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Unlocking the potential of transdermal drug delivery

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International Journal of Smart and Nano Materials 2024年第3期15卷 432-468页

作者： Shuang Li Jianhao Wu Xiangjun Peng Xi-Qiao Feng Institute of Biomechanics and medical engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijingChina

Transdermal drug delivery(TDD)has gained clinical approval over several decades,with extensive research dedicated to novel drug and device *** notable research progress,the mar-ket adoption of TDD devices has not met anticipated levels,with oral administration and injection remaining predominant delivery *** maximize the potential of TDD,we identify bottlenecks hinder-ing its widespread clinical application and propose promising research *** begin by analyzing stringent demands necessary to truly benefit patients,addressing significant challenges in biomechanics,nanomedicine,and flexible ***,we delve into skin anatomy,enhancement strategies,nano-carriers,and their under-lining mechanisms,highlighting the importance and framework of quantitative *** on these discussions,we highlight the core strength of TDD,such as automatic precise administration based on feedback and high delivery efficiencies,especially applicable to localized conditions(e.g.,central nervous system diseases,tumors).Finally,we envision the future of intelligent TDD device and its opera-tion scenario,aiming to steer research efforts toward faster translation of laboratory innovations into widely used products for sufferers.

关键词： Transdermal drug delivery biomechanics nanomedicine flexible electronics

Traceable Lactate-Fueled Self-Acting Photodynamic Therapy against Triple-Negative Breast Cancer

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Research 2024年第3期2024卷 723-733页

作者： Yifan Zhang Guangle Feng Ting He Min Yang Jing Lin Peng Huang Marshall laboratory of Biomedical engineering International Cancer CenterShenzhen Key Laboratory of Tumor Visualization Molecular MedicineLaboratory of Evolutionary Theranostics(LET)School of Biomedical EngineeringShenzhen University Medical SchoolShenzhen UniversityShenzhen518055China.

The depth of light penetration and tumor hypoxia restrict the efficacy of photodynamic therapy(PDT)in triple-negative breast cancer(TNBC),while the overproduction of lactate(LA)facilitates the development,aggressiveness,and therapy resistance of *** address these issues,a self-acting PDT nanosystem(HL@hMnO_(2)-LO_(x)@HA)is fabricated by loading 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha(HPPH),luminol,and LA oxidase(LO_(x))in a hyaluronic acid(HA)-coated hollow manganese dioxide(hMnO_(2))***_(x) catalyzes the oxidation of LA into pyruvate and hydrogen peroxide(H_(2)O_(2)),thus depleting the overproduced intratumoral *** the acidic tumor microenvironment,H_(2)O_(2) reacts with luminol and hMnO_(2) to yield blue luminescence as well as O_(2) and Mn^(2+),***^(2+)could further enhance this *** is then excited by the chemiluminescence through chemiluminescence resonance energy transfer for self-illuminated *** generated O_(2) alleviates the hypoxia state of the TNBC tumor to produce sufficient 1O_(2) for self-oxygenation *** Mn^(2+)performs T1 magnetic resonance imaging to trace the self-acting PDT *** work provides a biocompatible strategy to conquer the limits of light penetration and tumor hypoxia on PDT against TNBC as well as LA overproduction.

关键词： Breast Therapy manganese

Transfer film effects induced by 3D-printed polyether-ether-ketone with excellent tribological properties for joint prosthesis

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Bio-Design and Manufacturing 2024年第1期7卷 43-56页

作者： Yang Li Jibao Zheng Changning Sun Dichen Li State Key laboratory for Manufacturing System engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China National medical Products Administration(NMPA)Key laboratory for Research and Evaluation of Additive Manufacturing medical Devices Xi’an Jiaotong UniversityXi’an 710054China

Based on the building principle of additive manufacturing,printing orientation mainly determines the tribological properties of joint *** this study,we created a polyether-ether-ketone(PEEK)joint prosthesis using fused filament fabrication and investigated the effects of printing orientation on its tribological properties using a pin-on-plate tribometer in 25% newborn calf *** ultrahigh molecular weight polyethylene transfer film is formed on the surface of PEEK due to the mechanical capture of wear debris by the 3D-printed groove morphology,which is significantly impacted by the printing orientation of *** the printing orientation was parallel to the sliding direction of friction,the number and size of the transfer film increased due to higher steady *** transfer film protected the matrix and reduced the friction coefficient and wear rate of friction pairs by 39.13%and 74.33%,***,our findings provide a novel perspective regarding the role of printing orientation in designing knee prostheses,facilitating its practical applications.

