p53 INDEPENDENT G_1 ARREST AND APOPTOSIS INDUCED BY ADRIAMYCIN

作     者：邵志敏 江明 余黎明 韩企夏 沈镇宙 

作者机构：Department of Surgery Molecular Biology Lab Cancer Hospital Shanghai Medical University Shanghai 200032 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：1997年第12卷第2期

页      面：71-75页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：breast cancer apoptosis p53 

摘      要：The biological activity of adriamycin was investigated in human breast carcinoma (HBC) cells. Adri-amycin inhibited the growth of a number of HBC cell lines and induced G1 arrest followed by apoptosis. In MCF-7 cells that harbor wild-type p53, adriamycin-induced G1 arrest and apoptosis was accompanied by p53-independent regulation of WAF1/CIP1 as well as bax mRNA levels. In MDA-MB-231 cells which possess a mutant p53, adriamycin-induced G1 arrest and apoptosis was also associated with a cpncomitant up-regulation of WAF1/CIP1 mRNA while these cells did not express bax or bcl-2 messages. Thus, adriamycin induces G1 arrest and apoptosis via a unique pathway which appears to involve activation of downstream effectors of p53-independent manner.