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Who should be screened for colorectal cancer and how can it be prevented more effectively?

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3741-3746页

作者： You-Xiang Wang Kai-Juan Wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina College of Public Health Key Laboratory of Tumor Epidemiology of Henan ProvinceState Key Laboratory of Esophageal Cancer Prevention&TreatmentZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

In this editorial,we comment on the article published by Agatsuma et al in a recent issue of the World J Gastroenterol(2024;30:1368-1376).We firmly concur with Agatsuma et al regarding the vital significance of colorectal cancer(CRC)screening as a public health strategy to diminish disease *** exposed to risk factors for CRC,those with comorbid conditions,and those with limited health literacy should undergo ***,we believe that more regular screenings should be accompanied by a greater focus on primary prevention(PP)of *** remains a significant global health challenge,and its incidence is strongly linked to age,lifestyle,and socioeconomic *** is particularly noteworthy that the majority of CRC patients are diagnosed outside of established screening pathways and frequently at an advanced stage of the disease,and the majority of patients possess inadequate or even nonexistent knowledge regarding CRC,which significantly impacts the prognosis and imposes a substantial economic *** study revealed that CRC identified during hospital visits for comorbid conditions was typically diagnosed at an earlier stage than detected via symptomatic ***,early incidental detection of CRC aligns closely with the timing of discovery through routine cancer *** suggests that by adopting more inclusive screening protocols that combine opportunistic testing with traditional screening methods,health care systems can create a more comprehensive safety net for individuals at risk of ***,before maximizing the health benefits of screening programs,it is essential to make additional efforts prior to screening,such as raising awareness via public education,risk assessment,and personalized recommendations,enhancing the knowledge and skills of health care professionals,optimizing the accessibility and convenience of screening processes,ensuring the quality and safety of screening services,strengthening follow-up and su

关键词： Colorectal cancer Primary prevention Screening program Disease burden Health literacy Economic benefits

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Construction and applications of DNA-based nanomaterials in cancer therapy

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Chinese Chemical Letters 2022年第3期33卷 1131-1140页

作者： Hedong Qi Yuwei Xu Pin Hu Chi Yao Dayong Yang Frontiers Science Center for Synthetic Biology Key Laboratory of Systems Bioengineering(MOE)School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

As a biologically active macromolecule, deoxyribonucleic acid(DNA) has the advantages of sequence programmability and structure controllability and can accurately transmit sequence information to specific biological functions. Facing the complex internal microenvironment and heterogeneity in tumor treatment, the construction and applications of DNA-based nanomaterials have become a focus point of research. In particular, the hybridization of DNA molecules with other materials endows DNA-based nanomaterials with multiple functions such as targeting, stimulus responsiveness and regulations of biological activities, making DNA nanostructures great potential in the treatment of major human *** this review, the construction and characteristics of DNA-based nanomaterials are introduced. Then,the functions and applications of DNA-based nanomaterials in the delivery of chemotherapy drugs and gene drugs, stimulus-responsive release and regulation of cell homeostasis are reviewed. Finally, the future development and challenges of DNA-based nanomaterials are prospected. We envision that DNAbased nanomaterials can enrich the nanomaterial system by rational design and synthesis and address the growing demands on biological and biomedical applications in the real world.

关键词： DNA nanomaterials DNA nanotechnology Drug delivery Cancer therapy

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Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment

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Nano Research 2022年第1期15卷 728-737页

作者： Shiqi Huang Lang Deng Hanming Zhang Luyao Wang Yicong Zhang Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Key laboratory of Drug Targeting and Drug Delivery systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung,leading to sharply reduced patients'survival *** treating these tumors thus could improve late stage melanoma with lung *** this study,we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA)decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and paclitaxel(PTX)to lung melanoma tumor sites(TRAIL-[ND-PTX]^(CR(NMe)EKA)).These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles,while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded *** combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply,leading to stronger overall anti-tumor *** TRAIL-[ND-PTX]^(CR(NMe)EKA)system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice,without displaying significant ***,this designing strategy and the fabricated nanoplatform possess potential for further development.

关键词： nanodisks Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA) tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) lung melanoma metastasis tumor-targeting

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Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres

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Nano Research 2019年第10期12卷 2451-2459页

