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Blocking the Pd-1 signal transduction by occupying the phosphorylated ITSM recognition site of SHP-2

Science China Life Sciences 2024年

作者： Wenjie Li Wenyi Mei Hewei Jiang Jie Wang Xiaoli Li Lina Quan Yanyan diao Yanni Ma Sisi Fan Zhuwei Xie Mengdie Gong Huan Zhu dewen Bi Feng Zhang Lei Ma Jian Zhang Yufeng Gao Aris Paschalidis Honghuang Lin Fangfang Liu Kangdong Liu Mingliang Ye Zhenjiang Zhao Yajun duan Zhuo Chen Yufang Xu Weilie Xiao Shengce Tao Lili Zhu Honglin Li Innovation Center for AI and drug discovery East China Normal University Shanghai key laboratory of New drug design School of PharmacyEast China University of Science&Technology Shanghai Center for Systems Biomedicine Key Laboratory of Systems Biomedicine (Ministry of Education)Shanghai Jiao Tong University Lingang laboratory key laboratory of Medicinal Chemistry for Natural resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of Pharmacy and School of Chemical Science and TechnologyYunnan University CAS key laboratory of Separation Sciences for Analytical Chemistry National Chromatographic R&A CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences department of Cardiology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China department of Infectious diseases The First Affiliated Hospital of Anhui Medical University department of Medicine University of Massachusetts Chan Medical School department of Pathophysiology School of Basic Medical SciencesAcademy of Medical ScienceCollege of MedicineZhengzhou University

Targeting the Pd-1/Pd-L1 axis with small-molecular inhibitors is a promising approach for immunotherapy. Here, we identify a natural pentacyclic triterpenoid, Pygenic Acid A(PA), as a Pd-1 signaling inhibitor. PA exerts anti-tumor activity in hPd-1 knock-in C57BL/6 mice and enhances effector functions of T cells to promote immune responses by disrupting the Pd-1 signaling transduction. Furthermore, we identify SHP-2 as the direct molecular target of PA for inhibiting the Pd-1 signaling transduction. Subsequently, mechanistic studies suggest that PA binds to a new druggable site in the phosphorylated Pd-1 ITSM recognition site of SHP-2, inhibiting the recruitment of SHP-2 by Pd-1. Taken together, our findings demonstrate that PA has a potential application in cancer immunotherapy and occupying the phosphorylated ITSM recognition site of SHP-2 may serve as an alternative strategy to develop Pd-1 signaling inhibitors. In addition, our success in target recognition provides a paradigm of target identification and confirmation for natural products.

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Artificial intelligence-based analysis of tumor-infiltrating lymphocyte spatial distribution for colorectal cancer prognosis

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Chinese Medical Journal 2024年第4期137卷 421-430页

作者： Ming Cai Ke Zhao Lin Wu Yanqi Huang Minning Zhao Qingru Hu Qicong Chen Su Yao Zhenhui Li Xinjuan Fan Zaiyi Liu department of radiology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Guangdong provincial key laboratory of Artificial Intelligence in Medical Image Analysis and application GuangzhouGuangdong 510080China Guangdong Cardiovascular Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China Medical research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China department of Pathology The Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunmingYunnan 650118China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Institute of Computing Science and technology Guangzhou UniversityGuangzhouGuangdong 510006China department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong 510080China department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China

