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Two polymorphisms in methylenetetrahydrofolate reductase gene(C677T and A1298C) frequently associated with recurrentspontaneous abortion show no association in Saudi women

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BiOCELL 2020年第4期44卷 613-621页

作者： AFRAH ALKHURiJi ATEKAH abdullah MOHAMMED ALRAQiBAH AMAAL AWAD ALHARBi ZENEB BABAY FATiMAH BASiL AL-MUKAYNiZi ARWA ALTHOMALi SONYA S.ABDEL-RAZEQ ARJUMAND S.WARSY Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia Department of Obs/Gyn College of MedicineKing Saud UniversityRiyadh11451Saudi Arabia Prince Naif Bin AbdulAziz Health research Center(PNHRC) King Saud UniversityRiyadh11451Saudi Arabia Division of Maternal-Fetal Medicine Department of ObstetricsGynecologyand Reproductive SciencesYale University School of MedicineNew Haven06501USA Central Laboratory Center for Science and Medical Studies for GirlsKing Saud UniversityRiyadh11451Saudi Arabia

Methylenetetrahydrofolate reductase(MTHFR)deficiency is the most common genetic cause of hyperhomocysteinemia,which has been implicated in the etiology of recurrent spontaneous abortion(RSA).This study was designed to investigate the association between two single nucleotide polymorphisms(SNP)(rs1801133[C677T]and rs1801131[A1298C])in the MTHFR gene and RSA,in *** two SNPs were selected as these polymorphisms have a different effect on the activity and stability of the enzyme,and significantly diverse effects have been reported in relation to the association with *** approval was acquired from the iRB at king Saud University(KKUH),Saudi Arabia,and written informed consent was obtained from each *** study group comprised of 100 Saudi women with unexplained RSA and 100 age-matched controls,both attending KKUH for a routine *** was drawn in EDTA tubes,and DNA was *** was conducted using TaqMan SNP genotyping assay *** frequency of the T allele of C677T was 0.165 in patients and 0.17 in *** frequencies for CC,CT and TT genotypes were 70%,27%and 3%,respectively in RSA,and 71%,24%and 5%,respectively,in the controls(p>0.05).For the A1298C polymorphism,the C allele frequencies were 0.345 in patients and 0.28 in controls,while genotype frequencies for AA,AC and CC genotypes were 44%,43%,and 13%,respectively,in patients,and 54%,36%,and 10%,respectively,in controls(p>0.05).The frequency of CC genotype and C allele of A1298C were higher in the patients with RSA,but not significantly,while C677T genotypes and allele frequencies did not differ between patients and *** results suggested that MTHFR gene polymorphisms are population-specific and may not associate with RSA in Saudi women.

关键词： MTHFR RSA Single nucleotide polymorphism Hyperhomocystenemia

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Effect of various ratios of poly(3-hexylthiophene)with polyvinyl alcohol gel-polymer electrolytes in flexible sodium-ion batteries using Samanea saman tree-leaf-derived carbon quantum dots decorated with SnO_(2)and NaVO_(3)

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Clean Energy 2022年第1期6卷 226-237页

作者： Baskar Thangaraj Nutthapon Wongyao Pravin Raj Solomon Wachira Chaiworn Surawut Chuangchote Werasak Surareungchai Pilot Plant Development and Training institute King Mongkut’s University of Technology ThonburiBangkhuntien-chaitalay RoadThakamBangkok 10150Thailand Fuel Cells and Hydrogen research and Engineering Center Pilot Plant Development and Training InstituteKing Mongkut’s University of Technology ThonburiBangkok 10140Thailand Department of research and Development Velammal Medical College Hospital and Research InstituteMadurai 625009Tamil NaduIndia Department of Tool and Materials Engineering Faculty of EngineeringKing Mongkut’s University of Technology ThonburiBangmodBangkok 10140Thailand research Center of Advanced Materials for Energy and Environmental Technology King Mongkut’s University of Technology ThonburiBangmodBangkok 10140Thailand school of Bioresources and Technology Nanoscience&Nanotechnology Graduate ProgrammeFaculty of ScienceKing Mongkut’s University of Technology ThonburiBangkhuntien-chaitalay RoadThakamBangkok 10150Thailand