关键词： 3D printing orientation Transfer film Tribological properties Polyether-ether-ketone Knee prosthesis

Single nanozyme-based colorimetric biosensor for dopamine with enhanced selectivity via reactivity of oxidation intermediates

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Chinese Chemical Letters 2024年第10期35卷 399-403页

作者： Caixia Zhu Qing Hong Kaiyuan Wang Yanfei Shen Songqin Liu Yuanjian Zhang Jiangsu engineering laboratory of Smart Carbon-Rich Materials and Devices Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical ResearchSchool of Chemistry and Chemical EngineeringMedical SchoolSoutheast UniversityNanjing 211189China

Reliable and selective sensing of dopamine(DA)is essential for early diagnosis of mental *** the various potential methods,nanozyme-based sensing systems have demonstrated promising sensitivity and ***,owing to the lack of substrate specificity,it is challenging to selectively detect DA using ***,based on the reactivity of the DA oxidation intermediates,we report a cascade colorimetric sensing system for the selective detection of DA using only a single *** was disclosed that the oxidation product of DA catalyzed by Co-N-doped carbon sheets(Co-N-C,a common oxidase-like nanozyme),dopamine quinone(DAQ),showed significant biocatalytic electron-donating activity in the reduction of O_(2)to generate O_(2)·-.Further using O_(2)·-to oxidize3,3,5,5-tetramethylbenzidine(TMB),a colorimetric sensing platform for DA was constructed with a linear detection range of 50 nmol/L to 50μmol/L and a low limit of detection of 4 nmol/*** to the reactivity of the oxidation product,without any biometric units(such as nucleic acids,enzymes,and antibodies/antigens),the reaction selectivity of DA against other interferences(e.g.,ascorbic acid,adrenaline,5-hydroxytryptamine,and glutathione)was enhanced up to *** complicated cascade systems requiring at least two nanozymes,sophisticated artificial recognition via multiple interactions was simplified by exploiting the oxidative properties of product intermediates;thus,only a single common oxidase-like nanozyme was *** work offers a new strategy to enhance the selectivity of nanozymes for bioanalytical applications.

关键词： Nanozyme Colorimetry Selectivity Dopamine Artificial recognition

Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition

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Chinese Chemical Letters 2024年第6期35卷 456-461页

作者： Chenlu Huang Xinyu Yang Qingyu Yu Linhua Zhang Dunwan Zhu Tianjin Key laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tumor *** overcome these,we formulated targeted and multifunctional polymersomes ABC@ICGIMQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(IMQ)and photosensitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator NH_(4)HCO_(3) in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic *** AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conversion efficiency,effective reactive oxygen species generation,high tumor *** could be effectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs *** synergistic photoimmunotherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic immune response to eradicate primary tumors and inhibit the growth of distant ***,the endurable immunological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.

关键词： Polymersomes Phototherapy Immunotherapy TLR 7/8 agonist Gas-generating

Unveiling the next generation of MRI contrast agents:current insights and perspectives on ferumoxytol-enhanced MRI

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National Science Review 2024年第05期11卷 385-404页

作者： Guangxiang Si Yue Du Peng Tang Gao Ma Zhaochen Jia Xiaoyue Zhou Dan Mu Yan Shen Yi Lu Yu Mao Chuan Chen Yan Li Ning Gu Jiangsu Key laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast University Key laboratory for Bio-Electromagnetic Environment and Advanced medical Theranostics School of Biomedical Engineering and InformaticsNanjing Medical University Department of Radiology the First Affiliated Hospital of Nanjing Medical University MR Collaboration Siemens Healthineers Ltd. Department of Radiology Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School School of Mathematical Sciences Capital Normal University Nanjing Key laboratory for Cardiovascular Information and Health engineering Medicine Institute of Clinical Medicine Nanjing Drum Tower HospitalMedical SchoolNanjing University

