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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing key laboratory of Carcinogenesis and Translational Research (ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of liver Surgery & transplantation Liver Cancer InstituteZhongshan HospitalFudan University key laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State key laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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Effects of multimodal fast-track surgery on liver transplantation outcomes

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 364-369页

作者： Jian-Hua Rao Feng Zhang Hao Lu Xin-Zheng Dai Chuan-Yong Zhang Xiao-Feng Qian Xue-Hao Wang Ling Lu liver transplantation Center First Affiliated Hospital of Nanjing Medical University key laboratory of Living Donor liver transplantation of ministry of public health Nanjing 210029China

BACKGROUND: Fast-track surgery and enhanced recovery after surgery have been applied to many surgical procedures; however, data on fast-track surgery and enhanced recovery after surgery following liver transplantation is limited. This study aimed to conduct a prospective study to determine the effects of fast-track surgery on prognosis after liver transplantation. METHODS: This was a prospective, single-blinded, randomized study. One hundred twenty-eight patients undergoing liver transplantation were selected for the fast-track (FT group, n=54) or conventional process (NFT group, n=74). The primary endpoints were intensive care unit (ICU) stay and hospital stay. The secondary endpoints were as follows: operative time, anhepatic phase time, intraoperative blood loss, intraoperative blood transfusion volume, postoperative complications, readmission rate, and postoperative mortality. RESULTS: There was no significant difference in preoperative demographics between the two groups. The median ICU stay was 2 days (range 1-7 days) in the FT group and 5 days (range 3-12 days) in the NFT group (Pliver transplantation.

关键词： fast-track surgery liver transplantation surgical drainage ICU days hospital stay

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Gallstone ileus: Case report and literature review

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World Journal of Gastroenterology 2013年第33期19卷 5586-5589页

作者： Xin-Zheng Dai Guo-Qiang Li Feng Zhang Xue-Hao Wang Chuan-Yong Zhang liver transplantation Center First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor Liver TransplantationMinistry of Public Health

Gallstone ileus(GI)is characterized by occlusion of the intestinal lumen as a result of one or more *** is a rare complication of gallstones that occurs in1%-4%of all cases of bowel *** mortality associated with GI ranges between 12%and 27%.Classical findings on plain abdominal radiography include:(1)pneumobilia;(2)intestinal obstruction;(3)an aberrantly located gallstone;and(4)change of location of a previously observed *** optimal management of acute GI is controversial and can be:(1)enterotomy with stone extraction alone;(2)enterotomy,stone extraction,cholecystectomy and fistula closure;(3)bowel resection alone;and(4)bowel resection with fistula *** describe a case to highlight some of the pertinent issues involved in GI management,and propose a scheme to minimize recurrent disease and postoperative *** conclude that GI is a rare condition affecting mainly the older population with a female *** advent of computed tomography and magnetic resonance imaging has made it easier to diagnose *** with stone extraction alone remains the most common surgical method because of its low incidence of complications.

关键词： Gallstone ileus Fistula closure Intestinal obstruction Bowel obstruction Enterolithotomy

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Drainage by urostomy bag after blockage of abdominal drain in patients with cirrhosis undergoing hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 99-102页

作者： Guo-Qiang Li Feng Zhang Hao Lu Ling Lu Xiang-Cheng Li Xue-Hao Wang Bei-Cheng Sun liver transplantation Center First Affiliated HospitalNanjing Medical University key laboratory of Living Donor liver transplantation of ministry of public health

Abdominal drainage was previously recommended as a post-hepatectomy procedure for patients with *** report introduces a simple technique that prevents leakage of ascitic fluid after cirrhotic hepatectomy complicated by blockage of the abdominal *** 59 patients who had had cirrhotic hepatectomy complicated by leakage of ascites in the drain site after drainage removal between January 2001 and April 2011,31 underwent suture ligation(sutured group) and 28 were given urostomy bag at the abdominal drainage site(drainage group).The mean length of postoperative hospital stay in the drainage group was shorter than in the sutured group(16.11±2.61 vs 34.23±4.86 days,P=0.000).Meanwhile,the drainage group showed decreased postoperative complications,including leakage of ascites,wound infection,and collection of *** by urostomy bag can prevent prolonged leakage of ascitic fluid after the blockage of abdominal drains in patients undergoing cirrhotic hepatectomy.

