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Prediction of active ingredients and potential mechanisms of Alisma decoction against atherosclerosis:A study based on UHPLC-Q-Orbitrap-HRMS and network pharmacology

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Drug Combination Therapy 2021年第4期3卷 15-23页

作者： Yi-Ming Bi Wei Zhang Yi-Gui Lai Ying-Chang Fu Kong-Zheng Li Qiang Wang Xue-Feng Jiang Hong-Feng Liang Hui-Jie Fan School of traditional chinese medicine Southern Medical UniversityGuangzhou510515China Department of traditional chinese medicine People’s Hospital of YangjiangYangjiang529500China key laboratory of ministry of education for TCM Viscera-State Theory and Applications Liaoning University of Traditional Chinese MedicineShenyang110032China

Background:Atherosclerosis(AS)has been a potentially life-threatening disease *** decoction(AD)is a famous chinese formula in treating ***,the active components and potential mechanisms remain ***:In this study,the active compositions of AD were analyzed by ultrahigh-performance liquid chromatography quadrupole-orbitrap high-resolution mass spectrometry(UHPLC-Q-Orbitrap-HRMS).The putative targets were predicted and interpreted by a series of bio-informative tools such as Venn,STRING,NetworkAnalyzer,ClusterMarker,and ***,the results were validated by molecular docking using ***:The results showed that alisol A,alisol B,23-o-Acetylalisol B,atractylenolideⅢand atractylenolideⅡwere the major compositions in *** targets mainly distributed in three gene clusters were obtained after topological and cluster *** and GO analyses showed that genes in cluster 1 mainly participated in adipocytokine signaling pathway and played an important role in lipid metabolism,while genes in cluster 2 had regulatory actions via cAMP signaling pathway and may protect vascular function from AS,and genes in cluster 3 were closely related to ***,RXRA,AGT and CXCL8,the central gene of cluster 1,2 and 3,were verified to be strong binding with some major compositions in ***:The possible mechanisms of AD in the treatment of AS may be closely correlated with the regulation of lipid metabolism,vascular physiology and *** study provided a new insight into the anti-AS effect of AD,but more pharmacological experiments should be performed for verification in the future.

关键词： Alisma decoction Atherosclerosis Network pharmacology UHPLC-Q-Orbitrap-HRMS Molecular docking

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A pharmacological approach to study the active compounds in Jinshui Huanxian formula in treatment of pulmonary fibrosis

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Journal of traditional chinese medicine 2019年第3期39卷 364-379页

作者： Bai Yunping Zhao Peng Wu Mingming Li Jiansheng Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & chinese medicine Development of Henan Province Henan University of Chinese MedicineZhengzhou 450046 China Henan key laboratory of chinese medicine for Respiratory Disease Henan University of Chinese Medicine Zhengzhou 450046 China

OBJECTIVE:To study the active compounds in Jinshui Huanxian formula in the treatment of pulmonary fibrosis with a pharmacological ***:A systems pharmacology model,incorporating active compounds and targets prediction,and herbal-comPound-target-disease network analysis,was established to predict the active substances and therapeutic mechanisms of Jinshui Huanxian *** compounds from the herbs of Jinshui Huanxian formula were obtained from drug database and the ***,we analyzed the potential of herbs by predicting oral bioavailability and drug-likeness *** compounds with oral bioavailability≥ 30% and drug-likeness index ≥ 0.18 were obtained as candidate compounds for further *** then used the systematic drug targeting tool to screen the targets for candidate *** potential targets were projected into Therapeutic Target Database to collect their corresponding *** candidate compounds,potential targets and their related diseases were applied to construct the compound-target and target-disease ***:Totally 136 compounds from Jinshui Huanxian formula and 265 potential targets were ***-target network analysis suggested that different herbal drugs contained in the Jinshui Huanxian formula could regulate these similar targets to probably exert synergistic ***,target proteins were mainly related to oxidoreductase activity,nicotinamide adenine dinucleotide phosphate binding,and G-protein coupled amine receptor activity,which might be associated with the therapeutic mechanisms of Jinshui Huanxian *** addition,Jinshui Huanxian formula was probably efficient for many different diseases,such as respiratory tract diseases,neoplasm,nervous system diseases,and cardiovascular diseases,according to target-disease ***:This study may provide a method to explore the potential active compounds in Jinshui Huanxian formula used to treat pulmonary fibrosis.