Background:Artificial intelligence(AI)technology represented by deep learning has made remarkable achievements in digital pathology,enhancing the accuracy and reliability of diagnosis and prognosis *** spatial distribution of Cd3^(+)and Cd8^(+)T cells within the tumor microenvironment has been demonstrated to have a significant impact on the prognosis of colorectal cancer(CrC).This study aimed to investigate Cd3_(CT)(Cd3^(+)T cells density in the core of the tumor[CT])prognostic ability in patients with CrC by using AI ***:The study involved the enrollment of 492 patients from two distinct medical centers,with 358 patients assigned to the training cohort and an additional 134 patients allocated to the validation *** facilitate tissue segmentation and T-cells quantification in whole-slide images(WSIs),a fully automated workflow based on deep learning was *** the completion of tissue segmentation and subsequent cell segmentation,a comprehensive analysis was ***:The evaluation of various positive T cell densities revealed comparable discriminatory ability between Cd3_(CT) and Cd3-Cd8(the combination of Cd3^(+)and Cd8^(+)T cells density within the CT and invasive margin)in predicting mortality(C-index in training cohort:0.65 vs.0.64;validation cohort:0.69 vs.0.69).The Cd3_(CT) was confirmed as an independent prognostic factor,with high Cd3_(CT) density associated with increased overall survival(OS)in the training cohort(hazard ratio[Hr]=0.22,95%confidence interval[CI]:0.12–0.38,Pd validation cohort(Hr=0.21,95%CI:0.05–0.92,P=0.037).Conclusions:We quantify the spatial distribution of Cd3^(+)and Cd8^(+)T cells within tissue regions in WSIs using AI *** Cd3_(CT) confirmed as a stage-independent predictor for OS in CrC ***,Cd3_(CT) shows promise in simplifying the Cd3-Cd8 system and facilitating its practical application in clinical settings.

关键词： Colorectal cancer Artificial intelligence deep learning digital pathology Prognosis Immune cells Cd3 Cd8 TME

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Experimental study on the compression-shear performance of a new-type circumferential joint of shield tunnel

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Underground Space 2024年第1期14卷 138-155页

作者： Ziyang Zhou Kun Feng Yiteng Liu Bohan Wu Chunfang Lu Gang Lin Chuan He key laboratory of Transportation Tunnel Engineering of Ministry of education Southwest Jiaotong UniversityChengdu 610031China China Academy of railway Sciences Corporation Limited Beijing 100081China China railway Eryuan Engineering Group Co. Ltd.Chengdu 610031China

To investigate the compression-shear behavior of a new circumferential joint based on the sleeve-straight bolt combination type connection of large-diameter shield tunnels,a series of full-scale joint experiments was carried *** the process of the experiment,more attention was paid to the specimen displacement,bolt stress and joint damage *** the basis of these experiment phenomena,this study discussed the compression-shear bearing process of the new connector,analyzed the damage mode of the joint structure,and finally evaluated the performance of the new *** is found that the bearing process of the joint can be divided into four stages:the transitional stage for overcoming the friction of the concrete,the sleeve bearing stage for the sleeve bearing shear loads alone,the combined bearing stage for bearing shear loads by the connector system,and the structural damage stage for structural instability and *** speaking,affected by connector position and hand hole,the positive compression-shear stiffness of the joint is less than the negative compression-shear stiffness,and the positive shear strength of the joint is greater than the negative shear *** increase of longitudinal axial force will improve the compression-shear performance of the *** relationship between longitudinal axial force and joint stiffness is a logarithmic *** use of new type of connector can effectively improve the compression-shear stiffness of joints under low shear loads,but the application of straight bolts will lose part of the strength performance.

关键词： Shield tunnel New type of connector Shear resistance Full-scale experiment Circumferential joint

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环太平洋特大干旱导致公元1644年明朝首都的陷落（英文）

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Science Bulletin 2024年第19期 3106-3114页