关键词： abdominal drain ascitic fluid leak hepatectomy urostomy bag

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Hepatic perivascular epithelioid cell tumor in three patients

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 660-664页

作者： Bao-Bin Hao Jian-Hua Rao Ye Fan Chuang-Yong Zhang Xin-Zheng Dai Xiao Li Yan Leng Feng Zhang Department of liver Surgery First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor Liver Transplantation of Ministry of Public Health Nanjing 210029 China Department of Pathology First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor Liver Transplantation of Ministry of Public Health Nanjing 210029 China

Perivascular epithelioid cell tumor （PEComa） is a rare, soft tissue tumor that can occur in various locations. The present report included three patients （one male and two females; age range, 25-51 years） with hepatic PEComas. The collected data included the clinical manifestations, diagnosis, management, treatment, and prognosis. Since it is difficult to diagnose hepatic PEComas by imaging, the patients were diagnosed by tumor tissue examination such as immunohistochemistry, which was positive for HMB-45, Melan-A, and SMA on all slides. The tumor was composed of diverse tissues including smooth muscle, adipose tissue, and thick-walled blood vessels. During the follow-up period, one of the tumors was malignant （double-positive for CD34 and Ki-67） and recurred 3 months after surgery. In addition, malignant hepatic PECo- mas were reviewed in the literature, indicating that the majority of hepatic PEComas are benign, but few hepatic PEComas exhibit malignant behaviors in older female patients （〉50 years of age） with abdominal discomfort and pain, larger tumor size （〉10 cm）, or positive staining for CD34 and Ki-67. In conclusion, there is no effective method to diagnose PEComas. Currently, the diagnosis of PEComas depends on immunohistochemical staining. Tumor resection and close follow-up are the principal methods for the management of PEComas.

关键词： perivascular epithelioid cell tumor, hepatic diagnosis hepatectomy recurrence

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Oleanolic acid attenuates liver ischemia reper-fusion injury by HO-1/Sesn2 signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2016年第5期15卷 519-524页

作者： Bao-Bin Hao Xiong-Xiong Pan Ye Fan Ling Lu Xiao-Feng Qian Xue-Hao Wang Feng Zhang Jian-Hua Rao Department of liver Surgery First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor Liver Transplantation of Ministry of Public HealthNanjing 210029China

BACKGROUND: Ischemia reperfusion injury (IRI) is unavoid-able in liver transplantation and hepatectomy. The present study aimed to explore the possible mechanism and the effect of oleanolic acid (OA) in hepatic IRI. METHODS: Mice were randomly divided into 6 groups based on different treatment. IRI model: The hepatic artery, portal vein, and bile duct to the left and median liver lobes (70% of the liver) were occluded with an atraumatic bulldog clamp for 90 minutes and then the clamp was removed for reperfusion. The mice were sacriifced 6 hours after reperfusion, and blood and liver tissues were collected. liver injury was evaluated by biochemical and histopathologic examinations. The expressions of Sesn2, PI3K, Akt and heme oxygenase-1 (HO-1) were mea-sured with quantitative real-time RT-PCR and Western blotting. RESULTS: The serum aminotransferases level and scores of he-patic histology were increased after reperfusion. The increase was attenuated by pretreatment with OA (Plivers (P CONCLUSIONS: Our results demonstrate that OA can attenu-ate hepatic IRI. The protective mechanism may be related to the OA-induced HO-1/Sesn2 signaling pathway.

关键词： oleanolic acid liver injury ischemia reperfusion HO-1 Sesn2

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Effects of antiviral therapy on preventing liver tumorigenesis and hepatocellular carcinoma recurrence

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World Journal of Gastroenterology 2013年第47期19卷 8895-8901页

作者： Zhong-Ming Tan Bei-Cheng Sun liver transplantation Center of the First Affiliated Hospital Nanjing Medical University The key laboratory of Living Donor liver transplantation Ministry of Health

Chronic hepatitis B virus(HBV)infection is the key driving force of liver disease progression,resulting in the development of hepatic dysfunction,cirrhosis and hepatocellular carcinoma(HCC).The primary aim of therapy is to suppress or eliminate HBV replication to reduce the activity of hepatitis,thus reducing the risk of,or slowing the progression of,liver ***(t)ide analogues(Nucs)may result in rapid suppression of HBV replication with normalization of serum transaminases and restore liver function,thus increasing survival in patients with hepatic ***-term Nuc therapy may result in histological improvement or reversal of advanced fibrosis and reduction in disease progression,including the development of *** long-term benefits of a finite course of interferon(IFN)-αtherapy also include a sustained and cumulative response,as well as hepatitis B surface antigen seroclearance and reduction in the development of cirrhosis and/or *** IFN and newer Nucs may achieve better long-term outcomes because of improved efficacy and a low risk of drug ***,treatment outcomes are still far from *** the effects of anti-HBV treatment against HCC incidence and recurrence after hepatectomy or liver transplantation is required for further improvement of outcome.