Gel-polymer electrolytes with high thermal stability and mechanical properties were considered suitable in rechargeable batteries so as to overcome the problems encountered in liquid *** a previous study,flexible sodium-ion batteries(FSiBs)were fabri-cated using electrodes made of carbon quantum dots(CQDs)decorated with SnO_(2) and NaVO_(3) utilizing a polyvinyl alcohol(PVA)/P3HT gel-polymer electrolyte at a ratio of 1:*** addition,various separators such as indium-doped tin oxide/polyoxyethylene tridecyl ether(iTO/PTE),rice paper(RP),silicone with three big holes(SiL BH),silicone with many small holes(SiL SH)and cellulose paper(CP)were tested in flexible Na-ion *** SiL SH delivered a high specific discharge capacity of 4246 mAh g^(-1) in the initial cycle at 2 V and maintained a value of 71 mAh g^(-1) in the 50th *** the aim of improving the cyclic ability of FSiBs,different weight ratios of PVA/P3HT(1:0.025,1:0.05,1:0.1,1:0.15,1:0.2)were tried in this work using the electrodes CQDs@SnO_(2) and CQDs@NaVO_(3).The above ratios were referred to as B25,B50,B100,B150 and B200,*** SH was used as a *** voltammetry studies indicated that B150 had a high specific capacitance of 13062 F g^(-1).B25 and B100 exhibited high discharge capacities(171 mAh g^(-1))and(151 mAh g^(-1))compared to that of other ratios B50(75 mAh g^(-1)),B150(88 mAh g^(-1))and B200(54 mAh g^(-1))in the 50th cycle at 2.0 *** study reveals the scope of developing FSiBs of high capacity and cyclability at different voltages using carbonaceous electrodes and gel-polymer electrolytes with different ratios of PVA/*** focus of the present study is to bring out the optimum ratio of PVA/P3HT for maximizing the cyclic ability of FSiBs.

关键词： biomass carbon quantum dots gel-polymer electrolytes energy storage flexible Na-ion battery

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Synthesis and biological evaluation of novel derivatives of desloratadine

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Chinese Chemical Letters 2013年第6期24卷 531-534页

作者： Shuai Mu Xiao-Shuai Xie Duan Niu Da-Shuai Zhang Deng-Ke Liu Chang-Xiao Liu school of Chemical Engineering and Technology Tianjin University State Key Laboratory of Drug Delivery Technology and Pharmacokinetics Tianjin Institute of Pharmaceutical Research graduate school of Tianjin Medical University Tianjin Key Laboratory of Molecular Design and Drug Discovery Tianjin Institute of Pharmaceutical Research

Series of novel derivatives of desloratadine designed as arginine vasopressin receptor antagonists were synthesized and structurally characterized by melting points,^1H NMR and *** in vivo diuretic activities were evaluated on rats,and several target compounds showed promising diuretic results, especially compounds 8,18,27 and *** in vitro bonding assay and cAMP assay showed that these compounds had a higher affinity to vasopressin V2 receptor than Vi a *** studies indicated that desloratadine may be an active substructure for novel arginine vasopressin receptor antagonist development.

关键词： Derivatives of desloratadine Arginine vasopressin receptor antagonists Diuretic activity

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Literature Review of Nursing Education Promoting Professional Socialization among Nursing Students

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Open Journal of Nursing 2021年第10期11卷 828-846页

作者： Naomi Matsumori Yoshie Kageyama Department of Nursing Prefectural University of Hiroshima Hiroshima Japan graduate school of Comprehensive scientific research Prefectural University of Hiroshima Hiroshima Japan

