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Native Medicinal Plant Richness Distribution Patterns and Environmental Determinants of Xinjiang, Northwest China

chinese herbal medicines 2015年第1期7卷 45-53页

作者： Li-ping Li Ben-gang Zhang Pei-gen Xiao Zhao Zhang Yao-dong Qi Xiao-jin Li Guo-ping Wang Hai-tao Liu key laboratory of bioactive substances and resources utilization of chinese herbal medicine (Peking Union Medical College) Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union Medical College Xinjiang Institute of chinese Materia Medica and Ethical Materia Medica

Objective To comprehensively map the distribution patterns of native medicinal plants of Xinjiang Uygur Autonomous Region, China; To find the environmental determinants and to give suggestions for the conservation planning of medicinal plants in Xinjiang region. Methods Firstly, we compiled the distribution data of native medicinal plants at a county level in Xinjiang region, including the source plants of chinese Materia Medica （CMM）, Uygur medicine （UM）, and Kazak medicine （KM）; Secondly, we divided the distribution data into grid with a resolution of 0.1~ x 0.1~ and overlaid it on the topography and climate data in Arcgis 10.0; Finally, we analyzed the correlations of medicinal plant richness and environmental variables with ordinary least square （OLS） regressions and partial regressions. Results UM has more non-native species in Xinjiang region than KM. The species richness of medicinal plants is high in Altay Mountains, western Tianshan Mountains, and part of Kunlun Mountains. The richness of medicinal plants is highly correlated with the vascular plant species richness and climate, and further, the independent effects of vascular plant species richness are higher than the independent effects of climate. The whole plant, root ＆ rhizome, and seed ＆ fruit are more frequently used than stem and leaf for CMM in Xinjiang region. Conclusion The distribution patterns of medicinal plants are concordant with vascular plant species, which could be carefully considered in the conservation planning of this region. Taking full advantage of current nature reserves is a low-costing approach to the conservation of medicinal plants although they were not originally established for medicinal plant protection. Nevertheless, it is urgent to further study the distributions and protection status of medicinal plants in the nature reserves of Xinjiang region.

关键词： chinese Materia Medica distribution diversity Kazak medicine Traditional chinesemedicine Uygur medicine Xinjiang Uygur Autonomous Region

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Pharmacophylogenetic Study on Plants of Genus Salvia *** China

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chinese herbal medicines 2013年第3期5卷 164-181页

作者： LI Min-hui LI Qian-quan LIU Yan-ze CUI Zhan-hu ZHANG Na HUANG Lu-qi XIAO Pei-gen National Resource Center for chinese Materia Medica China Academy of Chinese Medical Science Baotou Medical College key laboratory of bioactive substances and resources utilization of chinese herbal medicine (Peking Union MedicalCollege) Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Science

In China,many species of genus Salvia L.(Lamiaceae) are important medicinal plants with a long *** to their marked ethnopharmacological uses in folk medicine and a large number of active constituents with therapeutic potential found recently,they have become a rich source for new drug discovery,mechanism research,and biological *** medicinal plants of Salvia *** be divided into three groups(Groups 1,2,and 3).The plants in Group 1 were used as 'Danshen' and are rich in diterpenoids and caffeic acid *** introduced plants in Group 2 from America or Europe have been used to clear body-heat and *** diterpenes of medicinal species in Group 3(the species are from *** Briq.,***,or ***)are absent,and the contents of caffeic acid derivatives are considerably lower than those in plants of Group 1.

关键词： ethnopharmacology Lamiaceae pharmacophylogenetics Salvia L. species

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Up-regulation of HO-1 via Akt/Nrf2 pathway by Notoginsenoside R1 rescues PC12 cells from oxidative stress

Up-regulation of HO-1 via Akt/Nrf2 pathway by Notoginsenosid...

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2013年全国老年性痴呆与相关疾病学术会议

作者： Jing Sun Guibo Sun Xiangbao Meng Hongwei Wang Meng Qin Jing Wang Bo Ma Min Wang Li Cao Liyan Ma Xiaobo Sun key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences & Peking Union Medical College Medical School Nanjing University

