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Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

Oncology Research 2023年第3期31卷 361-374页

作者： FRANCISCO RAÚL BORZONE MARÍA BELÉN GIORELLO LEANDRO MARCELO MARTINEZ MARÍA CECILIA SANMARTIN LEONARDO FELDMAN FEdeRICO DIMASE EMILIO BATAGELJ GUSTAVO YANNARELLI NORMA ALEJANDRA CHASSEING laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la Salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality *** this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MSCs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal *** work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(SA‑β‑gal)staining of BMderived MSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were *** levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,M-CAM,RUNX-2,BMP-2,CCL-2,M-CSF,and IL-6)were also *** results showed that MSCs from BCPs had reduced,self-renewal and proliferation *** cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened ***,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere *** also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene *** conclude that these changes could be responsible for the abnormal functional profile that MSCs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

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Cigarette smoking, dietary habits and genetic polymorphisms in GSTT1, GSTM1 and CYP1A1 metabolic genes: A case-control study in oncohematological diseases

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World Journal of Clinical Oncology 2016年第5期7卷 395-405页

作者： María Belén Cerliani Walter Pavicic Juan Antonio Gili Graciela Klein Silvia Saba Silvina Richard Instituto Multidisciplinario de biología Celular (CIC UNLP CONICET) laboratorio de Epidemiología Genética (ECLAMC CEMIC CONICET CABA) Unidad de Diagnóstico Tratamiento y Sostén de Enfermedades Hematológicas Hospital Interzonal General de Agudos Prof. Dr. Rodolfo Rossi

AIM To analyze the association between oncohematological diseases and GSTT1 /GSTM1 /CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control *** This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. deletions in GSTT1 and GSTM1 (null genotypes) were addressed by PCR. CYP1A1 MspI polymorphism was detected by PCR-RFLP. Odds ratio(OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological *** Women showed lower risk of disease compared to men(OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education(> 12 years) were significantly associated with an increased risk, compared to complete primary school or less(OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease(OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk(OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for GSTT1, GSTM1 and CYP1A1 polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found. CONCLUSION We reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer.

关键词： Cancer Oncohematological disease Casecontrol study Lifestyle Diet Tobacco Xenobiotic metabolizing genes GSTT1 GSTM1 CYP1A1

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Coronavirus disease-2019 and the intestinal tract:An overview

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World Journal of Gastroenterology 2021年第13期27卷 1255-1266页

作者： Gabriela Gama Freire Alberca Rosa Liliana Solis-Castro Maria Edith Solis-Castro Ricardo Wesley Alberca department of Microbiology Institute of Biomedical Sciences-University of São PauloSão Paulo 05508-000Brazil departamento Académico de biología Bioquímica Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru departamento Académico de Medicina Humana Facultad de Ciencias de la SaludUniversidad Nacional de TumbesPampa Grande 24000TumbesPeru laboratorio de dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.

关键词： COVID-19 SARS-CoV-2 Gastrointestinal Microbiota Antibiotics

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The relationship between morphology and flight in Drosophila:a study of two pairs of sibling species from a natural population

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Insect Science 2024年第3期31卷 885-900页

作者： Nicolás Flaibani Victoría Estefania Ortiz Juan JoséFanara Valeria Paula Carreira laboratorio de Evolucion Departamento de EcologiaGenética y Evolucion(DEGE)Facultad de Ciencias Exactas y Naturales(FCEN)Universidad de Buenos Aires(UBA)Instituto de GenéticaEcologia y Evolucion de Buenos Aires(IEGEBA)Consejo Nacional de Investigaciones Cientificasy Tecnicas(CONICET)-UBABuenos AiresArgentina

Insect flight is a complex trait involved in different behaviors,from the search for sexual partners,food,or breeding *** studies have postulated the adaptive advantages of certain morphological traits in relation to increased flight capacity,such as low values of wing loading or high values of wing:thorax ratio and wing-aspect ***,few studies have evaluated the relationship between variables related to flight and morphological traits in *** work aimed to study morphological traits in males and females of two pairs of sibling species:Drosophila buzzati Patterson and Wheeler-Drosophila koeferae Fontdevila and Wasserman,and Drosophila melanogaster Meigen-Drosophila simulans Sturtevant,and to analyze its relationship with *** detected the highest proportion of flight time in *** and *** compared to *** and ***,*** results also revealed sexual dimorphism,with males exhibiting a higher proportion of flight time than ***,we did not find a general pattern to explain the relationship between morphology and the proportion of flight time because associations varied depending upon the analyses(considering all groups together or each sex-species combination separately).Moreover,these associations explained a low percentage of variation,suggesting that other nonmorphological components related to flight,such as physiological variables,should be taken into *** work allowed us to show the variability and complexity of an aspect of flight,suggesting that the adaptive role of the morphological traits studied might have been overestimated.

