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Amomum villosum induces longitudinal bone growth in adolescent female rats

Journal of Traditional Chinese medicine 2012年第3期32卷 453-458页

作者： Sun Haeng Lee Ji Young Kim Hocheol Kim Seul Ki Park Cho Young Kim Sun Yong Chung Gyu Tae Chang Department of Pediatrics of korean medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134-727Republic of Korea Department of Herbal Pharmacology College of Korean MedicineKyung Hee University26 Kyungheedae-roDongdaemoon-guSeoul 130-701Republic of Korea Department of Neuropsychiatry of korean medicine Kyung Hee University Hospital at Gang-dong892 Dongnam-roGangdong-guSeoul 134727Republic of Korea

OBJECTIVE:This study was conducted to evaluate the effect of Amomum villosum on longitudinal bone ***:Adolescent female Sprague-Dawley rats were divided into 3 groups and treated for 4 days:control(distilled water,p.o.),recombinant human growth hormone(rhGH;100 μg/kg,s.c.),and ***(500 mg/kg,p.o.) *** day 3,tetracycline(20 g/kg,i.p.) was injected for growth plate *** days 2,3 and 4,5-bromo-2'-deoxyuridine(BrdU)(50 mg/kg,i.p.) was injected to label proliferating *** day 5,tibias were dissected and fixed in 4% paraformaldehyde,dehydrated,and sectioned for immunohistochemistry and ***:The rate of bone growth in the *** and rhGH groups increased to(410 ± 44) and(389 ± 46) μm/day(P<0.01),respectively,as compared with the control(330.7 ± 34.7) μm/*** thickness of the growth plates also increased to(591 ± 37) and(598 ± 32) μm,respectively,as compared with the control(524± 89) μm(P<0.001).The number of BrdU-positive cells in the chondrocytes of the *** and rhGH groups was also significantly higher(126±24) and(143±18) cells/mm 2,respectively) than in the control(109 ± 25) mm 2(P<0.05).Insulin-like growth factor-1 and bone morphogenetic protein-2 in the *** and rhGH groups were highly expressed in the growth plate as compared with the control samples,indicating increased bone ***:*** could be used to treat growth retardation during adolescence.

关键词： Amomum villosum Growth plate Bone Development Recombinant human growth hormone

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Promoter hypomethylation and reactivation of MAGE-A1 and MAGE-A3 genes in colorectal cancer cell lines and cancer tissues

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World Journal of Gastroenterology 2006年第35期12卷 5651-5657页

作者： Kyung-Hee Kim Jin-Sung Choi Il-Jin Kim Ja-Lok Ku Jae-Gahb Park Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744 Korea Laboratory of Cell Biology Korean Cell Line Bank Cancer Research Institute Seoul National University College of Medicine Seoul 110-744

AIM： To verify the expression and methylation status of the MAGE-A1 and MAGE-A3 genes in colorectal cancer tissues and cancer cell lines. METHODS： We evaluated promoter demethylation status of the MAGE-A1 and MAGE-A3 genes by RT-PCR analysis and methylation-specific PCR （MS-PCR）, as well as sequencing analysis, after sodium bisulfite modification in 32 colorectal cancer cell lines and 87 cancer tissues. RESULTS： Of the 32 cell lines, MAGE-A1 and MAGE-A3 expressions were observed in 59% and 66%, respectively. Subsequent to sodium bisulfite modification and MSPCR analysis, the promoter hypomethylation of MAGE-A1 and MAGE-A3 was confirmed in both at 81% each. Promoter hypomethylation of MAGE-A1 and MAGE-A3 in colorectal cancer tissues was observed in 43% and 77%, respectively. Hypomethylation of MAGE-A1 and MAGE-A3 genes in corresponding normal tissues were observed in 2% and 6%, respectively. CONCLUSION： The promoter hypomethylation of MAGE genes up-regulates its expression in colorectal carcinomas as well as in gastric cancers and might play a significant role in the development and progression of human colorectal carcinomas.

