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Targeting synaptic pathology in Alzheimer’s disease

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Zoological Research 2024年第4期45卷 875-876页

作者： Jing Cao Yun-Wu Zhang Fujian Provincial Key laboratory of Neurodegenerative disease and aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by memory and cognitive *** two primary pathological hallmarks of AD include the accumulation ofβ-amyloid(Aβ)plaques and formation of neurofibrillary tangles(NFTs)composed predominantly of hyperphosphorylated tau protein(Zhang et al.,2023).Moreover,synaptic dysfunction is considered another crucial factor in AD pathogenesis and is closely associated with cognitive ***,synaptic damage,loss,and dysfunction manifest earlier than the pathological features of Aβplaques and NFTs(Knopman et al.,2021).Therefore,understanding the mechanisms underlying synaptic dysfunction in AD is vital for providing insights into disease mechanisms and developing novel therapeutic strategies.

关键词： Alzheimer Aβ tau

CHIT1-positive microglia act as culprits for spinal motor neuron aging

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Science China(Life Sciences) 2024年第4期67卷 847-848页

作者： Zhao Wang Wantong Cai Weihong Song Oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceThe Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China

aging is one of the primary factors in spinal cord-associated disorders(Roberts,1990).However,the effects of aging on the spinal cord and the age-specific mechanisms underlying this relationship remain *** neurons(MNs... 详细信息

关键词： aging Roberts positive

Experimental models for preclinical research in kidney disease

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Zoological Research 2024年第5期45卷 1161-1174页

作者： Jin Miao Huanhuan Zhu Junni Wang Jianghua Chen Fei Han Weiqiang Lin Kidney disease Center First Affiliated HospitalZhejiang University School of MedicineInstitute of NephrologyZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang ProvinceZhejiang Clinical Research Center of Kidney and Urinary System DiseaseHangzhouZhejiang 310003China Department of Nephrology Center for Regeneration and Aging MedicineFourth Affiliated Hospital of School of Medicineand International School of MedicineInternational Institutes of MedicineZhejiang UniversityYiwuZhejiang 322000China

Acute kidney injury(AKI)and chronic kidney disease(CKD)are significant public health issues associated with a long-term increase in mortality risk,resulting from various etiologies including renal ischemia,sepsis,drug toxicity,and diabetes *** preclinical models have been developed to deepen our understanding of the pathophysiological mechanisms and therapeutic approaches for kidney *** these,rodent models have proven to be powerful tools in the discovery of novel therapeutics,while the development of kidney organoids has emerged as a promising advancement in the *** review provides a comprehensive analysis of the construction methodologies,underlying biological mechanisms,and recent therapeutic developments across different AKI and CKD ***,this review summarizes the advantages,limitations,and challenges inherent in these preclinical models,thereby contributing robust evidence to support the development of effective therapeutic strategies.

关键词： Acute kidney injury Chronic kidney disease Mouse models

The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1424-1448页

作者： Heng Yang Xiangqi Fan Xiangbing Mao Bing Yu Jun He Hui Yan Jianping Wang Institute of Animal Nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceNo.211Gongpinghuimin RoadWenjiang DistrictChengduSichuan Province 611130People’s Republic of China

Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关键词： Diarrhea Piglet Prebiotics Probiotics Rotavirus

Inflection Point Age in the Middle and Older Women—Jiangxi Province,China,2020-2022

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China CDC weekly 2024年第9期6卷 162-167页

作者： Shanlan Yang Langlang Zhang Helang Huang Jiaofeng Wang Lei Wu Zhijun Bao Shanghai Institute of Infectious disease and Biosecurity Fudan UniversityShanghaiChina Department of Gerontology Huadong Hospital Affiliated to Fudan UniversityShanghai Key Laboratory of Clinical Geriatric MedicineResearch Center on Aging and MedicineFudan UniversityShanghaiChina Jiangxi Provincial Key laboratory of Preventive Medicine School of Public HealthNanchang UniversityNanchang CityJiangxi ProvinceChina