关键词： morphological traits time in flight wing loading wing:thorax ratio wingaspect ratio wing second moment of area

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Gut microbiota in a population highly affected by obesity and type 2 diabetes and susceptibility to COVID-19

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World Journal of Gastroenterology 2021年第41期27卷 7065-7079页

作者： Jaime García-Mena Karina Corona-Cervantes Daniel Cuervo-Zanatta Tizziani Benitez-Guerrero JuanManuel Vélez-Ixta Norma Gabriela Zavala-Torres Loan Edel Villalobos-Flores Fernando Hernández-Quiroz Claudia Perez-Cruz Selvasankar Murugesan Fernando Guadalupe Bastida-González Paola Berenice Zárate-Segura departamento de Genética y biología Molecular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico departamento de Genética y biología Molecular and departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico department of Mother and Child Health SIDRA MedicineDoha 26999Qatar laboratorio Estatal de Salud Pública del Estado de México ISEMToluca de Lerdo 50180Estado de MéxicoMexico Escuela Superior de Medicina Instituto Politécnico NacionalMexico City 11340CDMXMexico

Coronavirus disease 2019(COVID-19)is a disease produced by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and it is currently causing a catastrophic pandemic affecting humans *** disease has been lethal for approximately 3.12 million people around the world since January ***,among the most affected countries,Mexico ranks third in deaths after the United States of America and *** the high number of deceased people might also be explained by social aspects and lifestyle customs in Mexico,there is a relationship between this high proportion of deaths and comorbidities such as high blood pressure(HBP),type 2 diabetes,obesity,and metabolic *** official epidemiological figures reported by the Mexican government have indicated that 18.4%of the population suffers from HBP,close to 10.3%of adults suffer from type 2 diabetes,and approximately 36.1%of the population suffers from *** in the gut microbiota(GM)have been associated with these diseases and with COVID-19 severity,presumably due to inflammatory *** data about the association between GM dysbiosis and metabolic diseases could suggest that the high levels of susceptibility to SARSCoV-2 infection and COVID-19 morbidity in the Mexican population are primarily due to the prevalence of type 2 diabetes,obesity,and metabolic syndrome.

关键词： SARS-CoV-2 COVID-19 High blood pressure Hypertension Type 2 diabetes Obesity Metabolic syndrome Gut microbiota Immunity

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Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs

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Insect Science 2020年第3期27卷 519-530页

作者： Silvia de Oliveira Dorta Juliana Balbinotte Rose Monnerat Joao Roberto Spotti Lopes Tatiane da Cunha Odimar Zanuzo Zanardi Marcelo Pedreira de Miranda Marcos Antonio Machado Juliana de Freitas-Astua Programs de Pos-Graduagao em Microbiologia Agricola Escola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil laboratorio de Biotecnologia Centro de Citricultura Sylvio MoreiraInstituto Agronomico de CampinasCordeiropolisSPBrazil laboratorio de Insetos Vetores de Fitopatdgenos Departamento de Entomologia e AcarologiaEscola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Embrapa Recursos Geneticos e Biotecnologia BrasiliaDFBrazil Fundo de defesa da Citricultura(Fundecitrus) AraraquaraSPBrazil Embrapa Mandioca e Fruticultura Cruz das AlmasBABrazil Laboratdrio de Bioquimica Fitopatoldgica Instituto BioldgicoSao PauloSPBrazil

Bacillus thuringiensis(Bt)toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic *** discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap‐sucking insects,such as the Asian citrus psyllid Diaphorina citri Kuwayama(Hemiptera:Liviidae),a vector of“Candidatus Liberibacter spp.,”associated with citrus huanglongbing(HLB).In this study,translocation of endophytic Bt strains in citrus seedlings inoculated with Bt suspension delivered by soil‐drench,and their systemic pathogenicity to *** nymphs were *** pathogenicity of three wild‐type Bt strains against *** third‐instar nymphs was *** the 10 recombinant strains tested(each of them harboring a single cry or cyt gene),3 can be highlighted,causing 42%–77%and 66%–90%nymphal mortality at 2 and 5 d after inoculation,*** isolation of Bt cells from young citrus shoots and dead nymphs,and PCR performed with specific primers,confirmed the involvement of the Bt strains in the psyllid *** is the first report showing the translocation of Bt strains from citrus seedling roots to shoots and their potential to control *** nymphs that fed on these soil‐drench inoculated *** Bt strains that caused the highest mortality rates have the potential to be used as bioinsecticides to control *** and the identified genes can be used for the production of transgenic Bt citrus.

