Landscape of global urban environmental resistome and its association with local socioeconomic and medical status
作者机构：Center for Bioinformatics and Computational Biologyand the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of BiologyProgram on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell MedicineNew York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational BiomedicineNew York 10065USA Department of Pulmonary MedicineShanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em SaúdeUniversidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do PortoPorto 4200-465Portugal Departamento de BiologiaFaculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing GroupZentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research CenterBogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR)Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of BiotechnologyJagiellonian UniversityKraków 30-005Poland Aix-Marseille UniversitéMediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and BiotechnologyFaculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur KoreaSeoul 13488Republic of Korea Faculty of Environment and Information StudiesKeio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at BoulderCivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New YorkBrooklyn 11210USA School of Energy and EnvironmentCity University of Hong KongHong Kong 999077China Department of MicrobiologyFaculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and Therapy Research CenterGuangxi Medical UniversityNanning 530021China College of Architecture and Urban PlanningTongji UniversityShanghai 200092China Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang University&Capital Medical UniversityBeijing 100083China
出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)
年 卷 期：2024年第67卷第6期
页 面：1292-1301页
核心收录：
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：supported by the National Key Research and Development Program of China(2023YFC2706503) the National Natural Science Foundation of China(32370720) Beihang University&Capital Medical University Plan(BHME-201904) the Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE,ECNU,Key Laboratory of MEA,Ministry of Education,ECNU,Key Laboratory of Ecology and Energy Saving Study of Dense Habitat(Tongji University),Ministry of Education-Shanghai Tongji Urban Planning&Design Institute Co.,Ltd Joint Research Project(KY-2022-LH-A03) Shanghai Tongji Urban Planning&Design Institute Co.,Ltd-China Intelligent Urbanization Co-creation Center for High Density Region Research Project(KY-2022-PT-A02) the Irma T.Hirschl and Monique Weill-Caulier Charitable Trusts Bert L and N Kuggie Vallee Foundation the World Quant Foundation The Pershing Square Sohn Cancer Research Alliance the National Institutes of Health(R01AI151059) the National Science Foundation(1840275) the Alfred P.Sloan Foundation(G-2015-13964)
主 题：urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters
摘 要：Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.
维普期刊数据库
同方期刊数据库