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Plant triterpenoid saponins function as susceptibility factors to promote the pathogenicity of Botrytis cinerea

molecular Plant 2024年第7期17卷 1073-1089页

作者： Francisco J.escaray Amelia Felipo-Benavent Cristian J.Antonelli Begona Balaguer Maria Pilar Lopez-Gresa Pablo Vera Instituto de Biologia molecular y celular de Plantas Universidad Politecnica de Valencia-C.S.l.CCiudad Politecnica de la InnovacionEdificio 8Eacceso GIngeniero Fausto Elios/n46022ValenciaSpain

The gray mold fungus Botrytis cinerea is a necrotrophic pathogen that causes diseases in hundreds of plant species,including high-value *** polyxenous nature and pathogenic success are due to its ability to perceive host signals in its *** this study,we found that laticifer cells of euphorbia lathyris are a source of susceptibility factors required by *** to cause ***,poor-in-latex(pil)mutants,which lack laticifer cells,show full resistance to this pathogen,whereas lot-of-latex mutants,which produce more laticifer cells,are *** S factors are triterpenoid saponins,which are widely distributed natural products of vast structural *** downregulation of laticifer-specific oxydosqualene cyclase genes,which encode the first committed step enzymes for triterpene and,therefore,saponin biosynthesis,conferred disease resistance to ***,the Medicago truncatula Iha-1 mutant,compromised in triterpenoid saponin biosynthesis,showed enhanced ***,the application of different purified triterpenoid saponins pharmacologically complemented the diseaseresistant phenotype ofpil and hla-1 mutants and enhanced disease susceptibility in different plant *** found that triterpenoid saponins function as plant cues that signal transcriptional reprogramming in ***,leading to a change in its growth habit and infection strategy,culminating in the abundant formation of infection cushions,the multicellular appressoria apparatus dedicated to plant penetration and biomass destruction in *** together,these results provide an explanation for how plant triterpenoid saponins function as disease susceptibility factors to promote *** pathogenicity.

关键词： euphorbia lathyris laticifer cell latex appressorium infection cushion necrotrophic fungi

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detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3S−Instituto de Investigação e Inovação em Saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAS−Instituto de Ciências Biomédicas Abel Salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

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Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

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Neural Regeneration Research 2024年第3期19卷 542-547页

作者： María Norte-Muñoz David García-Bernal Diego García-Ayuso Manuel Vidal-Sanz Marta Agudo-Barriuso Grupo de Investigación Oftalmología experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de Investigación Trasplante Hematopoyético y Terapia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical *** stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and *** studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional ***,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous ***,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation.

关键词： adaptive immunity cell therapy central nervous system immune system innate immunity mesenchymal stromal cells neuroregeneration preclinical studies retina transplantation

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Synaptic pathology in multiple sclerosis:a role for Nogo-A signaling in astrocytes?

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Neural Regeneration Research 2023年第1期18卷 127-128页

作者： Sheila espírito-Santo Vinícius Gabriel Coutinho Flávia Carvalho Alcantara Gomes laboratório de Biologia celular e Tecidual Universidade Estadual do Norte Fluminense Darcy RibeiroCampos dos GoytacazesRJBrazil laboratório de Neurobiologia celular Universidade Federal do Rio de JaneiroInstituto de Ciências BiomédicasRio de JaneiroRJBrazil

Multiple sclerosis(MS)is characterized as an inflammatory demyelinating disease that affects the central nervous system(CNS),leading to sensory,motor and cognitive ***,axonal denudation culminates in axonal lesions and *** demyelinating lesions in MS are associated with infiltration of immune cells combined with activation of the resident CNS inflammatory cells,astro-and microglia.

关键词： sclerosis impairment lesions

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The versatility of mesenchymal stem cells:From regenerative medicine to COVID,what is next?

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BIOCeLL 2022年第4期46卷 913-922页

作者： THAÍS CASAGRANde PAIM MÁRCIA ROSÂNGeLA WINK laboratório de Biologia celular Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-170Brazil

Mesenchymal stem cells(MSCs)play key roles in regenerative medicine by promoting tissue *** can be isolated from different adult tissues and they are able to differentiate into several *** to their antiinflammatory,angiogenic and immune-modulatory properties,MSCs are suitable for tissue engineering applications and,when associated with biomaterials,their benefits can be ***,recently,MSCs have been studied for new clinical applications,such as in the treatment of patients with *** regenerative potential has been attributed to their secretome,which comprises extracellular matrix,soluble proteins and several elements,including the release of extracellular *** though,in order to explore all their therapeutic potential,it is still necessary to advance in the investigation of their basic cell biology characteristics.

