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Progesterone effects on the oligodendrocyte linage: all roads lead to the progesterone receptor

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Neural Regeneration Research 2019年第12期14卷 2029-2034页

作者： Ignacio Jure Alejandro F. de Nicola Florencia Labombarda laboratorio de Bioquímica Neuroendocrina Instituto de Biología y Medicina Experimental CONICET Buenos Aires Argentina departamento de Bioquímica Humana Facultad de Medicina Universidad de Buenos Aires Buenos Aires Argentina

A new role has emerged for progesterone after discovering its potent actions away from reproduction in both the central and the peripheral nervous system. The aim of the present report is to discuss progesterone’s mechanisms of action involved in myelination, remyelination and neuroinflammation. The pivotal role of the classic progesterone receptor is described and evidence is compiled about progesterone’s direct effects on oligodendrocyte linage and its indirect effects on oligodendrocyte precursor cell differentiation by decreasing the neuroinflammatory environment.

关键词： progesterone progesterone receptor oligodendrocyte differentiation myelination remyelination neuroinflammation

Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule

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Neural Regeneration Research 2020年第10期15卷 1846-1847页

作者： Susana Laura González Universidad de Buenos Aires Facultad de Medicina Departamento de Bioquímica Humana Buenos Aires laboratorio de Nocicepción y Dolor Neuropático Instituto de Biología y Medicina Experimental

Central nervous system(CNS)injuries and neurodegenerative diseases show a broad spectrum of common pathophysiological processes,including oxidative stress,neuroinflammation,excitotoxicity,demyelination and neurotransmission *** the past decades,valuable experimental investigations have helped to clarify the role and timing of these multiple molecular and cellular mechanisms in each of these particular disorders,which usually overlap and critically contribute to long-term ***,up to now,no definite cures or effective disease-modifying therapies are available for any of these *** has led to an active search of novel therapeutic approaches,including the repositioning of existing drugs for new indications,as a valid approach to promptly move candidate molecules to clinical trials.

关键词： injuries disorders drugs

Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification

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Journal of Environmental Sciences 2021年第3期33卷 304-312页

作者： Bryan Butter Paola Santander Guadalupe del CPizarro Diego POyarzún Federico Tasca Julio Sánchez Facultad de Química y Biología Universidad de Santiago de ChileUSACHCasilla 40Correo 33SantiagoChile departamento de Química Universidad Tecnológica MetropolitanaJ.P.Alessandri 1242SantiagoChile laboratorio de Nanotecnología Recursos Naturales y Sistemas ComplejosFacultad de Ciencias NaturalesUniversidad de AtacamaCopayapu 485CopiapóChile

Chromium(Cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem *** concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this *** work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF *** electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan *** addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis *** results showed efficient reduction with well-defined peaks at approximately 0.3 V ***/AgCl,using a gold working *** the pH increased,the reduction signal strongly decreased until its *** optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)*** the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF.

关键词： Alginate solution Chromium Electroanalytical chemistry Ultrafiltration Water purification

Biorefinery of Rice Husk to Obtain Functionalized Bioactive Compounds

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Journal of Renewable Materials 2019年第4期7卷 313-324页

作者： M.Lopretti N.Lecot A.Rodriguez G.Lluberas F.Orozco L.Bolaños G.Montes de Oca H.Cerecetto J.Vega-Baudrit laboratorio de Técnicas Nucleares Aplicadas a Bioquímica y Biotecnología Centro de Investigaciones Nucleares-Facultad de CienciasMataojo 2055Montevideo CP 11400Uruguay Área de Radiofarmacia Centro de Investigaciones Nucleares-Facultad de CienciasMataojo 2055Montevideo CP 11400Uruguay Química Bioanalítica Instituto Polo Tecnológico de Pando-Facultad de QuímicaUdelaRBy Pass de Pando y Ruta 8Pando-Canelones CP 91000Uruguay laboratorio de Nacional de Nanotecnología-CeNAT-CONARE Costa Rica 1174-1200San JoséCP 10109Costa Rica laboratorio de Polímeros POLIUNA-Escuela de Química Universidad NacionalHerediaSan JoséCP 86-3000Costa Rica

