JMJD3 in the regulation of human diseases

作     者：Xiangxian Zhang Li Liu Xia Yuan Yuquan Wei Xiawei 

作者机构：Laboratory of Aging Research and NanotoxicologyState Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2019年第10卷第12期

页      面：864-882页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work is supported by the National Natural Science Foundation of China(Grant No.81602492) the National Key Research,Development Program of China(No.2016YFA0201402) the National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2018ZX09733001) 

主　　题：histone methylation JMJD3 epigenetics human diseases 

摘      要：In recent years,many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human *** Jumonji domain-containing protein D3(JMJD3),specifically demethylate di-and trimethyllysine 27 on histone H3(H3K27me2/3),has been widely studied in immune diseases,infectious diseases,cancer,developmental diseases,and aging related *** will focus on the recent advances of JMJD3 function in human diseases,and looks ahead to the future of JMJD3 gene research in this review.