关键词： Mesenchymal stem cells Regenerative medicine Secretome Biomaterials extracellular vesicles

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Tuning mesenchymal stem cell secretome therapeutic potential through mechanotransduction

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BIOCeLL 2022年第6期46卷 1375-1381页

作者： GIORDANO WOSGRAU CALLONI MARCO AUGUSTO STIMAMIGLIO laboratório de Plasticidade e Diferenciação de Células da Crista Neural Departamento de Biologia CelularEmbriologia e GenéticaCentro de Ciências BiológicasUniversidade Federal de Santa CatarinaCampus Universitário–TrindadeCEPFlorianópolis88040-900Brazil laboratório de Biologia Básica de Células-Tronco Instituto Carlos ChagasFiocruz/PRCEPCuritiba81350-010Brazil

Mesenchymal stem cells(MSCs)and their byproducts have been widely validated as potential therapeutic products for regenerative *** therapeutic effects result mainly from the paracrine activity of MSCs,which consists of the secretion of bioactive molecules,whether dispersed in medium conditioned by cell culture or encapsulated in extracellular *** composition of the MSC secretome,which represents the set of these secreted cellular products,is crucial for the performance of the desired therapeutic *** cell culture strategies have been employed to adjust the secretome composition of MSCs to obtain the best therapeutic responses for different clinical ***,the manipulation of culture conditions has focused mainly on the use of different biochemical elements for the preconditioning of MSCs and less on the physical conditions of the cell culture ***,we offer our point of view regarding the importance of the physical properties of cell culture substrates and their mechanotransduction responses in preconditioning the MSCs *** highlight the relevance of studying mechanotransduction events associating cell morphology and the modulation of gene expression to customize and expand the use of MSCs secretomes.

关键词： Mesenchymal stem cells Mechanotransduction Scaffolds Secretome Bioengineering

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Intracellular life of protozoan Toxoplasma gondii:Parasitophorous vacuole establishment and survival strategies

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BIOCeLL 2023年第4期47卷 929-950页

作者： JULIANA A.PORTeS ROSSIANe C.VOMMARO LUCIO AYReS CALDAS eRICA S.MARTINS-DUARTe laboratório de Ultraestrutura celular Hertha Meyer Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Núcleo Multidisciplinar de Pesquisa UFRJ–Xerém em Biologia Campus Duque de CaxiasUniversidade Federal do Rio de JaneiroDuque de CaxiasBrazil laboratório de Quimioterapia de Protozoários egler Chiari Departamento de ParasitologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil

Toxoplasma gondii is a protozoan of worldwide distribution and the agent of *** is estimated that 30%–50%of the world population could be infected with this *** the infection in immunocompetent individuals is mostly asymptomatic,the disease in immunosuppressed and pregnant is a risk *** a member of the phylum Apicomplexa,*** has an obligatory intracellular lifestyle;therefore,invading a host cell and establishing it inside a parasitophorous vacuole(PV)are mandatories for the survival of this *** construction of a perfect intracellular niche for *** requires the secretion of an arsenal of proteins from unique secretory *** proteins will remodel the vacuolar environment and the host cell organization and functions,allowing the parasite to access essential nutrients and stay“invisible”inside a host *** the present review,we will discuss the main steps involved in the PV formation and its differentiation to tissue cyst,focusing mainly on the strategies employed in the acquisition of nutrients and proteins involved in host cell modification.

关键词： dense granule proteins Rhoptry proteins Nutrient acquisition Intravacuolar network Immune evasion Tissue cyst

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher e Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e imunologia molecular da Universidade do Porto Porto 4200-465Portugal departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied environmental Metagenomics and Infectious Diseases Research(AeMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of energy and environment City University of Hong KongHong Kong 999077China department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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The left-right side-specific endocrine signaling:implications for neurological deficits in stroke and neurodevelopmental disorders

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Neural Regeneration Research 2022年第11期17卷 2431-2433页

作者： Georgy Bakalkin Nikolay Lukoyanov Igor Lavrov Mengliang Zhang department of Pharmaceutical Biosciences Uppsala University departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto Instituto de Investiga??o e Inova??o em SaúdeInstituto de Biologia Molecular e Celular department of Neurology Mayo Clinic department of molecular Medicine University of Southern Denmark

Brain injury-induced neurological deficits typically develop on the contralateral side of the body and include abnormal posture,motor weakness,and *** is believed that the interruption of descending neural pathways th... 详细信息

关键词： neurological typically deficit

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CRISPR-Cas-based plant genome engineering goes viral

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molecular Plant 2023年第4期16卷 660-661页

作者： Jose-Antonio Daros Fabio Pasin Fernando Merwaiss Instituto de Biologia molecular y celular de Plantas(CSiC-Universitat Politecnica deValencia) 46022ValenciaSpain

Biotechnological advances in the field of plant biology based on the bacterial and archaeal CRiSPR-Cas systems promise a new generation of crop plants that are more productive and nutritive,resistant to pest and pathogens,and better adapted to environmental ***,application of this technology in plants still encounters some burdens,especially related to the expression of the CRISPR-Cas reaction components in plant cells.

关键词： plant CRISPR adapted

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