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Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer

Chinese Medical Journal 2024年第3期137卷 338-349页

作者： Feng Xu Kun Xu Lingling Fan Xintong Li Yiqiu Liu Fang Yang Chengjun Zhu Xiaoxiang Guan Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjingJiangsu 210009China The Comprehensive Cancer Center of Nanjing Drum Tower Hospital Affiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu 210008China Jiangsu Key lab.of Cancer biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Background:Triple-negative breast cancer(TNBC)is an aggressive type of breast cancer associated with poor prognosis and limited treatment *** androgen receptor(AR)has emerged as a potential therapeutic target for luminal androgen receptor(LAR)***,multiple studies have claimed that anti-androgen therapy for AR-positive TNBC only has limited clinical *** study aimed to investigate the role of AR in TNBC and its detailed ***:Immunohistochemistry and TNBC tissue sections were applied to investigate AR and nectin cell adhesion molecule 4(NECTIN4)expression in TNBC ***,in vitro and in vivo assays were used to explore the function of AR and estrogen receptor beta(ERβ)in *** immunoprecipitation sequencing(ChIP-seq),co-immunoprecipitation(co-IP),molecular docking method,and luciferase reporter assay were performed to identify key molecules that affect the function of ***:Based on the TNBC tissue array analysis,we revealed that ERβand AR were positive in 21.92%(32/146)and 24.66%(36/146)of 146 TNBC samples,respectively,and about 13.70%(20/146)of TNBC patients were ERβpositive and AR *** further demonstrated the pro-tumoral effects of AR on TNBC cells,however,the oncogenic biology was significantly suppressed when ERβtransfection in LAR TNBC cell lines but not in AR-negative ***,we identified that NECTIN4 promoter–42 bp to–28 bp was an AR response element,and that ERβinteracted with AR thus impeding the AR-mediated NECTIN4 transcription which promoted epithelial–mesenchymal transition in tumor ***:This study suggests that ERβfunctions as a suppressor mediating the effect of AR in TNBC prognosis and cell ***,our current research facilitates a better understanding of the role and mechanisms of AR in TNBC carcinogenesis.

关键词： Androgen receptor Estrogen receptor beta Triple-negative breast cancer NECTIN4 Oncogenic effects Tumor progression

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Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

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Regenerative biomaterials 2020年第5期7卷 491-504页

作者： Peichuang Li Wanhao Cai Xin Li Kebing Wang Lei Zhou Tianxue You Rui Wang Hang Chen Yuancong Zhao Jin Wang Nan Huang Key lab.of Advanced Technology for Materials of Education Ministry Southwest Jiaotong UniversityChengdu 610031China School of Materials Science and Engineering Southwest Jiaotong UniversityChengdu 610031China Institute of Physical Chemistry University of FreiburgAlbertstraße 21aFreiburg 79104Germany

Polyurethanes are widely used in interventional devices due to the excellent physicochemical ***,non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous ***,a novel phospholipid-based polycarbonate urethanes(PCUs)were developed via two-step solution polymerization by direct synthesis based on functional raw ***,PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling *** results of stress–strain curves exhibited excellent tensile properties of PCUs *** scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender,leading to different biological *** vitro blood compatibility tests including bovine serum albumin adsorption,fibrinogen adsorption and denaturation,platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs *** cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ***,animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and *** results high light the strong anti-adhesion property of phospholipid-based PCUs films,which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future.

关键词： phospholipid polycarbonate urethanes non-specific adhesion anti-thrombosis histocompatibility

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Decorative Wood Fiber/High-Density Polyethylene Composite with Canvas or Polyester Fabric

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Journal of Renewable Materials 2020年第8期8卷 879-890页

作者： Jialin Lv Rao Fu Yinan Liu Xuelian Zhou Weihong Wang Pengbo Xie Tingwei Hu Key lab.of bio-Based Material Science&Technology of EducationMinistry Northeast Forestry UniversityHarbin150040China Taizhou University Taizhou318000China

