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Antibiotic ciprofloxacin removal from aqueous solutions by electrochemically activated persulfate process:Optimization,degradation pathways,and toxicology assessment

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Journal of Environmental Sciences 2024年第9期143卷 85-98页

作者： Elif Yakamercan Ahmet Aygün Halis Simsek Environmental Engineering Department Bursa Technical UniversityBursaTurkey Agricultural and Biological Engineering Department Purdue UniversityWest LafayetteINUSA

Ciprofloxacin(CIP)is a commonly used antibiotic in the fluoroquinolone group and is widely used in medical and veterinary medicine disciplines to treat bacterial *** CIP is discharged into the sewage system,it cannot be removed by a conventional wastewater treatment plant because of its recalcitrant *** this study,boron-doped diamond anode and persulfate were used to degrade CIP in an aquatic solution by creating an electrochemically activated persulfate(EAP)*** added to the system as a coactivator and the process was called EAP+*** effects of independent variables,including pH,Fe^(2+),persulfate concentration,and electrolysis time on the systemwere optimized using the response surface *** results showed that the EAP+Fe process removed 94%of CIP under the following optimum conditions:A pH of 3,persulfate/Fe^(2+)concentration of 0.4 mmol/L,initial CIP concentration 30 mg/L,and electrolysis time of 12.64 *** removal efficiency was increased from 65.10%to 94.35%by adding Fe^(2+)as a transition *** degradation products,7 pathways,and 78 intermediates of CIP were studied,and three of those intermediates(m/z 298,498,and 505)were *** toxicological analysis based on toxicity estimation software results indicated that some degradation products of CIP were toxic to targeted animals,including fathead minnow,Daphnia magna,Tetrahymena pyriformis,and *** optimumoperation costswere similar in EAP and EAP+Fe processes,approximately 0.54€/m^(3).

关键词： Ciprofloxacin Response surface methodology Electrochemically activated persulfate Electrooxidation

DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

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Engineering 2024年第7期38卷 39-51页

作者： Kai-Bo Wang Yingying Wang Jonathan Dickerhoff Danzhou Yang Borch Department of Medicinal Chemistry and Molecular Pharmacology College of PharmacyPurdue UniversityWest LafayetteIN 47907USA Purdue Center for Cancer Research Purdue UniversityWest LafayetteIN 47907USA Department of Chemistry Purdue UniversityWest LafayetteIN 47907USA Purdue Institute for Drug Discovery Purdue UniversityWest LafayetteIN 47907USA Jiangsu Key Laboratory of Bioactive Natural Product Research&State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed by two or more stacked Gtetrads in G-rich DNA *** structures have been found to play a crucial role in highly transcribed genes,especially in cancer-related oncogenes,making them attractive targets for cancer ***,targeting oncogene promoter G4 structures has emerged as a promising strategy to address the challenge of undruggable and drug-resistant proteins,such as MYC,BCL2,KRAS,and *** products have long been an important source of drug discovery,particularly in the fields of cancer and infectious *** progress has recently been made in the discovery of naturally occurring DNA G4-targeting *** DNA G4s,such as MYC-G4,BCL2-G4,KRAS-G4,PDGFR-b-G4,VEGF-G4,and telomeric-G4,have been identified as potential targets of natural products,including berberine,telomestatin,quindoline,sanguinarine,isaindigotone,and many ***,we summarize and evaluate recent advancements in natural and nature-derived DNA G4 binders,focusing on understanding the structural recognition of DNA G4s by small molecules derived from *** also discuss the challenges and opportunities associated with developing drugs that target DNA G4s.