作者：陈峰王涛赵晓恩 Jan Esper Fredrik Charpentier Ljungqvist Ulf Büntgen Hans W.Linderholm david Meko 许红娜岳伟鹏王世杰袁玉江郑景云潘威 Fidel roig Martín Hadad 胡茂魏家昌陈发虎 yunnan key laboratory of International rivers and Transboundary Eco-Security Institute of International Rivers and Eco-Security Yunnan University Southwest United Graduate School regional Climate Group Department of Earth Sciences University of Gothenburg Climate Change research Center and Nansen-Zhu International research Centre Institute of Atmospheric Physics Chinese Academy of Sciences department of Geography Johannes Gutenberg University Global Change research Institute (Czech Globe) Czech Academy of Sciences department of History Stockholm University Bolin Centre for Climate research Stockholm University Swedish Collegium for Advanced Study Linneanum department of Geography University of Cambridge department of Geography Faculty of Science Masaryk University Swiss Federal research Institute (WSL) laboratory of Tree-ring research University of Arizona Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters (CIC FEMd) Nanjing University of Information Science and Technology key laboratory of Tree-ring Physical and Chemical research Institute of Desert Meteorology China Meteorological Administration key laboratory of Land Surface Pattern and Simulation Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences key laboratory of digital human technology r&d and application of yunnan provincial department of education Yunnan University Laboratorio de dendrocronología e Historia Ambiental IANIGLA-CCT CONICET-Universidad Nacional de Cuyo Hémera Centro de Observación de La Tierra Escuela de Ingeniería Forestal Facultad de Ciencias Universidad Mayor Laboratorio de dendrocronología de Zonas áridas CIGEOBIO (CONICET-UNSJ) Gabinete de Geología Ambiental (INGEO-UNSJ) ALPHA State Key Laboratory of Tibetan Plateau Earth System Environment and Resources (TPESER) Institute of Tibetan Plateau Research Chinese Academy of Sciences College of resources and Environment University of Chinese Academy of Sciences MOE key laboratory of We

Historical documents provide evidence for regional droughts preceding the political turmoil and fall of Beijing in 1644 CE, when more than 20 million people died in northern China during the late Ming famine period. However, the role climate and environmental changes may have played in this pivotal event in Chinese history remains unclear. Here, we provide tree-ring evidence of persistent megadroughts from1576 to 1593 CE and from 1628 to 1644 CE in northern China, which coincided with exceptionally cold summers just before the fall of Beijing. Our analysis reveals that these regional hydroclimatic extremes are part of a series of megadroughts along the Pacific rim, which not only impacted the ecology and society of monsoonal northern China, but likely also exacerbated external geopolitical and economic pressures. This finding is corroborated by last millennium reanalysis data and numerical climate model simulations revealing internally driven Pacific sea surface temperature variations and the predominance of decadal scale La Ni?a-like conditions to be responsible for precipitation decreases over northern China,as well as extensive monsoon regions in the Americas. These teleconnection patterns provide a mechanistic explanation for reoccurring drought spells during the late Ming dynasty and the environmental framework fostering the fall of Beijing in 1644 CE, and the subsequent demise of the Ming dynasty.

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Amplitude analysis of the decays d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai r.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani d.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.r.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.r.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.dai J.P.dai A.dbeyssi r.E.de Boer d.dedovich C.Q.deng Z.Y.deng A.denig I.denysenko M.destefanis F.de Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.d.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.ding X.X.ding Y.ding Y.ding J.dong L.Y.dong M.Y.dong X.dong M.C.du S.X.du Z.H.duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo r.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.r.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia d.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.r.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.r.Li Q.M.Li Q.X.Li r.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays d^(0)→a_(1)(1260)π,d^(0)→π(1300)π,d^(0)→ρ(770)ρ(770),and d^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of d^(0)→π^(+)π^(−)π^(+)π^(−)and d^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of d^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→dK^(−)decay.

关键词： BESIII d^(0)meson decays amplitude analysis CP-even fraction

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determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai r.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-r.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani d.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko r.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang G.r.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.r.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.J.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio J.J.Cui H.L.dai J.P.dai A.dbeyssi r.E.de Boer d.dedovich C.Q.deng Z.Y.deng A.denig I.denysenko M.destefanis F.de Mori B.ding X.X.ding Y.ding Y.ding J.dong L.Y.dong M.Y.dong X.dong M.C.du S.X.du Y.Y.duan Z.H.duan P.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang r.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng M.Fritsch C.d.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo r.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.r.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia d.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz r.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li d.M.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.r.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li M.H.Li P.r.Li Q.M.Li Q.X.Li r.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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detection of scab in wheat ears using in situ hyperspectral data and support vector machine optimized by genetic algorithm

