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Effects of Danqu Capsules on Arterial Blood Pressure,Heart Rate and Myocardial Tension Time Index in Rats

medicinal plant 2019年第4期10卷 37-43页

作者： Jinfeng CHEN Li JING Cong GAO Renming XIE Zhongyi LEI Chaofeng LIU Hong FAN Shaanxi Provincial Hospital of Traditional Chinese Medicine Xi'an 710003 China Pharmacology laboratory of Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003 China Xi'an Peihua University Xi'an 710000 China Northwest University Xi'an 710127 China

[Objectives] To explore the effects of Danqu capsules(the prescription of Lei Zhongyi, the master of traditional Chinese medicine for the syndrome of intermingling of phlegm and static blood of coronary heart disease) on arterial blood pressure, heart rate and myocardial tension time index in rats. [Methods] A total of 50 SD rats, weighing(300±20) g, were randomly and evenly divided into Danqu capsule observation groups(low, middle and high-dose groups) and control groups(saline group and captopril group). Under anesthesia, the rats in each group were administered with 0.6, 1.2 and 2.4 g/kg of Danqu capsule suspension, 1 mL/100 g of saline and 10 mg/kg of captopril, respectively through duodena, and their systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure difference and heart rate were measured and recorded by RM6240 multi-channel physiological signal acquisition and processing system before administration, 10, 20, 30, 40, 50, 60, 90 and 120 min after the administration, respectively, and the myocardial tension time index was calculated. [Results] Compared with the saline group, the systolic, diastolic and mean pressure reduced 10, 20, 30, 40, 50, 60, 90 and 120 min after the administration, and the pulse pressure difference did not change significantly in the Danqu capsule groups(low, middle and high-dose groups), and the heart rate slowed down and the myocardial tension time index reduced in the high-dose Danqu capsule group. Compared with the captopril group, the Danqu capsule groups showed similar blood pressure-reducing effect. [Conclusions]Danqu capsules have obvious effect of lowering blood pressure and myocardial tension time index. High-dose Danqu capsules has the effect of slowing down the heart rate. The blood pressure-lowering effect of Danqu capsules shows a dose-dependent manner. Clinically, they can be used in patients with coronary heart diseases and hypertension, suggesting that they should be used with caution

关键词： Danqu capsules Hypertension Heart rate Myocardial tension time index

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Role of Notoginsenoside Rg1 in Improving Spatial Cognitive Ability and Lowering Phosphorylation Level of Tau Protein in AD Model Rats

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medicinal plant 2018年第2期9卷 73-77页

作者： Muzhe LI Wenhui WU Zhiping WU Meiling REN Shuxian CHEN Xiaoling GUO Ping WANG Li LIN Cell Biology laboratory College of Basic MedicineHubei University of Chinese Medicine/Hubei Research Institute of Geriatrics/New Products of TCM Senile Diseases Co-Innovation Center of Hubei Shuiguohu Street Community Health Service Center of Wuchang District

[Objectives] To study the effects and mechanism of notoginsenoside Rg1 on the spatial learning and memory and phosphorylated tau protein in the AD( Alzheimer's Disease) model rat. [Methods]The AD model rat was replicated by injection of Aβ_(25-35) in the left lateral ventricles of SD rats. The low dose( 25 mg/kg),middle dose( 50 mg/kg) and high dose( 100 mg/kg) notoginsenoside Rg1 was used for intragastric administration,respectively,two times every day. After 4 weeks,the Morris water maze test was done to detect the learning and memory capacity,and the immunoblotting,immunohistochemical methods were used to detect the changes in the phosphorylation level and distribution of tau protein in hippocampus of the rats. [Results] After the intracerebroventricular injection of Aβ_(25-35),the learning and memory capacity of the model rats was significantly lower than the learning and memory capacity of the normal control rats. The immunoblotting test results showed that the phosphorylation level of tau protein threonine 231 site( Thr231) in hippocampus was significantly increased,and the nonphosphorylation level was significantly decreased. The morphological testing results showed that the phosphorylation level of tau protein Thr231 of AD model rats was increased markedly in region of DG,CA1 and CA3 of the hippocampus. The intervention of the middle dose notoginsenoside Rg1 could significantly improve the learning and memory capacity of the model rats in Morris water maze. The notoginsenoside Rg1 in three different doses could all reduce the phosphorylation level of tau protein Thr231 in the hippocampal DG,CA1,CA3 regions,and there were no significant differences among the three doses. [Conclusions]The notoginsenoside Rg1 could improve Aβ_(25-35)-induced spatial learning and memory impairment of the AD model rats,and decreased the phosphorylation level of tau protein in hippocampus.

