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Ice flux of alpine glaciers controls erosion and landscape in the Nianbaoyeze Shan,northeastern Tibetan Plateau

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山地科学学报(英文) 2023年第7期20卷 1884-1899页

作者： CHEN Xiao-jing WANG Jie ZOU Li-yang YAO Pan LEI Man-hong LIAO Jing-sheng key laboratory of Western China’s Environmental Systems(ministry of education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Gansu Shiyang River Basin Scientific Observing Station Lanzhou 730000China 11th Geology Team of zhejiang province Wenzhou 325000China School of Geography and Tourism Jiaying UniversityMeizhou 514015China

The evolution of mountainous topography is the result of the interactions of climate,topography,and *** are one of the most active erosional forces sculpting mountainous ***,our ability to understand this erosional force is limited by the controversy regarding the major factors controlling glacial *** selected the Nianbaoyeze Shan,which is occupied by subcontinental glaciers(likely cold-based or polythermal glaciers)in the northeastern Tibetan Plateau,to study how erosion by alpine glaciers sculpts the *** first applied a power law model(y=axb)fit to the cross-profiles of glacial valleys and analyzed the controlling factor of glacial erosion;we then identified the morphometric characteristics of the cirques to analyze the influencing factors,and investigated the development patterns of glacial valleys and ***,we used hypsometry and the slopealtitude curves and reconstructed the palaeo-glacier surfaces and palaeo-Equilibrium Line Altitudes(ELAs)to determine if the glacial buzzsaw effect had impacted this glaciated region with subcontinental *** findings show that ice flux is the main factor controlling glacial *** this region,decreasing temperatures promote an increase in glacier mean size(i.e.,ice flux),which enhances the rate of glacial *** morphology is mainly influenced by aspect and the *** development patterns of glacial valleys and cirques were dominated by a widening *** ELAs of marine Isotope Stage(MIS)-3 derived from the cirque floor altitudes or the Accumulation Area Ratio(AAR)and Area-Altitude Balance Ratio(AABR)coincide with the hypsometric maximum and the reduction in slopealtitude curves,which indicates that glacial buzzsaw has impacted this ***,the glacial buzzsaw effect has profoundly influenced the mountain heights and topographic evolution in this subcontinental glaciated region.

关键词： Nianbaoyeze Mountain Glacial erosion Ice flux Glacier reconstruction PalaeoELAs reconstruction Topographic evolution Widening process

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A Lightweight Deep Learning-Based Algorithm for Array Imperfection Correction and DOA Estimation

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Journal of Communications and Information Networks 2022年第3期7卷 296-308页

作者： Wenwei Fang Zhihui Cao Dingke Yu Xin Wang Zixian Ma Bing Lan Chunyi Song Zhiwei Xu Institute of marine Electronic and Intelligent System Ocean CollegeZhejiang UniversityZhoushan 316021China Engineering Research Center of Oceanic Sensing Technology and Equipment Ministry of EducationZhoushan 316021China Donghai Lab Zhoushan 316021China

Array imperfections will lead to serious performance degradation of the deep neural network(DNN)based direction of arrival(DOA)estimation in the low earth orbit(LEO)satellite communication by producing a mismatch between inference data and training *** this paper,we propose a lightweight deep learning-based algorithm for array imperfection correction and DOA *** preprocessing the covariance matrix of the array antenna outputs to the image,the array imperfection correction and DOA estimation problems are correspondingly converted into the image-to-image transformation task and image recognition ***,for the deployment of real-time DNN-based DOA estimation on the resource-constrained edge system,generative adversarial network(GAN)model compression is applied to obtain a lightweight student generator of Pix2Pix for array imperfection *** Mobilenet-V2 is then used to extract the DOA information from the covariance matrix *** results demonstrate that the DOA estimation performance is significantly improved through the array imperfection *** proposed algorithm also better satisfies the real-time demand with decreased inference time on the resource-constrained edge system.

关键词： deep learning array imperfection DOA estimation model compression edge-AI

κ-Carrageenan exacerbatesTNBS-induced inflammation in BALB/c mice

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κ-Carrageenan exacerbatesTNBS-induced inflammation in BALB/...

