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Biliatresone:progress in biliary atresia study

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World Journal of Pediatrics 2023年第5期19卷 417-424页

作者： Jia‑Jie Zhu Yi‑Fan Yang Rui Dong Shan Zheng Department of Pediatric Surgery Shanghai Key Laboratory of Birth Defectand Key Laboratory of Neonatal DiseaseMinistry of HealthChildren’s Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background Biliary atresia(BA)is one of the main causes of neonatal end-stage liver *** timely diagnosis and treatment,most children with BA will develop irreversible liver fibrosis within the first two *** current theorized causes of BA include viral infection,immune disorders,and genetic defects,the comprehensive etiology is still largely ***,biliatresone attracted much interest for its ability to induce BA in both zebrafish and mice,so we summarized the latest progress of biliatresone research in BA and tried to answer the question of whether it could provide further clues to the etiology of human *** sources We conducted a PubMed search for any published articles related to the topic using search terms including“biliary atresia”,“biliatresone”,“GSH”,and“HSP90”.Relevant data were extracted from the original text or supplementary materials of the corresponding *** Biliatresone had shown its unique toxicity in multiple species such as zebrafish and mice,and pathogenic factors involved included glutathione(GSH),heat shock protein 90(HSP90)and the related *** combination with epidemiological evidence and recent studies on the intestinal flora in biliary atresia,a new pathogenic hypothesis that the occurrence of biliary atresia is partly due to biliatresone or its structure-like compounds depositing in human body via vegetables or/and the altered intestinal flora structure can be tentatively *** Based on the existing evidence,we emphasized that GSH and HSP90 are involved in the development of BA,and the maternal diet,especially higher vegetable intake of Asian women of childbearing age,accompanied by the altered intestinal flora structure,may contribute to the occurrence of biliary atresia and the higher incidence in the Asia ***,the evidence from large sample epidemiological research is necessary.

关键词： Biliary atresia Biliatresone Glutathione Gut flora

Imaging findings of multiple infantile hepatic hemangioma associated with cardiac insufficiency

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World Journal of Pediatrics 2014年第4期10卷 368-370页

作者： Jing-Jing Ye Yin-Can Shao Qiang Shu Department of Ultrasonography Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesKey Laboratory of Reproductive Genetics(Zhejiang University)Ministry of Education Department of Pediatric Cardiothoracic Surgery Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesKey Laboratory of Reproductive Genetics(Zhejiang University)Ministry of Education Department of Surgery 117 of the People's Liberation Army HospitalHangzhou 310003China

Background:Infantile hepatic hemangioma(IHH)as a benign liver tumor in infancy and childhood is commonly associated with high output cardiac *** present study aims to describe the imaging findings in a patient who was diagnosed as having multiple IHH with congestive cardiac insuffi ***:The imaging findings and clinical manifestations of the patient with multiple IHH associated with cardiac insuffi ciency were retrospectively ***:Ultrasonography showed multiple intrahepatic lesions with mixed echoes and markedly expanded hepatic veins and the inferior vena cava of the *** revealed right heart insufficiency and pulmonary ***-enhanced MRI showed early mild enhancement of lesions and more obvious delayed *** patient died after combined therapy of surgery and ***:The imaging findings of multiple IHH associated with cardiac insufficiency are typical and *** imaging assessment may facilitate the diagnosis and treatment of the disease.

关键词： congestive echocardiography heart failure infantile hepatic hemangioma

A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats

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World Journal of Pediatrics 2016年第4期12卷 489-497页

作者： Shao-Qing Ni Yin Lou Xiu-Min Wang Zheng Shen Jue Wang Zheng-Yan Zhao Su Zeng The National Clinical Trial Institute Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Pharmacy Department Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Endocrinology Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Lab Center Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Children's health and Care Children's HospitalZhejiang University School of Medicine and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal DiseasesHangzhouChina Department of Pharmaceutical Analysis and Drug Metabolism College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina

Background:The objective of this study was to investigate the effects of a high-fat,high-energy(HFHE)diet on the hepatic expression of CYP3A in low-birthweight developing female ***:Pregnant rats were divided into nourished and undernourished *** offspring of the nourished rats were defined as the normal-birth-weight(NBW)group,and those of undernourished rats were defined as the low-birth-weight(LBW)*** to their birth weights and diets,the rats were subdivided into the following four groups:NBW-normal diet(NN)group;NBW-HFHE(NH)group;LBW-normal diet(LN)group;and LBW-HFHE(LH)*** samples were isolated on days 3,7,14,21,28,56 and 84 after ***:The CYP3A1 mRNA levels in the LH group on days 3,56 and 84 were significantly higher than those of the NN group(P<0.05).CYP3A1 expression was significantly higher in the LH group than that in the NH group on days 21,28 and 84(P<0.05).CYP3A1 mRNA expression was higher in the LH group than that in the LN group on days 3 and 21(P<0.05).No zonal CYP3A1 expression pattern was observed in the LH developmental *** LH group had significantly higher mean activity than the LN group on days 7,14,28 and ***:Our results indicated that an HFHE diet can result in alterations of CYP3A expression in a developmental LBW rat model.