关键词： MAGE-A1 MAGE-A3 Promoter Hypomethylation Colorectal cancer

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The effectiveness and safety of acupuncture for poor semen quality in infertile males： a systematic review and meta-analysis

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Asian Journal of Andrology 2014年第6期16卷 884-891页

作者： Ui Min Jerng Jun-Young Jo Seunghoon Lee Jin-Moo Lee Ohmin Kwon Class of Oncology Class of Gynecology Department of Clinical Korean Medicine Kyung Hee University Graduate School Seoul Korea Conmaul Hospital Seoul Korea Class of Acupuncture and Moxibustion Department of Clinical Korean Medicine Kyung Hee University Graduate School Seoul Korea Medical History and Literature Group Korea Institute of Oriental Medicine Daejeon Korea

The aim of this review is to evaluate the effectiveness and safety of acupuncture for poor semen quality in infertile men. We searched for relevant trials registered up to May 2013 in 14 databases. We selected randomized controlled trials （RCTs） that compared acupuncture, with or without additional treatment, against placebo, sham, no treatment, or the same additional treatment. Two reviewers independently performed the study selection, data extraction, risk of bias and reporting quality appraisal. Risk of bias and reporting quality were appraised by the Cochrane risk of bias tool, the consolidated standards of reporting trials and Standards for Reporting Interventions in Clinical Trials of Acupuncture. The outcomes were sperm motility, sperm concentration, pregnancy rate, and adverse events. Pregnancy was defined as a positive pregnancy test. Four RCTs met the eligibility criteria. Acupuncture increased the percentage of sperm with rapid progression （mean difference - 6.35, 95% confidence interval （CI）. 4.38-8.32, P〈 0.00001） and sperm concentration （mean difference - 6.42, 95% CI. 4.91-7.92, P〈 0.00001）, but these two outcomes were substantially heterogeneous among the studies （F = 72% and 58%, respectively）. No differences in pregnancy rate were found between acupuncture and control groups （odds ratio 1.60, 95% CI. 0.70-3.69, P= 0.27, F = 0%）. No participants experienced adverse events. The current evidence showing that acupuncture might improve poor semen quality is insufficient because of the small number of studies, inadequacy of procedures and/or insufficient information for semen analysis, high levels of heterogeneity, high risk of bias, and poor quality of reporting. Further large, well-designed RCTs are required.

关键词： acupuncture asthenozoospermia male infertility oligozoospermia sperm quality

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Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma

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Cancer Communications 2024年第6期44卷 705-709页

作者： Jinkwon Lee Gyeonghwa Kim Tae-Su Han Eunsun Jung Taesang Son Kwangho Kim Kiyoon Kwon Yuna Roh Tae Young Ryu In Hwan Tae Yunsang Kang Byungheon Lee Yu Rim Lee Soo Young Park Won Young Tak Dae-Soo Kim Mi-Young Son Keun Hur Hyun-Soo Cho Stem Cell Convergence Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea Department of Bioscience Korea University of Science and TechnologyDaejeonRepublic of Korea Department of Biochemistry and Cell Biology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biological Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Internal medicine School of MedicineKyungpook National University HospitalDaeguRepublic of Korea Department of Biomedical Convergence Science and Technology School of ConvergenceKyungpook National UniversityDaeguRepublic of Korea

Hepatocellular carcinoma(HCC)is the second most common cancer and the third leading cause of cancer-related death worldwide[1].Recently,HCC incidence and mortality rates have further increased due to changes in the global social environment and dietary habits[2].HCC is treated by surgical resection or combination chemotherapy,but the overall survival rate of HCC patients has not improved,and the recurrence rate is still high due to strong invasiveness and resistance to chemotherapy[3].

关键词： chemotherapy mortality cancer

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Perception of pattern identification in traditional medicine:a survey of korean medical practitioners

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Journal of Traditional Chinese medicine 2014年第3期34卷 369-372页

作者： Mimi Ko Juah Lee Kyungjin Yun Sooseong You Myeongsoo Lee Medical Research Division Korea Institute of Oriental Medicine Daejeon305-811South Korea

