on-the-fly scanning scheme, line confocal microscopy can obtain complex structures of large biological tissues with high throughput. Yet, it suffers from lateral imaging asymmetry and thus introduces the potential deformations of the observation results. Here, we propose cross-line illumination microscopy (cLIM) that acquires the imaging data of two perpendicular directions simultaneously through the same objective lens in a line scanning and utilizes two-direction deconvolution fusion to achieve lateral symmetric imaging *** fluorescence beads indicates that cLIM reduces lateral resolution asymmetry from 46.1%to 2.5%and improves lateral resolution by 31.0%, compared with traditional line-scanning imaging. Compared with commercial point-confocal microscopy, the cLIM has a 25.84×increase in imaging speed and 1.93×better background-suppressing ability when imaging an 11,306μm×7783μm×100μm mouse kidney slice. We also show the advantages of the cLIM in observing direction-sensitive texture features by imaging a muscular tissue slice. cLIM offers a novel solution to achieve laterally symmetric line-scanning imaging with simple modifications while maintaining high throughput and accuracy for imaging large-scale samples.

关键词： illumination simultaneous scanning