关键词： CYP3A development high-energy diet low birth weight

Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants

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World Journal of Pediatrics 2016年第2期12卷 177-182页

作者： Bing-Bing Wu Yi Yang Xiu Xu Wei-Ping Wang Pediatrics Institute Key Laboratory of Neonatal DiseasesMinistry of HealthChildren's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Department of Pediatric healthcare Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China

Background:Intestinal microbiotas are thought to be the most important source of maturational stimuli to the development of the immune ***,few studies have focused on the development of T helper(Th)1 immune response and antibody response to vaccinations in healthy infants,especially in a large *** this randomized,double-blind control trial,we investigated the effects of Bifidobacterium longum BB536(BB536)supplementation on intestinal microbiota composition and the immune response in term ***:In total,300 healthy newborns were recruited,randomized and fed formula either supplemented with BB536 or with no *** samples were analyzed at months 2,4 and *** representative cytokine for Th1[interferon-γ(IFN-γ)]and Th2[interleukin-4(IL-4)]secretion cells were measured using enzyme-linked immunospot assay at 4 and 7 months of *** antibody response to vaccines was measured at months 7 and ***:A total of 264 infants completed the *** amount of bifidobacteria and the bifidobacteria/Enterobacteriaceae ratio(B/E)were signifi cantly higher in the BB536 supplementation group at months 2 and *** number of IFN-γsecretion cells and the ratio of IFN-γ/IL-4 secretion cells were increased in the BB536 supplementation group at 7 ***,the higher value of B/E in the early stages seems to be related to the increased Th1 *** difference was observed between groups in the antibody response after ***:BB536 has positive effects on establishing a healthy intestinal microbiota early in life,and it also plays an important role in improving the Th1 immune response.

关键词： intestinal microbiota probiotics supplementation term infants T helper 1/T helper 2 balance vaccination

The signal pathways and treatment of cytokine storm in COVID-19

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2371-2390页

作者： Lan Yang Xueru Xie Zikun Tu Jinrong Fu Damo Xu Yufeng Zhou Institute of Pediatrics Children's Hospital of Fudan UniversityNational Children's Medical Centerand the Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghaiChina National health Commission(NHC)key laboratory of neonatal diseases Fudan UniversityShanghaiChina General Department Children's Hospital of Fudan UniversityShanghaiChina State key laboratory of Respiratory Disease for Allergy at Shenzhen University Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen University School of MedicineShenzhenChina Institute of Infection Immunity and InflammationUniversity of GlasgowGlasgowUK

The Coronavirus Disease 2019(COVID-19)pandemic has become a global crisis and is more devastating than any other previous infectious *** has affected a significant proportion of the global population both physically and mentally,and destroyed businesses and *** evidence suggested that immunopathology may be responsible for COVID-19 pathogenesis,including lymphopenia,neutrophilia,dysregulation of monocytes and macrophages,reduced or delayed type I interferon(IFN-I)response,antibody-dependent enhancement,and especially,cytokine storm(CS).The CS is characterized by hyperproduction of an array of pro-inflammatory cytokines and is closely associated with poor *** excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells,resulting in complicated medical symptoms including fever,capillary leak syndrome,disseminated intravascular coagulation,acute respiratory distress syndrome,and multiorgan failure,ultimately leading to death in the most severe ***,it is clinically important to understand the initiation and signaling pathways of CS to develop more effective treatment strategies for ***,we discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines *** also discuss the induction,function,downstream signaling,and existing and potential interventions for targeting these cytokines or related signal *** believe that a comprehensive understanding of CS in COVID-19 will help to develop better strategies to effectively control immunopathology in this disease and other infectious and inflammatory diseases.

关键词： cytokine distress storm

neonatal necrotizing enterocolitis caused by umbilical arterial catheter-associated abdominal aortic embolism:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6557-6565页

作者： Xi Huang Yan-Ling Hu Yuan Zhao Qiong Chen Ying-Xin Li Department of neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina key laboratory of Birth Defects and Related diseases of Women and Children Sichuan UniversityMinistry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Reports of necrotizing enterocolitis(NEC)caused by umbilical arterial catheter(UAC)-associated abdominal aortic embolism in neonates are ***,we report the case of an extremely low birth weight(ELBW)infant with NEC caused by UAC-associated abdominal aortic *** SUMMARY A female infant,aged 21 min and weighing 830 g at 28+6 wk of gestational age,was referred to our hospital because of premature birth and shallow *** patient was diagnosed with ELBW,neonatal respiratory distress syndrome,neonatal intrauterine infection,and neonatal *** arterial and venous catheters were inserted on the day after birth and were removed 9 d later,according to the doctor’s *** 48 h after extubation,the patient’s manifestations included poor responsiveness,heart rate range of 175-185/min,and currant jelly ***,we considered a diagnosis of *** determine the cause,we used B-mode ultrasound,which revealed a partial abdominal aortic embolism(2 cm×0.3 cm)and abdominal *** patient was treated with nil per os,gastrointestinal decompression,anti-infective therapy,blood transfusion,and low-molecular-weight heparin sodium q12h for anticoagulant therapy(from May 20 to June 1,the dosage of low-molecular-weight heparin sodium was adjusted according to the anti-Xa activity during treatment).On the 67th day after admission,the patient fully recovered and was *** The abdominal aortic thrombosis in this patient was considered to be catheter related,which requires immediate treatment once *** choice of treatment should be determined according to the location of the thrombus and the patient’s condition.