关键词： Notoginsenoside Rg1 Alzheimer’s disease Learning and memory Phosphorylated tau protein

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GC-MS Analysis of Liposoluble Components in Seeds of Bitter Gourd from Different Sources

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medicinal plant 2019年第5期10卷 14-17页

作者： Ziji LIU Jie ZHU Yu NIU Yan YANG Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences/Key Laboratory of Crop Gene Resources and Germplasm Enhancement in South ChinaMinistry of AgricultureDanzhou 571737China College of Horticulture Hainan UniversityHaikou 570228China

[Objectives]This paper aimed to analyze the liposoluble components in seeds of different bitter gourd germplasms.[Methods]Taking 3 bitter gourd germplasms from different sources as materials,the composition and relative contents of liposoluble components in the seeds were analyzed using gas chromatography-mass spectrometry(GC-MS).[Results]A total of 22,18 and 18 compounds were detected from Papua,Y7 and Y108,respectively,accounting for 38.63%,90.20%and 92.53%of the total liposoluble *** them,eight liposoluble components were unique to Papua,and two liposoluble components were unique to *** composition and relative contents of liposoluble components differ among different bitter gourd *** main chemical components wereγ-tocopherol,vitamin E,andβ-*** content ofγ-tocopherol was high in the three germplasms,accounting for 8.885%,20.090%and 20.314%,respectively.[Conclusions]This study can lay the foundation for breeding functional bitter gourd varieties.

关键词： Bitter gourd Liposoluble component Gas chromatography-mass spectrometry

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Experimental Study on Analgesia and Hemostasis of Paris polyphylla,Scutellaria baicalensis and Their Compatibility

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medicinal plant 2020年第2期11卷 33-37页

作者： Shibo ZHAO Suoyi HUANG Zhenjing SI Lanlan GAN Shusheng HUANG Ye FU Jianjie LAN Xueying YU Yuekong CEN College of Clinical Medicine Youjiang Medical University for Nationalities Baise 533000 China College of Pharmacy Youjiang Medical University for Nationalities Baise 533000 China Key laboratory of Guangxi Universities on National Medicine in Youjiang River Youjiang Medical University for Nationalities Baise 533000 China

[Objectives]The analgesic and hemostatic effects of Paris polyphylla,Scutellaria baicalensis,and their compatibility were studied.[Methods](i)In the experiment on the writhing of mice induced by acetic acid,60 Kunming SPF mice were randomly selected,and were randomly divided into 6 groups according to the male-to-female ratio of 1∶1,including blank control group,*** group,*** group,and three *** and *** compatibility groups(with the ratio of 1∶2,1∶1 and 1∶2).There were 10 mice in each *** the experimental groups,the mice were given 1 g/mL Chinese medicine extract according to a dose of 20 mL/*** the control group,the mice were given 0.9%normal saline in equal *** was performed one time every 24 h and lasted for 14 d.1 h after the gavage on the 14th day,they were given 0.5%glacial acetic acid solution via intraperitoneal injection.(ii)In the hot plate experiment,60 Kunming SPF mice were selected,and the ratio of male to female,grouping,administration and gavage were the same as those of the glacial acetic acid-induced writhing *** was lasted for 14 d.1 h after the gavage on the 14th day,the mice were placed on a hot plate apparatus at(55±0.5)℃,and the time of licking hindfoot was measured.(iii)The hemostatic effect was explored through three experimental methods of tail hemostasis,femoral artery hemostasis and liver hemostasis.60 Kunming SPF mice were taken in each of the three experiments,and the male-female ratio and grouping were the same as *** powder was covered on the surface of the wound sites,and the bleeding was *** hemostatic time was recorded,and the hemostatic time was recorded as 3 min if it exceeded 3 min.[Results](i)In the acetic acid-induced writhing experiment,compared with the blank control group,the pain of mice in the experimental groups was *** them,*** group,*** group,compatibility 1∶2 group,compatibility 1∶1 group,and compatibilit

