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Combinatorial synthesis of redox-responsive cationic polypeptoids for intracellular protein delivery application

Science China Chemistry 2020年第11期63卷 1619-1625页

作者： Zhicheng Le Tong Xiao Zhijia Liu Xingliang Liu Hong Liu Lixin Liu Yongming Chen School of Materials Science and Engineering Key Laboratory of Polymeric Composite and Functional Materials of Ministry of EducationGD Research Center for Functional Biomaterials Engineering and TechnologySun Yat-sen UniversityGuangzhou 510275China

biologics play an essential role in treating various indications from cancers to the metabolic diseases,while the current development of new classes of intracellular-acting protein drugs is still hindered because of high molecular mass and overall hydrophilicity of proteins creating extremely poor permeability across cell ***,there remains an unmet need to develop safe,potent approaches to augment intracellular protein delivery ***,we described a facile multicomponent reaction system for generating a small library of redox-responsive cationic polypeptoids with high *** co-assembly of optimized polymer with protein leads to the formation of compacted nanocomplexes with smaller size and high encapsulation efficiency,thus improving cellular internalization via the macropinocytosis and/or caveolae-mediated endocytosis *** endo-lysosomal escape,the nanocomplexes can be disassociated to efficiently release cargo proteins into the cytosol,owing to the intracellular glutathione(GSH)-triggered rapid cleavage of disulfide bonds in polymers *** a result,we screened a promising platform reagent for efficient cytosolic protein delivery application.

关键词： multicomponent reaction cationic polypeptoid redox-responsive intracellular delivery protein

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Bioimaging of Dissolvable Microneedle Arrays: Challenges and Opportunities

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Research 2022年第4期2022卷 633-655页

作者： Yanni Wang Gehua Ma Guangzhi Gao Ji Tao Wenzhao Cao Haohao Sun Fengsen Ma Yilong Zhang Yen Wei Mei Tian laboratory of biologics and biomaterials Collge of PharmacyZhejiang University of TechnologyHangzhou 310014China Cllge of Computer Science and Technology Zhejiang UniversityHangzhou 310027China Human Phenome Institute Fudan UniversityShanghai 201203China College of Information Engineering Zhejiang University of TechnologyHangzhou 310023China Life Science Research Center Frontier Crossing InstituteZhejiang University of TechnologyHangzhou 310023China Engineering Research Center of Intelligent Sensing and System Ministry of EducationHangzhou 310023China College of Computer Science and Technology Zhejiang University of TechnologyHangzhou 310023China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua UniversityBeijing 100084China

The emergence of microneedle arrays(MNAs)as a novel,simple,and minimally invasive administration approach largely addresses the challenges of traditional drug *** particular,the dissolvable MNAs act as a promising,multifarious,and well-controlled platform for micro-nanotransport in medical research and cosmetic formulation *** effective delivery mostly depends on the behavior of the MNAs penetrated into the body,and accurate assessment is urgently *** imaging technologies offer high sensitivity and resolution visualization of cross-scale,multidimensional,and multiparameter information,which can be used as an important aid for the evaluation and development of new *** combination of MNA technology and imaging can generate considerable new knowledge in a cost-effective manner with regards to the pharmacokinetics and bioavailability of active substances for the treatment of various *** addition,noninvasive imaging techniques allow rapid,receptive assessment of transdermal penetration and drug deposition in various tissues,which could greatly facilitate the translation of experimental MNAs into clinical *** on the recent promising development of bioimaging,this review is aimed at summarizing the current status,challenges,and future perspective on in vivo assessment of MNA drug delivery by various imaging technologies.

关键词： needle mostly formulation

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Advances on the modification and biomedical applications of acellular dermal matrices

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Journal of Leather Science and Engineering 2022年第1期4卷 268-286页

作者： Yining Chen Xinhua Liu Xin Zheng Xuantao Huang Weihua Dan Zhengjun Li Nianhua Dan Yunbing Wang Key laboratory of Leather Chemistry and Engineering(Sichuan University) Ministry of EducationChengdu 610065China Research Center of Biomedical Engineering Sichuan UniversityChengdu 610065SichuanChina College of Bioresources Chemical and Materials Engineering Institute of Biomass&Functional MaterialsShaanxi University of Science&TechnologyXi’an 710021China National Engineering Research Center for biomaterials Sichuan University29 Wang Jiang RoadChengdu 610065China.

Acellular dermal matrix(ADM)is derived from natural skin by removing the entire epidermis and the cell components of dermis,but retaining the collagen components of *** can be used as a therapeutic alternative to“gold standard”tissue grafts and has been widely used in many surgical fields,since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of ***,the basic science of biologics with a focus on ADMs is comprehensively described,the modification principles and technologies of ADM are discussed,and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are *** addition,the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds,maintaining homeostasis in the filling of a tissue defect,guiding tissue regeneration,and delivering cells via grafts in surgical applications are thoroughly *** review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation.

关键词： homeostasis removing retaining

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Rational design of hydrogels for immunomodulation

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Regenerative biomaterials 2022年第1期9卷 979-1000页

作者： Wenhuan Bu Yuanhao Wu Amir M.Ghaemmaghami Hongchen Sun Alvaro Mata Liaoning Provincial Key laboratory of Oral Diseases School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Dental Materials School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China Department of Center laboratory School of StomatologyChina Medical UniversityNo.117Nanjing North StreetHeping DistrictShenyang 110001China School of Pharmacy University of NottinghamUniversity ParkNottingham NG72RDUK Biodiscovery Institute University of NottinghamUniversity ParkNottingham NG72RDUK Division of Immunology School of Life SciencesUniversity of NottinghamUniversity ParkNottingham NG72RDUK Terasaki Institute for Biomedical Innovation 1018 Westwood BlvdLos AngelesCA 90024USA Department of Chemical and Environmental Engineering University of NottinghamUniversity ParkNottingham NG72RDUK

The immune system protects organisms against endogenous and exogenous harm and plays a key role in tissue development,repair and *** immunomodulatory biologics exhibit limitations including degradation by enzymes,short half-life and lack of targeting *** or binding these biologics within biomaterials is an effective way to address these *** are promising immunomodulatory materials because of their prominent biocompatibility,tuneability and ***,to take advantage of these opportunities and optimize material performance,it is important to more specifically elucidate,and leverage on,how hydrogels affect and control the immune ***,we summarize how key physical and chemical properties of hydrogels affect the immune *** first provide an overview of underlying steps of the host immune response upon exposure to ***,we discuss recent advances in immunomodulatory strategies where hydrogels play a key role through(i)physical properties including dimensionality,stiffness,porosity and topography;(ii)chemical properties including wettability,electric property and molecular presentation;and(iii)the delivery of bioactive molecules via chemical or physical ***,this review aims to build a conceptual and practical toolkit for the design of immune-instructive hydrogels capable of modulating the host immune response.

关键词： hydrogels immunomodulation physical properties chemical properties

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