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Unveiling the morphogenetic code:A new path at the intersection of physical energies and chemical signaling

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World Journal of Stem Cells 2021年第10期13卷 1382-1393页

作者： Riccardo Tassinari Claudia Cavallini Elena Olivi Valentina Taglioli Chiara Zannini Carlo Ventura National laboratory of molecular biology and Stem Cell Engineering National Institute of Biostructures and Biosystems–ELDOR LABBologna 40129Italy

In this editorial,we discuss the remarkable role of physical energies in the control of cell signaling networks and in the specification of the architectural plan of both somatic and stem *** particular,we focus on the biological relevance of bioelectricity in the pattern control that orchestrates both developmental and regenerative *** this end,the narrative starts from the dawn of the first studies on animal electricity,reconsidering the pioneer work of Harold Saxton Burr in the light of the current *** finally discuss the most recent evidence showing that bioelectric signaling is an essential component of the informational processes that control pattern specification during embryogenesis,regeneration,or even malignant *** conclude that there is now mounting evidence for the existence of a Morphogenetic Code,and that deciphering this code may lead to unprecedented opportunities for the development of novel paradigms of cure in regenerative and precision medicine.

关键词： Physical energies Stem cells Bioelectricity Electromagnetic radiation Mechanical forces Morphogenetic code

Anticancer activity of crude acetone and water extracts of Tulbaghia violacea on human oral cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 456-462页

作者： Samkeliso Takaidza Arumugam Madan Kumar Cornelius Cano Ssemakalu Nagabishek Sirpu Natesh Gayathri Karanam Michael Pillay Department of Biotechnology Vaal University of Technology Cancer biology lab Molecular and Nanomedicine Research Unit Sathyabama Institute of Science and Technology

Objective: To evaluate the anticancer activity of crude acetone and water leaf extracts of Tulbaghia violacea on a human oral cancer cell line(KB).Methods: The antioxidant activity of the leaf extracts was evaluated by using the DPPH assay while the anti-proliferative activity was assessed by using the MTT *** morphological characteristics of apoptotic cells were examined by using the dual acridine orange/ethidium bromide *** cytometry was used to evaluate the induction of multi-caspase activity and changes in the cell ***: The acetone and water extracts exhibited antioxidant activity in a concentration dependent *** extracts inhibited the growth of the KB cell line with IC_(50) values of 0.2 mg/mL and 1 mg/mL, respectively for acetone and *** changes such as cell shrinkage, rounding and formation of membrane blebs were observed in the treated *** acridine orange/ethidium bromide staining, the number of apoptotic cells increased as the concentration of the extracts *** activation of multi-caspase activity in KB cells treated with Tulbaghia violacea extracts was concentration dependent, leading to cell death by apoptosis and cell cycle arrest at the G_2/M ***: The acetone and water extracts of Tulbaghia violacea appear to have anti-cancer activity against human oral cancer cells and need to be investigated further.

关键词： Anticancer activity Antioxidant Apoptosis Caspase Cell cycle Tulbaghia

A robust synthesis route of confined carbyne

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Nano Research 2024年第7期17卷 6274-6280页

作者： Yanghao Feng Wendi Zhang Kunpeng Tang Yingzhi Chen Jiou Zhang Kecheng Cao Weili Cui Lei Shi State Key laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSchool of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China School of Physical Science and Technology and Shanghai Key laboratory of High-resolution Electron Microscopy Shanghai Tech UniversityShanghai 201210China

The unique mechanical,optical,and electrical properties of carbyne,a one-dimensional allotrope of carbon,make it a highly promising material for various *** has been demonstrated that carbon nanotubes(CNTs)can serve as an ideal host for the formation of confined carbyne(CC),with the yield being influenced by the quality of the carbon nanotubes for confinement and the carbon source for carbyne *** this study,a robust synthesis route of CC within CNTs is proposed.C70 was utilized as a precursor to provide an additional carbon source,based on its ability to supply more carbon atoms than C60 at the same filling ***-step transformation processes,including defect creation,were designed to enhance the yield of *** a result,the yield of CC was significantly increased for the C70 encapsulated single-walled CNTs by more than an order of magnitude than the empty counterparts,which also surpasses that of the double-walled CNTs,making it the most effective route for synthesizing *** findings highlight the importance of the additional carbon source and the optimal pathway for CC formation,offering valuable insights for the application of materials with high yield.