关键词： Paris polyphylla Scutellaria baicalensis Compatibility Analgesic effect Hemostatic effect

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A Preliminary Study on Anti-inflammatory and Analgesic Effects of Millettia speciosa and Tinpspora sinensis and Their Compatibility

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medicinal plant 2020年第1期11卷 32-36页

作者： Shibo ZHAO Suoyi HUANG Xinpeng CHEN Huanhui DENG Zhi PAN Kairen XIE Haoming YU Fen MO College of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China College of Pharmacy Youjiang Medical University for NationalitiesBaise 533000China Youjiang Medical University for Nationalities Key Laboratory of Guangxi Universities on National Medicine in Youjiang River BasinBaise 533000China

[Objectives]To study the anti-inflammatory and analgesic effects of Millettia speciosa and Tinpspora sinensis and their compatibility.[Methods](i)In the glacial acetic acid writhing experiment,60 SPF-grade Kunming mice were adopted,and the mice were randomly divided into 6 groups at male-female ratio of 1∶1,namely,the blank control group,*** group,*** group,*** compatible with *** group at the ratio of 1∶2(expressed as 1∶2 compatibility group),*** compatible with *** group at the ratio of 1∶1(expressed as 1∶1 compatibility group),and *** compatible with *** group at the ratio of 2∶1(expressed as 2∶1 compatibility group),12 mice for each *** of the experimental groups were administered at a dose of 20 mL/kg,and the corresponding concentration of the Chinese medicine extract was given at 1 g/*** control group was administered with an equal volume of 0.9%physiological saline,and was intragastrically administered once every 24 h for 14 *** intragastric administration for one hour on day 14,intraperitoneal injection of 0.5%glacial acetic acid solution was performed to induce pain.(ii)In the hot plate experiment,60 Kunming female SPF mice were adopted,grouped,intragastrically administered with the same glacial acetic acid writhing experiment for 14 *** intragastric administration for one hour on day 14,the mice were placed on a hot plate apparatus at(55±0.5)℃.to measure the time of licking their hind feet.(iii)In the anti-inflammatory experiment,60 Kunming SPF mice were adopted,grouped,intragastrically administered with the same glacial acetic acid writhing experiment for 14 *** intragastric administration for one hour on day 14,xylylene was administered to the left ears of mice at a dose of 50μL/piece to induce inflammation.[Results](i)In the glacial acetic acid writhing experiment,compared with the blank control group,the experimental group showed analgesic ***,*** grou

关键词： Millettia speciosa Tinpspora sinensis Compatibility Anti-inflammatory effects Analgesic effects

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Chemical Composition, Proapoptotic and Antiosteoporosis Activities of the Essential Oil from the Aerial Part of <i>Alpinia officinarum</i>Hance

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Chinese Medicine 2018年第3期9卷 144-164页

作者： Yang Wang Ji Chen Keda Zhang Weigang Wu Lanlan Ge Haoqiang Wan Jiemei Li Jun Tian Xiaobin Zeng Key Lab for New Drug Research of TCM and Shenzhen Branch State R&D Centre for Viro-Biotech Research Institute of Tsinghua University in Shenzhen Shenzhen China Center Lab of Longhua Branch Shenzhen People’s Hospital Second Clinical Medical College of Jinan University Shenzhen China Shenzhen Hanyu Pharmaceutical Co. Ltd Shenzhen China Department of Orthopedics Shenzhen People’s Hospital 2nd Clinical Medical College of Jinan University Shenzhen China Department of Infectious Disease Shenzhen People’s Hospital 2nd Clinical Medical College of Jinan University Shenzhen China College of Life Science Jiangsu Normal University Xuzhou China Guangdong Key laboratory for Research and Development of Natural Drugs Guangdong Medical University Zhanjiang China