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International Journal of Agricultural and Biological Engineering 2020年第2期13卷 182-188页

作者： Linsheng Huang Hansu Zhang Chao ruan Wenjiang Huang Tingguang Hu Jinling Zhao National Engineering research Center for Agro-Ecological Big data Analysis&application Anhui UniversityHefeiChina key laboratory of digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina

A new method was proposed to extract sensitive features and to construct a monitoring model for wheat scab based on in situ hyperspectral data of wheat ears to achieve effective prevention and control and provide theoretical support for its large-scale *** sensitive features were selected through correlation analysis and wavelet *** features were as follows:three original bands of 350-400 nm,500-600 nm,and 720-1000 nm;three vegetation indices of modified simple ratio(MSr),normalized difference vegetation index,and structural independent pigment index;and two wavelet features of WF01 and *** combining the selected sensitive features with support vector machine(SVM)and SVM optimized by genetic algorithm(GASVM),a total of 16 monitoring models were built,and the monitoring accuracies of the two types of models were *** ability of the monitoring models built by GASVM to identify scab was better than that of SVM algorithm under the same characteristic *** the 16 models,MSr combined with GASVM had an overall accuracy of 75%and a Kappa coefficient of *** can be used to monitor wheat scab and its application can improve the accuracy of disease monitoring.

关键词： wheat scab hyperspectral data correlation analysis genetic algorithm wavelet transform support vector machine

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Observations of the Cabibbo-Suppressed decays ■→nπ+π0,nπ+π-π+and the Cabibbo-Favored decay ■→nK-π+π+

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Chinese Physics C 2023年第2期 5-22页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht r.Aliberti A.Amoroso 安美儒安琪白羽 O.Bakina r.Baldini Ferroli I.Balossino 班勇 V.Batozskaya d.Becker K.Begzsuren N.Berger M.Bertani d.Bettoni F.Bianchi E.Bianco J.Bloms A.Bortone I.Boyko r.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cibinettov F.Cossio 崔佳佳代洪亮代建平 A.dbeyssi r.E.de Boer d.dedovich 邓子艳 A.denig I.denysenko M.destefanis F.de Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 P.Egorov 范玉兰方建房双世方文兴方易 r.Farinelli L.Fava69B F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 r.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz r.Kiuchi r.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁昊梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘成刘春秀 d.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 r.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak P.Patteri M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.rashid C Institute of High Energy Physics G.I.Budker Institute of Nuclear Physics SB rAS (BINP) the Novosibirsk State University Uppsala University Bochum ruhr-University Johannes Gutenberg University of Mainz University of Turin INFN Liaoning Normal University State key laboratory of Particle detection and Electronics University of Science and technology of China Southeast University Joint Institute for Nuclear research INFN Laboratori Nazionali di Frascati INFN Sezione di Ferrara Peking University State key laboratory of Nuclear Physics and technology Peking University National Centre for Nuclear research Institute of Physics and technology University of Muenster Carnegie Mellon University Wuhan University University of Chinese Academy of Sciences Istinye University Nankai University the Moscow Institute of Physics and technology Soochow University Nanjing University Tsinghua University Institute of Modern Physics Hunan University School of Physics and Electronics Hunan University Shandong University yunnan University Helmholtz Institute Mainz Liaoning University Jilin University Zhengzhou University Sun Yat-Sen University University of Oxford University of Ferrara University of Manchester GSI Helmholtzcentre for Heavy Ion research GmbH Guangxi University Nanjing Normal University Shandong Normal University Fudan University key laboratory of Nuclear Physics and Ion-beam application (MOE) and Institute of Modern Physics Fudan University Henan Normal University University of Hawaii Suranaree University of technology University Avenue 111 South China Normal University i University of the Punjab Indiana University Huangshan College University of Jinan University of Groningen Justus-Liebig-Universitaet Giessen II.Physikalisches Institut Indian Institute of technology Madras Qufu Normal University Shanxi University Guangdong provincial key laboratory of Nuclear Science Institute of Quantum Matter South China Normal University Beijing Institute of Petrochemical technology Lanzhou University Frontiers Science Center for rare Is