关键词： G-quadruplex Natural products Alkaloids Cancer Promoter

Observer-Based Adaptive Robust Precision Motion Control of a Multi-Joint Hydraulic Manipulator

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1213-1226页

作者： Zheng Chen Shizhao Zhou Chong Shen Litong Lyu Junhui Zhang Bin Yao State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027 Ocean college Zhejiang UniversityZhoushan 316021China School of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050000 State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China School of Mechanical Engineering Purdue UniversityWest LafayetteIN 47907 USA

Hydraulic manipulators are usually applied in heavy-load and harsh operation ***,when faced with a complex operation,the traditional proportional-integral-derivative(PID)control may not meet requirements for high control ***-based full-state-feedback control is an effective alternative,but the states of a hydraulic manipulator are not always available and reliable in practical applications,particularly the joint angular velocity *** that it is not suitable to obtain the velocity signal directly from differentiating of position measurement,the low-pass filtering is commonly used,but it will definitely restrict the closed-loop bandwidth of the whole *** avoid this problem and realize better control performance,this paper proposes a novel observerbased adaptive robust controller(obARC)for a multi-joint hydraulic manipulator subjected to both parametric uncertainties and the lack of accurate velocity ***,a nonlinear adaptive observer is first designed to handle the lack of velocity measurement with the consideration of parametric ***,the adaptive robust control is developed to compensate for the dynamic uncertainties,and the close-loop system robust stability is theoretically proved under the observation and control ***,comparative experiments are carried out to show that the designed controller can achieve a performance improvement over the traditional methods,specifically yielding better control accuracy owing to the closed-loop bandwidth breakthrough,which is limited by low-pass filtering in fullstate-feedback control.

关键词： handle Observer filtering

Shoaling Internal Solitary Waves and the Formation of Boluses

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Open Journal of Fluid Dynamics 2024年第2期14卷 65-82页

作者： Hooman Enayati Brian T. Helenbrook Department of Mechanical Engineering Lafayette College Easton PA USA Department of Mechanical & Aerospace Engineering Clarkson University Potsdam NY USA

An internal solitary wave of elevation in a two-layer density stratified system of an incompressible, viscous and homogeneous fluid was studied. The run-up of a wave of elevation encountering different slopes was investigated numerically based on solving the continuity, Navier-Stokes and convective-diffusion equations within the Boussinesq approximation. The commercial software COMSOL Multiphysics was used to conduct the numerical simulations. For gradual shoals, a bolus formed that transported dense fluid up the shoal. The bolus disappeared when it reached its maximum height on the slope due to the draining of the dense fluid. Various shoal angles were simulated to detect the critical angle above which a bolus does not form. An angle of 30 or less resulted in the formation of a bolus. In addition, the simulations demonstrated that the size of the bolus induced by shallower slopes was larger and that the vertical height traveled by the bolus was insensitive to the slope of the shoal.

关键词： Internal Solitary Waves COMSOL Multiphysics Wave Breaking

Review and Perspectives on Human Emotion for Connected Automated Vehicles

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Automotive Innovation 2024年第1期7卷 4-44页

作者： Wenbo Li Guofa Li Ruichen Tan Cong Wang Zemin Sun Ying Li Gang Guo Dongpu Cao Keqiang Li School of Vehicle and Mobility Tsinghua University30 Shuangqing RdBeijing 100084China college of Mechanical and Vehicle Engineering Chongqing University174 Shazheng RdChongqing 400044China college of Computer Science and Technology Jilin University2699 Qianjin RdChangchun 130012China School of Mechanical Engineering Beijing Institute of Technology5 Zhongguancun South RdBeijing 100081China Lyles School of Civil Engineering Purdue University550 Stadium Mall DriveWest LafayetteIN 47907USA

The progression toward automated driving and the latest advancement in vehicular networking have led to novel and natural human-vehicle-road systems,in which affective human-vehicle interaction is a crucial factor affecting the acceptance,safety,comfort,and traffic efficiency of connected and automated vehicles(CAVs).This development has inspired increasing inter-est in how to develop affective interaction framework for intelligent cockpit in *** enable affective human-vehicle interactions in CAVs,knowledge from multiple research areas is needed,including automotive engineering,transportation engineering,human-machine interaction,computer science,communication,as well as industrial ***,there is currently no systematic survey considering the close relationship between human-vehicle-road and human emotion in the human-vehicle-road coupling process in the CAV *** facilitate progress in this area,this paper provides a comprehensive literature survey on emotion-related studies from multi-aspects for better design of affective interaction in intelligent cockpit for *** paper discusses the multimodal expression of human emotions,investigates the human emotion experiment in driving,and particularly emphasizes previous knowledge on human emotion detection,regulation,as well as their applications in *** promising research perspectives are outlined for researchers and engineers from different research areas to develop CAVs with better acceptance,safety,comfort,and enjoyment for users.

