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Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian Jiaru Chu Department of precision Machinery and precision instrumentation University of Science and Technology of ChinaHefei 230027China key laboratory of precision scientific instrumentation of anhui higher education institutes University of Science and Technology of ChinaHefei 230027China science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China anhui Provincial key laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China anhui Provincial Engineering laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform

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International Journal of Extreme Manufacturing 2024年第3期6卷 532-542页

作者： Youdi Hu Yanlei Hu Zhenyu Wang Jiale Yong Wei Xiong Dong Wu Shixiang Xu Shenzhen key laboratory of Micro-Nano Photonic Information technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China CAS key laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Wuhan National laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubeiPeople’s Republic of China

Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application *** structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions can be concentrated into localized active areas for highly sensitive ***,subject to the difficulty of the fabrication process,itremains challenging to balance hot-spot construction and the concentration capacity of analyte ***,preparing SERS substrates with densely ordered hot spots andefficient concentration capacity is of great significance for highly sensitive ***,we propose an Ag and fluoroalkyl-modified hierarchical armour substrate(Ag/F-HA),which has a double-layer stacking design to combine analyte concentration with hotspot *** microarmour structure is fabricated by femtosecond-laser processing to serve as asuperhydrophobic and low-adhesive surface to concentrate analyte,while the anodic aluminium oxide(AAO)template creates a nanopillar array serving as dense and ordered hot *** the synergistic action of hot spots and analyte concentration,Ag/F-HA achieves a detectionlimit down to 10^(-7)M doxorubicin(DOX)molecules with a RSD of 7.69%.Additionally,Ag/F-HA exhibits excellent robustness to resist external disturbances such as liquid splash or *** on our strategy,SERS substrates with directional analyte concentrations are further explored by patterning microcone arrays with *** work opens a way to the realistic implementation of SERS in diverse scenarios.

关键词： surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness

High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui Li Shaojun Jiang Shuneng Zhou Zehang Cui Yuan Tao Xinyuan Zheng Qianqian Zhang Jiawen Li Guoqiang Li Dong Wu Jiaru Chu Yanlei Hu CAS key laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China key laboratory of Testing technology for Manufacturing Process of Ministry of education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized *** use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and *** research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation *** address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer *** with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of *** actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

MAX-DOAS and in-situ measurements of aerosols and trace gases over Dongying,china:Insight into ozone formation sensitivity based on secondary HCHO

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Journal of Environmental sciences 2024年第1期135卷 656-668页

作者： Xiaojun Zheng Zeeshan Javed Cheng Liu Aimon Tanvir Osama Sandhu Haoran Liu Xiangguang Ji Chengzhi Xing Hua Lin Daolin Du Institute of Environment and Ecology School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Department of precision Machinery and precision instrumentation University of Science and Technology of ChinaHefei 230026China key laboratory of Environmental Optics&technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China key laboratory of precision scientific instrumentation of anhui higher education institutes University of Science and Technology of ChinaHefei 230026China Shanghai key laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China National Agromet Center Pakistan Meteorological DepartmentIslamabad 44000Pakistan Institute of Physical science and Information technology Anhui UniversityHefei 230601China Information Materials and Intelligent Sensing laboratory of anhui Province Anhui UniversityHefei 230601China School of Environmental science and Optoelectronic technology University of Science and Technology of ChinaHefei 230026China

This study presents a comprehensive overview of the atmospheric pollutants including Sulfur dioxide(SO_(2)),Nitrogen dioxide(NO_(2)),Formaldehyde(HCHO),Particulate Matter PM;PM_(10):diameter≤10μm,and PM_(2.5):diameter≤2.5μm,and Ozone(O_(3)),over Dongying(Shandong Province)from March-April 2018 and September-October 2019 by employing ground-based Multiple Axis Differential Optical Absorption Spectroscopy(MAX-DOAS)observations along with the in-situ measurements attained by the national air quality monitoring *** concentrations of SO_(2)and NO_(2)were under the acceptable level,while both PM_(2.5),and PM_(10)were higher than the safe levels as prescribed by national and international air quality *** results depict that 21%of the total observation days were found to be complex polluted days(PM_(2.5)>35μg/m^(3) and O_(3)>160μg/m^(3)).The secondary HCHO was used for accurate analysis of O_(3)sensitivity.A difference of 11.40%and 10%during March-April 2018 and September-October 2019 respectively in O_(3)sensitivity was found between HCHO_(total)/NO_(2)and HCHO_(sec)/NO_(2).The results indicate that primary HCHO have significant contribution in HCHO.O_(3)formation predominantly remained to be in VOC-limited and transitional regime during March-April 2018 and September-October 2019 in *** results imply that concurrent control of both NO_(x) and VOCs would benefit in ozone ***,the criteria pollutants(PM,SO_(2),and NO_(2))depicted strong correlations with each other except for O_(3)for which weak correlation coefficient was obtained with all the *** study will prove to be baseline for designing of air pollution control strategies.

