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Nano Research 2022年第9期15卷 8091-8100页

作者： Hui Pan Zhibin Cheng Jan Fransaer Jiangshui Luo Michael Wübbenhorst laboratory for Soft Matter and biophysics Department of Physics and AstronomyKU LeuvenLeuven 3001Belgium Fujian Key laboratory of Polymer Materials College of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007China Department of Materials Engineering KU LeuvenLeuven 3001Belgium Lab of Electrolytes and Phase Change Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610065China

High sulphur loading and lean electrolyte conditions are important to achieve the high theoretical energy density of lithiumsulphur(Li-S)***,serious problems such as low sulphur utilization and fast capacity fade are typically experienced under low electrolyte/sulphur(E/S)ratios and high sulphur loading *** address these issues,a cobaltcontaining three-dimensional conductive honeycomb(Co@N-HPC)is proposed in this work as a material for sulphur *** good electrical conductivity and high density of catalytic sites of(Co@N-HPC)allow fast redox kinetics of lithium polysulfide(LiPS)in high-sulphur-loading *** addition,the hierarchical structure and good wettability by the electrolyte of Co@NHPC facilitates electrolyte penetration and LiPS conversion,leading to a high utilization of sulphur under lean electrolyte ***,at a current density of 0.2 C,a volumetric capacity of 1,410 mAh·cm^(−3)was attained with a sulphur loading of 5.1 mg·cm^(−2)and an E/S ratio of 5μL·mg^(−1).This work provides ideas for the development of lean electrolyte Li-S batteries with a high sulphur loading.

关键词： honeycomb architecture cobalt nanoparticles high sulphur loading lean electrolyte lithium-sulphur battery

Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy

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SmartMat 2022年第2期3卷 269-285页

作者： Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan Henan Key laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Material PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhouChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Henan Key laboratory for Pharmacology of Liver Diseases Institute of Medical and Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Joint Key laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacaoChina

Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft ***,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL ***,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer *** results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.

关键词： cancer therapy carbon nanogels chemiluminescence inflammation imaging

Rhodium-catalyzed formal[4+3]annulation reaction of N-methoxybenzamides with gem–difluorocyclopropenes:A combination of experimental and theoretical studies

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Chinese Chemical Letters 2022年第6期33卷 2987-2992页

作者： Yimiao He Limei Tian Xuexue Chang Zeming Qu Yanmin Huang Chusheng Huang Qing Sun Honggen Wang Guangxi Key laboratory of Natural Polymer Chemistry and physics College of Chemistry and MaterialsNanning Normal UniversityNanning 530001China Key laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China School of pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

A rhodium-catalyzed[4+3]cycloaddition reaction between N-methoxybenzamides and gem–difluorocyclopropenes is *** reaction offers a mild and efficient approach towards the synthesis of fluorinated 2 H-azepin-2-ones with broad substrate scope.A consecutive HOAc-assisted C–N bond formation and fluorine elimination are involved as key steps for success as illustrated by detailed DFT studies.

关键词： gem-Difluorocyclopropene Fluorinated 2H-azepin-2-one C-H functionalization Oxidizing directing group Rhodium [4+3]Annulation

Influence of amphotericin B on liquid crystal state of the Cholesterol/Dipalmitoylphosphatidylcholine monolayer in the presence of different metal cations

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Chinese physics B 2016年第9期25卷 42-48页

作者：王娟史瑞新孙润广郝长春李俊花逯晓龙 laboratory of biophysics and Biomedicine College of Physics and Information TechnologyShaanxi Normal University School and Hospital of Stomatology Jilin University

Amphotericin B is a very effective antifungal drug,but it has an adverse reaction to the membrane of mammals＇ *** interaction between Am B and cholesterol（Chol） causes the formation of pores on the membrane to destroy its *** particular,Am B has a significant effect on the permeability of membrane for K~＋*** has been reported that Na＋ions and Ca^（2＋）ions may have some influence on the interaction between amphotericin B and lipid *** this work,the effects of these metal cations on the physical state and intermolecular interaction of the Cholesterol/Dipalmitoylphosphatidylcholine（Chol/DPPC） monolayer with and without Am B have been *** addition of Am B induces the change of physical state of the lipid monolayer from liquid-gel phase to liquid *** metal cations could influence the phase transition of the Am B-lipid *** K~＋ions and Ca2＋ions make the obvious phase transition ***,the presence of Na＋ions has little influence on the phase transition of the Am B-lipid *** addition of Am B and the presence of different metal cations weaken the attractive force on the *** addition of Am B,the force between the molecules is the strongest in the environment of K＋ions,thus is the weakest in the environment of Ca^（2＋）ions,which may be due to the distribution of these metal cations inside and outside of cells.A large number of K＋ions distribute inside of the cells,thus most of Na＋and Ca^（2＋）ions exist out of the ***,it may be possible that when Am B molecules are out of the cells,the reaction between the drug and lipid molecules is weaker than that inside the *** results may have a great reference value for further studying the toxicity mechanism of Am B and the influence of metal cations on the membrane.

