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Cellular & Molecular Immunology 2021年第9期18卷 2281-2283页

作者： Yong-Chan Kim Sae-Young Won Byung-Hoon Jeong korea zoonosis research institute Jeonbuk National UniversityIksanJeonbukRepublic of Korea Department of Bioactive Material Sciences and institute for Molecular Biology and Genetics Jeonbuk National UniversityJeonjuJeonbukRepublic of Korea

TO THE EDITOR Prion diseases are fatal and in curable n eurodegenerative diseases caused by a pathogenic form of prion protein(PrP^(Sc))derived from a cellular form of prion protein(PrP^(C)).Recent studies have reported that aquaporin 4(AQP4)expression is dramatically upregulated in the brains of individuals with several different prion *** AQP4 is a key protein of the glymphatic system,which is the perivascular waste clearing system of the brain,and since altered expression of AQP4 has been observed in prion diseases,the glymphatic system may be associated with prion diseases.

关键词： AQP4 diseases lymphatic

Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infection

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Cellular & Molecular Immunology 2020年第6期17卷 662-664页

作者： Yong-Chan Kim Min-Ju Jeong Byung-Hoon Jeong korea zoonosis research institute Chonbuk National UniversityIksanJeonbuk 54531Republic of Korea Department of Bioactive Material Sciences Chonbuk National UniversityJeonjuJeonbuk 54896Republic of Korea

The IFITM3 gene is classified as a member of the small interferonstimulated genes(ISGs)and plays a paramount role in defense against enveloped viruses,including influenza A viruses.1–6 Previous studies have reported that the rs12252 SNP,which is located in the open reading frame(ORF)of the IFITM3 gene,impacts the splicing procedure of protein production,which makes a truncated form of the IFITM3 protein and lowers its antiviral capacity.7–9 In addition,the rs34481144 SNP genotype affects the transcriptional regulation of the IFITM3 gene and IFITM3-neighboring genes and has a potent association with the clinical results of the H1N1 influenza 2009 pandemic in three human cohorts.10 Because several studies have reported that polymorphism of the IFITM3 gene is crucial in the host immune response,fine mapping of and extracting disease-associated SNPs from the human IFITM3 gene are important baseline studies necessary to understand how the IFITM3 protein functions in innate immunity.

关键词： IFITM3 influenza H1N1

Toxocariasis:a silent threat with a progressive public health impact

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Infectious Diseases of Poverty 2018年第1期7卷 570-582页

作者： Jia Chen Quan Liu Guo-Hua Liu Wen-Bin Zheng Sung-Jong Hong Hiromu Sugiyama Xing-Quan Zhu Hany M.Elsheikha State Key Laboratory of Veterinary Etiological Biology Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences1 XujiapingYanchangbuLanzhouGansu Province 730046People’s Republic of China Ningbo University School of Medicine NingboZhejiang ProvincePeople’s Republic of China Military Veterinary institute Academy of Military Medical SciencesKey Laboratory of Jilin Province for Zoonosis Prevention and ControlChangchunJilin ProvincePeople’s Republic of China College of Veterinary Medicine Hunan Agricultural UniversityChangshaHunan ProvincePeople’s Republic of China Department of Medical Environmental Biology Chung-Ang University College of MedicineSeoulSouth Korea Department of Parasitology National Institute of Infectious DiseasesTokyoJapan Faculty of Medicine and Health Sciences School of Veterinary Medicine and ScienceUniversity of NottinghamLoughboroughUK

Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished *** disease is caused by infection with the larvae of Toxocara canis and ***,the most ubiquitous intestinal nematode parasite in dogs and cats,*** this article,recent advances in the epidemiology,clinical presentation,diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are *** text:Over the past two decades,we have come far in our understanding of the biology and epidemiology of ***,lack of laboratory infrastructure in some countries,lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease *** encompasses four clinical forms:visceral,ocular,covert and *** or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care ***,multiple diagnostic modalities are available,which if effectively used together with the administration of appropriate pharmacologic therapies,can minimize any unnecessary patient ***:Although progress has been made in the management of toxocariasis patients,there remains much work to be *** of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers,which may help in increasing diagnostic ***,further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.

关键词： Toxocara canis Toxocariasis zoonosis Larva migrans Epidemiology Diagnosis Control

Pushing past the tipping points in containment trajectories of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)epidemics:A simple arithmetic rationale for crushing the curve instead of merely flattening it

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Infectious Disease Modelling 2020年第1期5卷 362-365页

作者： Gerry F.Killeen School of Biological Earth&Environmental Sciencesand Environmental Research InstituteUniversity College CorkIreland

Countries with ambitious national strategies to crush the curve of their Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)epidemic trajectories include China,korea,Japan,Taiwan,New Zealand and ***,the United States and many hard-hit European countries,like Ireland,Italy,Spain,France and the United Kingdom,currently appear content to merely flatten the curve of their epidemic trajectories so that transmission persists at rates their critical care services can cope *** I present a simple set of arithmetic modelling analyses that are accessible to non-specialists and explain why preferable crush the curve strategies,to eliminate transmission within months,would require only a modest amount of additional containment effort relative to the tipping point targeted by flatten the curve strategies,which allow epidemics to persist at supposedly steady,manageable levels for years,decades or even indefinitely.

关键词： Coronavirus COVID SARS2 Severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 Model Epidemiology Outbreak zoonosis Emerging infection

First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province,Northeastern China

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Virologica Sinica 2021年第2期36卷 329-332页

作者： Xu Zhang Nina Wang Zedong Wang Lihe Che Chen Chen Wen-Zhong Zhao Quan Liu School of Life Sciences and Engineering Foshan UniversityFoshan 528225China The First Hospital of Jilin University Changchun 130021China Key Laboratory of National Health and Family Planning Commission of China for Male Reproduction and Genetics Family Planning Research Institute of Guangdong ProvinceGuangzhou 510600China

Dear Editor,Severe fever with thrombocytopenia syndrome(SFTS),caused by SFTS virus(SFTSV)in the genus Banyangvirus of the family Phenuiviridae,is an emerging tick-borne viral zoonosis(Liu et al.2014).Typical clinical symptoms of SFTS include fever,headache,thrombocytopenia,and leukocytopenia(Yu et al.2011).Since SFTSV was identified in 2009,it has been found in more than 20 provinces in China and is closely related to strains from Japan and South korea(Kim et al.2013;Takahashi et al.2014).

关键词： eastern dynamic Jilin