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Roles of lncRNAs in Rice: Advances and Challenges

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Rice science 2020年第5期27卷 384-395页

作者： Gao Caixia Zheng Xiuwen Li Hubo Ussi Ali Mlekwa Gao Yu Xiong Jie College of Life Sciences and Medicine Zhejiang Sci-Tech University/Zhejiang Province Key Laboratory of Plant Secondary Metabolism and RegulationHangzhou 31001&China

Long non-coding RNAs(lncRNAs) larger than 200 nucleotides in length are eukaryotic RNAs, and do not encode proteins. lncRNAs are considered to be important regulators in many biological processes in plants. In this review, the latest advances in the roles of lncRNAs in rice were reviewed, and functions of lncRNAs were further summarized and classified. lncRNAs play crucial roles in tolerance to biotic and abiotic stresses such as disease, drought, heat, cold, heavy metal, and starvation of nitrogen and phosphorus in rice. In addition, lncRNAs also regulate various growth and development processes in rice. Finally, the prospect and challenges of rice lncRNA function research in future were proposed. This review will not only help us quickly grasp the frontiers of lncRNAs functional research progresses, but also propose suggestions and ideas for the directions of further lncRNA research in rice.

关键词： long non-coding RNA miRNA rice

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Effects of cerous nitrate on growth and tanshinone production in salvia miltiorrhiza hairy roots

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Journal of Rare Earths 2015年第11期33卷 1228-1235页

作者：韩名宇郭万里梁宗锁杨东风闫希军朱永宏刘岩 College of Life Science Zhejiang Sci-Tech University Key laboratory of plant secondary metabolism and regulation of zhejiang province Tasly R&D Institute Tasly Holding Group Co. Ltd.

Salvia miltiorrhiza, a popular traditional Chinese medicine, is widely used for treatments in cardiotonic disease. Tanshinones are a group of bioactive ingredients in S. miltiorrhiza. In this study, Ce^3＋ was used as an elicitor to enhance tanshinones production in S. miltiorrhiza hairy roots. The results showed that contents of dihydrotanshinone I（DTI） and cryptotanshinone（CT） were significantly enhanced by 50 μmol/L Ce^3＋, and reached to 0.875 mg/g and 0.271 mg/g, respectively. However, tanshinone II A（TIIA） and tanshinone I（TI） contents were significantly decreased to 59% and 62% of the control. Simultaneously, expressions of genes（HMGR, DXR, DXS1, DXS2 and GGPPS） involved in tanshinone biosynthesis were upregulated by Ce^3＋. Responses of DXS1, DXS2 and GGPPS to Ce^3＋ treatments were later than HMGR and DXR. We speculated that branch pathways of DTI and CT biosynthesis were probably different from TIIA and TI. This work will help us understand biosynthetic mechanism of tanshinones in plants.

关键词： tanshinones Salvia miltiorrhiza Ce^3+ secondary metabolism rare earth element

Epigenetics in the modern era of crop improvements

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Science China Life Sciences 2025年

作者： Yan Xue Xiaofeng Cao Xiangsong Chen Xian Deng Xingwang Deng Yong Ding Aiwu Dong Chengguo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng He Hang He Shengbo He Xinjian He Yan He Yuehui He Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai Zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao Liu Bing Liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jiawei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia Jun Xiao Lin Xu Zhengyi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing Zhang Yusheng Zhao Xuehua Zhong Daoxiu Zhou Ming Zhou Yue Zhou Bo Zhu Jiankang Zhu Qikun Liu College of Life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural Sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University State Key laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Center for Crop Functional Genomics and Molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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Genome-wide identification of NAC gene family and expression analysis under abiotic stresses in Salvia miltiorrhiza

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BIOCELL 2022年第8期46卷 1947-1958页

作者： XIN LI JIANMIN PAN FAISAL ISLAM JUANJUAN LI ZHUONI HOU ZONGQI YANG LING XU zhejiang province Key laboratory of plant secondary metabolism and regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China Institute of Crop Science Ministry of Agriculture and Rural Affairs Laboratory of Spectroscopy SensingZhejiang UniversityHangzhou310058China