关键词： confined carbyne yield enhancement carbon nanotube C70 encapsulation defect introduction Raman spectroscopy

Protective Effect of Propyl Gallate Against Oxidized Low-Density Lipoprotein-Induced Injury of Endothelial Cells

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Chinese Journal of Integrative Medicine 2015年第4期21卷 299-306页

作者：马路朱晓法吴育云陈可冀史大卓殷惠军 Department of Geriatric Cardiology the Navy General Hospital of Chinese PLA The lab of Cardiovascular molecular biology Xiyuan HospitalChina Academy of Chinese Medical Sciences

Objective： To evaluate the protective effect of propyl gallate （PG）, an alkyl ester of gallic acid which is an active ingredient of Radix Paeoniae, against oxidized low-density lipoprotein （ox-LDL）-induced apoptosis and death in endothelial cells （ECs） and to find out its preliminary mechanism. Methods： The cultured endothelial cells were divided into normal, model （ox-LDL）, control （fetal bovine serum）, PG high dose （20 p,g/mL）, PG middle dose （10 μg/mL）, and PG low dose （5 μg/mL） groups, each derived from three different pools of umbilical cords. The model of injured human umbilical vein endothelial cells （HUVECs） was induced by ox-LDL. The 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl-2H-tetrazolium bromide （MTT） assay, Hoechst 33258 staining, flow cytometry and measurement of nitrogen monoxidum （NO） release were used to evaluate the protective effect of PG against ox-LDL-induced apoptosis and death in HUVECs. To find out the mechanism of this protective effect, the expression of endothelial nitric oxide synthase （eNOS） mRNA, eNOS protein expression, immunofluorescence of intracellular reactive oxygen species （ROS） and activities of malondialdehyde （MDA）, superoxidedismutase （SOD） and glutathione peroxidase （GPx） were observed. Results： PG significantly reduced ox-LDL-induced apoptosis and cell death. The percentage of cells death and apoptosis was significantly higher in the ox-LDL group than that in the control group （P〈0.05）. Compared with the control group, the cells death and apoptosis of PG group was no different （P〉0.05）. As compared with the ox-LDL group, results of the PG high dose group showed that cell viability was significantly increased （P〈0.05）, the level of NO release, expression of eNOS mRNA, densitometric value of eNOS protein expression, as well as the activities of SOD and GPx were all significantly higher （all P〈0.05）. Conclusion： PG could potentially serve as a novel endothelial protective agent against ox-LDL-induced injury of endothelial cell.

关键词： propyl gallate oxidized low-density lipoprotein endotheliocyte reactive oxygen species Radix Paeoniae Chinese medicine

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Smart Breeding Platform:A web-based tool for high-throughput population genetics,phenomics,and genomic selection

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molecular Plant 2024年第5期17卷 677-681页

作者： Huihui Li Xin Li Peng Zhang Yingwei Feng Junri Mi Shang Gao Lele Sheng Mohsin Ali Zikun Yang Liang Li Wei Fang Wensheng Wang Qian Qian Fei Gu Wenbin Zhou State Key laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Nanfan Research Institute CAASSanyaHainan 572024China DAMO Academy Alibaba GroupHangzhou 310023China Hupan lab Hangzhou 310023China Yazhouwan National laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China State Key laboratory of Rice biology China National Rice Research InstituteHangzhouZhejiang 310006China

Dear Editor,In the era of big data and artificial intelligence,"smart breeding"has become a broad conceptual framework encompassing the paradigm shift of crop breeding to relying on analysis of high-throughput population genetics and phenomics data to conduct genomic selection,allowing identification and optimal use of the genetic potential in crop species(Xiao et al.,2022;Xu et al.,2022;Wang et al.,2023).Most existing tools for analyzing high-throughput breeding data require extensive computational power,complex installation processes,and command-line expertise and are therefore challenging and inconvenient for the majority of researchers and breeders(Brandies and Hogg,2021).

