Trojan horses in tumor:engineered pyroelectric and photodynamic nanocomposites for NIR-induced cell apoptosis and tumor growth inhibition

作     者：Yanxi Yang Xinru Kong Xueli Ren Yandai Lin Zhe Liu 

作者机构：Academy of Medical Engineering and Translational MedicineTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Brain Science and Neural EngineeringTianjin UniversityTianjin 300072China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2024年第67卷第9期

页      面：3050-3062页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(82072057 82311540023) 

主　　题：nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition 

摘      要：It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy,lesiontargeted precision and mild *** to traditional treatment modalities,photodynamic therapy has been widely studied since the generation of reactive oxygen species(ROS)at cancerous lesions unprecedentedly offers a convenient approach for localized tumor ***,the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and ***,the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic *** continuing ROS production derived from intracellular oxygen(O_(2))and water(H_(2)O)by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth ***,this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses,facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.