关键词： Hepatocelluar carcinoma Antiviral therapy Carcinogenesis Recurrence Nucleos(t)ide analogues Interferon Retrospective study Clinical trial

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC key laboratory of Combined Multi-Organ transplantation key laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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Emergency adult living donor right lobe liver transplantation for fulminant hepatic failure

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Frontiers of Medicine 2007年第3期1卷 282-286页

作者： ZHANG Feng WANG Xuehao LI Xiangcheng KONG Lianbao SUN Beicheng LI Guoqiang QIAN Xiaofen CHEN Feng WANG Ke LU Sheng PU Liyong LU Ling key laboratory of Living Donor liver transplantation of ministry of public health Liver Transplantation Centerthe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

Fulminant hepatitis is fatal in most cases and timely liver transplantation is the only effective *** study evaluates the survival outcomes of patients who underwent living-donor liver transplantation(LDLT)using right lobe liver grafts for fulminant liver failure due to hepatitis B *** cases of adult right lobe LDLT were performed in our department from September 2002 to August 2005 and the clinical and following-up data were *** to the pre-transplant Child-Pugh-Turcotte classification,the nine patients were classified as grade *** model for end-stage liver disease(MELD)score of these patients ranged from 16 to *** principal complications before transplantation included abnormal renal function,hepatic coma of different degrees and alimentary tract *** main complications after transplantation included pulmonary infection in two cases,acute renal failure in three cases and transplantation-related encephalopathy in one *** primary failure of vascular or biliary complications *** one-year survival rate was 55.6%.There were no serious complications or deaths in *** general,it is extremely difficult to treat fulminant hepatitis by conservative regimen,particularly,in cases with rapid *** adult living-donor liver transplantation is an effective treatment for fulminant hepatitis patients and is relatively safe for donors.

关键词： liver transplantation living donors hepatitis,liver disease

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Biological features of intrahepatic CD4^(+)CD25^(+)T cells in the naturally tolerance of rat liver transplantation

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Frontiers of Medicine 2007年第4期1卷 373-376页

作者： LU Ling ZHANG Feng PU Liyong YAO Aihua YU Yue SUN Beicheng LI Guoqiang WANG Xuehao key laboratory of Living Donor liver transplantation of ministry of public health Liver Transplantation CenterThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China

The biological features of intrahepatic CD4^(+)CD25^(+)T regulatory cells in the naturally tolerance of rat liver transplantation were *** liver transplan-tation was performed in two allogeneic rat strain combina-tions,one with fatal immunosuppression despite a complete major histocompatibility complex *** subjects were divided into three groups according to different donors and recipients[Tolerance group:LEW-to-DA;Rejection group:DA-to-LEW;Syngegnic group(control group):DA-to-DA].The proportion of intrahepatic CD4^(+)CD25^(+)T cells from three groups was determined by flow cytometry(FCM)in different *** intrahepaitc CD4^(+)CD25^(+)T cells were isolated by magnetic activated cell sorting(MACS)method and identified by *** Foxp3 mRNA was detected by reverse transcriptase polymerase chain reaction(RT-PCR).And their suppression on the proliferation of CD4^(+)CD25^(-)T effector cells was analyzed by cell proliferation assay in *** immediately after transplantation,the proportion of Treg cells increased over time in both allogeneic groups but was significantly greater in the Rejection *** pro-portion of Treg cells declined after day 5,and such reduction was more dramatic in the Rejection group than in the Tole-rance *** in the Tolerance group showed a second increase in the proportion after day *** CD4^(+)CD25^(+)T cells isolated from spontaneous tolerance models inhibited the proliferation of mixed lymphocyte *** purity of CD4^(+)CD25^(+)Tcells sorted by MACS was 86%–93%.The CD4^(+)CD25^(+)T cells could specifically express the Foxp3 gene compared with CD4^(+)CD25^(-)T *** vitro,the spleen cells from LEW rats can irritate the proliferation of CD4^(+)CD25^(+)T cells more obviously than the syngegnic spleen ***4^(+)CD25^(+)Tr cells could suppress the proliferation of CD4^(+)CD25^(-)T cells,but the inhibition was reversed by exo-genous IL-2(200 U/mL).The CD4^(+)CD25^(+)T regulatory

关键词： liver transplantation immune tolerance T-lymphocytes,regulatory CD4^(+)CD25^(+)T regulatory cells

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