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Research 2024年第2期2023卷 541-552页

作者： Zhaojie Xu Fan Mo Gucheng Yang Penghui Fan Botao Lu Wei Liang Fanli Kong Luyi Jing Wei Xu Juntao Liu Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of transducer technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Epilepsy severely impairs the cognitive behavior of *** remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex(MEC),a region known for its involvement in spatial *** explore this neural mechanism,we recorded the spikes and local field potentials from MEC neurons in lithium-pilocarpine-induced epileptic rats using self-designed microelectrode *** the open field test,we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of ***,we analyzed theta oscillations and theta modulation in both excitatory and inhibitory ***,we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic *** the epilepsy modeling,the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period(1 to 5 d).Subsequently,the firing characteristics and theta oscillations were *** the chronic period(>10 d),the performance in the novel object experiment *** conclusion,our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency,suggesting the potential use of these changes as a"functional biomarker"for predicting cognitive impairment caused by epilepsy.

关键词： epilepsy impaired involvement

Mitigating set-stuck failure in 3D phase change memory: substituting square pulses with surge pulses

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Science China(Information Sciences) 2024年第5期67卷 295-301页

作者： Ninghua LI Wang CAI Jun XIANG Hao TONG Weiming CHENG Xiangshui MIAO School of Integrated Circuits Huazhong University of Science and Technology Hubei Yangtze Memory laboratories Hubei Institute of Measurement and Testing technology

In the devices that integrate phase change memory(PCM) and ovonic threshold switching(OTS),the OTS threshold voltage often surpasses the RESET operation voltage of PCM. The conventional application of square pulses hinders the successful completion of the SET operation in these integrated devices. To address this challenge, a novel pulse called the surge pulse is introduced, which comprises a high amplitude pulse for OTS activation and a low amplitude pulse for PCM operation. By employing COMSOL simulation,the operational effectiveness of both square pulses and surge pulses is validated. Test results reveal that using a square pulse to operate the integrated device accelerates the occurrence of SET-stuck failure(SSF).In contrast, the surge pulse enables the integrated device to operate for at least 1000 cycles while preserving the essential cyclic characteristics. Additionally, an investigation into the overshoot component of the surge pulse is conducted, revealing that an increase in overshoot amplitude and pulse width also accelerates the emergence of SSF. By applying the theory of ion migration induced by the electric field, the root cause of SSF in integrated devices is explained, and the accuracy of the theory is validated through the application of a reverse pulse. In summary, this study elucidates the rationality of replacing the square pulse with a surge pulse, presenting a superior approach for operating PCM and OTS integrated devices.

关键词： surge pulse phase change memory (PCM) integration SET-stuck failure (SSF) square pulse

HF-VHF NEMS resonators enabled by 2D semiconductor ReSe2

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Science China(Information Sciences) 2024年第10期67卷 393-394页

作者： Jie TANG Ziluo SU Shuang CAI Yalan WANG Luming WANG Jiaqi WU Jiaze QIN Jiankai ZHU Bo XU Juan XIA Zenghui WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China State Key Lab of transducer technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China

Two-dimensional（2D） semiconductors offer a plethora of new opportunities for constructing novel *** them, rhenium diselenide(ReSe2, crystal structure in Figure 1（a）) stands out due to its unique interlayer couplin...

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Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson’s disease

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Bio-Design and Manufacturing 2024年第4期7卷 439-452页

作者： Luyi Jing Zhaojie Xu Penghui Fan Botao Lu Fan Mo Ruilin Hu Wei Xu Jin Shan Qianli Jia Yuxin Zhu Yiming Duan Mixia Wang Yirong Wu Xinxia Cai State Key Laboratory of transducer technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep *** microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise *** this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain *** results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned *** addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the ***,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN *** with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned *** may be a cause of sleep and motor disorders associated with ***,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

关键词： Functional localization Implantable microelectrode arrays Parkinson’s disease Subthalamic nucleus

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A resonant high-pressure microsensor based on a composite pressure-sensitive mechanism of diaphragm bending and volume compression

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Microsystems & Nanoengineering 2024年第2期10卷 57-66页

作者： Pan Qian Zongze Yu Jie Yu Yulan Lu Bo Xie Jian Chen Deyong Chen Junbo Wang The State Key Laboratory of transducer technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing100190China The School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049China

In this paper,a composite pressure-sensitive mechanism combining diaphragm bending and volume compression was developed for resonant pressure microsensors to achieve high-pressure measurements with excellent *** composite mechanism was explained,and the sensor structure was designed based on theoretical analysis and finite element *** all-silicon resonant high-pressure microsensor with multiple miniaturized cavities and dual resonators was developed,where dual resonators positioned in two resonant cavities with suitably different widths are used to perform opposite characteristics in pressure and the same characteristics at different temperatures,which can improve pressure sensitivities and realize temperature self-compensation by differential frequency *** microsensor was fabricated by microfabrication,and the experimental results showed that the sensor had an accuracy of±0.015%full scale(FS)in a pressure range of 0.1~100 MPa and a temperature range of−10~50℃.The pressure sensitivity of the differential frequency was 261.10 Hz/MPa(~2523 ppm/MPa)at a temperature of 20℃,and the temperature sensitivities of the dual resonators were−1.54 Hz/℃(~−14.5 ppm/℃)and−1.57 Hz/℃(~−15.6 ppm/℃)at a pressure of 2 *** differential output had an outstanding stability within±0.02 Hz under constant temperature and ***,this research provides a convenient solution for high-pressure measurements because of its advantages,namely,large range,excellent accuracy and stability.