Wood-plastic composite is an environmentally friendly material,due to its use of recycled thermoplastics and plant ***,its surface lacks attractive aesthetic *** this paper,a method of decorating wood fiber/high-density polyethylene(WF/HDPE)without adding adhesive was *** or polyester fabrics were selected as the surface decoration *** influence of hot-pressing temperature and WF/HDPE ratio on the adhesion was *** surface bonding strength,water resistance,and surface color were evaluated,and observation within the infrared spectrum and under scanning electron microscopy was used to analyze the bonding *** results showed that the fabric and WF/HDPE substrate could be closely laminated together depending on the HDPE layer accumulated on the WF/HDPE *** molten HDPE matrix penetrates canvas more easily than polyester fabric,and the canvasveneered composite shows a greater bonding strength than does the polyester fabric-veneered composite.A higher proportion of the thermoplastic component in the substrate improved the *** the hot-pressing temperature exceeded 160°C,the fabric-veneered WF/HDPE panels had greater water resistance,although the canvas fabric changed more obviously in terms of fiber shape and color,compared with the polyester *** the canvas fabric,140°C–160°C was a suitable hot-pressing temperature,whereas 160°C–180°C was more suitable for polyester *** proportion of the thermoplastic component in the composite should be not less than 30%to achieve adequate bonding strength.

关键词： wood-plastic composites high-density polyethylene polyester fiber canvas surface decoration

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Inhibitory Effect of Extracellular Polysaccharide EPS-II from Pseudoalteromonas on Candida adhesion to Cornea in vitro

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biomedical and Environmental Sciences 2012年第2期25卷 210-215页

作者： CHEN Hao ZHENG Zhou CHEN Peng WU Xiang Gen ZHAO Ge State Key lab Cultivation Base Shandong Provincial Key Lab of OphthalmologyShandong Eye InstituteQingdao 266071ShandongChina Key laboratory of Marine bio-active Substances First Institute of OceanographyState Oceanic AdministrationQingdao 266061ShandongChina.

Objective Fungal keratitis（FK） is a vision-threatening infection,whose treatment requires more effective and safer anti-fungal agent exploitation *** this aim,we focused on the effect of an extracellular polysaccharide on fungal adhesion to human corneal epithelial *** We performed the cytotoxicity assays of the extracellular polysaccharide EPS-II from an antarctic bacterium Pseudoaltermonas and evaluated its inhibitory effect on Candida albicans cells＇ adherence to human corneal epithelial cells（HCECs）.Results EPS-II,which displayed minor cytotoxicity but also promoted proliferation of HCECs,could inhibit the adherence of yeast cells to HCECs in a dose-dependent ***-II could also suppress the subsequent PI3K/AKT signaling pathway,and thereby decrease the expression of early inflammatory *** ExtracellularpolysaccharideEPS-IIwassuggestedasanewnaturalagentforattenuatingFK.

关键词： Extracellular polysaccharide EPS-II Candida albicans Cornea adhesion Inhibitory effect

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油墨粘度对卷对卷印刷有机光活性层的油墨转移速率和薄膜缺陷的影响机理

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Science China Materials 2024年第8期67卷 2600-2610页

作者：刘媛琪王振国潘雅琴刘天宇张亚宾张青莫黎昕骆群马昌期 Beijing Engineering Research Center of Printed Electronics Beijing Institute of Graphic CommunicationBeijing 102600China i-lab&Printable Electronics Research Center Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of Sciences(CAS)Suzhou 215123China Vacuum Interconnected Nanotech Workstation(Nano-X) Suzhou Institute of Nano-Tech and Nano-Bionics of Chinese Academy of Sciences(CAS)Suzhou 215123China

卷对卷(R2R)凹版印刷具有高的边缘分辨率、可图案化、高加工速度等优势,是制备大面积柔性有机太阳能电池(FOSCs)的一种可行技术.有机光活性层的薄膜质量是决定有机太阳能电池器件性能的关键.对于凹版印刷过程而言,墨水的转移是影响印刷... 详细信息

卷对卷(R2R)凹版印刷具有高的边缘分辨率、可图案化、高加工速度等优势,是制备大面积柔性有机太阳能电池(FOSCs)的一种可行技术.有机光活性层的薄膜质量是决定有机太阳能电池器件性能的关键.对于凹版印刷过程而言,墨水的转移是影响印刷薄膜厚度和质量的关键.本文深入研究了有机光活性层的墨水粘度对墨水转移率和薄膜缺陷的影响.我们开发了紫外可见光谱法,量化凹版印刷过程中墨水的转移率.通过对墨水的流变行为分析、流体动力学模拟和实验验证,深入研究了油墨粘度与油墨转移率、膜厚和膜均匀性之间的关系.结果表明,油墨粘度约为25 m Pa·s是R2R凹版印刷有机光活性层薄膜的适合粘度.通过对油墨配方的优化,我们制备了全R2R印刷FOSCs,其中1 cm^(2);电池的效率超过12%.