关键词： breeding artificial breed

Interfacial modification using the cross-linkable tannic acid for highly-efficient perovskite solar cells with excellent stability

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Journal of Energy Chemistry 2024年第4期91卷 236-244页

作者： Xing Gao Lirong Rong Fei Wu Yen-Hung Lin Ye Zeng Junhong Tan Rongxing He Cheng Zhong Linna Zhu Chongqing Key laboratory for Advanced Materials and Technologies of Clean Energy School of Materials&EnergySouthwest UniversityChongqing 400715China Hubei Key lab on Organic and Polymeric Optoelectronic Materials Department of ChemistryWuhan UniversityWuhan 430072HubeiChina Key laboratory of Luminescence Analysis and molecular Sensing Ministry of EducationSchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloon 999077Hong KongChina State Key laboratory of Advanced Displays and Optoelectronics Technologies The Hong Kong University of Science and TechnologyClear Water BayKowloon 999077Hong KongChina

Although the performance of perovskite solar cells(PSCs)has been dramatically increased in recent years,stability is still the main obstacle preventing the PSCs from being *** device instability can be caused by a variety of reasons,including ions diffusion,surface and grain boundary defects,*** this work,the cross-linkable tannic acid(TA)is introduced to modify perovskite film through post-treatment *** numerous organic functional groups(–OH and C=O)in TA can interact with the uncoordinated Pb^(2+)and I^(-)ions in perovskite,thus passivating defects and inhibiting ions *** addition,the formed TA network can absorb a small amount of the residual moisture inside the device to protect the perovskite ***,TA modification regulates the energy level of perovskite,and reduces interfacial charge ***,following TA treatment,the device efficiency is increased significantly from 21.31%to 23.11%,with a decreased hysteresis ***,the treated device shows excellent air,thermal,and operational *** light of this,the readily available,inexpensive TA has the potential to operate as a multipurpose interfacial modifier to increase device efficiency while also enhancing device stability.

关键词： Tannic acid Defect passivation lons diffusion Hydrophilic Stability Perovskite solar cells

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Rice Bran-derived Peptide KF-8 Attenuates Dexamethasone-induced Myopathy in Caenorhabditis elegans by Regulating Locomotion-related Genes

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Food Science and Human Wellness 2024年

作者： Yixin Wu Jianqiang Wang Fang Huang Yajuan Chen Qinlu Lin Zhongxu Chen Zhigang Liu Yao Jiang Wenqing Xie Hengzhen Li Yusheng Li Ying Liang National Clinical Research Center for Geriatric Disorders， Xiangya Hospital， Central South University molecular Nutrition Branch， National Engineering Research Center of Rice and By-product Deep Processing， College of Food Science and Engineering， Central South University of Forestry and Technology laboratory of Functional Chemistry and Nutrition of Food， College of Food Science and Engineering， Northwest A&F University The Key lab of Non-wood Forest Cultivation and Protection of Education Ministry， The Key lab of Non-wood Forest Products of Forestry Ministry， Forestry Institute， Central South University of Forestry & Technology Department of Orthopedics， Xiangya Hospital， Central South University

Background and aims: Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy， but no drug intervention has been approved or recommended for this condition. KF-8 is a rice bran-derived anti-oxidant peptide that extends the life span of Caenorhabditis elegans. Methods: We established a C. elegans model of dexamethasone-induced myopathy to evaluate the potential therapeutic effects of KF-8 in this model. C. elegans muscle function was assessed in terms of locomotory behaviors including crawling， swimming， burrowing， pharyngeal pumping， and head swing. Muscle actin filament integrity was evaluated using fluorescence imaging. The molecular mechanisms of KF-8 were investigated using transcriptome sequencing， qRT-PCR， RNA interference， and western blot analysis. Results: Dexamethasone disrupted actin filaments in the striated muscles of the body wall and inhibited C. elegans crawling， swimming， burrowing， pharyngeal pumping， and head swing. KF-8 reversed the actin filament disruption and locomotor dysfunction induced by dexamethasone. Transcriptome sequencing， pathway enrichment， and qRT-PCR analyses revealed that KF-8 regulated the locomotion-related genes W04G5.10， vha-12， and ddr-1， as well as age-1 (the catalytic subunit ortholog of PI3K)， and akt1. RNA interference， conducted using a genetically engineered E. coli HT115 strain as a food source， confirmed age-1 as a key regulator of locomotor function of C. elegans. Further mechanistic studies with C2C12 myotubes showed that KF-8 regulated the IRS-PI3K-Akt pathway， the master regulator of protein synthesis and degradation. Conclusion: Together， these findings suggest that KF-8 protects against dexamethasone-induced myopathy in C. elegans by regulating locomotion-related genes and the IRS-PI3K-Akt pathway.