Using electron-positron annihilation data samples corresponding to an integrated luminosity of 4.5 fb-1,collected by the BESⅢ detector in the energy region between 4599.53 MeV and 4698.82 MeV,we report the first observations of the Cabibbo-suppressed decays Λc+→nπ+π0,Λc+→nπ+π-π+,and the Cabibbo-favored decayΛc+→nK-π+π+with statistical significances of 7.9σ,7.8σ,and >10σ,*** branching fractions of these decays are measured to be B（Λc+→nπ+π0）=（0.64±0.09±0.02）%,B（Λc+→nπ+π-π+）=（0.45±0.07±0.03）%,and B（Λc+→nK-π+π+）=（1.90±0.08±0.09）%,where the first uncertainties are statistical and the second are *** find that the branching fraction of the decay Λc+→nπ+π0is about one order of magnitude higher than that of Λc+→nπ+.

关键词： ∧c+ baryon Branching fraction BESⅢ detector

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Observation of e+e-→■-+c.c.

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Chinese Physics C 2023年第4期 22-31页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht r.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina r.Baldini Ferroli I.Balossino 班勇 V.Batozskaya d.Becker K.Begzsuren N.Berger M.Bertani d.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko r.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.dbeyssi r.E.de Boer d.dedovich 邓子艳 A.denig I.denysenko M.destefanis F.de Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 r.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 r.Kappert 柯百谦 I.K.Keshk A.Khoukaz P.Kiese r.Kiuchi r.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J.Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇梁昊梁浩梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘春秀 d.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 r.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.rashid C.F.redmer 任旷洁 A.rivetti V.rodin M.rolo 荣刚 Ch.rosn Institute of High Energy Physics G.I. Budker Institute of Nuclear Physics SB rAS(BINP) Novosibirsk State University Uppsala University Bochum ruhr-University Johannes Gutenberg University of Mainz University of Turin INFN Liaoning Normal University State key laboratory of Particle detection and Electronics University of Science and technology of China University of Jinan Southeast University Joint Institute for Nuclear research INFN Laboratori Nazionali di Frascati INFN Sezione di Ferrara Peking University State key laboratory of Nuclear Physics and technology Peking University National Centre for Nuclear research Institute of Physics and technology University of Muenster Carnegie Mellon University Wuhan University University of Chinese Academy of Sciences Istinye University Moscow Institute of Physics and technology Nankai University Soochow University Nanjing University Tsinghua University Institute of Modern Physics Hunan University School of Physics and Electronics Hunan University Shandong University yunnan University Helmholtz Institute Mainz Liaoning University Zhengzhou University University of Eastern Piedmont Sun Yat-Sen University University of Oxford University of Ferrara University of Manchester GSI Helmholtzcentre for Heavy Ion research GmbH Guangxi University Nanjing Normal University Shandong Normal University Fudan University key laboratory of Nuclear Physics and Ion-beam application (MOE) and Institute of Modern Physics Fudan University Henan Normal University University of Hawaii Suranaree University of technology Goethe University Frankfurt South China Normal University Guangdong provincial key laboratory of Nuclear Science Institute of Quantum Matter South China Normal University University of South China University of the Punjab Indiana University Huangshan College University of Groningen Justus-Liebig-Universitaet Giessen Ⅱ. Physikalisches Institut Indian Institute of technology Madras Qufu Normal University Shanxi Normal University Beijing Institute of Petrochemical technology Lanzhou Univ

Using data taken at 29 center-of-mass energies between 4.16 and 4.70 GeV with the BESⅢ detector at the Beijing Electron Positron Collider corresponding to a total integrated luminosity of approximately 18.8 fb-1, the process e+e-→■+ c.c. is observed for the first time with a statistical significance of 11.5σ. The average Born cross sections in the energy ranges of（4.160, 4.380） GeV,（4.400, 4.600） GeV and（4.610, 4.700） GeV are measured to be（21.5±5.7±1.2） fb,（46.3±10.6±2.5） fb and （59.0±9.4±3.2） fb, respectively, where the first uncertainties are statistical and the second are systematic. The line shapes of the ■ and ppπ-invariant mass spectra are consistent with phase space distributions, indicating that no hexaquark or di-baryon state is observed.