Effects of dietary fucoidan on the blood constituents,anti-oxidation and innate immunity of juvenile yellow catfish(Pelteobagrus fulvidraco)

全国第二届海洋与陆地多糖多肽及天然创新药物研发学术会议

作者： Zhujun Zhu Wei Wu Xin Gao Tingting Niu Haimin Chen key laboratory of applied marine biotechnology of zhejiang province Ningbo university

Carrageenan is a traditional ingredient that has been widely usedin the food *** aggravating effect of K-carrageenan on2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced intestinal inflammationwas investigated in amouse *** administration ofκ-carrageenan to BALB/c mice prior to the induction of TNBS colitis resulted in an aggravation of body weight loss and a decrease in the survival *** analysis and scanning electron microscopy revealed that the colonic inflammation was aggravated by the administration ofκ-*** ratio of CD4+CD25+CD127dim/CD4+of the carrageenan+TNBS group was significantly lower than that of the TNBS *** expression of critical inflammatory cytokines,interleukin-2(IL-2),tumor necrosis factor(TNF),and interleukin-6(IL-6)significantly increased,and interleukin-10(IL-10)significantly decreased in TNBS-induced inflammation after K-carrageenan administration.K-Carrageenan,together with TNBS,suppressed the expression of forkhead box(FOX)p3 and increased the expression of Toll-like receptor 4(TLR4)and Nuclear factor-KB(NF-κB)in the colonic mucosa of the experimental ***,we verified the result by real-time quantitative RT-PCR in molecular *** conclusion,κ-carrageenan aggravated TNBS-induced intestinal inflammation in BALB/c *** effect is associated with anactivation of the TLR4-NF-κB pathway,a decreased ratio of Treg cells,and the immunomodulator mechanism of carrageenan depending on T lymphocyte cytokine network switch Th2 type anti-inflammatory response toward to Thl type inflammatory response by elevation of IL-2 and reduction on IL-10 level.

关键词： κ-carrageenan TNBS intestinal inflammation Th1

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Effects of dietary fucoidan on the blood constituents,anti-o...

Recent advances in RNA structurome

全国第二届海洋与陆地多糖多肽及天然创新药物研发学术会议

作者： Qing Yang Rui Yang Ming Li Xiongpei Liang Qincun Zhou Cassian Elmada key laboratory of applied marine biotechnology of zhejiang province Ningbo university

This experiment was conducted to investigate the effects of fucoidan on the blood constituents,anti-oxidation and innate immunity of juvenile yellow catfish,Pelteobagrus *** 420individuals of juvenile yellow catfish were randomly allocated to 7 groups with 3 replicates per group and20 fishes per *** same experimental fish were randomly subjected to one of the following 7treatments for 12 weeks:The basal diet was applied as control group,the experimental groups were fed on fucoidan extracted from Sargassum horneri(SF)and commodity fucoidan purchased from the market(MF),and the effective dosages were 0.05%,0.1%and 0.2%per kilogram feed(the groups were respectively marked as SF1,SF2,SF3,MF1,MF2 and MF3).The capabilities of anti-oxidation and innate immunity were detected by the blood characters,serum enzyme activity,serum MDA content,respiratory burst activity and phagocytic index of head-kidney *** test was conducted *** results indicated that the triglyceride(TG)and total cholesterol(TC)values of the yellow catfish were significantly decreased when dietary with SF and MF,while there was no significant difference between the MF1 and the control *** fed on SF and MF diet had a lower high density lipoprotein(HDL)level than those fed on basal diet except SF2 *** density lipoprotein(LDL)and glucose(GUL)levels of the fish were significantly decreased at the 0.2%dietary fucoidan level,and there were no significant difference between the other *** activities of serum superoxide dismutase(SOD)were significantly increased and the contents of malondialdehyde(MDA)were significantly decreased when the fish fed dietary with SF and *** CAT activities of SF groups were higher than the control groups,while the values were not significantly changed in MF1 and MF3 *** maximum of catalase(CAT)activities were obtained in the SF2 and MF2 groups(fucoidan=0.1%).The serum lyso2yme(LZM)activities of the yellow ca

关键词： Pelteobagrus fulvidraco fucoidan blood constituents anti-oxidantion innate immunity.