Object:To study the neuroprotective effects of Notoginsenoside Rl(NGRl) against HO-induced oxidative stress in PCI2 cells and the underlying mechanism. Results:In this study,for the first time,we clearly showed protective effects of NGRl against HO-induced oxidative stress in PC 12 ***(10 and 100μM) pretreatment obviously inhibited HO-induced ROS accumulation and oxidative stress in *** pretreatment could also suppress HO-induced the imbalance of Bcl-2 family protein,disruption of mitochondrial membrane potential and activation of caspase-3 as well as inactivation of Akt/Nrf2 ***,we fatherly clarified a novel underlying *** treatment alone could up-regulate HO-1 in dose- and time- dependent manners,and NGRl-mediated up-regulation of HO-1 was abolished by transfection with Nrf2 siRNA and supplementation with a PI3K specific inhibitor *** treatment alone could also induce phosphorylation of Akt,facilitate the nuclear accumulation of Nrf2,and enhance the binding activity of Nrf2-ARE in dose- and time- dependent *** importantly, NGRl-mediated activation of Nrf2/ARE patliway was suppressed by transfection with Akt siRNA and ***,NGRl-mediated protection was also attenuated by a HO-1 specific inhibitor Snpp and LY294002. Conclusion:NGRl provides neuroprotective effects against oxidative stress in PC 12 cells by up-regulation of HO-1 through Akt/Nrf2 pathway.

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A New Caffeate from the Aerial Parts of Anabasis aphylla

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chinese herbal medicines 2010年第4期2卷 248-249页

作者： LI Wei-lin1, 3, WANG Zhen-zhong2, WANG Hong-qing1, GONG Ting1, CHEN Ruo-yun1 1. key laboratory of bioactive substances and resources utilization of chinese herbal medicine, ministry of education, Institute of Materia Medica, chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China 2. Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China 3. Department of Pharmacology, Pharmacy College of Xinxiang Medical College, Xinxiang 453003, China key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationInstitute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China Department of Pharmacology Pharmacy College of Xinxiang Medical College Xinxiang 453003 China Jiangsu Kanion Pharmaceutical Co. Ltd. Lianyungang 222001 China key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationInstitute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

Objective To study the chemical constituents from the aerial parts of Anabasis aphylla. Methods The chemical constituents were isolated and purified by silica gel column and Sephadex LH-20 column chromatography. Spectroscopic methods such as MS and NMR spectra were used for the structural identification. Results A new caffeate ester, named eicosyl-(Z)-caffeate (1), along with fourteen known compounds was isolated from the EtOAc part. Conclusion Compound 1 is a new compound and compounds 2-13 are isolated from the plants of Anabasis L. for the first time.

关键词： Anabasis L. Anabasis aphylla L eicosyl-(Z)-caffeate

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Proteomics analysis on hypolipidemic mechanisms of total phenylpropanoid glycosides from Ligustrum robustum(Roxb.) Blume in hamsters fed a high fat diet

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中国药理学与毒理学杂志 2018年第4期32卷 325-325页

作者： Run-mei YANG Zi-wen ZHANG Le SUN Ning ZHAO Yong XIE Wen JIN Rui-le PAN Nan-nan GAO key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of Education Pharmacology and Toxicology Research Center Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Peking Union

OBJECTIVE To explore the hypolipidemic mechanisms of the total phenylpropanoid glycosides fromLigustrum robustum(Roxb.) Blume(LRTPG) in hamsters using proteomics *** The hamsters were fed with a high fat diet to induce *** LRTPG of high(1.2 g·kg^(-1)),medium(0.6 g·kg^(-1)) and low(0.3 g·kg^(-1)) doses were administrated daily for 4 *** the concentrations of plasma and hepatic lipids were determined using enzymic *** total protein was extracted from livers of the model group and the group treated with the high dose of LRTPG for label-free quantitative *** LRTPG significantly reduced the concentrations of plasma and hepatic lipids in hamsters fed a high fat *** proteomics data showed that a total of 2231 proteins were identified,and 549 proteins were found to be differentially expressed between the model group and the group treated with *** the 549 proteins,93 proteins were up-regulated and 59 proteins were down-regulated,and 397 proteins were absent or *** some of these proteins were much related to the lipid ***,gene ontology(GO) analysis indicated metabolic process,transport,oxidation-reduction process,phosphorylation,signal transduction,lipid metabolic process were the main biological processes that those differentially expressed proteins *** pathway analysis showed that those proteins were involved in several metabolic pathways including oxidative phosphorylation,non-alcoholic fatty liver disease(NAFLD),PI3K-Akt signaling pathway,cAMP signaling pathway,cGMP-PKG signaling *** The proteomics study could provide valuable clues to help us to understand the hypolipidemic mechanisms of LRTPG much better.

关键词：蛋白质降血脂治疗方法临床分析

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Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats

Aconitine-induced Ca2+ overload causes arrhythmia and trigge...

