Bioimaging of Dissolvable Microneedle Arrays: Challenges and Opportunities
作者机构：Laboratory of Biologics and BiomaterialsCollge of PharmacyZhejiang University of TechnologyHangzhou 310014China Cllge of Computer Science and TechnologyZhejiang UniversityHangzhou 310027China Human Phenome InstituteFudan UniversityShanghai 201203China College of Information EngineeringZhejiang University of TechnologyHangzhou 310023China Life Science Research CenterFrontier Crossing InstituteZhejiang University of TechnologyHangzhou 310023China Engineering Research Center of Intelligent Sensing and SystemMinistry of EducationHangzhou 310023China College of Computer Science and TechnologyZhejiang University of TechnologyHangzhou 310023China Department of Chemistry and the Tsinghua Center for Frontier Polymer ResearchTsinghua UniversityBeijing 100084China
出 版 物：《Research》 (研究（英文）)
年 卷 期：2022年第2022卷第4期
页 面：633-655页
核心收录：
学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学]
基 金：Wethank Yuan Wangforher valuable discussion.This work was supported in part bythe National Natural Science Foundation of China under Grant No.21788102 81725009 61527808 and 61905218
主 题：needle mostly formulation
摘 要：The emergence of microneedle arrays(MNAs)as a novel,simple,and minimally invasive administration approach largely addresses the challenges of traditional drug *** particular,the dissolvable MNAs act as a promising,multifarious,and well-controlled platform for micro-nanotransport in medical research and cosmetic formulation *** effective delivery mostly depends on the behavior of the MNAs penetrated into the body,and accurate assessment is urgently *** imaging technologies offer high sensitivity and resolution visualization of cross-scale,multidimensional,and multiparameter information,which can be used as an important aid for the evaluation and development of new *** combination of MNA technology and imaging can generate considerable new knowledge in a cost-effective manner with regards to the pharmacokinetics and bioavailability of active substances for the treatment of various *** addition,noninvasive imaging techniques allow rapid,receptive assessment of transdermal penetration and drug deposition in various tissues,which could greatly facilitate the translation of experimental MNAs into clinical *** on the recent promising development of bioimaging,this review is aimed at summarizing the current status,challenges,and future perspective on in vivo assessment of MNA drug delivery by various imaging technologies.
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