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Science China(Life Sciences) 2022年第7期65卷 1285-1324页

作者： Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou MOE laboratory of Biosystems Homeostasis&Protection Innovation Center for Cell Signaling NetworkCollege of Life SciencesZhejiang UniversityHangzhou 310058China key laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Life Sciences Institute Zhejiang UniversityHangzhou 310058China State key laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China State key laboratory of Virology College of Life SciencesWuhan UniversityWuhan 430072China Beijing Advanced Innovation Center for Structural Biology School of Life SciencesTsinghua UniversityBeijing 100084China Stem Cell and Regenerative Biology Genome Institute of SingaporeA*STARSingaporeSingapore Department of Chemistry and State Key Laboratory of Marine PollutionCity University of Hong KongHong KongChina MOE key laboratory of Bioinformatics Beijing Advanced Innovation Center for Structural Biology and Frontier Research Center for Biological StructureCenter for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Department of Cell and Developmental Biology John Innes CentreNorwich Research ParkNorwich NR47UHUnited Kingdom Shenzhen Research Institute of City University of Hong Kong Shenzhen 518057China University of Chinese Academy of Sciences Beijing 100101China key laboratory of Molecular Epigenetics of the ministry of education Northeast Normal UniversityChangchun 130024China

RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications.

关键词： RNA structurome high-throughput techniques genome-wide 3D structure RNA secondary structure SARS-CoV-2 decoding function

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水声FBMC-OQAM通信的时变信道估计与符号检测

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哈尔滨工程大学学报（英文版） 2023年第3期22卷 636-649页

作者：陆雪松江雨林李静萱魏艳涂星滨瞿逢重 key laboratory of Ocean Observation-Imaging Testbed of zhejiang province Zhoushan 316021China Engineering Research Center of Oceanic Sensing Technology and Equipment Ministry of EducationZhejiang UniversityZhoushan 316021China

Filter bank multicarrier(FBMC)systems with offset quadrature amplitude modulation(OQAM)need long data blocks to achieve high spectral ***,the transmission of long data blocks in underwater acoustic(UWA)communication systems often encounters the challenge of time-varying *** paper proposes a time-varying channel tracking method for short-range high-rate UWA FBMC-OQAM communication ***,a known preamble is used to initialize the channel estimation at the initial time of the signal ***,the estimated channel is applied to detect data symbols at several symbol *** detected data symbols are then reused as new pilots to estimate the next time *** the above steps,the unified transmission matrix model is extended to describe the time-varying channel input-output model in this paper and is used for symbol *** results show that the channel tracking error can be reduced to less than−20 dB when the channel temporal coherence coefficient exceeds 0.75 within one block period of FBMC-OQAM *** with conventional known-pilot-based methods,the proposed method needs lower system overhead while exhibiting similar time-varying channel tracking *** sea trial results further proved the practicability of the proposed method.

关键词： FBMC-OQAM Underwater acoustic communications Channel estimation Time-varying channel Data reuse Iterative estimation

Cathepsin D knockdown regulates biological behaviors of granulosa cells and affects litter size traits in goats

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Journal of zhejiang University-Science B(Biomedicine & biotechnology) 2021年第11期22卷 893-905页

作者： Zhinan ZHOU Xiang CHEN Min ZHU Weiwei WANG Zheng AO Jiafu ZHAO Wen TANG Lei HONG key laboratory of Plateau Mountain Animal Genetics Breeding and Reproduction of Ministry of EducationKey Laboratory of Animal GeneticsBreeding and Reproduction of Guizhou ProvinceCollege of Animal ScienceGuizhou UniversityGuiyang 550025China

Cathepsin D(CTSD),the major lysosomal aspartic protease that is widely expressed in different tissues,potentially regulates the biological behaviors of various *** granulosa cells are responsive to the increase of ovulation number,hence indirectly influencing litter ***,the mechanism underlying the effect of CTSD on the behaviors of goat granulosa cells has not been fully *** study used immunohistochemistry to analyze CTSD localization in goat ovarian ***,western blotting was applied to examine the differential expression of CTSD in the ovarian tissues of monotocous and polytocous ***,the effects of CTSD knockdown on cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of the prolific traits,including bone morphogenetic protein receptor IB(BMPR-IB),follicle-stimulating hormone(FSHR),and inhibinα(INHA),were determined in granulosa *** showed that CTSD was expressed in corpus luteum,follicle,and granulosa ***,CTSD expression in the monotocous group was significantly higher than that in the polytocous *** addition,CTSD knockdown could improve granulosa cell proliferation,inhibit cell apoptosis,and significantly elevate the expression of proliferating cell nuclear antigen(PCNA)and B cell lymphoma 2(Bcl-2),but it lowered the expression of Bcl-2-associated X(Bax)and ***,CTSD knockdown significantly reduced the ratios of cells in the G0/G1 and G2/M phases but substantially increased the ratio of cells in the S *** expression levels of cyclin D2 and cyclin E were elevated followed by the obvious decline of cyclin A1 ***,the expression levels of BMPR-IB,FSHR,and INHA clearly increased as a result of CTSD ***,our findings demonstrate that CTSD is an important factor affecting the litter size trait in goats by regulating the granulosa cell proliferation,apoptosis,cell cycle,and the expression of candidate genes of th