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中国微循环学会2014年全国学术会议

作者： Gui-bo Sun Hong Sun Xiang-bao Meng Jin Hu Qiang Zhang Bo Liu Min Wang Hui-bo Xu Xiao-bo Sun key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences & Peking Union Medical College Academy of chinese Medical Sciences of Jilin Province

Aconitine is a major bioactive diterpenoid alkaloid with high content derived from herbal aconitum *** evidence indicates that voltage-dependent Na+channels have pivotal roles in the cardiotoxicity of ***,no reports are available on the role of Ca2+in aconitine *** this study,we explored the importance of pathological Ca2+signaling in aconitine poisoning in vitro and in *** found that Ca2+overload lead to accelerated beating rhythm in adult rat ventricular myocytes and caused arrhythmia in conscious freely moving *** investigate effects of aconitine on myocardial injury,we performed cytotoxicity assay in neonatal rat ventricular myocytes（NRVMs）,as well as measured lactate dehydrogenase level in the culture medium of NRVMs and activities of serum cardiac enzymes in *** results showed that aconitine resulted in myocardial injury and reduced NRVMs viability *** confirm the pro-apoptotic effects,we performed flow cytometric detection,cardiac histology,transmission electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling *** results showed that aconitine stimulated apoptosis *** expression analysis of Ca2+handling proteins demonstrated that aconitine promoted Ca2+overload through the expression regulation of Ca2+handling *** expression analysis of apoptosis-related proteins revealed that pro-apoptotic protein expression was upregulated,and anti-apoptotic protein BCL-2expression was ***,increased phosphorylation of MAPK family members,especially the P-P38/P38 ratio was found in cardiac ***,our results suggest that aconitine significantly aggravates Ca2+overload and causes arrhythmia and finally promotes apoptotic development via phosphorylation of P38mitogen-activated protein kinase.

关键词： Aconitine Apoptosis Arrhythmia Heart Calcium overload Cardiotoxicity

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Polyclonal antibody preparation of BcbZIP134 for transcriptional regulation analysis on saikosaponin biosynthesis

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chinese herbal medicines 2018年第3期10卷 285-289页

作者： Jiao Xu Xuan Liu Su-rui Wu Chun Sui Jian-He Wei key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of Education&National Engineering Laboratory forBreeding of Endangered Medicinal MaterialsInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China

Objective: We are trying to verify how a transcription factor BcbZIP134 regulates the synthesis of saikosaponin using specific antibody. However, it is hard to obtain this soluble protein expressed in vitro, a prerequisite for antibody preparation. So we explored a condition in which the soluble protein can efficiently express followed by preparation of the specific polyclonal ***: Firstly, the cDNA of BcbZIP134 from Bupleurum chinense was expressed in Transetta(DE3) ***. Different concentrations of IPTG(0.05 and 0.5 mmol/L) and different culture temperatures(16 and37 °C) were explored for efficient expression of target protein. Then, the expressed protein with His Tag was purified using Ni Sepharose 6 Fast Flow. Different concentrations of imidazole elution(15, 60, and300 mmol/L) were used to elute the target protein. The purified protein of BcbZIP134 was used to immunize rabbits. Using the purified polyclonal antibody, the expression of BcbZIP134 in transgenic B. chinense hairy root lines was analyzed by Western blot ***: Under the conditions, IPTG 0.5 mmol/L, 16 °C, and overnight, recombinant protein of BcbZIP134 was obtained in high content using pEASY?-Blunt E1 vector and Transetta(DE3) E. coli. Anti-serum against BcbZIP134 was obtained with a high titer of 1: 51 200 after immunization in rabbits. The polyclonal antibody could react with BcbZIP134 overexpressed in transgenic B. chinense hairy root ***: An efficient protein expression system in E. coli was constructed and the soluble recombinant protein for BcbZIP134 was obtained. By using this protein, the specific and high-performance polyclonal antibody was prepared. Furthermore, by using BcbZIP134 overexpressed hairy roots, the availability of the polyclonal antibody was verified by Western Blotting.

关键词： BcbZIP134 Bupleurum chinense DC polyclonal antibody prokaryotic expression

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Phenolic compounds from the aqueous extract of Acacia catechu

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chinese Chemical Letters 2011年第11期22卷 1331-1334页

作者： Xing Cui Li Li Xin Yang Hong Qing Wang Ruo Yun Chen State key laboratory of bioactive substances and Functions of Natural medicines Institute of Materia Medica Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100050 China

From the aqueous extract of Acacia catechu,two new phenolic compounds（3R,4R）-3-（3,4-dihydroxyphenyl）-4-hydroxycy-clohexanone （1） and（4R）-5-（1-（3,4-dihydrophenyl）-3-oxobutyl）-dihydrofuran-2（3H）-one（2） w... 详细信息

关键词： Acacia catechu Phenolic compounds Free-radical scavenging activity

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Comparing chloroplast genomes of traditional chinese herbs Schisandra sphenanthera and ***