关键词： Asian citrus psyllid Citrus sinensis Cry toxins endophytic Bt huanglongbing young shoots

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Liver disorders in COVID-19,nutritional approaches and the use of phytochemicals

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World Journal of Gastroenterology 2021年第34期27卷 5630-5665页

作者： Nancy Vargas-Mendoza Jazmín García-Machorro Marcelo Angeles-Valencia Marlet Martínez-Archundia Eduardo Osiris Madrigal-Santillán Ángel Morales-González Liliana Anguiano-Robledo JoséA Morales-González laboratorio de Medicina de Conservacion Instituto Politécnico NacionalMéxico 11340Mexico laboratorio de Diseño y desarrollo de Nuevos Fármacos e Innovación Biotécnológica Instituto Politécnico NacionalMéxico 11340Mexico Superior de Medicina Instituto Politécnico NacionalMéxico 11340Mexico Escuela Superior de Cómputo Instituto Politécnico NacionalMéxico 07738Mexico laboratorio de Farmacología Molecular Instituto Politécnico NacionalMéxico 11340Mexico laboratorio Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalMéxico 11340Mexico

Coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),has affected millions of people *** was declared a pandemic by the World Health Organization in March *** hyperinflammatory response to the entry of SARS-CoV-2 into the host through angiotensin-converting enzyme 2 is the result of a“cytokine storm”and the high oxidative stress responsible for the associated *** only respiratory symptoms are reported,but gastrointestinal symptoms(diarrhea,vomiting,and nausea)and liver abnormalities(high levels of aspartate aminotransferase,alanine aminotransferase transaminases,and bilirubin)are observed in at least 30%of *** food intake and a delay in medical services may lead to malnutrition,which increases mortality and poor *** review provides some strategies to identify malnutrition and establishes nutritional approaches for the management of COVID-19 and liver injury,taking energy and nutrient requirements and their impact on the immune response into *** roles of certain phytochemicals in the prevention of the disease or as promising target drugs in the treatment of this disease are also considered.

关键词： COVID-19 Infection Liver Nutrition therapy Phytochemicals

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Role of gene polymorphisms in gastric cancer and its precursor lesions:Current knowledge and perspectives in Latin American countries

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World Journal of Gastroenterology 2014年第16期20卷 4503-4515页

作者： Miguel Angel Chiurillo laboratorio de Genética Molecular "Dr.Jorge Yunis-Turbay" Decanato de Ciencias de la SaludUniversidad Centroccidental Lisandro AlvaradoBarquisimeto 3001Venezuela

Latin America shows one of the highest incidence rates of gastric cancer in the world,with variations in mortality rates among nations or even within countries belonging to this *** cancer is the result of a multifactorial complex process,for which a multistep model of carcinogenesis is currently *** to the infection with Helicobacter pylori,that plays a major role,environmental factors as well as genetic susceptibility factors are significant players at different stages in the gastric cancer *** differences in population origin,demographic structure,socio-economic development,and the impact of globalization lifestyles experienced in Latin America in the last decades,all together offer opportunities for studying in this context the influence of genetic polymorphisms in the susceptibility to gastric *** aim of this article is to discuss current trends on gastric cancer in Latin American countries and to review the available published information about studies of association of gene polymorphisms involved in gastric cancer susceptibility from this region of the world.A total of 40 genes or genomic regions and69 genetic variants,58%representing markers involved in inflammatory response,have been used in a number of studies in which predominates a low number of individuals(cases and controls)*** of IL-1B(-511 C/T,14 studies;-31 T/C,10 studies)and IL-1RN(variable number of tandem repeats,17 studies)are the most represented ones in the reviewed *** genetic variants recently evaluated in large metaanalyses and associated with gastric cancer risk were also analyzed in a few studies[e.g.,prostate stem cell antigen(PSCA),CDH1,Survivin].Further and better analysis centered in gene polymorphisms linked to other covariates,epidemiological studies and the information provided by meta-analyses and genome-wide association studies should help to improve our understanding of gastric cancer etiology in order to d

关键词： Latin America Gastric cancer Precancerous lesions Gene polymorphisms Single nucleotide polymorphisms

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Hydrodynamics and suspended particulate matter retention in macrotidal estuaries located in Amazonia-semiarid interface(Northeastern-Brazil)

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International Journal of Sediment Research 2020年第4期35卷 417-429页

