检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

多发性硬化症确诊的改变

世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 29-29页

作者： Marrie R.A. Cutter G. Tyry T. 方伯言 Mellen Center for ms Treatment and Research Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States

Objective: With diagnostic criteria alterations, increased MRI availability, and awareness of therapies, temporal changes in incidence and prevalence rates may occur, with an increase in the proportion of mildly affected persons diagnosed with multiple sclerosis (ms). The authors assessed temporal trends in the delay from symptom onset to diagnosis (DONDX), and determined whether the degree of disability at diagnosis differs by year of symptom onset (YONSET), using the NARCOms Registry. Methods: The authors selected US participants with an age at sympt om onset of 10 to 60 years, and YONSET >1980 (n = 16,581). The authors divided YONSET into 5-year groups and compared DONDX between groups using multivariate Cox regression. The authors classified participants enrolled within 2 years of diagnosis (n = 5,548) as having mild, moderate, or severe disability using Patient Determined Disease Steps, and assessed the association of disability with YONSET using polytomous logistic regression. Results: DONDX decreased with later YONSET (r =-0.43, p ms. An increasing proportion of patients with ms have mild disability at diagnosis after accounting for confounders. As the effectiveness of therapies is influenced by disease duration, this has impli cations for comparison of treatment effects in modern clinical trials to earlier study results.

关键词：多发性硬化症重度残疾轻度残疾残疾程度发病年龄多变量诊断标准延迟时间临床试验人口统计

在线全文

学校读者我要写书评

暂无评论

空腹呼吸丙酮在糖尿病筛查中的应用分析

国际生物医学工程杂志 2018年第6期41卷 475-481,498页

作者：李静李青原艾钰凯袁渊孙美秀李迎新王储记中国医学科学院北京协和医学院生物医学工程研究所天津300192 美国密西西比州立大学物理与天文学院美国密西西比MS39762

目的了解糖尿病患者与健康志愿者空腹呼吸丙酮的分布差异,探索个体指标对空腹呼出气体中丙酮浓度的影响,研究空腹呼吸丙酮单个指标在糖尿病筛查中的作用.方法利用基于光腔衰荡光谱(CRDS)技术的实时在线呼吸丙酮分析仪,对265名健康受... 详细信息

目的了解糖尿病患者与健康志愿者空腹呼吸丙酮的分布差异,探索个体指标对空腹呼出气体中丙酮浓度的影响,研究空腹呼吸丙酮单个指标在糖尿病筛查中的作用.方法利用基于光腔衰荡光谱(CRDS)技术的实时在线呼吸丙酮分析仪,对265名健康受试者、39例1型糖尿病(T1D)患者和300例2型糖尿病(T2D)患者进行空腹呼吸丙酮浓度测量,使用SPSS19.0软件剔除异常值后,与相应的性别、年龄、身高、体质量、身体质量指数(BMI)以及血糖浓度(BGL)等指标进行相关统计分析.应用受试者工作特征(ROC)曲线评价空腹呼吸丙酮浓度用于糖尿病的诊断价值.结果 T1D患者的平均空腹呼吸丙酮浓度[(2.24±1.43)×10-6]明显高于健康志愿者[(1.43±0.55)×10-6]与T2D患者[(1.410.73)×10-6],差异均具有统计学意义(均P0.05.结论空腹呼吸丙酮浓度检测对T1D的诊断有意义,对T2D的诊断准确性较低且无统计学意义.

