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聚集体(英文) 2020年第1期1卷 69-79页

作者： Hongqian Cao Yang Yang Junbai Li CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and TechnologyBeijingChina School of Public Health Shandong UniversityJinanShandong ProvinceChina CAS Key laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijingChina

Aggregation-induced emission(AIE)molecules possess notable advantages outperforming traditional aggregation caused quenching(ACQ)materials on various *** are rapidly developed these *** and more AIE luminogens(AIEgens)are designed to possess multifunctions such as the abilities of near-infrared two-photon absorption and reactive oxygen species(ROS)generation,which could be used for deep tissue imaging and photodynamic *** AIEgens exhibit great potential in biological application ***,despite the photophysics stability and ROS generation ability in aggregated states are favorable conditions,their applications in biological field are retarded by uncontrolled size,single imaging mode,low targeting efficiency,and also poor biocompatibility and dispersibility in physiological *** combination of AIEgen and lipid is a straightforward,promising,and intensively used way to solve the above *** to the special amphipathic property of lipid,which results from a hydrophilic head and hydrophobic tail structure,there are various possibilities of combination modes between lipid and *** a little procedure or condition change during the synthesis process will impact the structure of obtained product,which can further influence its ***,we summarize the synthesis methods of different AIEgen-lipid compounds with diverse structures and properties,as well as their biological applications in this contribution,which has not been presented before,being aimed at serving as a synthesis and application reference for these promising AIEgen-lipid compounds applied in biological region.

关键词： aggregation-induced emission bioimaging lipid photodynamic therapy self-assembly

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Nanotechnology-based platform for early diagnosis of cancer

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Science Bulletin 2015年第4期60卷 488-490,M0004页

作者：李金霞 Chinese Academy of Sciences Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of Sciences

Can you image a wearable wrist detector for cancer diag- nosis？ Recently, Google, keen on the improvement in healthcare recourses, issued its ambitious plan to develop the nanotechnology-based cancer diagnosis devices, which has attracted intensive attention and discussion. They announced to produce intelligent magnetic nanoparticles that circulated through the blood to detect and report the signs of cancer via a magnet held near superficial blood vessels on the wrist. This idea of nanoparticle-based pas- sive or active cancer targeting is not fresh; however, the impetus from bench to bed issued by Google sounds encouraging. Maybe there is a long way for Google to FDA approval and clinical application, nanotechnology, with increasing development especially in the recent years, may revitalize the current diagnostic devices.

关键词：纳米技术癌症早期诊断平台磁性纳米粒子诊断设备循环检测纳米颗粒

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Recent advances of DNA sequencing via nanopore-based technologies

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Science Bulletin 2015年第3期60卷 287-295,I0001页

作者：郭秉元曾涛吴海臣 Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences National Center for Nanoscience and Technology of China

This review briefly summarizes recent progress in nanopore DNA sequencing from the beginning of 2012 to July 2014. Although partial successes have been achieved in different types of nanopores, biological pores such ... 详细信息

关键词： DNA sequencing. Nanopore α-Hemolysin MspA phi29 connector Solid-state nanopore Graphene SWCNT

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Engineering hierarchical metal-organic@metal-DNA heterostructures for combinational tumor treatment

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Nano Research 2023年第11期16卷 12633-12640页

作者： Xueyan Feng Bei Liu Zehao Zhou Wei Li Jian Zhao Lele Li Yuliang Zhao CAS Key laboratory for biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and TechnologyBeijing 100190China College of Materials Science and Optoelectronic Technology University of Chinese Academy of SciencesBeijing 100049China Department of Nanomedicine&Shanghai Key Lab of Cell Engineering Naval Medical UniversityShanghai 200433China

Development of simple methods for controlled integration of DNA molecules with metal-organic frameworks(MOFs)is important for various biomedical applications,yet remains a ***,a simple and general approach to load DNA on the surface of MOFs is developed via one-pot self-assembly of DNA and FeII ions on nanoscale MOFs,resulting in hierarchical core-shell nanostructures of metal-organic@metal-DNA coordination *** strategy enables assembly of DNA molecules on MOFs with ultra-high contents and precise *** incorporation of a chemotherapeutic drug into the Fe-DNA shell,the systems allow to integrate chemotherapy and gene therapy with photodynamic therapy for combinational tumor ***,the hybrid nanostructures enable light-triggered production of cytotoxic singlet oxygen,which further boosts the endosomal escape of the system for an enhanced gene silencing efficacy and thus improved therapeutic *** work highlights a robust approach for the construction of coordination-based drug delivery systems to combat tumor.