The aim of this review was to clarify the elements that promote socialization of nursing professionals from the findings of previous studies, with keywords related to socialization among undergraduate nursing students, and obtain indicators for promoting professional socialization in nursing students in the current nursing education. The literature review was conducted using a qualitative analysis of the promotion of professional socialization among nursing students. The results were reported according to the reporting checklist of the Preferred Reporting items for Systematic Reviews and Meta-Analysis (PRiSMA) statement. The authors conducted a literature search using electronic databases in July 2021, such as CiNAHL (EBSCOhost), MEDLiNE (EBSCOhost) for English articles, and ichushi for Japanese articles. included studies were from 1985 to 2021. Previous studies were integrated to current studies. A total of 23 articles in English and 34 articles in Japanese were analyzed. The methods for promoting professional socialization in nursing students include self-learning, online media, extracurricular elements, and clinical practice. Socialization process differed for each school year;the first-year students tend to have ideological answers, while the fourth-year students tend to have practical answers as a result of education. The process needs supports from instructors and mentors. Nursing education promoting professional socialization in nursing students has developed diverse modeling, positive effects for improving social skills, and impact of self-efficacy and self-esteem and has fostered professional commitment and professional identity. However, loss of idealism of professional identity after graduation should be considered with supports from instructors and mentors. To establish nursing professional identity smoothly, nursing instructors supporting skills should be developed by understanding students’ stage of professional socialization.

关键词： Professional Socialization Nursing Students Systematic Review Basic Social Competency Nursing Education

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Analysis of TESS Field Eclipsing Binary Star V948 Her: A Pulsating or Non-pulsating Star?

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research in Astronomy and Astrophysics 2022年第1期22卷 137-147页

作者： F Kahraman Alicavus O Ekinci Canakkde Onsekiz Mart University Faculty of Sciences and ArtsPhysics Department17100QanakkaleTurkey Canakkale Onsekiz Mart University Astrophysics Research Center and Ulupinar ObservatoryTR-17100CanakkaleTurkey Canakkale Onsekiz Mart University School of Graduate StudiesDepartment of Space Sciences and TechnologiesTR-17100CanakkaleTurkey

Pulsating stars occupy a significant place in the H-R diagram and it was thought that all stars inside the classical instability strip should pulsate. However, recent studies showed that there are many non-pulsating stars located inside the classical instability strip. The existence of these non-pulsating stars is still a mystery. To deeply understand the properties of these non-pulsating and pulsating stars, one needs precise fundamental stellar parameters(e.g. mass).For this purpose, the eclipsing binaries are unique systems. Hence, in this study, we present the TESS data analysis of one candidate pulsating eclipsing binary system, V948 Her. TESS data were used for the binary modeling with the literature radial velocity measurements, and the precise fundamental parameters of the system were obtained. The system’s age was derived as 1 ± 0.24 Gyr. The positions of the binary components in the H-R diagram were examined and the primary component was found inside the δ Scuti instability strip. However, in the frequency analysis of TESS data, we found no significant pulsation frequencies. Only the harmonics of the orbital periods were obtained in the analysis. Therefore, the system was classified as a non-pulsator. V948 Her is an important object to understand the nature of non-pulsating stars inside the δ Scuti instability strip.

关键词： (stars:)binaries:eclipsing stars:fundamental parameters techniques:photometric

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Cortical transcriptome analysis after spinal cord injury reveals the regenerative mechanism of central nervous system in CRMP2 knock-in mice

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Neural Regeneration research 2021年第7期16卷 1258-1265页

作者： Ayaka Sugeno Wenhui Piao Miki Yamazaki Kiyofumi Takahashi Koji Arikawa Hiroko Matsunaga Masahito Hosokawa Daisuke Tominaga Yoshio Goshima Haruko Takeyama Toshio Ohshima Laboratory for Molecular Brain Science Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Biomolecular Engineering Laboratory Department of Life Science and Medical BioscienceGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Computational Bio Big-Data Open innovation Laboratory(CBBD-OiL) National Institute of Advanced Industrial Science and Technology(AIST)TokyoJapan research Organization for Nano and Life innovation Waseda UniversityTokyoJapan institute for Advanced research of Biosystem Dynamics Waseda Research Institute for Science and EngineeringGraduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan Cellular and Molecular Biotechnology research institute National Institute of Advanced Industrial Science and Technology(AIST)TsukubaJapan Department of Molecular Pharmacology and Neurobiology Graduate School of MedicineYokohama City UniversityYokohamaJapan