关键词：糖尿病空腹呼吸丙酮光腔衰荡光谱

呼吸丙酮用于糖尿病监管的研究进展及临床应用前景

在线全文

学校读者我要写书评

暂无评论

国际生物医学工程杂志 2019年第3期42卷 231-238页

作者：李青原孙美秀王储记李迎新中国医学科学院北京协和医学院生物医学工程研究所天津300192 美国密西西比州立大学物理与天文学系美国密西西比MS39762

人体呼出气体中含有数千种痕量挥发性有机化合物(VOCs),其中某些内源性物质可作为潜在的疾病生物标志物.丙酮作为人体呼出气体中含量第二高的VOCs,已被广泛用于糖尿病的无创诊断与监管研究.目前关于糖尿病患者呼吸丙酮浓度范围及其影响... 详细信息

人体呼出气体中含有数千种痕量挥发性有机化合物(VOCs),其中某些内源性物质可作为潜在的疾病生物标志物.丙酮作为人体呼出气体中含量第二高的VOCs,已被广泛用于糖尿病的无创诊断与监管研究.目前关于糖尿病患者呼吸丙酮浓度范围及其影响因素、其与血糖和糖化血红蛋白之间量化关系的独立研究已超过30项,然而呼吸丙酮能否作为糖尿病监管参数应用于临床还存在诸多挑战.综述了国内外呼吸丙酮分析的研究进展,讨论了呼吸丙酮在糖尿病诊断及监管方面的研究现状和存在的问题,并结合当前技术水平对未来发展前景进行了分析.

关键词：糖尿病丙酮呼吸分析生物标志物光腔衰荡光谱

在线全文

学校读者我要写书评

暂无评论

抗病原真菌药物的研究进展

天然产物研究与开发 2011年第5期23卷 983-991,997页

作者：张影王东李兴从杨崇仁张颖君中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室昆明650204 美国密西西比大学国家天然产物研究开发中心 MS38677 吉林农业科技学院中药学院吉林132101 维和生物技术研发中心玉溪653100

本文概述了抗病原真菌药物的作用机制、研究现状和发展趋势。同时,结合本课题组的研究结果,对从甾体皂苷中寻找新型抗菌药物提出展望。

关键词：抗真菌药物作用机制发展趋势天然产物甾体皂苷

记忆功能未受损的多发硬化病人的海马结构及功能改变

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2010年第4期 378-378页

作者： S.D.Roosendaal H.E.Hulst H.Vrenken H.E.M.Feenstra M.J.A.Castelijns P.J.W.Pouwels 郭丽君 Department of Radiology MS Center AmsterdamVU University Medical CenterDe Boelelaan 11171007 MB Amsterdamthe Netherlands

目的进展期多发硬化(ms)海马认知区常受累,研究记忆功能未受损的ms病人的海马网络功能变化及海马结构损伤的测量。材料与方法本研究方案经机构审查伦理学委员会批准,研究前所有研

关键词：多发硬化记忆功能海马体积病人

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

拮抗大豆根腐病细菌的Biolog鉴定

华北农学报 2012年第2期27卷 234-238页

作者：许艳丽刘海龙李春杰潘凤娟李淑娴刘新晶中国科学院东北地理与农业生态研究所黑土区农业生态院重点实验室黑龙江哈尔滨150081 黑龙江倍丰农业生产资料集团有限公司黑龙江哈尔滨150020 United States Department of Agriculture-Agricultural Research Service(USDA/ARS) Crop Genetics Research Unit(CGRU)StoncvilleMS 38776USA 黑龙江生态工程职业学院黑龙江哈尔滨150025

为明确2株生防细菌的分类地位,采用传统形态学方法结合Biolog微生物自动分析系统,鉴定了大豆根腐病的2株生防细菌。结果表明,菌株B021a与塔式弧菌相似度值为0.634,可能性是86%,遗传距离为4.00。菌株B04b与海藻巴斯德菌相似度值为0.610,... 详细信息

为明确2株生防细菌的分类地位,采用传统形态学方法结合Biolog微生物自动分析系统,鉴定了大豆根腐病的2株生防细菌。结果表明,菌株B021a与塔式弧菌相似度值为0.634,可能性是86%,遗传距离为4.00。菌株B04b与海藻巴斯德菌相似度值为0.610,可能性是75%,遗传距离为2.77。综合形态学和Biolog鉴定结果,认为菌株B021a是塔式弧菌,菌株B04b是海藻巴斯德菌。