关键词： metal-organic frameworks DNA hierarchical nanostructures coordination combinational tumor treatment

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Functional Peptides from One-bead One-compound High-throughput Screening Technique

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Chemical Research in Chinese Universities 2023年第1期39卷 83-91页

作者： YAN Yaqiong WANG Lei WANG Hao CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing100190P.R.China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049P.R.China

Combinatorial chemistry provides a cost-effective method for the rapid discovery of new functional ***-bead one-compound(OBOC)high-throughput screening technique offers a lot of structurally diverse peptides to be rapidly synthesized and screened for binding to a target of *** OBOC peptide library screening involves three main steps:library construction,positive beads separation,and peptide *** review mainly summarizes some special technique tips during functional peptide screening and potential future directions of the OBOC high-throughput screening technique.

关键词： Combinatorial chemistry One-bead one-compound(OBOC) Cyclic peptide Peptide screening Self-assembly

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Microscale methods to assemble mammalian cells into tissue-like structures

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Science China(Life Sciences) 2012年第10期55卷 862-871页

作者： GONG PeiYuan ZHENG WenFu XIAO Dan JIANG XingYu College of Chemistry Sichuan UniversityChengdu 610064China Key Lab for Biological effects of nanomaterials and nanosafety National Center for Nanoscience and TechnologyBeijing 100190China

Different cell types make up tissues and organs hierarchically and communicate within a complex, three-dimensional (3D) en- vironment. The in vitro recapitulation of tissue-like structures is meaningful, not only for fundamental cell biology research, but also for tissue engineering (TE). Currently, TE research adopts either the top-down or bottom-up approach. The top-down approach involves defining the macroscopic tissue features using biomaterial scaffolds and seeding cells into these scaffolds. Conversely, the bottom-up approach aims at crafting small tissue building blocks with precision-engineered structural and functional microscale features, using physical and/or chemical approaches. The bottom-up strategy takes advantage of the repeating structural and functional units that facilitate cell-cell interactions and cultures multiple cells together as a functional unit of tissue. In this review, we focus on currently available microscale methods that can control mammalian cells to assemble into 3D tissue-like structures.

关键词： microscale cell assembly tissue-like structures tissue engineering

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Engineered nanoparticles circumvent the adaptive treatment tolerance to immune-checkpoint blockade therapy

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Science China Chemistry 2019年第12期62卷 1557-1560页

作者： Weisheng Guo Lu Liu Chenyang Xiang Jingqi Chen Xing-Jie Liang Translational Medicine Center Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences&The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China CAS Key laboratory for biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China

The fight against cancer has witnessed the rapid develop・ment of various therapeutic methodologies,including chemotherapy,surgery,radiotherapy,phototherapy,and the emerging immunotherapy[1].However,malignancies evolve adaptive tolerance under the threatening conditions upon therapies because of some potential biological or genetic mutations,which may cause serious adverse events,compromised therapeutic efficacy and even treatment *** instance,following the standard chemotherapy with paclitaxel,primary breast cancer can release exosomes that facilitate the seeding and growth of metastatic cancer cells in distant organs[2].Therefore,the term"adaptive treatment tolerance"(ATT),rather than"drug resistance",has been employed to better describe the dynamic evolution of this phenomenon during/post cancer therapy.