作者： Vinicius Henrique Maciel dos Santos Francisco Jose da Silva Dias Audalio Rebelo Torres Romulo Araujo Soares Lais Costa Terto Antonio Carlos Leal de Castro Ricardo Luvizotto Santos Marco Valerio Jansen Cutrim laboratorio de Hidrodinamica Costeira Estuarina e de Aguas Interiores (LHiCEAI) Do Programa de Pos-Graduacao Em Oceanografia (PPGOceano) da Universidade Federal Do Maranhao (UFMA)Cidade Universitaria Dom Delgado laboratorio de Ictiologia (LabIctio) da Universidade Federal Do Maranhao (UFMA) Cidade Universitaria Dom Delgado laboratorio de Ecotoxicologia (LabEcotox) Do Programa de Pos-Graduacao Em Oceanografia (PPGOceano) da Universidade Federal Do Maranhao (UFMA) Cidade Universitaria Dom Delgado laboratorio de Ficologia (LabFic) Do Programa de Pos-Graduacao Em Oceanografia (PPGOceano) da Universidade Federal Do Maranhao (UFMA) Cidade Universitaria Dom Delgado

The aim of the current study was to determine the nature of the seasonal variability of the Suspended Particulate Matter(SPM) fluxes from the drainage basin to the estuary in a macrotidal region(Northeastern Brazil),and the estuarine response to a seawater intrusion regarding sediment deposition,which will support the understanding of the global transport of materials at the continent-ocean *** structure data was acquired using a Conductivity,Temperature,and depth(CTD) probe with a sampling frequency of 4 *** particulate material was measured by gravimetric measurements applied to exact filtered volume *** outflows were measured through the use of an Acoustic Doppler Current Profiler(ADCP) with frequency of 1.5 *** horizontal thermal and saline gradients varied from warmer and less saline waters(2014) to cooler and saline waters(2015).The gradient behavior when linked to volume transport and SPM flows,suggests a minimization of the fluvial flows in 2015,easing the advance of coastal water(CW) towards the inner estuary,leading to an inversion of the baroclinic pressure *** bottom saline front,generated by the entrance of coastal water masses,caused an increase in SPM concentrations due to increased fluid density,resuspension of previously deposited sediment,and erosion of *** concentrations of SPM indicate higher volume transport suggesting a hydraulic barrier due to the change/inversion of the baroclinic pressure gradient,resulting in water and material *** deposition was observed during neap tide,while during spring tide the material is resuspended,increasing the concentration,generating cycles of deposition and erosion during the neap-spring *** sediment in suspension that reach the estuary,even with low fluvial volume,stay in this environment forming new islands because of *** deposition rates or sediment cycling,if generated by the hydraulic barrier,may indicate that the flo

关键词： Brazilian Amazonia Materials discharges Macrotidal estuaries Freshwater percentage Residence time

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Effects of Plant Extracts and Beauveria bassiana on the Activity of defense-Related Enzymes in Solanum lycopersicum *** Interaction with Fusarium oxysporum ***

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Phyton-International Journal of Experimental Botany 2023年第9期92卷 2503-2518页

作者： JoséAdrian Perez-Robles Carlos Alberto Lecona-Guzmán Víctor Manuel Ruíz-Valdiviezo Joaquín Adolfo Montes-Molina laboratorio de Biotecnología Vegetal Tecnológico Nacional de MexicoCampus Tuxtla GutiérrezTuxtla Gutiérrez29050Mexico

The objective to this work was to evaluate the enzymatic activity in the culture of Solanum lycopersicum *** with Fusarium oxysporum after the combined application of Beauveria bassiana and plant *** lycopersicum plantlets were transplanted 15 days after the *** days after transplanting,Beauveria bassiana spores were applied at a concentration of 1×10^(7)spores mL^(−1)onto soil(along with ***(N)and ***(H)leaf extracts)where *** plants were *** days after transplanting,spores of *** strain were applied at a concentration of 1×10^(6)spores mL^(−1)to soil where *** plants were *** development of *** plants was monitored for 114 days,whereby a randomized complete block treatment design was used,the roots of the plants were crushed with liquid nitrogen,after which UV/VIS spectrophotometry was used to determine protein concentration,as well as the activity ofβ-1,3-glucanases,peroxidases(POX,EC1.***.1.7),catalase and *** treatments combining *** and *** and *** extracts,had a significant difference in enzymatic activity levels,thus contributing to better defense mechanisms and a greater protection to *** plants in the presence of *** application of *** and plant extracts to the ground mitigated damage caused by *** on *** plants.

关键词： Glucanases chitinases peroxidases catalase defense mechanisms

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