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Luminosities and energies of e+e- collision data taken between ■=4.61 GeV and 4.95 GeV at BESⅢ

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Chinese Physics C 2022年第11期46卷 70-81页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht r.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.Bakina Ferroli r.Baldini I.Balossino 班勇 V.Batozskaya d.Becker K.Begzsuren N.Berger M.Bertani d.Bettoni F.Bianchi J.Bloms A.Bortone I.Boyko r.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.dbeyssi Boer r.E.de d.dedovich 邓子艳 A.denig I.denysenko M.destefanis Mori F.de 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 r.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold M.Himmelreich 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍黄震 T.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson N.Kalantar-Nayestanaki 康晓珅 r.Kappert 柯百谦 I.K.Keshk A.Khoukaz P.Kiese r.Kiuchi r.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann T.Lenz 李翠李聪李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科李林健李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇梁昊梁浩梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘春秀 d.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏 Z.H.Lu 罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 r.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K.H.rashid C.F.redmer 任旷洁 A.rivetti V.rodin M.rolo 荣刚 Ch.rosner Institute of High Energy Physics G. I. Budker Institute of Nuclear Physics SB rAS (BINP) the Novosibirsk State University Uppsala University Bochum ruhr-University Johannes Gutenberg University of Mainz University of Turin INFN Liaoning Normal University State key laboratory of Particle detection and Electronics University of Science and technology of China University of Jinan Southeast University Joint Institute for Nuclear research INFN Laboratori Nazionali di Frascati INFN Sezione di Ferrara Peking University State key laboratory of Nuclear Physics and technology Peking University National Centre for Nuclear research Institute of Physics and technology University of Muenster Carnegie Mellon University Wuhan University University of Chinese Academy of Sciences Istinye University the Moscow Institute of Physics and technology Nankai University Soochow University Nanjing University Tsinghua University Institute of Modern Physics Hunan University School of Physics and Electronics Hunan University Shandong University yunnan University Helmholtz Institute Mainz Liaoning University Zhengzhou University University of Eastern Piedmont Sun Yat-Sen University University of Oxford University of Ferrara University of Manchester GSI Helmholtzcentre for Heavy Ion research GmbH Guangxi University Nanjing Normal University Shandong Normal University Fudan University key laboratory of Nuclear Physics and Ion-beam application (MOE) and Institute of Modern Physics Fudan University Henan Normal University University of Hawaii Suranaree University of technology Goethe University Frankfurt South China Normal University Guangdong provincial key laboratory of Nuclear Science Institute of Quantum Matter South China Normal University University of South China University of the Punjab Indiana University Huangshan College University of Groningen Justus-Liebig-Universitaet Giessen Ⅱ.Physikalisches Institut Indian Institute of technology Madras Qufu Normal University Shanxi Normal University Beijing Institute of Petrochemical technology Lan

From december 2019 to June 2021,the BESⅢ experiment collected approximately 5.85 fb-1of data at center-of-mass energies between 4.61 and 4.95 *** is the highest collision energy BEPCⅡ has reached to *** accumulated e+e-annihilation data samples are useful for studying charmonium（-like） states and charmed-hadron *** adopting a novel method of analyzing the production of ■ pairs in e+e-annihilation,the center-of-mass energies are measured with a precision of ～0.6 *** luminosities are measured with a precision of better than 1% by analyzing the events of large-angle Bhabha *** measurements provide important inputs to analyses based on these data samples.

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