关键词： Pulmonary fibrosis Pharmacology Jinshui Huanxian formula

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Clinical relevance of chinese syndrome factors and thromboelastography levels in patients with phlegm-heat and fu-organ excess syndrome

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Journal of traditional chinese Medical Sciences 2019年第3期6卷 211-217页

作者： Shuang Wu Pei Chen Yihuai Zou Lan Jiang Hualei Geng Ruyu Yan Shan Wang Lingqun Zhu key laboratory of chinese Internal medicine of ministry of education and Beijing&key Office of Encephalopathy TCM Research Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China The National Clinical Research Center for Mental Disorders&Beijing key laboratory of Mental Disorders Beijing Anding Hospital Affiliated to Capital Medical UniversityBeijing 100088China Department of Neurology and Stroke Center Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing 100700China Department of Neurology Pinggu Hospital Affiliated to Beijing Hospital of Traditional Chinese MedicineBeijing 101299China

Objective:syndrome differentiation is a unique part of traditional chinese medicine(TCM).syndrome factors play an important role in the diagnosis and treatment of TCM ***(TEG)intuitively reflects the blood status of patients with acute ischemic stroke(AIS)and is important in the treatment and prognosis of *** identify the relationship between TCM syndrome factors and TEG in AIS patients and standardize TCM syndrome differentiation and treatment objectives,we designed a prospective cohort study of 103 AIS ***:We used the diagnostic criteria for AIS in the chinese Guideline for Diagnosis and Management of Acute Ischemic Stroke *** of phlegm-heat and fu-organ excess syndrome was based on the TCM Scale for the syndrome of Phlegm-heat and fu-organ *** ischemic Stroke TCM syndrome Factor Diagnostic Scale was used to identify and diagnose syndrome *** information,scores of syndrome factors and values of TEG parameters of all enrolled patients were ***:There were significant differences in internal fire and phlegm-dampness scores between patients with and without phlegm-heat and fu-organ excess syndrome(Psyndrome,internal fire was negatively correlated with TEG parameters R and K(Psyndrome factors and MA(P Z.058)and LY30(P>.05)or between both syndrome factors and TEG parameters in patients without phlegm-heat and fu-organ excess ***:The syndrome factor internal fire is a potential predictor of increased platelet function and fibrinogen activity in AIS patients with phlegm-heat and fu-organ excess,and a potentially important predictor of blood hypercoagulability in TCM.

关键词： Clinical relevance Phlegm-heat and fuorgan excess syndrome syndrome factors Thromboelastography

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Can chinese medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs

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chinese Journal of Integrative medicine 2020年第4期26卷 243-250页

作者： LUO Hui TANG Qiao-ling SHANG Ya-xi LIANG Shi-bing YANG Ming Nicola Robinson LIU Jian-ping Institute for Tibetan medicine China Tibetology Research CenterBeijing(100101)China Centre for Evidence-Based chinese medicine Beijing University of Chinese MedicineBeijing(100029)China School of traditional chinese medicine Beijing University of Chinese MedicineBeijing(100029)China School of Health and Social Care London South Bank Un iversityLon don(SE10AA)UK In stitute of Integrated traditional chinese medicine and Western medicine Guangzhou Medical UniversityGuangzhou(510120)China

Objective:Since December 2019,an outbreak of corona virus disease 2019(COVID-19)occurred in Wuhan,and rapidly spread to almost all parts of *** was followed by prevention programs recommending chinese medicine(CM)for the *** order to provide evidenee for CM recommendations,we reviewed ancient classics and human ***:Historical records on prevention and treatment of infections in CM classics,clinical evidence of CM on the prevention of severe acute respiratory syndrome(SARS)and H1N1 in flue nza,and CM preve ntion programs issued by health authorities in China since the COVID-19 outbreak were retrieved from differe nt databases and websites till 12 February,*** evide nee in eluded data from clinical trials,cohort or other population studies using CM for preventing contagious respiratory virus ***:The use of CM to prevent epidemics of infectious diseases was traced back to ancient chinese practice cited in Huangdi's Internal Classic(Huang Di Nei Jing)where preventive effects were *** were 3 studies using CM for prevention of SARS and 4 studies for H1N1 *** of the participants who took CM contracted SARS in the 3 *** infection rate of H1N1 in flue nza in the CM group was significantly lower than the non-CM group(relative risk 0.36,95%confidence interval 0.24-0.52;n=4).For prevention of COVID-19,23 provinces in China issued CM *** main principles of CM use were to tonify qi to protect from external pathoge ns,disperse wind and discharge heat,and resolve damp *** most frequently used herbs in eluded Radix astragali(Huangqi),Radix glycyrrhizae(Gancao),Radix saposhnikoviae(Fangfeng),Rhizoma Atractylodis Macrocephalae(Baizhu),Lonicerae Japonicae Flos(Jinyinhua),and Fructus forsythia(Lianqiao).Conclusions:Based on historical records and human evidenee of SARS and H1N1 influenza prevention,chinese herbal formula could be an alternative approach for prevention of COVID-19 in high-risk