关键词： Intelligent vehicles Intelligent cockpit Human-machine interaction Emotion recognition Emotion regulation

New solutions for four novel generalized nonlinear fractional fifth-order equations

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Journal of Ocean Engineering and Science 2024年第1期9卷 59-65页

作者： Mehmet Senol Lanre Akinyemi Henrietta Nkansah Waleed Adel Nevsehir HacıBekta¸s Veli University Department of MathematicsNevsehirTurkey Department of Mathematics Lafayette CollegeEastonPennsylvaniaUSA Department of Mathematics University of Cape CoastCape CoastGhana Department of Mathematics and Engineering Physics Faculty of EngineeringMansoura UniversityEgypt UniversitéFrançaise dÉgypte Ismailia Desert RoadEl ShoroukCairoEgypt

In this paper,new four fifth-order fractional nonlinear equations are derived and *** frac-tional terms are defined in the conformable sense and these equations are then solved using two effective methods,namely,the sub-equation and the generalized Kudryashov *** methods were tested on the proposed models and succeeded in finding new solutions with different values of parameters.A graphical representation of some results is provided and proves the efficiency and applicability of the proposed methods for providing solutions with known physical *** methods are good candi-dates for solving other similar problems in the future.

关键词： Conformable derivative Generalized Kudryashov method Sub-equation method Riccati equation Solitons

Stomatal dynamics are regulated by leaf hydraulic traits and guard cell anatomy in nine true mangrove species

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Plant Diversity 2024年第3期46卷 395-405页

作者： Ya-Dong Qie Qi-Wei Zhang Scott A.M.McAdam Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Forest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection Ministry of EducationGuangxi Normal UniversityGuilin 541001China Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guangxi Normal UniversityGuilin 541001China Purdue Center for Plant Biology Department of Botany and Plant PathologyPurdue UniversityWest LafayetteIN 47907USA

Stomatal regulation is critical for mangroves to survive in the hyper-saline intertidal zone where water stress is severe and water availability is highly ***,very little is known about the stomatal sensitivity to vapour pressure deficit(VPD)in mangroves,and its co-ordination with stomatal morphology and leaf hydraulic *** measured the stomatal response to a step increase in VPD in situ,stomatal anatomy,leaf hydraulic vulnerability and pressure-volume traits in nine true mangrove species of five families and collected the data of genome *** aimed to answer two questions:(1)Does stomatal morphology influence stomatal dynamics in response to a high VPD in mangroves?with a consideration of possible influence of genome size on stomatal morphology;and(2)do leaf hydraulic traits influence stomatal sensitivity to VPD in mangroves?We found that the stomata of mangrove plants were highly sensitive to a step rise in VPD and the stomatal responses were directly affected by stomatal anatomy and hydraulic ***,denser stomata was correlated with faster stomatal closure at high VPD across the species of Rhizophoraceae,and stomata size negatively and vein density positively correlated with genome *** negative leaf osmotic pressure at the full turgor(πo)was related to higher operating steady-state stomatal conductance(gs);and a higher leaf capacitance(Cleaf)and more embolism resistant leaf xylem were associated with slower stomatal responses to an increase in *** addition,stomatal responsiveness to VPD was indirectly affected by leaf morphological traits,which were affected by site salinity and consequently leaf water *** results demonstrate that mangroves display a unique relationship between genome size,stomatal size and vein packing,and that stomatal responsiveness to VPD is regulated by leaf hydraulic traits and stomatal *** work provides a quantitative framework to better understand of stomatal regulation in mangroves

关键词： Stomatal temporal kinetics Vapour-pressure deficit(VPD) Leaf water relations Leaf hydraulic vulnerability Leaf osmotic potential Genome size

Hydrogel microspheres for bone regeneration through regulation of the regenerative microenvironment

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Biomaterials Translational 2024年第3期5卷 205-235页

作者： Pengrui Zhang Qiwei Qin Xinna Cao Honglin Xiang Dechao Feng Dilinaer Wusiman Yuling Li Department of Orthopaedics Laboratory of Biological Tissue Engineering and Digital MedicineAffiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina Division of Surgery&Interventional Science University College LondonLondonUK Department of Comparative Pathobiology College of Veterinary MedicinePurdue UniversityWest LafayetteINUSA