关键词： stability resonant bending

Polyphenol-mediated interfacial deposition strategy for supported manganese oxide catalysts with excellent pollutant degradation performance

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Chinese Chemical Letters 2024年第5期35卷 493-498页

作者： Dong Cheng Youyou Feng Bingxi Feng Ke Wang Guoxin Song Gen Wang Xiaoli Cheng Yonghui Deng Jing Wei The Key Laboratory of Biomedical Information Engineering of Ministry of Education State Key Lab of Transducer TechnologySchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China School of Environmental and Municipal Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersState Key Laboratory of Transducer TechnologyFudan UniversityShanghai 200433China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China

In persulfate-based advanced oxidation process(PS-AOPs),fixing nanosized metal oxide on processable substrates is highly desirable to avoid the aggregation and loss of nanocatalysts during the practical ***,it is still challenging to develop a versatile strategy for the deposition of metal oxide nanocatalysts on various substrates with different physicochemical ***,polyphenols are utilized as a“molecular glue”and reductant to mediate the interfacial deposition of MnO_(2) nanocatalysts on different ***_(2) nanocatalysts were in-situ grown on macroscope mineral substrates(e.g.,airstone)via an interfacial redox strategy between tannic acid(TA)and oxidized KMnO4,and then employed as a fixed catalyst of peroxymonosulfate(PMS)activation for treating pharmaceutical and personal care products(PPCPs)in *** fixed MnO_(2) exhibited superior catalytic performance toward different PPCPS via a singlet oxygen(^(1)O_(2))-dominated nonradical oxidation *** in the secondary effluent of wastewater treatment plants could be effectively removed by a fixed-bed column of the fixed MnO_(2) with long term *** cycle of Mn^(4+)/Mn^(3+)and surface hydroxyl group of the fixed MnO_(2) was proved to be responsible for the activation of *** work provides a new avenue for developing fixed metal oxides for sustainable water treatment.

关键词： Redox strategy Manganese oxides Fixed catalyst Peroxymonosulfate PPCPs

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Oriented mesoporous nanofibers show nature's wisdom

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National Science Review 2024年第6期11卷 90-91页

作者： Yonghui Deng Department of Chemistry State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy Material (iChEM) Fudan University State Key Lab of transducer technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences

Electrodes assembled with conventional nanoparticulate materials in electrochemical energy devices usually have a random and torturous porous system. To meet ever-increasing demands for higher volumetric energy density at packagelevel, packing more active materials in a limited volume becomes increasingly difficult since transportation of reactants(e.g. electrolyte) and charges through high-tortuosity channels/pathways in thick electrodes meets large impedance[1].

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MEMS reservoir computing system with stiffness modulation for multi-scene data processing at the edge

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Microsystems & Nanoengineering 2024年第3期10卷 421-432页

作者： Xiaowei Guo Wuhao Yang Xingyin Xiong Zheng Wang Xudong Zou The State Key Laboratory of transducer technology Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijingChina QILU Aerospace Information Research Institute JinanChina

Reservoir computing(RC)is a bio-inspired neural network structure which can be implemented in hardware with *** has been applied across various fields such as memristors,and electrochemical reactions,among which the microelectro-mechanical systems(MEMS)is supposed to be the closest to sensing and computing *** previous MEMS RCs have demonstrated their potential as reservoirs,the amplitude modulation mode was found to be inadequate for computing directly upon *** achieve this objective,this paper introduces a novel MEMS reservoir computing system based on stiffness modulation,where natural signals directly influence the system stiffness as *** this innovative concept,information can be processed locally without the need for advanced data collection and *** present an integrated RC system characterized by small volume and low power consumption,eliminating complicated setups in traditional MEMS RC for data discretization and *** simulation and experiment were conducted on our *** performed nonlinearity tuning for the resonator and optimized the post-processing algorithm by introducing a digital mask ***,our MEMS RC is capable of both classification and forecasting,surpassing the capabilities of our previous non-delay-based *** method successfully processed word classification,with a 99.8%accuracy,and chaos forecasting,with a 0.0305 normalized mean square error(NMSE),demonstrating its adaptability for multi-scene data *** work is essential as it presents a novel MEMS RC with stiffness modulation,offering a simplified,efficient approach to integrate sensing and *** approach has initiated edge computing,enabling emergent applications in MEMS for local computations.

关键词： computing hardware stiffness

A self-selecting memory element based on a method of interconnected ovonic threshold switching device

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Science China(Information Sciences) 2024年第3期67卷 319-320页

作者： Jinyu WEN Lun WANG Jiangxi CHEN Hao TONG Xiangshui MIAO School of Integrated Circuits Huazhong University of Science & Technology Institute of Artificial Intelligence Huazhong University of Science & Technology Hubei Yangtze Memory laboratories

Currently, the 3-D cross-point structure has been successfully applied in phase change memory(PCM) to achieve scalable and stackable memory arrays [1]. The ovonic threshold switching(OTS) selector consists of a memory element that is used to suppress the parasitic current in the 3-D cross-point arrays due to its highly nonlinear currentvoltage(I-V)characteristics which are significant for largescale memory arrays [2].

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Efficient implementation of majority-inverter graph logic and arithmetic functions with memristor arrays

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Science China(Information Sciences) 2024年第7期67卷 345-346页

作者： Zhouchao GAN Dongdong ZHANG Chenyu ZHANG Yinghao MA Xiangshui MIAO Xingsheng WANG School of Integrated Circuits & Wuhan National Lab. for Optoelectronics Huazhong University of Science and Technology Hubei Yangtze Memory laboratories

Memristors are characterized by several outstanding features that permit them to function both as memory and logic units, enabling logic-in-memory (LIM) computing that potentially breaks the von Neumann bottleneck. Typically,in-memory logic is categorized into stateful logic and nonstateful logic based on the physical quantities of inputs and outputs.

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