OBJECTIVE: To survey assesses the perception of pattern identification(PI) diagnosis of Traditional medicine(TM)by korean medical doctors(KMDs).METHODS: A total of 14 485 KMDs affiliated with the Association of korean medicine were sent surveys via email, and 1646(11.1%) responded to the questionnaire on their perception of PI ***: Of the 1646 respondents, more than ninety percent(1562, 94.9%) reported that they treated patients using *** most critical problem with PI diagnosis was the lack of objective diagnostic indicators(561, 34.1%). Ninety percent had issues diagnosing patients because of different diagnoses between KMDs(1491, 90.5%). The majority of respondents thought herbal medicine was most related to PI(1528, 92.8%). Half of the respondents answered that PI of Ba Gang was the most commonly used PI system. Participants reported that it was most important to study standardisation of PI diagnosis and to develop standardised PI diagnoses using the classification system of the korean Standard Classification of Diseases. The foremost PI type that physicians thought should be included in standardisation and objectification of PI of TKM was the PIof Ba ***: Our data suggest that we should focus on the standardisation of PI diagnosis and PI of Ba Gang in future research on PI diagnosis ***, we cannot completely discount the possibility that a biased selection of subjects and a low response rate limit the generalisability of the findings.

关键词： Pattern identification medicine,traditional korean Data collection

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Acupuncture for Bell's Palsy:A Systematic Review and Meta-analysis

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Chinese Journal of Integrative medicine 2012年第1期18卷 48-55页

作者： Jong-In Kim Myeong Soo Lee Tae-Young Choi Hyangsook Lee Hyo-Jung Kwon Department of Acupuncture and Moxibustion College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea Brain Disease Research Center Korea Institute of Oriental medicine DaejeonRepublic of Korea Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea

Objective： To assess the clinical evidence for and against acupuncture as a treatment for Bell＇s palsy. Methods： We conducted a literature search of 15 databases from their inception to December 2010 without language restrictions. We included all randomized clinical trials （RCTs） regardless of their controls. Methodological quality was evaluated using the Cochrane risk of bias assessment tool. Results： Of the 3 474 articles, only eight RCTs met our inclusion criteria. Four RCTs tested the effects of acupuncture against drug therapy on disease response rate. The meta-analysis of these data showed significant improvements in the acupuncture group [n=463, risk ratio （RR）=1.07, 95% CI： 1.02 to 1.13; P=0.006, I^2=0%]. Six RCTs tested the effects of acupuncture plus drug therapy versus drug therapy alone. The meta-analysis of this set of RCTs also showed the favorable effects of acupuncture on disease response rate （n=512, RR=1.11, 95% CI： 1.05 to 1.17; P=0.001, I^2=13%）. Conclusions： The evidence supporting the effectiveness of acupuncture for treating Bell＇s palsy is limited. The number and quality of trials are too low to form firm conclusions. Further rigorous RCTs are warranted but need to overcome the many limitations of the current evidence.

关键词： acupuncture Bell's palsy systematic review

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A Comparison of Brain Activity between Healthy Subjects and Stroke Patients on fMRI by Acupuncture Stimulation

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Chinese Journal of Integrative medicine 2013年第4期19卷 269-276页

作者： Seung-Yeon Cho Mia Kim Jong Joo Sun Geon-Ho Jahng Hengjun J Kim Seong-Uk Park Woo-Sang Jung Chang-Nam Ko Jung-Mi Park Department of Cardiology and Neurology of korean medicine College of Korean MedicineKyung Hee UniversitySeoulKorea Department of Radiology Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoulKorea Division of Magnetic Resonance Research Korea Basic Science InstituteCheongwongunChungbukKorea

Objective： To investigate brain activity patterns during acupuncture in stroke patients, and to compare the result with normal subjects using functional magnetic resonance imaging （fMRI）. Methods： A total of 11 stroke patients with motor weakness and 10 healthy subjects were studied, fMRI was performed during acupuncture on the left side at points Quchi （Llll） and Zusanli （ST36）. Data were analyzed using statistical parametric maps of brain activation induced by acupuncture stimulation. Results： The results showed that stimulation of both LI11 and ST36 produced significantly different brain activation patterns between the two groups. The normal group showed a greater overall activation than the stroke group. In the normal group, parts of the frontal lobe, parietal lobe, sub-lobar, cerebellum and midbrain regions were activated by acupuncture at the left LI11. On the other hand, only the right side of the inferior parietal Iobule region was activated in the stroke patients. When the left ST36 was stimulated in the normal group, both sides of the frontal lobe, parietal lobe, temporal lobe, and sub-lobar, and the left side of occipital lobe, and the right side of cerebellum and midbrain regions were activated. For the same stimulation in the stroke group, only both sides of the inferior parietal Iobule and cerebellum regions were activated （P〈0.05, cluster level）. Deactivation pattern was not noted during any acupuncture stimulation in both groups. Conclusion： Brain signal activations during the same acupuncture were different between the healthy and the stroke patients, and the effects showed a correlation of different acupuncture points.