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CLP gene family,a new gene family of Cotesia vestalis bracovirus inhibits melanization of Plutella xylostella hemolymph

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Insect Science 2021年第6期28卷 1567-1581页

作者： Ze-Hua Wang Yue-Nan Zhou Xi-Qian Ye Xiao-Tong Wu Pei Yang Min Shi Jian-Hua Huang Xue-Xin Chen Institute of Insect Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhouChina Ministry of Agriculture Key lab of molecular biology of Crop Pathogens and Insects Zhejiang UniversityHangzhouChina Zhejiang Provincial Key lab of biology of Crop Pathogens and Insects Zhejiang UniversityHangzhouChina State Key lab of Rice biology Zhejiang UniversityHangzhouChina

Polydnaviruses(PDVs)are obligatory symbionts of parasitoid wasps and play an important role in suppressing host immune *** PDV genes that inhibit host melanization are known in Microplitis bracovirus,the functional homologs in Cotesia bracoviruses remain ***,we find that Cotesia vestalis bracovirus(CvBV)can inhibit hemolymph melanization of its host,Plutella xylostella larvae,during the early stages of parasitization,and that overexpression of highly expressed CvBV genes reduced host phenoloxidase ***,CvBV-7-I in particular reduced host phenolox-idase activity within 12 h,and the injection of anti-CvBV-7-1 antibody increased the melanization of parasitized host *** analyses showed that CvBV-7-1 and three homologs from other Cotesia bracoviruses possessed a C-terminal leucine/isoleucine-rich region and had a similar flinction in inhibiting ***,a new family of bracovirus genes was proposed and named as C-terminal Leucine/isoleucine-rich Protein(CLP).Ectopic expression of CvBV-7-1 in Drosophila hemocytes increased susceptibility to bacterial repression of melanization and reduced the melanotic encapsulation of par-asitized *** by the parasitoid Leptopilina *** formation rate of wasp pupae and the eclosion rate of *** were affected when the function of CvBV-7-1 was *** findings suggest that CLP genes from Cotesia bracoviruses encoded proteins that contain a C-terminal leucine/isoleucine-rich region and function as melanization inhibitors during the early stage of parasitization,which is important for successful parasitization.

关键词： host immunity immunosuppression new gene family Plutella xylostella polydnavirus wasp

A multimodal integration pipeline for accurate diagnosis, pathogen identification, and prognosis prediction of pulmonary infections

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The Innovation 2024年第4期5卷 63-73,62页

作者： Jun Shao Jiechao Ma Yizhou Yu Shu Zhang Wenyang Wang Weimin Li Chengdi Wang Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory Health and MultimorbidityWest China HospitalWest China School of MedicineSichuan UniversityChengdu 610041China Targeted Tracer Research and Development laboratory Institute of Respiratory HealthFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610213China AI lab Deepwise HealthcareBeijing 100080China Department of Computer Science The University of Hong KongHong Kong SARChina

Pulmonary infections pose formidable challenges in clinical settings with high mortality rates across all age groups *** diagnosis and early intervention are crucial to improve patient *** intelligence(AI)has the capability to mine imaging features specific to different pathogens and fuse multimodal features to reach a synergistic diagnosis,enabling more precise investigation and individualized clinical *** this study,we successfully developed a multimodal integration(MMI)pipeline to differentiate among bacterial,fungal,and viral pneumonia and pulmonary tuberculosis based on a real-world dataset of 24,107 *** area under the curve(AUC)of the MMI system comprising clinical text and computed tomography(CT)image scans yielded 0.910(95%confidence interval[CI]:0.904–0.916)and 0.887(95%CI:0.867–0.909)in the internal and external testing datasets respectively,which were comparable to those of experienced ***,the MMI system was utilized to rapidly differentiate between viral subtypes with a mean AUC of 0.822(95%CI:0.805–0.837)and bacterial subtypes with a mean AUC of 0.803(95%CI:0.775–0.830).Here,the MMI system harbors the potential to guide tailored medication recommendations,thus mitigating the risk of antibiotic ***,the integration of multimodal factors in the AI-driven system also provided an evident advantage in predicting risks of developing critical illness,contributing to more informed clinical *** revolutionize medical care,embracing multimodal AI tools in pulmonary infections will pave the way to further facilitate early intervention and precise management in the foreseeable future.

关键词： diagnosis modal integration