作者： Luyao Wang Bingjie Zhou Shiqi Huang Mengke Qu Qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang Key laboratory of Drug Targeting and Drug Delivery systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate ***,common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration,even with the help of conventional drug delivery ***,encouraged by recent studies showing possible drug retention and tissue pen etration advan tages of unconventional non-spherical nan oparticles over conventional spherical nan oparticles,we design and construct a novel non-spherical nano disk drug delivery system for treating prostate *** to enhance tumor-targeting capability,these nanodisks are further modified with targeting peptide,Cys-Arg-Glu丄ys?Ala peptide with N-methylated Glu(CR(NMe)EKA),which recognizes extracellular matrix fibronectin and its complexes specifically expressed on the walls of tumor vessels and in tumor *** with conventional nano spheres,the nano disks achieve much higher drug accumulati on at prostate tumor *** loaded with paclitaxel,the CR(NMe)EKA-modified nan odisks display superior an titumor efficacy to free paclitaxel,unmodified nan odisks and nano *** summary,our study provides an attractive therapeutic strategy for targeted therapy against prostate cancer with simple preparation,high efficiency and low toxicity,and supplements a theoretical support for treatments realized by different shaped nano *** study also offers valuable data for understa nding biological effects of non-spherical nano disks and highlights the great pote ntial of unconventional nan oparticles in biomedical applicati ons.

关键词： Cys-Arg-Glu-Lys-Ala peptide with N-methylated Glu(CR(NMe)EKA) fibronectin nanodisks prostate cancer tumor-targeting

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Synthesis and cytotoxic activity of novel curcumin analogues

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Chinese Chemical Letters 2008年第3期19卷 281-285页

作者： Qin Zhang Yao Fu Hao Wei Wang Tao Gong Yong Qin Zhi Rong Zhang Key laboratory of Drug Targeting Drug Delivery systems Ministry of Education West China School of Pharmacy Sichuan University Chengdu 610041 China

Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues （1A-1C, 1E） with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.

关键词： Curcumin analogues Synthesis Cytotoxic activity Anti-tumor activity

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Revealing Tissue Heterogeneity and Spatial Dark Genes from Spatially Resolved Transcriptomics by Multiview Graph Networks

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Research 2024年第2期6卷 629-645页

作者： Ying Li Yuejing Lu Chen Kang Peiluan Li Luonan Chen School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang471023China Longmen laboratory LuoyangHenan471003China Key laboratory of systems Biology Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai201100China Key laboratory of systems Health Science of Zhejang Province Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou310000China School of Life Science and Technology ShanghaiTech UniversityShanghai201100.China

Spatially resolved transcriptomics(SRT)is capable of comprehensively characterizing gene expression patterns and providing an unbiased image of spatial *** fully understand the organizational complexity and tumor immune escape mechanism,we propose stMGATF,a multiview graph attention fusion model that integrates gene expression,histological images,spatial location,and gene *** better extract information,stMGATF exploits SimCLRv2 for visual feature exaction and employs edge feature enhanced graph attention networks for the learning potential embedding of each view.A global attention mechanism is used to adaptively integrate 3 views to obtain low-dimensional *** to diverse SRT datasets,stMGATF is robust and outperforms other methods in detecting spatial domains and denoising data even with different resolutions and *** particular,stMGATF contributes to the elucidation of tissue heterogeneity and extraction of 3-dimensional expression ***,considering the associations between genes in tumors,stMGATF can identify the spatial dark genes ignored by traditional methods,which can be used to predict tumor-driving transcription factors and reveal tumor immune escape mechanisms,providing theoretical evidence for the development of new immunotherapeutic strategies.

关键词： Spatial integrate driving

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Bioprinting of novel 3D tumor array chip for drug screening

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Bio-Design and Manufacturing 2020年第3期3卷 175-188页

作者： Mingjun Xie Qing Gao Jianzhong Fu Zichen Chen Yong He State Key laboratory of Fluid Power and Mechatronic systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Key laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

Biomedical field has been seeking a feasible standard drug screening system consisting of 3D tumor model array for drug researching due to providing sufficient samples and simulating actual in vivo tumor growth situation,which is still a challenge to rapidly and uniformly establish ***,we propose a novel drug screening system,namely 3D tumor array chip with“layer cake”structure,for drug *** gelatin methacryloyl hydrogel droplets(~0.1μL)containing tumor cells can be automatically deposited on demand with electrohydrodynamic 3D *** conductive membrane is introduced as a chip basement for preventing charges accumulation during fabricating and convenient observing during *** chambers formed by stainless steel and silicon interlayer is convenient to be assembled and *** this chip is compatible with the existing 96-well culturing plate,the drug screening protocols could keep the same as *** properties of this chip,namely printing stability,customizability,accuracy,microenvironment,tumor functionalization,are detailly *** a demonstration,it is applied for screening of epirubicin and paclitaxel with breast tumor cells to confirm the compatibility of the proposed screening system with the traditional screening *** believe this chip will potentially play a significant role in drug evaluation in the future.