关键词： chinese medicine corona virus disease 2019(COVID-19) prevention program clinical evidence review

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Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction

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World Journal of Gastroenterology 2015年第16期21卷 4852-4863页

作者： Hai-Lian Shi Chu-Hsuan Liu Li-Li Ding Yu Zheng Xiao-Yan Fei Lu Lu Xue-Ming Zhou Jian-Ye Yuan Jian-Qun Xie Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese Medicine Institute of chinese Materia Medica Shanghai Key Laboratory of Complex PrescriptionShanghai University of Traditional Chinese Medicine Experimental Animal Center Shanghai University of Traditional Chinese Medicine

AIM:To determine the molecular mechanisms of Shugan decoction(SGD) in the regulation of colonic motility and visceral hyperalgesia(VHL) in irritable bowel syndrome(IBS).METHODS:The chemical compounds contained in SGD were measured by high-performance liquid chromatography.A rat model of IBS was induced by chronic water avoidance stress(WAS).The number of fecal pellets was counted after WAS and the pain pressure threshold was measured by colorectal *** changes in colonic mucosa were detected by hematoxylin-eosin *** contents of tumor necrosis factor(TNF)-αin colonic tissue and calcitonin-gene-related peptide(CGRP)in serum were measured by *** protein expression of serotonin[5-hydroxytryptamide(5-HT)],serotonin transporter(SERT),chromogranin A(Cg A)and CGRP incolon tissue was measured by ***:SGD inhibited colonic motility dysfunction and VHL in rats with *** of transient receptor potential(TRP)vanilloid 1(TRPV1)(Ruthenium Red)and TRP ankyrin-1(TRPA1)(HC-030031)and activator of protease-activated receptor(PAR)4 increased the pain pressure threshold,whereas activators of PAR2and TRPV4 decreased the pain pressure threshold in rats with *** effect of SGD on pain pressure threshold in these rats was abolished by activators of TRPV1(capsaicin),TRPV4(RN1747),TRPA1(Polygodial)and PAR2(AC55541).In addition,CGRP levels in serum and colonic tissue were both increased in these ***-αlevel in colonic tissue was also significantly ***,the levels of 5-HT,SERT and Cg A in colonic tissue were *** these pathological changes in rats with IBS were attenuated by ***:SGD alleviated VHL and attenuated colon motility in IBS,partly by regulating TRPV1,TRPV4,TRPA1,PAR2,5-HT,Cg A and SERT,and reducing CGRP and TNF-αlevel.

关键词： Shugan decoction Visceral hyperalgesia Serotonin Transient receptor potential Proteaseactivatedreceptor Serotonin transporter Calcitoningene-related peptide Tumor necrosis factor-α

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Tong xie yao fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P

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World Journal of Gastroenterology 2015年第15期21卷 4536-4546页

作者： Yue Yin Lei Zhong Jian-Wei Wang Xue-Ying Zhao Wen-Jing Zhao Hai-Xue Kuang chinese medicine Teaching and Research Office Basic Medical College of Heilongjiang University of Chinese Medicine Heilongjiang chinese medicine key laboratory Department of Breast Surgery Second Affiliated Hospital of Harbin Medical University Basic and Applied Research key laboratory Heilongjiang University of Chinese Medicine and Department of Education Natural Drug Efficacy Material Basic Research key laboratory Heilongjiang Traditional Chinese Medicine

AIM: To investigate whether the chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral *** normal rats and 4.5 ± 1.58 in IBS model rats(P < 0.001). However, the defecation frequency was significantly decreased(3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.