NAC(NAM,ATAF,CUC)is a class of transcription factors involved in plant growth regulation,abiotic stress responses,morphogenesis and *** miltiorrhiza is an important Chinese medicinal herb,but the characterization of NAC genes in this species is *** this study,based on the Salvia miltiorrhiza genomic databases,82 NAC transcription factors were identified,which were divided into 14 ***,phylogenetic analysis,gene structure,chromosomal localization and potential role of SmNACs in abiotic stress conditions were also *** results revealed that some SmNACs had different structures than others,which advised that these genes may have multiple/distinct ***-time quantitative polymerase chain reaction(RT-qPCR)analysis showed that SmNACs exhibited differential expression patterns under salt and drought *** NaCl induced salinity treatments modulated the expression of several SmNAC genes more in roots compared with ***,under drought stress conditions,more genes were upregulated in leaves compared with *** results will be useful for the further study involved in the functional characteristics of SmNAC genes,especially in response to salt and drought stresses,thereby may facilitate genetic breeding in Salvia miltiorrhiza.

关键词： Salvia miltiorrhiza Arabidopsis thaliana NAC transcription factors Genome-wide analysis Abiotic stress

Physiological Responses of Dendrobium officinale under Exposure to Cold Stress with Two Cultivars

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 599-617页

作者： Shuaishuai Zhang Jin Li Yongchang Shen Linda Nartey Korkor Qian Pu Jin Lu Balock Shakeela Dedong Kong Ou Li Guohong Zeng Xiufang Hu zhejiang province Key laboratory of plant secondary metabolism and regulation College of Life ScienceZhejiang Sci-Tech UniversityHangzhou310018China College of Agriculture and Biology Zhejiang UniversityDeqing Ecoagriculture Biotechnology Co.Ltd.Hangzhou310018China

This study aimed to explore the cold tolerance of two cultivars of Dendrobium officinale(MG1,MG2)grown in different regions of ***-2℃ incubation,cultivar MG1 remained active after 3 d,and continued to grow after returning to room ***,MG2 could only maintain its activity after 2 d treatment at−2℃,and the seedlings died with the low temperature treatment *** of the characteristics of the plants grown in the south(Hangzhou)or north(Zhengzhou)of China indicated that the leaves of MG1 also had reduced stomatal density,the highest thickness,and a compact *** contents of proline and soluble sugars were higher in MG1 than those in *** cultivar MG1 had higher SOD enzyme activity than MG2,while CAT and POD activities in samples from Zhengzhou were higher than those from *** contents of polysaccharides and alkaloids in stems of in MG1 were higher than those in MG2,while the content of flavonoids in the Zhengzhou samples was higher than that in the Hangzhou *** addition,plant heights,stem diameters,and chlorophyll content were higher in ***,MG1 had better cold resistance than ***1 is a cold tolerant cultivar with thick leaves and reduced stomatal density,higher contents of soluble sugars,proline,CAT,POD,polysaccharides,flavonoids and alkaloids,which together make it more adaptable to low ***,the cultivar MG1,with its demonstrated cold tolerance,can accordingly be grown on a large scale in cold regions,thereby expanding the available planting area for this important traditional medicinal plant to meet the increasing commercial demand for it.

关键词： Dendrobium officinale cold stress microstructure characteristics physiological characteristics biochemical characteristics

Chemico-biological conversion of carbon dioxide

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Journal of Energy Chemistry 2024年第2期89卷 371-387,I0009页

作者： Liangwei Hu Junzhu Yang Qi Xia Jin Zhang Hongxin Zhao Yuan Lu zhejiang province Key laboratory of plant secondary metabolism and regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Key laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China College of Biological and Chemical Engineering Jiaxing UniversityJiaxing 314000ZhejiangChina

The unabated carbon dioxide(CO_(2))emission into the atmosphere has exacerbated global climate change,resulting in extreme weather events,biodiversity loss,and an intensified greenhouse *** address these challenges and work toward carbon(C)neutrality and reduced CO_(2)emissions,the capture and utilization of CO_(2)have become imperative in both scientific research and *** cutting-edge approach to achieving efficient catalytic performance involves integrating green bioconversion and chemical *** innovative strategy offers several advantages,including environmental friendliness,high efficiency,and *** study provides a comprehensive review of existing technical routes for carbon sequestration(CS)and introduces two novel CS pathways:the electrochemicalbiological hybrid and artificial photosynthesis *** also thoroughly examines the synthesis of valuable Cnproducts from the two CS systems employing different catalysts and *** both systems heavily rely on electron transfer,direct and mediated electron transfer has been discussed and summarized in ***,this study explores the conditions suitable for different catalysts and assesses the strengths and weaknesses of *** also explored the biocompatibility of the electrode materials and developed novel *** materials were specifically engineered to combine with enzymes or microbial cells to solve the biocompatibility problem,while improving the electron transfer efficiency of ***,this review summarizes the relevant systems developed in recent years for manufacturing different products,along with their respective production efficiencies,providing a solid database for development in this *** novel chemical-biological combination proposed herein holds great promise for the future conversion of CO_(2)into advanced organic ***,it offers exciting prospects for utilizing CO_(2)in synthesizing

