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Effect of adrenalectomy and hydrocortisone on ventral prostate of rats

Asian Journal of Andrology 2001年第4期3卷 289-300页

作者： Neena Nair R.S.Bedwal R.S.Mathur cell biology laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 India

Aim: To study the effects of adrenalectomy and hydrocortisone on the ventral prostate of SD rats. Methods: Inadrenalectomised (ADX) and ADX + hydrocortisone (1, 2, or 4 mg) treated rats, the prostatic histology.and thecholesterol, protein, zinc, and copper levels and the enzymic profile (acid phosphatase, alkaline phosphatase, aryl sul-phatase, lactic dehydrogenase, and leucine aminopeptidase) in the prostatic tissue were determined; the serum hormon-al profile (testosterone, FSH and LH) was also assayed. Results; Adrenalectomy caused a progressive degenerationin prostatic structure that was not reversed by hydrocortisone treatment. The serum testosterone were significantly lowerin ADX than in sham operated rats and lower in ADX + hydrocortisone than in ADX-C rats (P < 0.01). The serumFSH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham op-erated rats and higher in ADX + hydrocortisone than in ADX-C rats (P<0.05-0.01). The prostatic zinc levels weresignificantly higher in sham operated than in ADX, and higher in ADX-C than in ADX + hydrocortisone rats (P < 0.05-0.01). The prostatic copper level was significantly lower in sham operated than in ADX, and lower in ADX-C thanin the ADX + hydrocortisone rats (P <0.01). Conclusion; In rats, adrenalectomy leads to pathological and func-tional changes of the prostate. Hydrocortisone treatment at the doses employed did not reverse these changes. (Asian JAndrol 2001 Dec; 3: 289 - 300)

关键词： adrenalectomy ventral prostate hydrocortisone testosterone FSH LH cholesterol zinc copper acid phosphatase alkaline phosphatase aryl sulphatase lactic dehydrogenase leucine aminopeptidase

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Celebrating Plant cells:A Special Issue on Plant cell biology

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Journal of Integrative Plant biology 2007年第8期49卷 1089-1090页

作者： Zhenbiao Yang Center for Plant cell biology,Department of Botany and Plant Sciences,University of California,Riverside,CA 92521,USABe Liu Section of Plant biology,University of California,Davis,CA 95616,USA Center for Plant cell biology Department of Botany and Plant Sciences University of California Riverside CA 92521 USA Section of Plant biology University of California Davis CA 95616 USA

A special issue on plant cell biology is long overdue for JIPB! In the last two decades or so, the plant biology community has been thrilled by explosive discoveries regarding the molecular and genetic basis of plant growth, development, and responses to the environment, largely owing to recent maturation of model systems like Arabidopsis thaliana and the rice Oryza sativa, as well as the rapid development of high throughput technologies associated with qenomics and proteomics.

关键词： Celebrating Plant cells

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Research advancements in nanoparticles and cell-based drug delivery systems for the targeted killing of cancer cells

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Oncology research 2025年第1期33卷 27-44页

作者： Meryem A Abdessalem Sirin A Adham Department of biology College of Science Sultan Qaboos University Muscat 123 Oman.

Nanotechnology in cancer therapy has significantly advanced treatment precision, effectiveness, and safety, improving patient outcomes and personalized care. Engineered smart nanoparticles and cell-based therapies are designed to target tumor cells, precisely sensing the tumor microenvironment (TME) and sparing normal cells. These nanoparticles enhance drug accumulation in tumors by solubilizing insoluble compounds or preventing their degradation, and they can also overcome therapy resistance and deliver multiple drugs simultaneously. Despite these benefits, challenges remain in patient-specific responses and regulatory approvals for cell-based or nanoparticle therapies. cell-based drug delivery systems (DDSs) that primarily utilize the immune-recognition principle between ligands and receptors have shown promise in selectively targeting and destroying cancer cells. This review aims to provide a comprehensive overview of various nanoparticle and cell-based drug delivery system types used in cancer research. It covers approved and experimental nanoparticle therapies, including liposomes, micelles, protein-based and polymeric nanoparticles, as well as cell-based DDSs like macrophages, T-lymphocytes, dendritic cells, viruses, bacterial ghosts, minicells, Simcells, and outer membrane vesicles (OMVs). The review also explains the role of TME and its impact on developing smart DDSs in combination therapies and integrating nanoparticles with cell-based systems for targeting cancer cells. By detailing DDSs at different stages of development, from laboratory research to clinical trials and approved treatments, this review provides the latest insights and a collection of valuable citations of the innovative strategies that can be improved for the precise treatment of cancer.

关键词： Cancer Combination therapies Drug delivery Liposomes Micelles Nanoparticles Precision medicine Targeted therapy Tumor microenvironment (TME)

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&cell biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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NK cell-based cancer immunotherapy: from basic biology to clinical application

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Science China(Life Sciences) 2015年第12期58卷 1233-1245页

作者： LI Yang YIN Jie LI Ting HUANG Shan YAN Han LEAVENWORTH Jian Mei WANG Xi Department of cell biology 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics Laboratory of Epigenetics in Development and Tumorigenesis Tianjin Research Center of Basic Medical Sciences Tianjin Key Laboratory of Medical Epigenetics Tianjin Medical University Department of Cancer Immunology and Virology Dana-Farber Cancer Institute Department of Microbiology and Immunobiology Division of Immunology Harvard Medical School

Natural killer(NK) cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex(MHC) matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. Thus, understanding mechanisms underlying regulation of NK cell phenotype and function within the tumor environment is instrumental for designing new approaches to improve the current cell-based immunotherapy. In this review, we elaborate the main biological features and molecular mechanisms of NK cells that pertain to regulation of NK cell-mediated anti-tumor activity. We further overview current clinical approaches regarding NK cell-based cancer therapy, including cytokine infusion, adoptive transfer of autologous or allogeneic NK cells, applications of chimeric antigen receptor(CAR)-expressing NK cells and adoptive transfer of memory-like NK cells. With these promising clinical outcomes and fuller understanding the basic questions raised in this review, we foresee that NK cell-based approaches may hold great potential for future cancer immunotherapy.