关键词：凹版印刷油墨粘度油墨转移率有机太阳能电池油墨配方紫外可见光谱法流体动力学模拟活性层

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adhesion is safe to the refractive surgeries: A theoretical analysis

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Medicine in Novel Technology and Devices 2022年第3期15卷 154-160页

作者： Jiajin Yang Shuai Wu Qiaomei Ren Junjie Wang Zhipeng Gao Xiaona Li Weiyi Chen Department of biomedical Engineering Taiyuan University of TechnologyTaiyuanChina The First People's Hospital of Jinzhong Shanxi Medical UniversityJinzhongChina Eye Hospital WenZhou Medical UniversityWenzhouChina State Key lab.of Traction Power Southwest Jiaotong UniversityChengduChina

adhesion behavior,existed on the damaged interface,was responsible for the safety and stability of the postoperative cornea refer to the refractive *** this study,we inferred that the force loss generated by the post-operative cornea must do not surpass the interfacial adhesion force of the *** case of that,the corneal flap(or cap)would trend to separate from the residual stromal bed,and then became a threat to the visual health of the corrected myopic *** to this inference,we derived the theoretical maximum ablated ratio,which was well matched with the empirically clinical safety standard employing the commonly programmed optical zone.

关键词： Force loss Ablated ratio Interfacial adhesion SMILE LASIK

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Ta_(3)N_(5)–LaTaON_(2) heterojunction with matched interfaces to accelerate charge separation for efficient photocatalytic water oxidation

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Journal of Materials Science & Technology 2023年第23期154卷 241-250页

作者： Guoan Lin Chi Zhang Xiaoxiang Xu Clinical and Central lab Putuo People's Hospital Tongji University Shanghai 200060 China Shanghai Key lab.of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Shanghai 200092 China

Charge separation is generally considered as the most critical step to achieve efficient photocatalytic reactions. Although charge separation can be promoted by a semiconductor heterojunction, its efficacy is inherently restrained by the mismatched atomic arrangements across the heterojunction interfaces. Here, Ta3N5–LaTaON2 heterojunction with matched interfaces has been fabricated by one-step ammonolysis treatment of KLaTa2O7. The match interfaces are formed by nearly perfect adhesion of Ta3N5 (010) and LaTaON2 (101¯) facets whose interatomic distance is similar. Compared with conventional heterojunction, the so-formed Ta3N5–LaTaON2 heterojunction are extremely efficient in accelerating charge separation which in turn enables a high photocatalytic activity. An apparent quantum efficiency as high as 11.6% at 420 ± 20 nm has been reached by Ta_(3)N_(5)–LaTaON_(2) heterojunction, which is almost three times higher than Ta_(3)N_(5)-LaTaON_(2) mixtures. These results signify the importance of matched heterojunction interfaces for charge separation and provide a paradigm in the design of efficient heterojunction-based semiconductor photocatalysts.

关键词： Semiconductor heterojunction LaTaON_(2) Ta_(3)N_(5) Photocatalyst Water oxidation

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NuBot:A Magnetic adhesion Robot with Passive Suspension to Inspect the Steel Lining

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 161-178页

作者： Hao Xu Youcheng Han Mingda He Yinghui Li Weizhong Guo State Key lab.of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

The steel lining of huge facilities is a significant structure,which experiences extreme environments and needs to be inspected periodically after ***,due to the complexity(crisscross welds,curved surface,etc.)of their inside environments,high demands for stable adhesion and curvature adaptability are put *** paper presents a novel wheeled magnetic adhesion robot with passive suspension applied in nuclear power containment called NuBot,and mainly focuses on the following aspects:(1)proposing the wheeled locomotion suspension to adapt the robot to the uneven surface;(2)implementing the parameter optimization of NuBot.A comprehensive optimization model is established,and global optimal dimensions are properly chosen from performance atlases;(3)determining the normalization factor and actual dimensional parameters by constraints of the steel lining environment;(4)structure design of the overall robot and the magnetic wheels are *** show that the robot can achieve precise locomotion on both strong and weak magnetic walls with various inclination angles,and can stably cross the 5 mm weld ***,its maximum payload capacity reaches 3.6 *** show that the NuBot designed by the proposed systematic method has good comprehensive capabilities of surface-adaptability,adhesion stability,and ***,the robot can be applied in more ferromagnetic environments and the design method offers guidance for similar wheeled robots with passive suspension.