关键词： MAX-DOAS Trace gases Ozone sensitivity Secondary HCHO Complex Pollution

First satellite observation of total column water vapor from the Chinese Environmental Trace Gases Monitoring Instrument

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science china Earth sciences 2024年

作者： Ran ZHAO Chengxin ZHANG Wenjing SU Jin YE Ziwei LI Cheng LIU School of Environmental science and Optoelectronic technology University of Science and Technology of China Department of precision Machinery and precision instrumentation University of Science and Technology of China Department of Environmental science and Engineering University of Science and Technology of China key laboratory of Environmental Optics and technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences key laboratory of precision scientific instrumentation of anhui higher education institutes University of Science and Technology of China

Atmospheric water vapor is a critical component of the Earth's water cycle and has significant impacts on weather,climate, and atmospheric chemistry. However, deficiencies remain in the coverage and accuracy of water vapor monitoring. In this study, we first retrieved the total column water vapor（TCWV） in the visible blue spectral band from two Chinese satellite UV-Vis spectrometers, the Environmental Trace Gases Monitoring Instruments（EMIs）, which are onboard the Chinese GaoFen-5（GF-5, since May 2018） and GaoFen-5B（GF-5B, since September 2021） satellites. Nevertheless, limited by factors such as the relatively lower spectral signal-to-noise ratio and weak absorption of water vapor, the accurate retrieval of TCWV from the EMI spectrum is rather challenging. Therefore, we improved the baseline TCWV retrieval based on the differential optical absorption technique, including the re-calibration of the on-orbit spectra, optimization of the spectral fitting, and bias correction in the fitted result. Sensitivity tests show that the mean retrieval TCWV error of the EMI decreased by 1.47 kg m–2compared to that using uncalibrated spectra. The improved spectral fitting significantly reduced the relative uncertainty of the water vapor slant column densities（SCD） by 13.42%, and increased the number of successful fits by 11.64%. The improved EMI TCWV retrieval results from both the GF-5 and GF-5B satellites show a trend consistent with the TROPOspheric Monitoring Instrument（TROPOMI）satellite observations, with a correlation coefficient（R） of 0.98 and a mean bias of 1.04 kg m–2（6.88%）. Ground-based validations showed that the correlation between the EMI TCWV retrievals from the GF-5B satellite（R=0.91） and sun photometer measurements was significantly higher than that from the GF-5 satellite（R=0.87）, which may have been due to the improved performance of the EMI instrument on the GF-5B satellite. Finally, we showed that an intense atmospheric river event could be successfully captu

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从中国首台紫外-可见光高光谱卫星仪器反演得到的高空间分辨率臭氧廓线

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Engineering 2024年第1期32卷 106-115页

作者： Fei Zhao Cheng Liu Qihou Hu Congzi Xia Chengxin Zhang Wenjing Su Department of precision Machinery and precision instrumentation University of Science and Technology of ChinaHefei 230026China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China key Lab of Environmental Optics and technology Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China key laboratory of precision scientific instrumentation of anhui higher education institutes University of Science and Technology of ChinaHefei 230026China anhui Province key laboratory of Polar Environment and Global Change University of Science and Technology of ChinaHefei 230026China Greater Bay Area(GBA)Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700China Department of Environmental science and Engineering University of Science and Technology of ChinaHefei 230026China

Understanding the vertical distribution of ozone is crucial when assessing both its horizontal and vertical transport,as well as when analyzing the physical and chemical properties of the *** of the most effective ways to obtain high spatial resolution ozone profiles is through satellite *** Environmental Trace Gases Monitoring Instrument(EMI)deployed on the Gaofen-5 satellite is the first Chinese ultraviolet-visible hyperspectral ***,retrieving ozone profiles using backscattered radiance values measured by the EMI is challenging due to unavailable measurement errors and a low signal-to-noise *** algorithm developed for the Tropospheric Monitoring Instrument did not allow us to retrieve 87%of the EMI ***,we developed an algorithm specific to the characteristics of the *** fitting residuals are smaller than 0.3%in most *** retrieved ozone profiles were in good agreement with ozonesonde data,with maximum mean biases of 20%at five latitude *** applying EMI averaging kernels to the ozonesonde profiles,the integrated stratospheric column ozone and tropospheric column ozone also showed excellent agreement with ozonesonde data,The lower layers(0-7.5 km)of the EMI ozone profiles reflected the seasonal variation in surface ozone derived from the china National Environmental Monitoring Center(CNEMC).However,the upper layers(9.7-16.7 km)of the ozone profiles show different trends,with the ozone peak occurring at an altitude of 9.7-16.7 km in March,2019.A stratospheric intrusion event in central china from August 11 to 15,2019,is captured using the EMI ozone profiles,potential vorticity data,and relative humidity *** increase in the CNEMC ozone co ncentration showed that downward transport enhanced surface ozone pollution.