Bone defects are a prevalent category of skeletal tissue disorders in clinical practice,with a range of pathogenic factors and frequently suboptimal clinical treatment *** bone regeneration of bone defects,the bone regeneration microenvironment-composed of physiological,chemical,and physical components-is the core element that dynamically coordinates to promote bone *** recent years,medical biomaterials with bioactivity and functional tunability have been widely researched upon and applied in the fields of tissue replacement/regeneration,and remodelling of organ structure and *** biomaterial treatment system based on the comprehensive regulation strategy of bone regeneration microenvironment is expected to solve the clinical problem of bone *** microspheres(HMS)possess a highly specific surface area and porosity,an easily adjustable physical structure,and high encapsulation efficiency for drugs and stem *** can serve as highly efficient carriers for bioactive factors,gene agents,and stem cells,showing potential advantages in the comprehensive regulation of bone regeneration microenvironment to enhance bone *** review aims to clarify the components of the bone regeneration microenvironment,the application of HMS in bone regeneration,and the associated *** also discusses various preparation materials and methods of HMS and their applications in bone tissue ***,it elaborates on the relevant mechanisms by which HMS regulates the physiological,chemical,and physical microenvironment in bone regeneration to achieve bone ***,we discuss the future prospects of the HMS system application for comprehensive regulation of bone regeneration microenvironment,to provide novel perspectives for the research and application of HMS in the bone tissue engineering field.

关键词： bone regeneration bone tissue engineering hydrogel microspheres regeneration microenvironment

The proximity between hydroxyl and single atom determines the catalytic reactivity of Rh1/CeO_(2) single-atom catalysts

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Nano Research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou Congcong Du Juan Li Jianyu Huang Hong-xia Shen Abhaya K.Datye Shan Jiang Jeffrey T.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China college of Biology and Chemical Engineering Jiaxing UniversityJiaxing 314000China Department of Chemical&Biological Engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

The local structure of the metal single-atom site is closely related to the catalytic activity of metal single-atom catalysts(SACs).However,constructing SACs with homogeneous metal active sites is a challenge due to the surface heterogeneity of the conventional ***,we prepared two Rh1/CeO_(2)SACs(0.5Rh1/r-CeO_(2)and 0.5Rh1/c-CeO_(2),respectively)using two shaped CeO_(2)(rod and cube)exposing different facets,i.e.,CeO_(2)(111)and CeO_(2)(100).In CO oxidation reaction,the T100 of 0.5Rh1/r-CeO_(2)SACs is 120°C,while the T100 of 0.5Rh1/c-CeO_(2)SACs is as high as 200°*** in-situ CO diffuse reflectance infrared Fourier transform spectroscopy(CO-DRIFTS),we found that the proximity between OH group and Rh single atom on the plane surface plays an important role in the catalytic activity of Rh1/CeO_(2)SAC system in CO *** Rh single atom trapped at the CeO_(2)(111)crystal surface forms the Rh1(OH)adjacent species,which is not found on the CeO_(2)(100)crystal surface at room ***,during CO oxidation,the OH group far from Rh single atom on the 0.5Rh1/c-CeO_(2)disappears and forms Rh1(OH)adjacent species when the temperature is above 150°*** formation of Rh1(OH)adjacentCO intermediate in the reaction is pivotal for the excellent catalytic activity,which explains the difference in the catalytic activity of Rh single atoms on two different CeO_(2)*** formed Rh1(OH)adjacent-O-Ce structure exhibits good stability in the reducing atmosphere,maintaining the Rh atomic dispersion after CO oxidation even when pre-reduced at high temperature of 500°*** functional theory(DFT)calculations validate the unique activity and reaction path of the intermediate Rh1(OH)adjacentCO species *** work demonstrates that the proximity between metal single atom and hydroxyl can determine the formation of active intermediates to affect the catalytic performances in catalysis.

关键词： crystal plane Rh1/CeO_(2)single-atom catalyst proximity of Rh and hydroxyl coordination structure CO oxidation