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chinese herbal medicines 2020年第3期12卷 247-256页

作者： Xue-ping Wei Hui-juan Li Peng Che Hao-jie Guo Ben-gang Zhang Hai-tao Liu Yao-dong Qi key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China Engineering Research Center of Tradition chinese medicine Resource Ministry of EducationInstitute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China

Objective:Schisandra sphenanthera and *** are the two important medicinal plants that have long been used under the names of"Nan-Wuweizi"and"Wuweizi",*** misuse of"NanWuweizi"and"Wuweizi"in herbal medical products calls for an accurate method to distinguish these ***(cp)genomes have been widely used in species delimitation and phylogeny due to their uniparental inheritance and lower substitution rates than that of the nuclear *** develop more efficient DNA markers for distinguishing ***,***,and the related species,we sequenced the cp genome *** and compared it to that of ***:The cp genome of *** was sequenced at the lllumina HiSeq platform,and the reference-guided mapping of contigs was obtained with a de novo assembly ***,comparative analyses of the cp genomes of *** and *** were carried ***:The cp genome of *** was 146853 bp in length and consisted of a large single copy(LSC)region of 95627 bp,a small single copy(SSC)region of 18292 bp,and a pair of inverted repeats(IR)of 16467 *** content was 39.6%.A total of 126 functional genes were predicted,of which 113 genes were unique,including 79 protein-coding genes,30 transfer RNA(tRNA)genes,and four ribosomal RNA(rRNA)*** tRNA,four protein-coding genes,and all rRNA were duplicated in the IR *** were 18 intron-containing genes,including six tRNA genes and 12 protein-coding *** addition,45 SSRs were *** whole cp genome of *** was 123 bp longer than that of ***.A total of 474 SNPs and 97 InDels were *** genetic regions with high levels of variation(Pi>0.015),trnS-trnG,ccsA-ndhD,psbI-trnS,trnT-psbD and ndhF-rpl32 were ***:We reported the cp genome *** and revealed the SNPs and InDels between the cp genomes of *** and *** study shed light on the species identifi

关键词： chloroplast genome Nan-Wuweizi Schisandra chinensis(Turcz.)Baill Schisandra sphenanthera Rehd.et Wils. Wuweizi

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A new strategy of enhancing absorptivity and safety for evodiamine: polyamidoamine derivatives modified by polyethylene glycol chain

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Traditional medicine Research 2021年第2期6卷 100-110页

作者： Yao-Chun Gao Yuan-Sheng Lao Meng-Xue Zhang Nan Li Chen-Yang Wu Zheng-Qi Dong Institute of Medicinal Plant Development Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100193China key laboratory of bioactive substances and resources utilization of chinese herbal medicine Ministry of EducationChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100094China key laboratory of New Drug Discovery Based on Classic chinese medicine Prescription Beijing 100700China

Background:Traditional chinese medicine involves complex ingredients and mixtures of ingredients that often exhibit low bioavailability,and excipients are often lacking to increase the absorption-enhancing *** study modified the generation 4 polyamidoamine dendrimer with polyethylene glycol of different molecular weights(5000,2000,1000)to form a series of polyamidoamine-co-polyethylene glycol(PAMAM-co-PEG)as a novel class of oral absorption ***,the major alkaloid found in the traditional chinese medicine Wu Zhu Yu(Fructus Evodiae),was used as a model drug to verify the absorption-enhancing effects and the safety of this ***:This study utilized the solubility determination method documented in the Pharmacopoeia of the People’s Republic of China(2015 edition)and the D0 values recommended in the US FDA guidelines to comprehensively evaluate the solubility of *** permeability of evodiamine was assessed using the apparent permeability coefficient in experiments based on in vitro cell *** aspects of the biological safety of PAMAM-co-PEG were explored using the MTT assay,LDH assay,and total protein release of the rat intestinal ***,the absorption-enhancing effects of PAMAM-co-PEG at different molecular weights on evodiamine were verified via the use of in vitro cell models and in vivo intestinal loop circulation experiments with ***:Evodiamine exhibited low solubility and permeability and was classified into class IV compounds using the biopharmaceutical classification ***-co-PEG 2000 demonstrated improvement in the biosafety and absorption-enhancement effect of evodiamine at a specific *** study showed that 0.05%(w/v)of PAMAM-co-PEG 2000 increased the cumulative penetration of evodiamine via cell transport by 1.32 times,and 0.10%(w/v)of PAMAM-co-PEG 2000 increased the area under curve value of evodiamine by 1.31 ***:Evodiamine possesses low solubility and

关键词： Polyamidoamine dendrimers Polyethylene glycol Intestinal absorption enhancer Bioavailability Evodiamine Fructus Evodiae

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