关键词： Langmuir monolayer liquid state potassium ion intermolecular interaction

Infrared nanoimaging of nanoscale sliding dislocation of collagen fibrils

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Nano Research 2022年第3期15卷 2355-2361页

作者： Zhi Qiao Mengfei Xue Yongqian Zhao Yindong Huang Ming Zhang Chao Chang Jianing Chen Key laboratory for Physical Electronics and Devices of the Ministry of Education School of Electronic Science and EngineeringXi'an Jiaotong UniversityXi’an 710049China Innovation laboratory of Terahertz biophysics National Innovation Institute of Defense TechnologyBeijing 100071China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Institute of physics Chinese Academy of Sciences and Beijing National Laboratory for Condensed Matter PhysicsBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Neurobiology Collaborative Innovation Center for Brain Science and Shaanxi Key Laboratory of Brain DisordersSchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Songshan Lake Materials laboratory Dongguan 523808China

Collagen,one of the major components in the mammalian connective tissues,plays an essential role in many vital physiological *** common diseases,such as fibrosis,overuse injuries,and bone fracture,are associated with collagen arrangement ***,the underlying mechanism of collagen arrangement defects remains *** this study,we applied infrared scattering-type scanning near-field optical microscopy to study collagen fibrils’structural ***,we observed two types of collagen fibrils’arrangement with different periodic characteristics.A crystal sliding model was employed to explain this observation *** results suggest that the collagen dislocation propagates in collagen fibrils,which may shed light on many collagen diseases’*** findings help to understand the regulation mechanism of hierarchical biological structure.

关键词： scattering near-field optical microscopy collagen fibrils dislocation D periodicity

Mechanism for propagation of rate signals through a 10-layer feedforward neuronal network

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Chinese physics B 2009年第12期18卷 5560-5565页

作者：李捷于婉卿徐定刘锋王炜 National laboratory of Solid State Microstructure and Department of physics Nanjing University State Key laboratory of pharmaceutical Biotechnology and School of Life Nanjing University

Using numerical simulations, we explore the mechanism for propagation of rate signals through a 10-layer feed-forward network composed of Hodgkin-Huxley （HH） neurons with sparse connectivity. When white noise is afferent to the input layer, neuronal firing becomes progressively more synchronous in successive layers and synchrony is well developed in deeper layers owing to the feedforward connections between neighboring layers. The synchrony ensures the successful propagation of rate signals through the network when the synaptic conductance is weak. As the synaptic time constant Tsyn varies, coherence resonance is observed in the network activity due to the intrinsic property of HH neurons. This makes the output firing rate single-peaked as a function of Tsyn, suggesting that the signal propagation can be modulated by the synaptic time constant. These results are consistent with experimental results and advance our understanding of how information is processed in feedforward networks.

关键词： feedforward network synchrony rate coding Hodgkin-Huxley model

Structure-based simulations complemented by conventional all-atom simulations to provide new insights into the folding dynamics of human telomeric G-quadruplex

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Chinese physics B 2021年第7期30卷 646-654页

作者：边运强宋峰曹赞霞于家峰王吉华 Shandong Key laboratory of biophysics Institute of BiophysicsDezhou UniversityDezhou 253023China

The hybrid atomistic structure-based model has been validated to be effective in investigation of G-quadruplex *** this study,we performed large-scale conventional all-atom simulations to complement the folding mechanism of human telomeric sequence Htel24 revealed by a multi-basin hybrid atomistic structure-based ***,the real time-scale of folding rate,which cannot be obtained from the structure-based simulations,was estimated directly by constructing a Markov state *** results show that Htel24 may fold as fast as on the order of milliseconds when only considering the competition between the hybrid-1 and hybrid-2 G-quadruplex ***,in comparison with the results of structure-based simulations,more metastable states were identified to participate in the formation of hybrid-1 and hybrid-2 *** findings suggest that coupling the hybrid atomistic structure-based model and the conventional all-atom model can provide more insights into the folding dynamics of DNA *** a result,the multiscale computational framework adopted in this study may be useful to study complex processes of biomolecules involving large conformational changes.