The biomass industrialization valorisation of grains and cereals is considered an opportunity for the countries where agro-industrial activity is one of its main economic activities,rendering new higher-value products with a concomitant solution to waste accumulation *** that end,in this work we describe and characterise bioactive compounds generation from rice husk by semisolid fermentation,obtained from 500 g of the material at room temperature and 60%humidity with mixed cultures of Phanerochaete chrysosporium and Gloeophyllum *** extract was evaluated in different situations:murine mammary tumour cells(4T1),normal cells(NIH 3T3)and in Lactobacillus acidophilus,and Trichoderma *** results exhibited that the extract inhibited 4T1 cells at concentrations higher than 20μg/mL,but did not inhibit normal cells,and displayed germicide activity after 3 days *** propose that these functionalized compounds have a potential application in industry/agriculture/medicine obtained from rice husk waste.

关键词： Biorefinery rice husk bioactive compounds valorisation of biomass veratryl alcohol

Ultrastructure of multicellular dwarf males with external gametangium in Oedogonium macrandrium(Oedogoniales,Chlorophyta)

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BIOCELL 2013年第3期37卷 85-90页

作者： Silvana L.D’AMICO Patricia I.LEONARDI Eduardo J.CÁCERES laboratorio de Ficología y Micología Departamento de BiologíaBioquímica y FarmaciaUniversidad Nacional del SurBahía BlancaArgentina CERZOS-CONICET Camino La Carrindanga Km 7Bahía BlancaArgentina

This is the first comprehensive ultrastructural study on dwarf males with external gametangia in the ge in the genus Oedogonium,from androspore germination to the liberation of mature male *** ultrastructure of the process in *** Wittrok is similar to that of Bulbochaete hiloensis(Nordstedt)Tiffany,butwith two remarkable *** ***:(1)instead of a true transverse wall,only condensed mucilage appears between the gametes of each antheridial cell,and (2)the cell wall between the basal cell and the basal most antheridial cell has simple plasmodesmata similar to those present in the transverse walls of vegetative cells,which are absent in ***.

关键词： androspores Chlorophyta dwarf males Oedogoniales Oedogonium macrandrium ultrastructure

Evaluation of Clinical Characteristics and Plasma Cortisol Concentrations in Individuals with COVID-19 and Post-COVID Syndrome

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Case Reports in Clinical Medicine 2024年第1期13卷 12-24页

作者： David Alejandro García López Stephania Ramos Hernández yamile López-Hernández María Argelia López Luna Elena Donaji Ramírez Alvarado Rosa María Ramírez Santoyo Sergio Hugo Sánchez Rodríguez laboratorio de Biología Celular y Neurobiología Universidad Autónoma de Zacatecas México Zacatecas Unidad Académica de Ciencias Químicas Universidad Autónoma de Zacatecas México Zacatecas laboratorio de metabolómica y proteómica Universidad Autónoma de Zacatecas México Zacatecas laboratorio de Bacterias y Hongos filamentosos Universidad Autónoma de Zacatecas México Zacatecas

COVID-19 generates systematic alterations in humans both in active stages of infection and over time, called post-COVID syndrome. Cortisol is a hormone that is overexpressed in inflammation and cellular stress processes. Its main function is to return to physiological homeostasis, so its evaluation together with other clinical parameters can allow us to determine the degree of systemic affectation by COVID-19. Objective: To evaluate changes in clinical parameters and plasma cortisol concentrations in patients with active COVID-19 and post-COVID syndrome. Material and Methods: Healthy patients, in stages of mild infection, critical and with post-COVID syndrome, were recruited, obtaining, through clinical diagnoses and interviews, their main clinical characteristics, in addition to plasma, in which cortisol concentrations were determined using competitive ELISA. Results: The critical stage group had higher frequencies of comorbidities, clinical symptoms, as well as more altered laboratory parameters compared to the other subgroups. In the post-COVID syndrome group after the initial infection, most laboratory parameters recovered, however, several clinical symptoms remained latent over time. The determination of cortisol showed an increase in its concentration, being higher in patients in critical stage and with post-COVID syndrome. Conclusion: COVID-19 disease generates clinical alterations that trigger an increase in plasma cortisol. These alterations increase as the stages of infection become more severe and some of them remain altered in patients with post-COVID syndrome.