关键词： Carbon dioxide Bioelectric synthesis Artificial photosynthesis Synthetic product

Temporal control of the Aux/IAA genes BnIAA32 and BnIAA34 mediates Brassica napus dual shade responses

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Journal of Integrative plant Biology 2024年第5期66卷 928-942页

作者： Yafei Li Yiyi Guo Yue Cao Pengguo Xia Dongqing Xu Ning Sun Lixi Jiang Jie Dong Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China Key laboratory of plant secondary metabolism and regulation of zhejiang province College of Life Sciences and MedicineZhejiang Sci-TechUniversityHangzhou310018China State Key laboratory of Crop Genetics and Germplasm Enhancement College of AgricultureNanjing Agricultural UniversityNanjing 210095China Key laboratory of Growth regulation and Transformation Research of zhejiang province School of Life SciencesWestlake UniversityHangzhou 310024China

Precise responses to changes in light quality are crucial for plant growth and *** example,hypocotyls of shade-avoiding plants typically elongate under shade *** this typical shade-avoidance response(TSR)has been studied in Arabidopsis(Arabidopsis thaliana),the molecular mechanisms underlying shade tolerance are poorly *** we report that ***(Brassica napus)seedlings exhibit dual shade *** addition to the TSR,*** seedlings also display an atypical shade response(ASR),with shorter hypocotyls upon perception of early-shade ***-wide selective sweep analysis indicated that ASR is associated with light and auxin ***,genetic studies demonstrated that phytochrome A(BnphyA)promotes ASR,whereas BnphyB inhibits *** ASR,YUCCA8 expression is activated by early-shade cues,leading to increased auxin *** inhibits hypocotyl elongation,as young *** seedlings are highly sensitive to ***,two non-canonical AUXIN/INDOLE-3-ACETIC ACID(Aux/IAA)repressor genes,BnIAA32 and BnIAA34,are expressed during this early ***32 and BnIAA34 inhibit hypocotyl elongation under shade conditions,and mutations in BnIAA32 and BnIAA34 suppress ***,our study demonstrates that the temporal expression of BnIAA32 and BnIAA34 determines the behavior of *** seedlings following shade-induced auxin biosynthesis.

关键词： Brassica napus high-density planting IAA32/34 light signal transduction shade response temporal gene expression

Genome-wide identification of U-box gene family and expression analysis under abiotic stresses in Salvia miltiorrhiza

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BIOCELL 2022年第7期46卷 1751-1762页

作者： JIANMIN PAN XIN LI JUANJUAN LI HUI LIU ZHUONI HOU ZONGQI YANG LING XU zhejiang province Key laboratory of plant secondary metabolism and regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou310018China UWA School of Agriculture and Environment and The UWA Institute of Agriculture Faculty of ScienceThe University of Western AustraliaPerth6009Australia

plant U-box(PUB)E3 ubiquitin ligases play important roles in hormone signaling pathways and in response to different abiotic stresses,but little is known about U-box genes in Danshen(root of Salvia miltiorrhiza Bunge).Here,we identified and characterized 70 SmPUB genes based on its genome *** analysis of U-box genes from *** and Arabidopsis suggested that they can be clustered into seven subgroups(I–VII).Typical U-box domains were found in all identified SmPUB genes through the analysis of conserved ***,qRT-PCR was applied to analyze the relative expression levels of U-box genes in *** roots and leaves under PEG-induced water deficit and salt *** revealed that the SmPUB genes exhibited stronger response to drought than to salt *** the best of our knowledge,this report is the first to perform genome-wide identification and analysis of the U-box gene family in ***,and the results provide valuable information for better understanding of the function of U-box in ***.

关键词： Salvia miltiorrhiza U-box E3 ubiquitin ligase Gene-family Abiotic stresses Expression pattern