关键词： acupuncture functional magnetic resonance imaging stroke LI11 ST36 basal ganglia

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Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea:A nationwide retrospective cohort

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Journal of Integrative medicine 2023年第2期21卷 176-183页

作者： Hyejin Jung Tiana Won Ga-Yeon Kim Jowon Jang Sujung Yeo Sabina Lim Department of Meridian&Acupoint College of Korean MedicineKyung Hee UniversitySeoul02447Republic of Korea WHO Collaborating Center for Traditional medicine East-West Medical Research InstituteKyung Hee UniversitySeoul02447Republic of Korea Department of Meridian and Acupoint College of Korean MedicineSang Ji UniversityWonju26339Republic of Korea

Objective The main aim of this study is to investigate whether acupuncture could be an effective complementary treatment for reducing the risk of macrovascular complications in diabetic patients currently taking antidiabetic medications using a nationwide population-based *** We conducted a retrospective cohort study to assess the efficacy of acupuncture on cardiovascular complications in diabetic patients using data from patients between 40 and 79 years of age,newly diagnosed with diabetes between 2003 and 2006,found in the National Health Insurance Service-National Sample Cohort(NHIS-NSC)in *** the data,we identified 21,232 diabetic patients who were taking antidiabetic medication between 2003 and *** selected patients were divided into two groups-those who received acupuncture at least three times and those who received no acupuncture(non-acupuncture)in the year following their diagnosis of *** 1:1 propensity score matching(PSM),each group had 3350 patients,and the observation ceased at the occurrence of a major adverse cardiovascular event(MACE),which was defined as either myocardial infarction,stroke,or death due to cardiovascular *** After PSM,the acupuncture group had a lower incidence of MACE(hazard ratio[HR]:0.87;95%confidence interval[CI]:0.81-0.94;P=0.0003)and all-cause mortality(HR:0.77;95%CI:0.70-0.84;P<0.0001)than the non-acupuncture group;the HRs for stroke-related mortality(HR:0.75;95%CI:0.56-1.00;P=0.0485),ischemic heart disease mortality(HR:0.53;95%CI:0.34-0.84;P=0.006)and circulatory system disease mortality(HR:0.67;95%CI:0.55-0.82;P<0.0001)were lower in the acupuncture group than in the non-acupuncture group in the secondary *** Our results indicate that diabetic patients receiving acupuncture treatment might have a lower risk of MACE,all-cause mortality and cardiovascular *** population-based retrospective study suggests beneficial effects of acupuncture in preventing macro

关键词： Acupuncture Diabetes Major adverse cardiovascular event Myocardial infarction Stroke Macrovascular complication

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Effect of dexamethasone injection into Zusanli(ST 36) acupoint on ovalbumin-induced allergic rhinitis

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Journal of Traditional Chinese medicine 2019年第3期39卷 307-314页

作者： Na-Ra Han Seung-Jun Han Phil-Dong Moon Sungwei Hong Hyeongjin Kim Yanhua Li Hyung-Min Kim Hyun-Ja Jeong Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of korean medicine Graduate School of Wonkwang University Iksan 54538 Republic of Korea Department of Pharmacology Graduate School Kyung Hee University Seoul 02447Republic of Korea Department of Clinical korean medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea Department of Food Science & Technology and Research Institute for Basic Science Hoseo UniversityChungnam 31499 Republic of Korea

OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(***)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)***:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control *** hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(*** group),while three groups received *** at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,*** symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th *** isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing *** weight was measured using an electronic *** levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent *** serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde *** blot analysis was performed on nasal mucosal tissue ***:*** significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized *** significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized *** significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-l

关键词： Dexamethasone Point ST36 (Zusanli) Pharmaceutical research Acupuncture Rhinitis,allergic Ovalbumin Thymic stromal lymphopoietin

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