关键词： Cathepsin D(CTSD) Litter size trait Granulosa cells Cell apoptosis Cell cycle Cell proliferation

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水声FBMC-OQAM通信的时变信道估计与符号检测（英文）

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Journal of marine Science and Application 2023年第3期 636-649页

作者：陆雪松江雨林李静萱魏艳涂星滨瞿逢重 key laboratory of Ocean Observation-Imaging Testbed of zhejiang province Engineering Research Center of Oceanic Sensing Technology and Equipment Ministry of Education Zhejiang University

Filter bank multicarrier(FBMC) systems with offset quadrature amplitude modulation(OQAM) need long data blocks to achieve high spectral efficiency. However, the transmission of long data blocks in underwater acoustic(UWA) communication systems often encounters the challenge of time-varying channels. This paper proposes a time-varying channel tracking method for short-range high-rate UWA FBMCOQAM communication applications. First, a known preamble is used to initialize the channel estimation at the initial time of the signal block. Next, the estimated channel is applied to detect data symbols at several symbol periods. The detected data symbols are then reused as new pilots to estimate the next time channel. In the above steps, the unified transmission matrix model is extended to describe the time-varying channel input – output model in this paper and is used for symbol detection. Simulation results show that the channel tracking error can be reduced to less than-20 dB when the channel temporal coherence coefficient exceeds 0.75 within one block period of FBMC-OQAM signals. Compared with conventional known-pilot-based methods, the proposed method needs lower system overhead while exhibiting similar timevarying channel tracking performance. The sea trial results further proved the practicability of the proposed method.

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Acetylcholinesterase inhibitors and antioxidants mining from marine fungi:bioassays,bioactivity coupled LC-MS/MS analyses and molecular networking

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marine Life Science & Technology 2020年第4期2卷 386-397页

作者： Yingying Nie Wencong Yang Yayue Liu Jingming Yang Xiaoling Lei William HGerwick Yi Zhang Center for marine Drugs Research and Development Shenzhen Institute of Guangdong Ocean UniversityShenzhen 518000China College of Food Science and Technology Key Laboratory of Guangdong Province Aquatic Products Processing and SafetyGuangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of Marine FoodKey Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education InstitutionZhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain HealthResearch Institute for Marine Drugs and NutritionGuangdong Ocean UniversityZhanjiang 52408&China Center for marine biotechnology and Biomedicine Scripps Institution of OceanographyUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

marine fungi are potentially important resources for bioactive lead compounds for discovering new drugs for diseases such as Alzheimer's *** this paper,the combined bioassay model of acetylcholinesterase(AChE)inhibition,1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging,and Artemi ci larval lethality was used to evaluate the activity and toxicity of 35 n narine fun gal strains from seas around *** bioactive constitue nfs were revealed by thin layer chromatography(TLC)autography,bioactivity coupled LC-MS/MS and Global Natural Products Social Molecular Networking(GNPS).The results show that the extracts of five strains exhibited higher AChE inhibition ratios than the positive control compound,'tacrine;for which the ratio was 89.8%at 200 pig/*** strains displayed both AChE inhibition(inhibition ratios>20%at 200 pg/ml)and DPPH scavenging activity(scavenging ratios>30%at 200 pg/ml)together with low Artemia larval toxicity(lethal rates<12%).TLC autography showed that the fractioned extracts of four strains contained highly diverse and different bioactive constituents,includi ng strains Talaromyces sp.C2\-\,Aspergillus ter re us C23-3,Trichoderma harzianum DLEN2008005,and Penicillium corylophilum *** the most potent sample F-l 1-1-b(derived from Aspergillus tern us C23-3),five AChE inhibitors and seven antioxida nts were recognized as bioactive molecules by AChE coupled ultrafiltration followed by LC-MS/MS,and LC-MS/MS coupled with DPPH ***,with the aid of GNPS,the AChE inhibitors were plausibly annotated as territrem analogues including territrems A-C/D,arisugacin A and an unknown compound 4,and the seven antioxidants were assigned as butyrolactone *** E,a phenolic derivative and possibly unknown compounds 8-10 and 12.

关键词： Acetylcholinesterase inhibition Antioxida marine fungi LC-MS/MS Molecular networking