Background: Alpinia officinarum Hance is valued as an edible medicinal plant. The rhizome is widely reported to have anticancer activity whereas little information is available on the aerial part. This study investigates chemical composition, proapoptotic and anti-osteoporosis activities of essential oil from aerial parts of A. officinarum (APEO). Methods: In this study, APEO was extracted by hydrodistillation and analyzed using GC-MS. The inhibitive activity of 0 - 2.5 μL/mL. APEO was investigated using MTT assay, while in vivo effect was evaluated in nude mice. The cell cycle, apoptosis, Δψm and expression of proteins analyses influenced by 0 - 0.313 μL/mL APEO were detected by PI, Annexin V/PI, JC-1, and Western blot, respectively. Alkaline phosphatase activity and mineralized nodules formation of rat osteoblasts with 0 - 0.156 μL/mL APEO were assayed using colorimetric method and alizarin red staining, respectively. Results: Total 45 constituents were identified accounting for 91.1% of APEO (sesquiterpene hydrocarbons for 44.4%). APEO significantly inhibited cancer cells growth in a dose-dependent manner. APEO also inhibited cancer growth in vivo. The percentage of S phase cells is up to 64.846% with 0.313 μL/mL APEO. The proportion of total apoptotic cells significantly increased to 79.6% at 0.313 μL/mL concentration. APEO treated cells accompanied with Bcl-2 and Δψm decrease, and caspase-3 and p53 upregulation. Furthermore, addition of APEO in rat osteoblasts led to a dose-dependent increase in ALP activity and formation of mineralized bone nodules. Conclusions: Our data suggest that APEO could be developed as an agent against human lung cancer and osteoporosis, especially cancer-induced bone loss.

关键词： Alpinia officinarum Hance Essential Oil Cancer Apoptosis Anti-Osteoporosis

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Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker

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TMR Modern Herbal Medicine 2020年第2期3卷 86-112页

作者： Hui Peng Peng Lu Yiting Liu Chuanxin Liu Yanquan Gao EbukaOlisaemeka Nwafor Yuelin Zhang Zhidong Liu Tianjin State Key laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjinChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijingChina

Lianqiao(Forsythia suspensa(Thunb.)Vahl,Abbreviated as“***”below)is traditional Chinese medicine in China,widely distributed all over the country and also highly rich in *** Northwest Territories is a genuine producing *** are many chemical components in ***,including lignans,phenylethanolic glycosides,flavonoids,C6-C2 natural alcohols and their glycosides,phenolic acids,terpenes and volatile *** them,lignans and phenylethanolic glycosides are the main active *** on the review of chemical components or constituents and main pharmacological activities,according to the definition of quality marker,the components of quality marker of *** were predicted and analyzed from the aspects of plant genetics and chemical composition,traditional efficacy,traditional medicine,new efficacy,blood entering composition,measurable composition,effective composition in different compatibility,and the influence of storage conditions of *** research on its medicinal active ingredients will provide scientific basis for the evaluation of *** quality.

关键词： F. suspensa Phenylethanol glycosides Lignans Quality control Q-marker

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Phenotypic Diversity of Different Populations of Paeonia ludlowii in Nyingchi of Tibet

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medicinal plant 2019年第4期10卷 62-65页

作者： Qingsong GE Yi GAO Hang WANG Jiangping FANG Res. Institute of Tibet Plateau Ecology Tibet Agriculture & Animal Husbandry University Nyingchi 860000 China Tibet Key laboratory of Forest Ecology in Plateau Area Ministry of Education Nyingchi 860000 China National Key Station of Field Scientific Observation & Experiment Nyingchi 860000 China Key laboratory of Forest Ecology in Plateau Area Tibet Autonomous Region Nyingchi 860000 China United Key Laboratories of Ecological Security Tibet Autonomous Region Nyingchi 860000 China Resources & Environment College Tibet Agriculture & Animal Husbandry University Nyingchi 860000 China Food Science College Tibet Agriculture & Animal Husbandry University Nyingchi 860000 China