关键词： NK cell cancer cytokine infusion adoptive transfer immunotherapy

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Effect of adrenalectomy on rat epididymidis

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Asian Journal of Andrology 2002年第4期4卷 273-279页

作者： Neena Nair R.S. Bedwal R.S. Mathur cell biology laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 India

AIM: To investigate the effect of adrenalectomy (ADX) on the epididymidis of Sprague-Dawley rats. METHODS: The histological, biochemical (cholesterol protein, zinc, copper, alkaline and acid phosphatase aryl sulphatase, lactic dehydrogenase and leucine amino peptidase) and hormonal (FSH, LH and testosterone) changes of caput and cauda epididymis in ADX rats were observed. RESULTS: Organ wet weight, histological studies and morphometric measurements indicated a cellular degeneration in caput and cauda epididymis of ADX rats. Serum testosterone level was significantly lower in ADX than in sham-operated rats, while the serum FSH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham-operated rats. Epididymal zinc level increased whereas copper level decreased in ADX rats compared to the sham-operated. CONCLUSION: Adrenalectomy leads to degeneration of caput and cauda epididymidis epithelial cells as a result of decreased supply of testosterone.

关键词： Adrenalectomy Acid Phosphatase Alkaline Phosphatase Animals Arylsulfatases Cholesterol Comparative Study Copper Epididymis Follicle Stimulating Hormone L-Lactate Dehydrogenase Leucyl Aminopeptidase Luteinizing Hormone Male Organ Size Rats Rats, Sprague-Dawley Reference Values Research Support, Non-U.S. Gov't Testosterone Time Factors Zinc

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The genome-wide molecular regulation of mouse gastrulation embryo

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Science China(Life Sciences) 2017年第4期60卷 363-369页

作者： Guangdun Peng Naihe Jing State Key laboratory of cell biology Shanghai Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of Sciences

The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region-and population-specific genetic activity underpinning this fundamental developmental process. In this review, we outline the recent progress and the future directions in studies of genome activity for the regulation of mouse embryogenesis at gastrulation.

关键词： embryo morphogenetic spatially vertebrate diverse fertilization coordinated streak organized ensemble

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microRNAs: critical regulators in Th17 cells and players in diseases

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cellular & Molecular Immunology 2010年第3期7卷 175-181页

作者： Bin Wei Gang Pei laboratory of Molecular cell biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina

microRNAs are a novel group of small,conserved,non-coding RNA molecules that are present in all *** molecules post-transcriptionally regulate gene expression by targeting mRNAs for degradation or by repressing the translation of the mRNAs.A good understanding of miRNA-mediated gene regulation is critical to gain a comprehensive view of many physiological processes and disease *** evidence demonstrates that miRNAs play an important role in the differentiation and function of the adaptive immune *** review provides an overview of the diverse functions of miRNAs in modulating immune responses and in immune cell development,particularly the development of Th17 cells,and explores the involvement of miRNAs in several autoimmune diseases including multiple sclerosis(MS),rheumatoid arthritis(RA),inflammatory bowel disease(IBD)and diabetes.

关键词： autoimmune diseases microRNAs Th17 cells

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MAPK signaling in inflammation-associated cancer development

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Protein & cell 2010年第3期1卷 218-226页

作者： Pengyu Huang Jiahuai Han Lijian Hui laboratory of Molecular cell biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Key laboratory of the Ministry of Education for cell biology and Tumor cell Engineering School of Life SciencesXiamen UniversityXiamen 361005China

Mitogen-activated protein(MAP)kinases comprise a family of protein-serine/threonine kinases,which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms,including *** kinases,including ERKs,JNKs and p38s,are regulated by a phosphorelay cascade,with a prototype of three protein kinases that sequentially phosphorylate one *** transduce extracellular signals into a variety of cellular processes,such as cell proliferation,survival,death,and *** with their essential cellular functions,MAPKs have been shown to play critical roles in embryonic development,adult tissue homeostasis and various *** this review,we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and,particularly,inflammation-associated cancer development.

关键词： inflammation cancer homeostasis

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Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic-ischemic brain injury

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Neural Regeneration Research 2013年第8期8卷 731-744页

作者： Lara-Celador I. Goi-de-Cerio F. Antonia Alvarez Enrique Hilario Department of cell biology and histology School of Medicine and DentistryUniversity of the Basque Country GAIKER Technology Centre Bizkaia Science and Technology Park

One of the most important causes of brain injury in the neonatal period is a perinatal hypoxicischemic *** devastating condition can lead to long-term neurological deficits or even *** hypoxic-ischemic brain injury,a variety of specific cellular mechanisms are set in motion,triggering cell damage and finally producing cell *** therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain *** a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury,various neuroprotective therapies have been developed for alleviating brain injury and improving long-term *** them,the endocannabinoid system emerges as a natural system of *** endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury,acting as a natural *** aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury,and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.

关键词： neural regeneration reviews perinatal hypoxia-ischemia brain injury brain plasticity,neuroprotective strategies cannabinoid system grants-supported paper photographs-containingpaper neuroregeneration

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