关键词： COVID-19 Cortisol Post-COVID Syndrome

Artificial Triterpenoid Fatty Acid Ester Isolated From the Leaves of Phytolacca icosandra L

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Natural Products and Bioprospecting 2020年第4期10卷 221-225页

作者： Elier Galarraga Andersson Mavares Neudo Urdaneta Rafael ERodríguez-Lugo Juan Manuel Amaro-Luis departamento de Química.Edificio de Química y Procesos Universidad Simón Bolívar(USB)Apartado 89000.Caracas-1080AVenezuelaUSA laboratorio de Química Bioinorgánica Centro de QuímicaInstituto Venezolano de Investigaciones Científicas(IVIC)VenezuelaCaracas 1020-AUSA laboratorio de Productos Naturales Departamento de Química.Facultad de CienciasUniversidad de Los Andes(ULA)MéridaVenezuela-5101USA

The methanol extract form the leaves of Phytolacca icosandra L.,afforded the unprecedented artificial triterpenoid fatty acid ester 1 derived from the new natural triterpenoid phytolaccagenic acid 3-O-myristate(1a),along with the three known triterpenoids serjanic,acinosolic and phytolaccagenic acid(2-4).Their structures were stablished by HR-EI-MS,1D and 2D NMR *** possible mechanistic formation of 1 is proposed,and the in vitro toxicity of all compounds was assessed using the brine shrimp lethality assay(BSLA).

关键词： Phytolacca icosandra.triterpenoid fatty acid ester NMR artificial products BSLA

Intestinal Ca2+ absorption revisited: A molecular and clinical approach

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World Journal of Gastroenterology 2020年第24期26卷 3344-3364页

作者： Vanessa A Areco Romina Kohan Germán Talamoni Nori G Tolosa de Talamoni María E Peralta López laboratorio“Dr.Fernando Canas” Cátedra de Bioquímica y Biología MolecularFacultad de Ciencias MédicasINICSA(CONICET-Universidad Nacional de Córdoba)Córdoba 5000Argentina

Ca2+has an important role in the maintenance of the skeleton and is involved in the main physiological *** homeostasis is controlled by the intestine,kidney,bone and parathyroid *** intestinal Ca2+absorption occurs mainly via the paracellular and the transcellular *** proteins involved in both ways are regulated by calcitriol and other hormones as well as dietary *** growth factor 23(FGF-23)is a strong antagonist of vitamin D *** of the intestinal Ca2+movement seems to be vitamin D *** Ca2+absorption changes according to different physiological *** is promoted under high Ca2+demands such as growth,pregnancy,lactation,dietary Ca2+deficiency and high physical *** contrast,the intestinal Ca2+transport decreases with *** stress inhibits the intestinal Ca2+absorption whereas the antioxidants counteract the effects of prooxidants leading to the normalization of this physiological *** pathologies such as celiac disease,inflammatory bowel diseases,Turner syndrome and others occur with inhibition of intestinal Ca2+absorption,some hypercalciurias show Ca2+hyperabsorption,most of these alterations are related to the vitamin D endocrine *** research work should be accomplished in order not only to know more molecular details but also to detect possible therapeutic targets to ameliorate or avoid the consequences of altered intestinal Ca2+absorption.

关键词： Ca2+absorption Transcellular pathway Paracellular pathway Hormones Dietary calcium Physiological conditions Pathological alterations

Glutathione depleting drugs, antioxidants and intestinal calcium absorption

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World Journal of Gastroenterology 2018年第44期24卷 4979-4988页

作者： Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni laboratorio "Dr. Fernando Canas" Cátedra de Bioquímica y Biología Molecular Facultad de Ciencias Médicas INICSA (CONICET-Universidad Nacional de Córdoba) Córdoba 5000 Argentina

Glutathione （GSH） is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2＋ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2＋ ab-sorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxida-tive/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca transport or the paracellular Ca route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2＋ pathway are decreased. The favonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2＋ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2＋ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2＋ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety,pharmacokinetics and pharmacodynamics of them.

关键词： Glutathione Transcellular and paracellular Ca^2+pathways DL-buthionine-S,R-sulfoximine Fructose rich diet Menadione Sodium deoxycholate Glutamine Ursodeoxycholic acid Melatonin Quercetin Naringin