[Objectives] To study the differences in fruit traits of different populations of Paeonia ludlowii , and to provide basic data for the identification, protection and utilization of germplasm resources of P. ludlowii .[Methods] Nine fruit traits of three different populations of P. ludlowii in Tibet were tested and analyzed.[Results] The mean values of 9 fruit traits of P. ludlowii were different in different populations;the coefficients of variation of different traits of different populations were also different;there were morphological differences of different sizes among individuals in each population;there were significant differences in 8 traits (pod length, pod width, pod thickness, pod weight, seeds per pod, seed length, seed width, and seed weight) among different populations. Among the 9 traits of the three P. ludlowii populations, the variability of the five traits was higher in the fruit pods, the variation degree of five traits including pod weight, pod thickness, seeds per pod, and seed weight was higher. It is of great significance for the screening and preservation of the germplasm resources of P. ludlowii . According to the principal component analysis (PCA), the seed weight, seed width, and seed length, i.e. the seed traits, were the main factors causing differences in fruit traits among populations. There was a certain correlation between different traits of P. ludlowii . Among the 36 Pearson- related combinations of 9 fruit traits, 11 combinations had extremely significant correlations, and 8 combinations had significant correlations, indicating that there was a certain correlation between fruit traits in the growth and development. Through cluster analysis, three populations of P. ludlowii can be divided into two categories. The BV population was a category, which is characterized by long pods, long seeds, wide seeds, thick seeds and large seed weight. Therefore, the BV population is suitable material for breeding excellent varieties.[Conclusions

关键词： Paeonia ludlowii Different populations Fruit traits Diversity

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Determination of Enantiomers in ET-26-HCl by Ultra Performance Convergence Chromatography

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medicinal plant 2021年第3期12卷 62-64页

作者： Yaru MA Ting KANG Zhihua CAO Jianrui MU Xianghan YE Hanlin GONG Liying QIU School of Pharmacy Southwest Minzu University Chengdu 610041 China laboratory of Anesthesia & Critical Care Medicine Translational Neuroscience Center West China Hospital of Sichuan University Chengdu 610041 China Department of Integrated Traditional Chinese and Western Medicine of West China Hospital Sichuan University Chengdu 610041 China

[Objectives]To establish an ultra performance convergence chromatography(UPC2)method to determine the content of enantiomers in(R)-2-methoxyethyl1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride(ET-26 HCl).[Methods]ChiralpakAD-3 chromatographic column(4.6 mm×100 mm,3μm)was used,with 0.1%diethylamine methanol solution-supercritical carbon dioxide(1∶9)as mobile phase;flow rate 2.0 mL/min;back pressure 2000 psi,detection wavelength 240 nm,and column temperature 35℃.[Results]ET-26-HCl was completely separated from the enantiomers,and the linear relationship was good;the detection limit was 1.5μg/mL.[Conclusions]This method is suitable for the determination of the content of enantiomers in ET-26-HCl.

关键词： Ultra performance convergence chromatography(UPC2) ET-26 HCl Enantiomers

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Optimization of Ultrasonic Extraction Process of Oenanthe benghalensis Polysaccharide by Orthogonal Test

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medicinal plant 2018年第5期9卷 23-26页

作者： Liufu LU Aiyue LUO Bingyang LIN Zhenlian XIE Guangyu GAN Xiuzhen HUANG Zhidong LEI Shimei CHEN Suoyi HUANG School of Clinical Medicine Youjiang Medical University for Nationalities School of Pharmacy Youjiang Medical University for Nationalities School of Pharmacy Guangxi University of Chinese Medicine Basic Medical College Youjiang Medical University for Nationalities Key laboratory of Characteristic Ethnic Medicine Research in Youjiang River Basin of Guangxi Colleges and Universities Youjiang Medical University for Nationalities

[Objectives] The research aimed to explore extraction method of Oenanthe benghalensis polysaccharide,and determine the optimal process of its ultrasonic extraction by orthogonal test. [Methods] Phenol-sulfuric acid method was used to determine polysaccharide's content. Based on single-factor experiment and orthogonal test,the influences of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide were studied,and the optimal process of ultrasonic extraction was selected. [Results] The influence order of solid-liquid ratio( A),ultrasonic extraction temperature( B),ultrasonic power( C) and ultrasonic time( D) on extraction rate of O. benghalensis polysaccharide was A > D > B > C. Via the orthogonal test,it was determined that the optimal extraction condition of O. benghalensis polysaccharide was as below: solid-liquid ratio 1∶ 25( g/mL),extraction temperature 60℃,extraction power 80 W,extraction time 40 min. Under the condition,extraction rate of O. benghalensis polysaccharide was9. 80%. [Conclusions] The process could provide the reference basis for extracting and producing O. benghalensis polysaccharides.

关键词： Orthogonal test Oenanthe benghalensis Polysaccharide Ultrasonic method

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