Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment
作者机构：Key Laboratory of Drug Targeting and Drug Delivery SystemsMinistry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第1期
页 面：728-737页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0836[工学-生物工程] 0702[理学-物理学] 10[医学]
基 金：supported by the Regional Innovation and Development Joint Fund(No.U20A20441) the National Science Fund for Excellent Young Scholars(No.82022070)
主 题：nanodisks Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA) tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) lung melanoma metastasis tumor-targeting
摘 要：Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung,leading to sharply reduced patients survival *** treating these tumors thus could improve late stage melanoma with lung *** this study,we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA)decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and paclitaxel(PTX)to lung melanoma tumor sites(TRAIL-[ND-PTX]^(CR(NMe)EKA)).These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles,while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded *** combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply,leading to stronger overall anti-tumor *** TRAIL-[ND-PTX]^(CR(NMe)EKA)system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice,without displaying significant ***,this designing strategy and the fabricated nanoplatform possess potential for further development.
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