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National Science Review 2019年第6期6卷 1105-1106页

作者： Xiawei Wei Yuquan Wei laboratory of aging research and nanotoxicology State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University

Nanoparticle-based nucleic acid therapeutics have drawn considerable attention over recent decades. By using terms such as ‘nanoparticle’ and ‘gene delivery’ in a Pub Med search, we found that 10 years ago throughout 2008 there were only 725 such papers published;however, in 2017, over 4700 papers were published with the same keywords.

关键词： the first approval of an RNAi nanoparticle for treatment of a rare disease Opportunities and challenges in the nanoparticles for nucleic acid therapeutics

Mitochondrial DNA in the regulation of innate immune responses

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Protein & Cell 2016年第1期7卷 11-16页

作者： Chunju Fang Xiawei Wei Yuquan Wei lab of aging research and nanotoxicology State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan University and National Collaborative Innovation Center Chengdu 610041 China

Mitochondrion is known as the energy factory of the cell, which is also a unique mammalian organelle and con. sidered to be evolved from aerobic prokaryotes more than a billion years ago. Mitochondrial DNA, similar to that of its bacterial ancestor＇s, consists of a circular loop and contains significant number of unmethylated DNA as CpG islands. The innate immune system plays an important role in the mammalian immune response. Recent research has demonstrated that mitochondrial DNA （mtDNA） activates several innate immune path- ways involving TLR9, NLRP3 and STING signaling, which contributes to the signaling platforms and results in effector responses. In addition to facilitating antibac- terial immunity and regulating antiviral signaling, mounting evidence suggests that mtDNA contributes to inflammatory diseases following cellular damage and stress. Therefore, in addition to its well-appreciated roles in cellular metabolism and energy production, mtDNA appears to function as a key member in the innate immune system. Here, we highlight the emerging roles of mtDNA in innate immunity.

关键词： mitochondrial DNA innate immunity,TLR9 NLRP3 STING pathway

JMJD3 in the regulation of human diseases

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Protein & Cell 2019年第12期10卷 864-882页

作者： Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei laboratory of aging research and nanotoxicology State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human *** Jumonji domain-containing protein D3(JMJD3),specifically demethylate di-and trimethyllysine 27 on histone H3(H3K27me2/3),has been widely studied in immune diseases,infectious diseases,cancer,developmental diseases,and aging related *** will focus on the recent advances of JMJD3 function in human diseases,and looks ahead to the future of JMJD3 gene research in this review.

关键词： histone methylation JMJD3 epigenetics human diseases

Recent advances of biomaterials in biotherapy

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Regenerative Biomaterials 2016年第2期3卷 99-105页

作者： Ling Li Zhi-Yao He Xia-Wei Wei Yu-Quan Wei laboratory of aging research and nanotoxicology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengduSichuan610041People’s Republic of China

Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs,which include gene therapy,immunotherapy(vaccines and antibodies),bone marrow transplantation and stem-cell *** recent years,numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and ***,biomaterials can be classified into natural or synthetic polymers according to their source,both of which have attracted much ***,biomaterials-based non-viral gene delivery vectors in gene therapy are undergoing rapid development with the emergence of surface-modified or functionalized *** immunotherapy,biomaterials appear to be attractive means for enhancing the delivery efficacy and the potency of ***,hydrogels and scaffolds are ideal candidates in stem-cell therapy and tissue *** this review,we present an introduction of biomaterials used in above biotherapy,including gene therapy,immunotherapy,stem-cell therapy and tissue *** also highlighted the biomaterials which have already entered the clinical evaluation.

关键词： biomaterials biotherapy gene delivery immunotherapy tissue engineering

Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro Susana Monteiro Nuno A.Silva Life and Health Sciences research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

Nucleic acids and analogs for bone regeneration

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Bone research 2018年第4期6卷 331-339页

作者： Yuxin Zhang Wenjuan Ma Yuxi Zhan Chenchen Mao Xiaoru Shao Xueping Xie Xiawei Wei Yunfeng Lin State Key laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Department of Oral Surgery West China Hospital of Stomatology Sichuan University lab of aging research and nanotoxicology State Key Laboratory of Biotherapy West China Hospital Sichuan University

With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination of various technologies and biological materials. Bone tissue engineering has also been considered as a promising strategy to repair various bone defects. Therefore, different biological materials that can promote stem cell proliferation, migration, and osteoblastic differentiation to accelerate bone tissue regeneration and repair have also become the focus of research in multiple fields. Stem cell therapy, biomaterial scaffolds, and biological growth factors have shown potential for bone tissue engineering; however, off-target effects and cytotoxicity have limited their clinical use. The application of nucleic acids(deoxyribonucleic acid or ribonucleic acid)and nucleic acid analogs(peptide nucleic acids or locked nucleic acids), which are designed based on foreign genes or with special structures, can be taken up by target cells to exert different effects such as modulating protein expression, replacing a missing gene, or targeting specific gens or proteins. Due to some drawbacks, nucleic acids and nucleic acid analogs are combined with various delivery systems to exert enhanced effects, but current studies of these molecules have not yet satisfied clinical requirements. In-depth studies of nucleic acid or nucleic acid analog delivery systems have been performed, with a particular focus on bone tissue regeneration and repair. In this review, we mainly introduce delivery systems for nucleic acids and nucleic acid analogs and their applications in bone repair and regeneration. At the same time, the application of conventional scaffold materials for the delivery of nucleic acids and nucleic acid analogs is also discussed.

关键词： Nucleic regeneration defects

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz Juan D.Navarro-López NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva Life and Health Sciences research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao XIA Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI Chen XIAO Renyou XU Wenwen WANG Xiantao SHANG Shiyang LU Dapeng ZHU Hong-Xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key lab of Spintronics Institute of International Innovation Beihang University Qingdao research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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Role of tumor gene mutations in treatment response to immune checkpoint blockades

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Precision Clinical Medicine 2019年第2期2卷 100-109页

作者： Manni Wang Liu Yu Xiawei Wei Yuquan Wei laboratory of aging research and nanotoxicology State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityNo.17Block 3Southern Renmin RoadChengdu 610041PR China

Early studies shed light on the immune suppression of immune checkpoint molecules in the cancer microenvironment,with later studies applying immune checkpoint blockade(ICB)in treatment of various *** the encouraging efficacy of ICBs in a substantial subset of cancer patients,the treatment response *** mutations of both tumor cells and immune cells in the tumor microenvironment have recently been identified as potential predictors of the ICB *** developments in gene expression profiling of tumors have allowed identification of a panel of mutated genes that may affect tumor cell response to ICB *** this review,we discuss the association of the ICB response with gene expression and mutation profiles in tumor cells,which it is hoped will help to optimize the clinical application of ICBs in cancer patients.

关键词： gene mutation immune checkpoint blockade tumor