Recent studies have shown that mutation at Ser522 causes inhibition of collapsin response mediator protein 2(CRMP2) phosphorylation and induces axon elongation and partial recovery of the lost sensorimotor function after spinal cord injury(SCi).We aimed to reveal the intracellular mechanism in axotomized neurons in the CRMP2 knock-in(CRMP2Ki) mouse model by performing transcriptome analysis in mouse sensorimotor cortex using micro-dissection punching *** to that, we analyzed the structural pathophysiology in axotomized or neighboring neurons after SCi and found that somatic atrophy and dendritic spine reduction in sensorimotor cortex were suppressed in CRMP2Ki *** analysis of the transcriptome has aided in the identification of four hemoglobin genes Hba-a1, Hba-a2, Hbb-bs, and Hbb-bt that are significantly upregulated in wild-type mice with concomitant upregulation of genes involved in the oxidative phosphorylation and ribosomal pathways after ***, we observed substantial upregulation in channel activity genes and downregulation of genes regulating vesicles, synaptic function, glial cell differentiation in CRMP2Ki ***, the transcriptome profile of CRMP2Ki mice has been discussed wherein energy metabolism and neuronal pathways were found to be differentially *** results showed that CRMP2Ki mice displayed improved SCi pathophysiology not only via microtubule stabilization in neurons, but also possibly via the whole metabolic system in the central nervous system, response changes in glial cells, and *** together, we reveal new insights on SCi pathophysiology and the regenerative mechanism of central nervous system by the inhibition of CRMP2 phosphorylation at *** these experiments were performed in accordance with the guidelines of the institutional Animal Care and Use Committee at Waseda University, Japan(2017-A027 approved on March 21, 2017;2018-A003 approved on March 25, 2018;2019-A026 approved on March

关键词： CNS regeneration cortex CRMP2 hemoglobin metabolic pathway spinal cord injury spine transcriptome

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Towards improving Predictive Statistical Learning Model Accuracy by Enhancing Learning Technique

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Computer Systems Science & Engineering 2022年第7期42卷 303-318页

作者： Ali Algarni Mahmoud Ragab Wardah Alamri Samih MMostafa Statistics Department Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Mathematics Department Faculty of ScienceAl-Azhar UniversityNaser City11884Egypt Centre of Artificial intelligence for Precision Medicines King Abdulaziz UniversityJeddah21589Saudi Arabia Educational Technology Department Educational Graduate Studies FacultyKing Abdulaziz UniversityJeddah21589Saudi Arabia Computer Science Department Faculty of Computers and InformationSouth Valley UniversityQena83523Egypt

The accuracy of the statistical learning model depends on the learning technique used which in turn depends on the dataset’s *** most research studies,the existence of missing values(MVs)is a vital *** addition,any dataset with MVs cannot be used for further analysis or with any data driven tool especially when the percentage of MVs are *** this paper,the authors propose a novel algorithm for dealing with MVs depending on the feature selec-tion(FS)of similarity classiﬁer with fuzzy entropy *** proposed algo-rithm imputes MVs in cumulative *** candidate feature to be manipulated is selected using similarity classiﬁer with Parkash’s fuzzy entropy *** predictive model to predict MVs within the candidate feature is the Bayesian Ridge Regression(BRR)***,any imputed features will be incorporated within the BRR equation to impute the MVs in the next chosen incomplete *** proposed algorithm was compared against some practical state-of-the-art imputation methods by conducting an experiment on four medical datasets which were gathered from several databases repository with MVs gener-ated from the three missingness *** evaluation metrics of mean abso-lute error(MAE),root mean square error(RMSE)and coefﬁcient of determination(R2 score)were used to measure the *** results exhibited that perfor-mance vary depending on the size of the dataset,amount of MVs and the missing-ness mechanism ***,compared to other methods,the results showed that the proposed method gives better accuracy and less error in most cases.