关键词： Tong Xie Yao Fang Irritable bowel syndrome 5-hydroxytryptamine Substance P traditional chinesemedicine

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Evaluation of autophagy-related genes and lncRNAs signature for prognositic prediction in thyroid carcinoma via bioinformatics analysis

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TMR Clinical Research 2021年第2期4卷 25-41页

作者： Shan-Qi Guo Ying-lie lia Deng Hao xiao-jiang Li Department of Oncology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300387China Tianjin key laboratory of Translational Research of TCM Prescription and syndrome First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin300381China

Autophagy plays a significant role in the pathogenesis and prognosis of thyroid *** role of autophagy-related genes and long non-coding RNAs,as well as the risk model of thyroid carcinoma patients were investigated to predict clinical outcome of thyroid *** expression of autophagy-related genes and long non-coding RNAs in thyroid carcinoma patients was identified in The Cancer Genome Atlas *** enrichment analysis and gene set enrichment analysis was used to hint the mechanism that autophagy might act in thyroid *** and multivariate Cox regression analyses were performed for screening the prognostic autophagy-related genes and long non-coding RNAs to construct prognostic related risk *** carcinoma patients were divided into the low-risk and high-risk *** overall survival time was both shorter in the high-risk groups than that in the low-risk *** for autophagy-related genes prognostic risk model,age and autophagy-related genes risk score are independent prognostic factors that affect the survival of thyroid *** and CDKN2A expression was closely related to pathological stage and T status,DNAJB1 expression was closely related to M status,age and *** autophagy-associated long non-coding RNA related prognostic risk model consequently demonstrated that the long non-coding RNA risk score could significantly predict the survival rate of thyroid carcinoma patients with areas under the curve of *** set enrichment analysis presented that a total of 16 gene sets including 10 up-regulated and 6 down-regulated gene sets were significantly *** autophagy-related genes and long non-coding RNAs based prognostic risk models are a reliable forecasting tool for thyroid carcinoma patients.

关键词： Autophagy-related gene Long non-coding RNA Prognosis Thyroid carcinoma The Cancer Genome Atlas

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Effect of acupuncture treatment on nonketotic hyperglycemic hemichorea-hemiballismus:a case report

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Journal of traditional chinese medicine 2023年第4期43卷 829-833页

作者： CHEN Ying SUN Jingqing LYU Tianli HONG Jiahui LIU Yuhan ZHU Liying LI Bin LIU Lu Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China

Nonketotic hyperglycemic hemichorea-hemiballismus is a rare syndrome in the clinic,and treatment is often *** therapy is the most widely used and effective treatment,but some patients experience a slower *** symptomatic treatment medicines have some degree of side *** treatment is beneficial for hemichoreahemiballismus.A male patient,aged 59 years,first visited our hospital outpatient department due to motor agitation with involuntary movements of the right *** had a history of type 2 diabetes mellitus and poor blood glucose *** serum glucose was 26.5 mmol/L(normal:4.4-6.1 mmol/L),and magnetic resonance imaging demonstrated an irregular area of high signal intensity in T1-weighted imaging,low signal intensity on T2-weighted imaging,and high signal intensity in the left corpus striatum in T2-FLAIR *** was recommended for the *** ruling out other possibilities,he was eventually diagnosed with nonketotic hyperglycemic *** glycemic control was immediately started with subcutaneous injection and acupuncture treatment at“governor vessel 13 acupoints”,and the involuntary movements completely disappeared on the ninth day of *** pathophysiology of nonketotic hyperglycemic hemichorea-hemiballismus is *** patient histories lead to different brain tissue conditions,and relapses and uncontrolled blood glucose add difficulties to *** to traditional chinese medicine theory,insufficient kidney essence leads to brain dystrophy and causes the symptoms of *** evidence has shown that acupuncture at"governor vessel 13 acupoints"has a beneficial treatment effect on nonketotic hyperglycemic hemichorea-hemiballismus.