Contrast-enhanced magnetic resonance imaging(CE-MRI) is a pivotal tool for global disease diagnosis and management. Since its clinical availability in 2009, the off-label use of ferumoxytol for ferumoxytol-enhanced MRI(FE-MRI) has significantly reshaped CE-MRI practices. Unlike MRI that is enhanced by gadolinium-based contrast agents, FE-MRI offers advantages such as reduced contrast agent dosage, extended imaging windows, no nephrotoxicity, higher MRI time efficiency and the capability for molecular imaging. As a leading superparamagnetic iron oxide contrast agent, ferumoxytol is heralded as the next generation of contrast agents. This review delineates the pivotal clinical applications and inherent technical superiority of FE-MRI, providing an avant-garde medical-engineering interdisciplinary lens, thus bridging the gap between clinical demands and engineering innovations. Concurrently, we spotlight the emerging imaging themes and new technical breakthroughs. Lastly, we share our own insights on the potential trajectory of FE-MRI, shedding light on its future within the medical imaging realm.

关键词： ferumoxytol contrast agent contrast-enhanced MRI ferumoxytol-enhanced MRI

Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury

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Neural Regeneration Research 2024年第3期19卷 629-635页

作者： Jingzhou Liu Xin Xin Jiejie Sun Yueyue Fan Xun Zhou Wei Gong Meiyan Yang Zhiping Li Yuli Wang Yang Yang Chunsheng Gao State Key laboratory of Toxicology and medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijingChina Academy of medical engineering and Translational Medicine Medical CollegeTianjin UniversityTianjinChina

Traumatic brain injury results in neuronal loss and glial scar *** neurons and eliminating the consequences of glial scar formation are essential for treating traumatic brain *** reprogramming is a promising strategy to convert glial scars to neural ***,previous studies have reported inconsistent *** this study,an AAV9P1 vector incorporating an astrocyte-targeting P1 peptide and glial fibrillary acidic protein promoter was used to achieve dual-targeting of astrocytes and the glial scar while minimizing off-target *** results demonstrate that AAV9P1 provides high selectivity of astrocytes and reactive ***,neuronal reprogramming was induced by downregulating the polypyrimidine tract-binding protein 1 gene via systemic administration of AAV9P1 in a mouse model of traumatic brain *** summary,this approach provides an improved gene delivery vehicle to study neuronal programming and evidence of its applications for traumatic brain injury.

关键词： AAV9P1 astrocytes astrocyte-to-neuron conversion GFAP promoter glial scar induced neurons neuronal reprogramming P1 peptide PTBP1 traumatic brain injury

Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition

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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang Xinru Kong Xueli Ren Yandai Lin Zhe Liu Academy of medical engineering and Translational Medicine Tianjin UniversityTianjin 300072China Tianjin Key laboratory of Brain Science and Neural engineering Tianjin UniversityTianjin 300072China

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

Concentration sensing system with monolithic InGaN/GaN photonic chips

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Chinese Optics Letters 2024年第6期22卷 170-176页

作者： Feifei Qin Xueyao Lu Yang Chen Xumin Gao Yue Cao Lei Zhang Junfeng Lu Xiaoxuan Wang Gangyi Zhu Yongjin Wang GaN Optoelectronic Integration International Cooperation Joint laboratory of Jiangsu Province College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China College of Physics and Key laboratory of Aerospace Information Materials and Physics(MIIT) Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key laboratory of Digital medical engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Using an identical monolithic InGaN/GaN light emitting diode (LED) array as the sensing module and a well-designed data processing module, we demonstrate a small-size concentration sensing prototype. Overlap between the emission and the response spectra of the InGaN/GaN LED makes each pair of LEDs in the arrayed chip form a sensing channel. The changes in liquid concentration can be transformed into variation of photocurrent. The system's sensing properties are further optimized by varying the position, number of receivers, and packaging reflectors. With methyl orange as a tracer agent, the sensing system's resolution is 0.286 μmol/L with a linear measurement region below 40 μmol/L.

关键词： InGaN/GaN diodes array liquid concentration sensing coexistence of luminescence detection