关键词： molecular dynamics simulation structure-based model all-atom model DNA G-quadruplex

Evaluating the JEFF 3.1, ENDF/B‑VII.0, JENDL 3.3, and JENDL 4.0 nuclear data libraries for a small 100 MWe molten salt reactor with plutonium fuel

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Nuclear Science and Techniques 2022年第12期33卷 173-189页

作者： Cici Wulandari Abdul Waris Sidik Permana Syeilendra Pramuditya Department of physics Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungBandung 40132Indonesia Nuclear physics and biophysics Research Division Department of PhysicsFaculty of Mathematics and Natural SciencesInstitut Teknologi BandungBandung 40132Indonesia Department of Nuclear Science and Engineering Faculty of Mathematics and Natural SciencesInstitut Teknologi BandungJl.Ganesa 10Bandung 40132Indonesia

This study evaluated the nuclear data libraries for a small 100 Mega Watt electric(MWe)Molten Salt Reactor with plutonium *** reactor has a power output of 100 MWe,which meets the demand for electricity generation in several regions or provinces outside Java *** nuclear data libraries,such as JEFF 3.1,ENDF/B-VII.0,JENDL 3.3,and JENDL 4.0,were used for a more comprehensive ***–BeF_(2)–ThF_(4)–PuF_(4) was used as the initial fuel *** thorium and plutonium concentrations in the fuel salt were varied to obtain the optimum fuel composition,leading to critical *** results showed some neutronic parameters,such as the conversion ratio,neutron spectra,and effective multiplication factors,from three different nuclear data *** changing the plutonium concentration in the initial fuel salt composition,the minimum plutonium loaded for the reactor criticality during 2000 days of operation time was determined to be 0.995,0.91,0.87,and 0.90 mol%for JEFF 3.1,ENDF/B-VII.0,JENDL 3.3,and JENDL 4.0,*** differences in the values of each parameter were due to several factors,such as the cross-section values and number of nuclides in the nuclear data *** safety parameters were also investigated to ensure the possibility of utilizing PuF_(4) in the reactor.

关键词： Neutronics Plutonium Small MSR Thorium SRAC

A single-point measurement scheme for quantum work based on the squeezing state

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Communications in Theoretical physics 2021年第6期73卷 51-58页

作者：徐宝明邹健涂展春 Shandong Key laboratory of biophysics Institute of BiophysicsDezhou UniversityDezhou 253023China School of physics Beijing Institute of TechnologyBeijing 100081China Department of physics Beijing Normal UniversityBeijing 100875China

To investigate the role of initial quantum coherence in work-probability distribution,it is necessary to consider an incomplete or partial measurement,in which the energy cannot be fully discriminated by the *** this paper,we use a harmonic oscillator with a coherent or squeezing state to realize this incomplete or partial measurement,and propose a unified framework of quantum work statistics for a closed system with an arbitrary initial *** find that work is proportional to the change of the real part of the coherent state parameter,i.e.,quantum work can be estimated by the coherent state *** resulting work-probability distribution includes the initial quantum coherence,and can be reduced to the result of the traditional two projective energy measurement scheme(TPM)by squeezing the state of the harmonic *** measurement scheme reveals the fundamental connections between measurement error and coherent *** introducing a‘coherent work-to-noise ratio’,we find the optimal measurement error,which is determined by the energy difference between the superposed energy *** an application,we consider a driven two-level system and investigate the effects of driving velocity on work *** find that only when the driving velocity matches the transition frequency of the system can initial quantum coherence play an important role.

关键词： work distribution quantum coherence coherent state squeezing state

Naringenin reduces lung metastasis in a breast cancer resection model

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Protein & Cell 2011年第6期2卷 507-516页

作者： Lei Qin Lingtao Jin Linlin Lu Xiaoyan Lu Chunling Zhang Fayun Zhang Wei Liang Protein&Peptide pharmaceutical laboratory National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Graduate University of Chinese Academy of Sciences Beijing 100049China pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China

Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients.

关键词： naringenin breast cancer surgery metastasis immunosuppression Tregs