关键词： Ozone profiles EMI Soft calibration Floor noise correction Stratospheric ozone intrusion

A dual-use probe for nano-metric photoelectric characterization using a confined light field generated by photonic crystals in the cantilever

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Nano Research 2021年第11期14卷 3848-3853页

作者： Yaoping Hou Chengfu Ma Wenting Wang Yuhang Chen Department of precision Machinery and precision instrumentation University of Science and Technology of ChinaHefei230027China key laboratory of precision scientific instrumentation of anhui higher education institutes University of Science and Technology of ChinaHefei230027China

We propose a plasmonic atomic force microscopy (AFM) probe, which takes a part of the laser beam for monitoring cantilever deflection as the excitation light source. Photonic crystal cavities are integrated near the cantilever’s free end where the laser spot locates. The transmitted light excites surface plasmon polaritons on the metal-coated tip and induces a confined hot-spot at the tip apex. Numerical simulations demonstrate that the plasmonic probe can couple a tilted, linearly polarized beam efficiently and yield a remarkable local electromagnetic enhancement with the intensity being around 21 times stronger than that of the original probe. For demonstration, we employ the plasmonic probe in electrostatic force microscopy and scanning Kelvin probe microscopy to study the impact of local light field on the photoelectric characteristics of SiO_(2) and Au nanoparticles. Compared with the original probe, obvious differences are observed in the electrostatic force gradients on SiO_(2) nanoparticles and in the surface potentials of Au nanoparticles. The plasmonic probe can enable AFM as a powerful tool for simultaneous optical, mechanical and electrical characterizations.

关键词： atomic force microscopy near-field scanning optical microscopy plasmonic probe photoelectric characterization surface plasmon polaritons

Femtosecond laser direct writing of functional stimulus-responsive structures and applications

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International Journal of Extreme Manufacturing 2023年第4期5卷 375-414页

作者： Yuxuan Zhang Dong Wu Yachao Zhang Yucheng Bian Chaowei Wang Jiawen Li Jiaru Chu Yanlei Hu CAS key laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China

Diverse natural organisms possess stimulus-responsive structures to adapt to the surrounding *** by nature,researchers have developed various smart stimulus-responsive structures with adjustable properties and functions to address the demands of ever-changing application environments that are becoming more *** many fabrication methods for stimulus-responsive structures,femtosecond laser direct writing(FsLDW)has received increasing attention because of its high precision,simplicity,true three-dimensional machining ability,and wide applicability to almost all *** paper systematically outlines state-of-the-art research on stimulus-responsive structures prepared by *** on the introduction of femtosecond laser-matter interaction and mainstream FsLDW-based manufacturing strategies,different stimulating factors that can trigger structural responses of prepared intelligent structures,such as magnetic field,light,temperature,pH,and humidity,are emphatically *** applications of functional structures with stimuli-responsive dynamic behaviors fabricated by FsLDW,as well as the present obstacles and forthcoming development opportunities,are discussed.

关键词： stimulus-responsive structures femtosecond laser direct writing laser–matter interaction multifunctionality

Environmental temperature effect on dimensional measurements of atomic force microscopy

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Nanotechnology and precision Engineering 2021年第2期4卷 20-24页

作者： Chengfu Ma Yuhang Chen Wenhao Huang key laboratory of precision scientific instrumentation of anhui higher education institutes Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230026China CAS key laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230026China

Atomic force microscopy(AFM)is increasingly being used as a fundamental tool for dimensional measurements at the nanoscale in the laboratory and in *** the environmental temperature is not controlled in many measurements,or is even varied on purpose,quantification of its effects on AFM dimensional measurements is *** this paper,the influences of the temperature in the entire environment of the AFM(excluding only the controller and computer)and that in the local environment around the tip–sample are *** results show that lateral dimensional measurements are affected mainly by the entire environmental ***,vertical measurements are influenced by the temperature of both the entire environment and the local *** effects become significant for temperatures higher than some threshold,here between 35 and 40 XC.

关键词： Atomic force microscopy Environmental temperature Dimensional measurement Pitch Height