关键词： nonketotic hyperglycemic hemichorea-hemiballismus governor vessel acupuncture therapy case reports

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The Effectiveness of Herbal Enema for Irritable Bowel syndrome: A Meta-Analysis of Randomized, Calcium Channel Blocker-Controlled Trials

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World Journal of traditional chinese medicine 2017年第2期3卷 1-7页

作者： Chun-Yan Wang Xu-Dong Tang Pei-Yong Zheng Zhen Xiao Li Zhang Guang Ji Institute of Digestive Diseases Longhua Hospital Shanghai University of Chinese Medicine Xiyuan Hospital of China Academy of chinese Medical Sciences E-institute of Shanghai Municipal education Commission Shanghai University of Traditional Chinese Medicine

Objective: Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder, and a symptom-based diagnosis. Because of the unclear mechanisms, the treatment available have not acquired the satisfied effect. We performed a meta-analysis to assess the effectiveness and safety of herbal enema in treating IBS compared to the calcium channel blocker administration. Methods: We searched for randomized controlled trials(RCTs) testing herbal enema in patients with IBS which compared to the calcium channel blocker administration in Pub Med, EMMBASE, the chinese National Knowledge Infrastructure(CNKI), the Wan-fang Database and the VIP Database up to May 2016 with no language restrictions. Primary outcome was the global symptom improvement and secondary outcome was the symptom severity scale score. Safety was also assessed. We used Revman 5.3 to estimate the pooled mean difference(MD) for continuous outcomes and relative risk(RR) for binary outcome measures, with a 95% confidence interval(CI).Results: Five studies(230 patients in experimental group and 209 patients in control group) were included in the meta-analysis. The results showed that herbal enema as the sole intervention or combined with other treating methods could significantly promote the global symptom improvement and mucous stool scale and has potential to improve abdominal distention compared to the calcium channel blocker administration. But there was no difference between the two groups in abdominal pain. The recurrence rate was lower than the control group. Conclusions: The study indicated that herbal enema may be an effective assistant means for IBS.

关键词： Herbal enema Irritable bowel syndrome Meta-analysis

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Effect of Salivary Antimicrobial Factors on Microbial Composition of Tongue Coating in Patients with Coronary Heart Disease with Phlegm-Stasis syndrome

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World Journal of traditional chinese medicine 2022年第1期8卷 123-130页

作者： Juan Ye Ke-Lei Su Yue-Hua Xu Yang Yang Qian Zhou Wei Gao Xue-Ting Cai Qing-Yun Wei Meng Cao Peng Cao Affiliated Hospital of Integrated traditional chinese and Western medicine Nanjing University of Chinese Medicine Department of Pharmacology School of PharmacyNanjing University of Chinese MedicineNanjing 210023 Institute of Comparative medicine College of Veterinary MedicineJiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and ZoonosesJoint International Research Laboratory of Agriculture and Agri-Product SafetyThe Ministry of Education of ChinaYangzhou UniversityYangzhou225009China

Objective: Phlegm-stasis syndrome is one of the most common traditional chinese medicine(TCM) syndromes and found in 59% of patients with coronary heart disease(CHD) in routine TCM clinical practice in China. One of the diagnostic criteria of phlegm-stasis syndrome is its characteristic white-greasy and thin tongue coating. We have previously reported that different types of tongue coating have different microbiome characteristics that can be used as diagnostic markers. However, the microbial characteristics of tongue coating of CHD patients with phlegm-stasis syndrome, including coating feature and underlying reason of formation, have rarely been reported. Herein, we examined the characteristic microbiome of tongue coating, and discussed the cause of tongue coating formation via salivary proteins in patients with phlegm-stasis syndrome. Methods: We examined white-greasy and thin tongue coatings obtained from 10 patients with CHD having phlegm-stasis syndrome(n = 10), and compared with those of patients with almost no coating – patients with Qi-Yin deficiency syndrome(n = 10) – and healthy controls(n = 10). 16S r RNA sequencing of tongue coating microbiome and isobaric tags for relative and absolute quantitation(i TRAQ)-based quantitative analysis of salivary proteins were used to detect tongue coating and salivary protein separately. Salivary levels of s Ig A, lysozyme, and amylase were detected by ELISA. Results: We identified Candidatus_Saccharimonas and Candidate_division_TM7_norank as the prominent members of tongue coating in patients with CHD having phlegm-stasis syndrome. Salivary proteins involved in biological processes, pentose phosphate pathway, and complement and coagulation cascades were among the differentially expressed proteins identified in patients with CHD having phlegm-stasis syndrome on i TRAQ analysis. Moreover, the formation of microbiota in tongue coating was associated with salivary s Ig A, lysozyme, and saliva flow rate. Conclusions: We ex

关键词： Coronary heart disease oral microbiome salivary proteins traditional chinese medicine syndrome tongue diagnosis

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