关键词： Wheeled robot Passive suspension Magnetic adhesion Steel lining Design method

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Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair

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bioactive Materials 2023年第11期29卷 36-49页

作者： Zhifeng You Xu Gao Xinyi Kang Wen Yang Tiandi Xiong Yue Li Feng Wei Yan Zhuang Ting Zhang Yifu Sun He Shen Jianwu Dai Key laboratory for Nano-bio Interface Research Division of NanobiomedicineSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China Department of Orthopaedic Surgery China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow UniversitySuzhou215004China School of Nano-Tech and Nano-bionics University of Science and Technology of ChinaHefei230026China i-lab Key Laboratory of Multifunction Nanomaterials and Smart SystemsSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou215123China State Key laboratory of Molecular Developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China

Neural regeneration after spinal cord injury (SCI) closely relates to the microvascular endothelial cell (MEC)- mediated neurovascular unit formation. However, the effects of central nerve system-derived MECs on neovascularization and neurogenesis, and potential signaling involved therein, are unclear. Here, we established a primary spinal cord-derived MECs (SCMECs) isolation with high cell yield and purity to describe the differences with brain-derived MECs (BMECs) and their therapeutic effects on SCI. Transcriptomics and proteomics revealed differentially expressed genes and proteins in SCMECs were involved in angiogenesis, immunity, metabolism, and cell adhesion molecular signaling was the only signaling pathway enriched of top 10 in differentially expressed genes and proteins KEGG analysis. SCMECs and BMECs could be induced angiogenesis by different stiffness stimulation of PEG hydrogels with elastic modulus 50-1650 Pa for SCMECs and 50-300 Pa for BMECs, respectively. Moreover, SCMECs and BMECs promoted spinal cord or brain-derived NSC (SNSC/BNSC) proliferation, migration, and differentiation at different levels. At certain dose, SCMECs in combination with the NeuroRegen scaffold, showed higher effectiveness in the promotion of vascular reconstruction. The potential underlying mechanism of this phenomenon may through VEGF/AKT/eNOS- signaling pathway, and consequently accelerated neuronal regeneration and functional recovery of SCI rats compared to BMECs. Our findings suggested a promising role of SCMECs in restoring vascularization and neural regeneration.

关键词： Microvascular endothelial cells Spinal cord injury NeuroRegen scaffold Neural regeneration

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Electronic characteristic,tensile cracking behavior and potential energy surface of TiC(111)/Ti(0001)interface:A first principles study

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中国航空学报:英文版 2023年第9期36卷 451-463页

作者： Silong ZHANG Jibo WANG Lixiang RAO Qizhen HE Xiaolei XING Yefei ZHOU Qingxiang YANG State Key lab.of Metastable Materials Science&Technology Hebei Key Lab for Optimizing Metal Product Technology and PerformanceCollege of Materials Science&EngineeringYanshan UniversityQinhuangdao 066004China College of Physics and Mechanical&Electrical Engineering Longyan UniversityLongyan 364012China College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China

The preparation of TiC coating on Ti alloy surface to improve the wear resistance has attracted attention from researchers in aerospace *** service life of TiC coating is related to the interfacial adhesion properties between TiC coating and Ti alloy ***,it is difficult to explain its interfacial adhesion mechanism by experimental *** on the termination of atoms on the TiC surface,two TiC/Ti interface models named as the C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(11)/Ti(0001) interface were constructed by *** interfacial electronic characteristic of C-Ti bond is a mixture of polar covalent and metal bonds,and that of Ti-Ti bond is the metal *** tensile strains of both C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface in the fracture stage are ranged from 12% to 14%.Their maximum tensile stresses are 16.201 GPa and 15.590GPa,*** sliding potential energy surface maximum of C-terminated-TiC(111)/Ti(0001) and Ti-terminated-TiC(111)/Ti(0001) interface are 5.387 J/m^(2) and 0.271 J/m^(2),*** the sliding potential barriers on the minimum energy path are 2.094 J/m2and 0.136 J/m^(2) with an ideal shear strength of 20.32 GPa and 1.61 GPa,*** summary,the interfacial adhesion property of C-terminated-TiC(111)/Ti(0001) interface is better than that of Ti-terminated-TiC(111)/Ti(0001) interface.

关键词： Electronic First-principles Potential energy surface Tensile TiC/Ti interface

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