关键词： Bayesian ridge regression fuzzy entropy measure feature selection imputation missing values missingness mechanisms similarity classiﬁer medical dataset

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Optimal Logistics Activities Based Deep Learning Enabled Traffic Flow Prediction Model

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Computers, Materials & Continua 2022年第12期73卷 5269-5282页

作者： Basim Aljabhan Mahmoud Ragab Sultanah M.Alshammari abdullah S.Al-Malaise Al-Ghamdi Ports and Maritime Transportation Department Faculty of Maritime StudiesKing Abdulaziz UniversityJeddah21589Saudi Arabia information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Mathematics Faculty of ScienceAl-Azhar UniversityNaser City11884CairoEgypt Center of Excellence in Smart Environment research King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia information Systems Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia S 7information Systems Department HECI SchoolDar Alhekma UniversityJeddahSaudi Arabia

Traffic flow prediction becomes an essential process for intelligent transportation systems(iTS).Though traffic sensor devices are manually controllable,traffic flow data with distinct length,uneven sampling,and missing data finds challenging for effective *** traffic data has been considerably increased in recent times which cannot be handled by traditional mathematical *** recent developments of statistic and deep learning(DL)models pave a way for the effectual design of traffic flow prediction(TFP)*** this view,this study designs optimal attentionbased deep learning with statistical analysis for TFP(OADLSA-TFP)*** presentedOADLSA-TFP model intends to effectually forecast the level of traffic in the *** attain this,the OADLSA-TFP model employs attention-based bidirectional long short-term memory(ABLSTM)model for predicting traffic *** order to enhance the performance of the ABLSTM model,the hyperparameter optimization process is performed using artificial fish swarm algorithm(AFSA).A wide-ranging experimental analysis is carried out on benchmark dataset and the obtained values reported the enhancements of the OADLSA-TFP model over the recent approaches mean square error(MSE),root mean square error(RMSE),and mean absolute percentage error(MAPE)of 120.342%,10.970%,and 8.146%respectively.

关键词： Traffic flow prediction deep learning artificial fish swarm algorithm mass gatherings statistical analysis logistics

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Doubly coupled matter fields in massive bigravity

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Chinese Physics C 2018年第7期42卷 94-102页

作者： Xian Gao Lavinia Heisenberg school of Physics and Astronomy Sun Yat-sen University Guangzhou 510275 China research Center for the Early Universe（RESCEU） Graduate School of Science The University of Tokyo Tokyo 113-0033 Japan Department of Physics Tokyo Institute of Technology 2-12-1 Ookayama Meguro Tokyo 152-8551 Japan institute for Theoretical studies ETH Zurich Clausiusstrasse 47 8092 Zurich Switzerland

in the context of massive （bi-）gravity, non-minimal matter couplings have been proposed. These couplings are special in the sense that they are free of the Boulware-Deser ghost below the strong coupling scale and can be used consistently as an effective field theory. Furthermore, they enrich the phenomenology of massive gravity. We consider these couplings in the framework of bimetric gravity and study the cosmological implications for background and linear tensor, vector, and scalar Previous works have investigated special branches of solutions. Here we perform a complete perturbation analysis for the general background equations of motion, completing previous analyses.

关键词： modified gravity cosmological perturbation theory inflation

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New tomographic reconstruction technique based on Laplacian eigenfunction

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Plasma Science and Technology 2020年第10期22卷 5-9页

作者： Yasuhiro SUZUKi Shishir PUROHiT Satoshi OHDACHi Satoshi YAMAMOTO Kazunobu NAGASAKi National institute for Fusion Science Toki 509-5292Japan The graduate University for Advanced studies SOKENDAIToki 509-5292Japan institute for Plasma research Gandhinagar 382428India graduate school of Frontier Science The University of TokyoKashiwa 277-8561.Japan Naka Fusion institute National Institutes for Quantum and Radiological Science and TechnologyNaka 311-0193Japan institute of Advanced Energy Kyoto UniversityUji 611-0011Japan

This letter proposes a new tomographic reconstruction procedure based on the Laplacian eigenfunction(LEF) patterns, which are independent of the plasma cross-section and do not require the flux surface information. The process is benchmarked for the experimental data of Heliotron J plasma and the results are compared with the least-squares approximation by a Phillips–Tikhonov(PT)-type regularization, which is widely used as the standard technique for tomographic reconstruction. The reconstruction based on the LEF is found to be capable of determining the magnetic axis at different time locations efficiently in comparison with the PT-type regularization.

关键词： tomography Laplacian eigenfunction Heliotron J soft x-ray

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