关键词：大豆根腐病拮抗细菌 Biolog自动分析系统鉴定

Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

在线全文

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 62-75页

作者： Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq Ur Rehman Kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino Sanjaya K Satapathy Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hepatology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),P<0.001].The frequency of transplant rejections among hospitalized LT recipients increased from 0.2%to 3.6% between January 2019 and December *** hospitalizations during the COVID-19 pandemic had a higher associ

关键词： Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality

一血液/肿瘤诊所门诊患者暴发丙型肝炎病毒感染

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 6-6页

作者： De Oliveira A.M. White K.L. Leschinsky D.P. 张诗峰 Centers for Disease Control and Prevention MS F-22 4770 Buford Highway Atlanta GA 30341 United States Dr.

Background: Approximately 2.7 million persons in the United States have chroni c hepatitis C virus (HCV) infection. Health care-associated HCV transmission ca n occur if aseptic technique is not followed. The authors suspected a health car e-associated HCV outbreak after the report of 4 HCV infections among patients a t the same hematology/oncology clinic. Objective: To determine the extent and me chanism of HCV transmission among clinic patients. Design: Epidemiologic analysi s through a cohort study. Setting: Hematology/oncology clinic in eastern Nebrask a. Participants: Patients who visited the clinic from March 2000 through December 2001. Measurements: HCV infection status, relevant medical history, and clinic -associated exposures. Bivariate analysis and logistic regression were used to identify risk factors for HCV infection. Results: Of 613 clinic patients contacted, 494 (81%) underwent HCV testing. The authors documented infection in 99 pat ients who lacked previous evidence of HCV infection; all had begun treatment at the clinic before July 2001. Hepatitis C virus genotype 3a was present in all 95 genotyped samples and presumably originated from a patient with chronic hepatit is C who began treatment in March 2000. Infection with HCV was statistically sig nificantly associated with receipt of saline flushes (P 1 y ear) may have contributed to an underestimate of cases. Conclusions: This large health care-associated HCV outbreak was related to shared saline bags contamina ted through syringe reuse. Effective infection-control programs are needed to ensure high standards of care in outpatient care facilities, such as hematology/o ncology clinics.

关键词：丙型肝炎病毒医源性传播慢性感染者双变量分析盐水瓶感染程度研究指标医源性感染回归分析研究基因型检测

在线全文

学校读者我要写书评

暂无评论

动态预涂层在CE联用技术中的应用

生命科学仪器 2007年第2期5卷 24-27页

作者： William W.P. Chang Christine Hobson David C. Bomberger Luke V. Schneider Dr. Chang is Scientist Ms. Hobson is Associate Scientist Target Discovery Inc. Palo Alto CA 94303 U.S.A Dr. Bomberger is Director of Manufacturing Target Discovery Inc. Palo Alto CA 94303 U.S.A Dr. Schneider is Chief Scientific Officer Target Discovery Inc. Palo Alto CA 94303 U.S.A

毛细管电泳与传统分离方法相比,具有分析时间短、分辨率高、样品/缓冲液用量少、易于自动化、功能多样性等优点。尽管如此,毛细管电泳在分析领域仍未能展现出全部的潜力。这是由于在大多数要求比较苛刻的实际应用中,毛细管电泳难以获得... 详细信息

毛细管电泳与传统分离方法相比,具有分析时间短、分辨率高、样品/缓冲液用量少、易于自动化、功能多样性等优点。尽管如此,毛细管电泳在分析领域仍未能展现出全部的潜力。这是由于在大多数要求比较苛刻的实际应用中,毛细管电泳难以获得较高的重现性。本文对该问题进行了阐述,并提出了一个很有前途的解决方法。

关键词：联用技术应用预涂层毛细管电泳 CE 功能多样性分离方法分辨率