关键词： Umbilical arterial catheter Abdominal aortic thrombosis Necrotizing enterocolitis Neonate Case report

Peripherally inserted central catheter placement in neonates with persistent left superior vena cava: Report of eight cases

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World Journal of Clinical Cases 2021年第26期9卷 7944-7953页

作者： Qiong Chen Yan-Ling Hu Ying-Xin Li Xi Huang Department of neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina key laboratory of Birth Defects and Related diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND Reports on peripherally inserted central catheter(PICC)placement in neonates with persistent left superior vena cava(PLSVC)are *** majority of PLSVC patients have no clinical symptoms or hemodynamic changes,which are usually detected during cardiac catheterization,cardiac pacemaker implantation,or PICC ***,in neonates with PLSVC,PICC placement can be ***,we report PICC placement in eight neonates with *** SUMMARY This article introduces the concept of the“TIMB”*** PICC implantation,we found PLSVC in all eight *** key points of care regarding PICC placement in neonates with PLSVC included“TIMB”,where“T”indicates a reasonable choice of the catheterization time,“I”refers to a retrospective analysis of imaging data before catheterization,“M”refers to correct measurement of the body surface length,and“B”indicates that the tip of the PICC is placed in the middle and lower 1/3 of the left superior vena cava under the guidance of ***“TIMB”is a bundle for PICC placement in neonates,especially for those with *** this new approach can improve the first-attempt success rate of PICC placement,reveal cardiovascular abnormalities in advance,allow the selection of different measurement methods reasonably according to the puncture site,and finally,improve the accuracy of catheter positioning through the use of B-ultrasound guidance.

关键词： Neonate Persistent left superior vena cava Peripherally inserted central catheter Complications “TIMB”bundle Case report

“AFGP” bundles for an extremely preterm infant who underwent difficult removal of a peripherally inserted central catheter:A case report

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World Journal of Clinical Cases 2021年第17期9卷 4253-4261页

作者： Qiong Chen Yan-Ling Hu Shao-Yu Su Xi Huang Ying-Xin Li Department of neonatal Nursing West China Second University HospitalSichuan University/West China School of NursingSichuan UniversityChengdu 610041Sichuan ProvinceChina key laboratory of Birth Defects and Related diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041Sichuan ProvinceChina

BACKGROUND There have been few reports on level 3 difficult removal of peripherally inserted central catheter(PICC)in ***,we reported a case of an extremely preterm infant who underwent level 3 difficult removal of a *** SUMMARY Female baby A,weighing 1070 g at 27^(+1) wk of gestational age,was diagnosed with extremely preterm infant and neonatal respiratory distress *** underwent PICC insertion *** first PICC insertion went well;the second PICC was inserted in the right lower extremity,however,phlebitis occurred on the second day after the *** the third day of catheterization,phlebitis was aggravated,while the right leg circumference increased by 2.5 *** the fourth day of catheterization,more red swelling was found in the popliteal part,covering an area of about 1.5 cm×4 cm,which was diagnosed as phlebitis level 3;thus,we decided to remove the *** tube removal,the catheter rebounded and could not be pulled out(several conventional methods were performed).Finally,we successfully removed the PICC using a new approach termed“AFGP”.On the 36th day of admission,the baby fully recovered and was *** The“AFGP”bundle approach was effective for an extremely preterm infant,who underwent level 3 difficult removal of a PICC.

关键词： Infant,Newborn Extremely preterm infant Catheterization,Peripheral Nursing Complications Case report

Development and Impacts of the Sierra Leone-China laboratory for Parasitic diseases Testing and Surveillance

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China CDC weekly 2021年第15期3卷 327-330页

作者： Lei Duan Lili Wang Shenning Lu Bei Wang Yanbing Li Qiuli Xu Lulu Huang Wei Ding Yingjun Qian Hongmei Li Xuejiao Ma Duoquan Wang Yayi Guan Xiaochun Wang Ning Xiao Xiao-nong Zhou National Institute of Parasitic diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyNational Health Commission of ChinaShanghaiChina Center for Global Public health Chinese Center for Disease Control and PreventionBeijingChina Department of laboratory Medicine Central South UniversityChangshaHunanChina.

BACKGROUND The Republic of Sierra Leone is located on the west coast of Africa,bordering Guinea and Liberia,with a population of 7.8 million in 2019(1).It has a tropical monsoon climate,with high temperatures and plentiful *** one of the least developed countries in the world(2),Sierra Leone has long struggled with poor health outcomes with a life expectancy at birth of 59 for male and 61 for female,and high maternal and neonatal mortality,threatened by infectious diseases such as malaria,tuberculosis,typhoid fever,cholera,and Lassa fever(3).

关键词： mortality diseases Sierra