关键词： 3D tumor array chip(3D-TAC) Gelatin methacryloyl(GelMA) Drug screening In vitro model Bioprinting

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p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis

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Cancer Biology & Medicine 2019年第1期16卷 79-88页

作者： Haili Li Yongjin Zhang Juhua Dan Ruoyu Zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo Faculty of Environmental Science and Engineering Kunming University of Science and Technology laboratory of Molecular Genetics of Aging &tumor Kunming University of Science and Technology Division of Nephrology The First People's Hospital of Yunnan Province Department of Cancer systems Imaging The University of Texas MD Anderson Cancer Center Department of Integrative Biology and Pharmacology University of Texas Health Science Center at Houston Department of Pathology Kunming General Hospital

Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is ***: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological *** RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease ***: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc^(-/-)WRN^(-/-)p53^(S/S)(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and ***: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis.

关键词： p53 mutation telomere dysfunction polycystic kidney disease tumorigenesis

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Manganese nanodepot augments host immune response against coronavirus

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Nano Research 2021年第5期14卷 1260-1272页

作者： Yizhe Sun Yue Yin Lidong Gong Zichao Liang Chuanda Zhu Caixia Ren Nan Zheng Qiang Zhang Haibin Liu Wei Liu Fuping You Dan Lu Zhiqiang Lin Institute of systems Biomedicine Department of PathologySchool of Basic Medical SciencesBeijing Key Laboratory of Tumor Systems BiologyPeking-Tsinghua Center for Life SciencesPeking University Health Science CenterBeijing100191China Department of Human Anatomy Histology and EmbryologyPeking University Health Science CenterBeijing100191China Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) National Drug Clinical Trial CenterPeking University Cancer Hospital&InstituteBeijing100142China Department of Pharmaceutics School of Pharmaceutical SciencesPeking UniversityBeijing100191China Department of General Surgery Xinjiang Production and Construction Corps HospitalUrumchiXinjiang Uygur Autonomous Region830002China

Interferon(IFN)responses are central to host defense against coronavirus and other virus ***(Mn)is capable of inducing IFN production,but its applications are limited by nonspecific distributions and ***,we exploit chemical engineering strategy to fabricate a nanodepot of manganese(nanoMn)based on Mn2+.Compared with free Mn2+,nanoMn enhances cellular uptake and persistent release of Mn2+in a pH-sensitive manner,thus strengthening IFN response and eliciting broad-spectrum antiviral effects in vitro and in *** phagocytosed by macrophages,nanoMn promotes M1 macrophage polarization and recruits monocytes into inflammatory foci,eventually augmenting antiviral immunity and ameliorating coronavirus-induced tissue ***,nanoMn can also potentiate the development of virus-specific memory T cells and host adaptive immunity through facilitating antigen presentation,suggesting its potential as a vaccine *** and safety evaluations uncover that nanoMn treatment hardly induces neuroinflammation through limiting neuronal accumulation of ***,nanoMn offers a simple,safe,and robust nanoparticle-based strategy against coronavirus.

关键词： interferon coronavirus manganese nanodepot(nanoMn) macrophage polarization vaccine adjuvant

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Development of a hydrogen peroxide-responsive and oxygen-carrying nanoemulsion for photodynamic therapy against hypoxic tumors using phase inversion composition method

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 75-83页

作者： Liang Hong Jia Zhang Junxian Geng Junle Qu Liwei Liu Key laboratory of Optoelectronic Devices and systems of Ministry of Education and Guangdong Province College of Optoelectronic Engineering Shenzhen University Shenzhen 518060P.R.China

Photodynamic therapy(PDT)has become an attractive tumor treatment modality because of its noninvasive feature and low side ***,extreme hypoxia inside solid tumors severely impedes PDT therapeutic *** overcome this obstacle,various strategies have been developed *** them,in situ oxygen generation,which relies on the decom-position of tumor endogenous H_(2)O_(2),and oxygen delivery tactic using high oxygen loading capacity of hemoglobin or perfluorocarbons,have been widely *** in situ oxygen generation strategy has high specificity to tumors,but its oxygen-generating efficiency is lim-ited by the intrinsically low tumor H_(2)O_(2)*** contrast,the oxygen delivery approach holds advantage of high oxygen loading efficiency,nevertheless lacks tumor *** this work,we prepared a nanoemulsion system containing H_(2)O_(2)-responsive catalase,highly efficient ox-ygen carrier perfiuoropolyether(PFPE),and a near-infrared(NIR)light activatable photo-sensitizer IR780,to combine the high tumor specificity of the in situ oxygen generation strategy and the high efficiency of the oxygen delivery *** concisely prepared nanoplatform exhibited enhanced and H_(2)O_(2)-controllable production of singlet oxygen under light excitation,satisfactory cytocompatibility,and ability to kill cancer cells under NIR light *** highlights the potential of this novel nanoplatform for highly efficient and selective NIR light mediated PDT against hypoxic *** research provides new insight into the design of intelligent nanoplatform for relieving tumor hypoxia and enhancing the oxygen-dependent PDT effects in hypoxic tumors.

关键词： Hypoxia catalase oxygen delivery perfluorocarbon near-infrared

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