关键词： chemotherapy organs treatment

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Regulating metalloimmunology with nanomedicine for cancer therapy

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Nano Research 2023年第12期16卷 13164-13181页

作者： Saibo Ma Lin Chen Muhammad Hamza Jing Chang Motao Zhu College of Marine Life Science Ocean University of ChinaQingdao 266003China CAS Key laboratory for biomedical effects of nanomaterials&nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266235China University of Chinese Academy of Sciences Beijing 100049China

Metals are essential components of both micronutrients and macronutrients in living organisms and are involved in a variety of immune processes in the forms of free ions or protein-coupled complexes(metalloproteins).Multiple aspects of the immune system,from the structural and functional control of immune-related proteins to the cellular responses to immunotherapy,could be affected by ***,the employment of metal for the regulation of immunity,termed as metalloimmunology,is gaining interest as a prevalent and efficacious approach to combating ***,the manipulation of metalloimmunology using traditional drugs presents several challenges,including limited bioavailability,adverse effects,and a lack of targeting *** review provides an overview of the latest findings in metal and metal-regulatory therapeutic agents for the treatment of *** trace metal elements,such as iron,zinc,copper,manganese,magnesium,and calcium,as well as heavy metal drugs and their mechanisms of action,will be discussed with a particular focus on their roles in regulating the tumor-immune *** latest nanotechnology employed in the administration of metal-regulatory drugs and the design concepts for tailored therapeutic interventions will be *** concepts and information offer promising clinical possibilities of modulating cancer immunology by targeting metal metabolism.

关键词： metalloimmunology metal metabolism cancer immunotherapy nano-enabled delivery system cGAS-STING pathway ferroptosis and cuprotosis

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A highly efficient protein corona-based proteomic analysis strategy for the discovery of pharmacodynamic biomarkers

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Journal of Pharmaceutical Analysis 2022年第6期12卷 879-888页

作者： Yuqing Meng Jiayun Chen Yanqing Liu Yongping Zhu Yin-Kwan Wong Haining Lyu Qiaoli Shi Fei Xia Liwei Gu Xinwei Zhang Peng Gao Huan Tang Qiuyan Guo Chong Qiu Chengchao Xu Xiao He Junzhe Zhang Jigang Wang Artemisinin Research Center and Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing100700China Department of Biological Sciences National University of Singapore117543Singapore Key laboratory for biomedical effects of nanomaterials and nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

The composition of serum is extremely complex,which complicates the discovery of new pharmacodynamic biomarkers via serum proteome for disease prediction and ***,nanoparticles have been reported to efficiently reduce the proportion of high-abundance proteins and enrich lowabundance proteins in ***,we synthesized a silica-coated iron oxide nanoparticle and developed a highly efficient and reproducible protein corona(PC)-based proteomic analysis strategy to improve the range of serum proteomic *** identified 1,070 proteins with a median coefficient of variation of 12.56%using PC-based proteomic analysis,which was twice the number of proteins identified by direct *** were also more biological processes enriched with these *** applied this strategy to identify more pharmacodynamic biomarkers on collagen-induced arthritis(CIA)rat model treated with methotrexate(MTX).The bioinformatic results indicated that 485 differentially expressed proteins(DEPs)were found in CIA rats,of which 323 DEPs recovered to near normal levels after treatment with *** strategy can not only help enhance our understanding of the mechanisms of disease and drug action through serum proteomics studies,but also provide more pharmacodynamic biomarkers for disease prediction,diagnosis,and treatment.

关键词： Protein corona Nanoparticles Mass spectrometry Proteomic analysis Pharmacodynamic biomarkers

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Self-Motivated Supramolecular Combination Chemotherapy for Overcoming Drug Resistance Based on Acid-Activated Competition of Host–Guest Interactions

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CCS Chemistry 2021年第8期3卷 1413-1425页

作者： Hua Wang Han Wu Yu Yi Ke-Fei Xue Jiang-Fei Xu Hao Wang Yuliang Zhao Xi Zhang Key laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084 CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190

In this work,we propose a nanoparticle-based strategy of self-motivated supramolecular combination chemotherapy that carries drugs stably and releases them actively in the acidic tumor microenvironment to overcome the drug resistance of cancer *** self-motivated nanoparticle consists of a cucurbit[7]uril-containing polymer(PCB)-based core.

关键词： drug resistance supramolecular chemistry acid-responsive combination chemotherapy drug delivery

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