Summary What is already known about this topic?Previous studies have predominantly examined the micro-level aspects of women aging inflection points,while macro-level research using big data on the inflection points o... 详细信息

关键词： Middle Jiangxi currently

A commentary of“Unravelling the mechanisms of human genomic‘dark matter’in driving aging”:Top 10 Scientific Advances of 2023,China

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Fundamental Research 2024年第3期4卷 693-694页

作者： Zhao Wang Chenglin Guo Weihong Song Oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Institute of AgingKey Laboratory of Alzheimer's Disease of Zhejiang Provincethe Second Affiliated HospitalWenzhou Medical UniversityWenzhou 325035China

aging is related to physiological decline and the development of chronic diseases,yet molecular changes and mechanisms underlying the aging process remain *** certain“dark matter”,such as transposable elements with viral origins in the genome,be activated and participate in the aging process?Excitingly,a study by Liu and colleagues revealed that the reactivation of endogenous retroviruses(ERVs)during aging enhances senescence[1].By using cross-species models and multiple techniques,the team uncovered the unusual role of ERV reactivation as a hallmark and driver of *** authors identified that ERV expression is associated with cellular and tissue aging(Fig.1).They found that the accumulation of human ERV group K(HERVK)retrovirus-like particles(RVLPs)mediates aging-promoting effects in recipient cells.

关键词： aging mechanisms driving

Updates of developments in interventional therapy for elderly patients with cardiovascular diseases

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Journal of Geriatric Cardiology 2024年第1期21卷 1-3页

作者： Hua SHEN Xun-Xun FENG Qian-Yun GUO Yu-Jie ZHOU Beijing Key laboratory of Precision Medicine of Coronary Atherosclerotic disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina

Cardiovascular diseases(CVD)are the leading cause of death in the world and one of the most common diseases in the elderly,with high prevalence and poor prognosis,which seriously affect the health of the elder *** report showed that global deaths from CVD increased from 12.4 million in 1990 to 19.8 million in 2022,reflecting the global population growth and aging,as well as the impact of metabolic,environmental,and behavioral risks.[1]With the progress of aging population,the burden of CVD in the elderly in China has increased year by year,and factors including multiple complications,organ function decline,and high complication rate have made the interventional treatment of CVD in the elderly one of the difficulties and focuses in the field of cardiology in China.

关键词： diseases patients prognosis

The role of anesthesia in peri-operative neurocognitive disorders:Molecular mechanisms and preventive strategies

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Fundamental Research 2024年第4期4卷 797-805页

作者： Ran Li Yun Zhang Qinxin Zhu Yili Wu Weihong Song The Second Affiliated Hospital and Yuying Children's Hospital Institute of AgingKey Laboratory of Alzheimer's Disease of Zhejiang ProvinceWenzhou Medical UniversityWenzhou325035China The National Clinical Research Center for Geriatric disease Xuanwu HospitalCapital Medical UniversityBeijing 100053China Oujiang laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 32500o0China

Peri-operative neurocognitive disorders(PNDs)include postoperative delirium(POD)and postoperative cognitive dysfunction(POCD).Children and the elderly are the two populations most vulnerable to the development of POD and POCD,which results in both high morbidity and *** are many factors,including neuroinflammation and oxidative stress,that are associated with POD and *** anesthesia is a major risk factor of ***,the molecular mechanisms of PNDs are poorly ***(DEX)is a useful sedative agent with analgesic properties,which significantly improves POCD in elderly *** this review,the current understanding of anesthesia in PNDs and the protective effects of DEX are summarized,and the underlying mechanisms are further discussed.

关键词： Peri-operative neurocognitive disorders General anesthesia Postoperative cognitive dysfunction Postoperative delirium Dexmedetomidine Alzheimer'sdisease

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic diseases International 2024年第2期23卷 186-194页

作者： Meng-Xiao Feng Hua Zou Yuan-Qiang Lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key laboratory for Diagnosis and Treatment of aging and Physic-chemical Injury diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning Clinical characteristics Liver injury