Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy

作     者：Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan 

作者机构：Henan Key Laboratory of Diamond Optoelectronic Materials and DevicesKey Laboratory of Material PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhouChina Department of Respiratory and Critical Care MedicineThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Henan Key Laboratory for Pharmacology of Liver DiseasesInstitute of Medical and Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Joint Key Laboratory of the Ministry of EducationInstitute of Applied Physics and Materials EngineeringUniversity of MacaoMacaoChina 

出 版 物：《SmartMat》 (智能材料（英文）)

年 卷 期：2022年第3卷第2期

页      面：269-285页

核心收录：

学科分类：1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.12074348,U2004168,U1904142,and U21A2070) the China Postdoctoral Science Foundation(No.2020M682310) the Natural Science Foundation of Henan Province(No.212300410078) Science and Technology Department of Henan Province(No.182102410010) 

主　　题：cancer therapy carbon nanogels chemiluminescence inflammation imaging 

摘      要：Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft ***,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL ***,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer *** results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents.