检索结果-南通市图书馆

Artificial parasin I protein(API)supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic Escherichiacoli

引用

animal nutrition 2024年第3期18卷 154-165页

作者： Congzhi Zou Wanxin Zhao Shenggang Yin Xiaoyu Xiang Jiayong Tang Gang Jia Lianqiang Che Guangmang Liu Xiaoling Chen Gang Tian Jingyi Cai Bo Kang Hua Zhao key laboratory for animal Disease-Resistance nutrition of Ministry of Education Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Agriculture and Rural AffairsKey Laboratory for Animal Disease-Resistance Nutrition of Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China College of animal science and Technology Sichuan Agricultural UniversityChengdu 611130China

Diarrheas are common risks faced by piglets during the weaning *** study investigated the alleviating effects of artificial parasin I protein(API)on growth performance and intestinal health of weaned pigs upon enterotoxigenic Escherichia coli(ETEC)*** piglets were randomly divided into five groups and fed a basal diet(CON)or basal diet supplemented with API at 0,750,and 1500 mg/kg or antibiotics for 5 *** d 15 and 25,piglets were challenged with ETEC K88 except for the CON *** the ETEC challenge(d 1–14),dietary API supplementation improved growth performance,and 750 mg API increased(Pfeed to gain ratio(F/G)and diarrhea index of weaned *** challenge(during d 15–35)reduced growth performance and increased(P<0.01)the F/G,diarrhea rate,and diarrhea *** event was accompanied by the numerically increased malondialdehyde(MDA)levels in serum and ileum,the decreased(P<0.05)zonula-occludens-1(ZO-1)and interleukin-6(IL-6)in the ileum,and the increased(P=0.04)secretory immunoglobulin A(sIgA)protein in the *** parasin I protein supplementation alleviated the negative impact of *** 750 mg/kg API inclusion elevated(P<0.05)ADG and decreased(P<0.05)F/*** levels of API decreased(P<0.01)the diarrhea rate and diarrhea ***,API inclusion decreased(P<0.01)the crypt depth in the jejunum,elevated(P<0.05)villus height in the duodenum and villus height to crypt depth ratio in the duodenum and ileum,up-regulated(P<0.05)ZO-1 gene,and down-regulated(P<0.05)mucin-2 gene in the jejunum,and 1500 mg/kg API decreased(P<0.01)sIgA level and down-regulated(P<0.05)IL-1βgene in the ***,750 mg/kg API elevated(P<0.01)Bifidobacteria population and acetic acid concentrations in the cecal *** conclusion,API supplementation alleviates the negative impact of ETEC on growth performance and intestinal health,thus can be applied as an antibiotic alternative in weane

关键词： Artificial parasin I protein Growth performance Intestinal barrier Diarrhea Weaned piglet

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prevotella-rich enterotype may benefit gut health in finishing pigs fed diet with a high amylose-to-amylopectin ratio

引用

animal nutrition 2021年第2期7卷 400-411页

作者： Wen Ren Honglin Yan Bing Yu Maria C.Walsh Jie Yu Ping Zheng Zhiqing Huang Junqiu Luo Xiangbing Mao Jun He Hui Yan Daiwen Chen Yuheng Luo key laboratory for animal Disease-Resistance nutrition of Ministry of Education of China Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of ChinaKey Laboratory of Animal Disease-resistant Nutrition of Sichuan ProvinceAnd Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China DSM(China)animal nutrition Research Center Co. LtdBazhou 065799China School of Life science and Engineering Southwest University of Science and TechnologyMianyangSichuan 621010China DSM nutritional Products Kaiseraugst 4303Switzerland

To investigate the influence of baseline enterotypes and dietary starch type on the concentration of short-chain fatty acids(SCFA),numbers of butyrate producing bacteria and the expression of genes related to intestinal barrier and inflammatory response in the colon of finishing pigs,a 60-d in vivo trial was conducted.A 2-wk pre-trial with 102 crossbred(Duroc×[Landrace×Yorkshire])finishing barrows(90 d old)was conducted to screen ***,a total of 32 pigs(87.40±2.76 kg)with high(HPBR,>14)and low(LPBR,<2)Prevotella-to-Bacteroides ratios(PBR)in equal measure were selected and randomly divided into 4 groups with 8 replicates per group and 1 pig per *** trial was designed following a 2(PBR)×2(amylose-to-amylopectin ratio,AMR)factorial *** with different PBR were fed diets based on corn-soybean meal with high AMR(HAMR,1.24)or low AMR(LAMR,0.23),*** showed that neither PBR nor AMR influenced the growth performance of *** pigs fed HAMR diet had a higher number of colonic Clostridium cluster XIVa and higher gene expression of butyrate kinase compared to the LPBR pigs(P<0.05).The HPBR pigs fed HAMR diets also had increased colonic concentrations of total SCFA and propionate compared to the LPBR pigs(P<0.05).Comparing with other pigs,HPBR pigs fed HAMR diets showed a lower(P<0.05)expression of histone deacetylases(HDAC)gene and higher(P<0.05)expression of G protein-coupled receptor 43 gene(GPR 43)in the colonic *** interaction(P<0.05)of HPBR and HAMR was also found to decrease the gene expression of interleukin(IL)-6,IL-12,IL-1βand tumor necrosis factor-α(TNF-α)in colonic *** findings show that HAMR diet increased the abundance and activity of butyrate-producing bacteria and the concentration and absorption of SCFA,which may be associated with the decreased gene expression of inflammatory cytokines in the colonic mucosa of pigs with Prevotella-rich *** these alterations are likely to have a pos

关键词： Enterotype Amylose-to-amylopectin ratio Gut health Finishing pig

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Methionine deficien y inhibited pyroptosis in primary hepatocytes of grass carp(Ctenopharyngodon idella):possibly via activating the ROS-AMPK-autophagy axis

引用

Journal of animal science and Biotechnology 2024年第6期15卷 2607-2624页

作者： Yuanlin He Pei Wu Weidan Jiang Yang Liu Xiaowan Jin Hongmei Ren Ruinan Zhang Xiaoqiu Zhou Lin Feng animal nutrition Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Fish nutrition and Safety Production University Key Laboratory of Sichuan ProvinceSichuan Agricultural UniversityChengdu 611130SichuanChina key laboratory of animal Disease-Resistant nutrition and feed Ministry of Agriculture and Rural AffairsChengduChina key laboratory of animal Disease-Resistant nutrition ChengduSichuanChina

Background Methionine(Met)is the only sulfur-containing amino acid among animal essential amino acids,and methionine deficiency(MD)causes tissue damage and cell death in *** common modes of cell death include apoptosis,autophagy,pyroptosis,*** r,the studies about the major modes of cell death caused by MD have not been reported,which worth further *** Primary hepatocytes from grass carp were isolated and treated with different doses of Met(0,0.5,1,1.5,2,2.5 mmol/L)to examine the expression of apoptosis,pyroptosis,autophagy and necroptosis-related *** on this,we subsequently modeled pyroptosis using lipopolysaccharides and nigericin sodium salt,then autophagy inhibitors chloroquine(CQ),AMP-activated protein kinase(AMPK)inhibitors compound C(CC)and reactive oxygen species(ROS)scavengers N-acetyl-L-cysteine(NAC)were further used to examine the expression of proteins related to pyroptosis,autophagy and AMPK pathway in MD-treated cells *** MD up-regulated B-cell lymphoma protein 2(Bax),microtubule-associated protein 1 light chain 3Ⅱ(LC3Ⅱ),and down-regulated the protein expression levels of B-cell lymphoma-2(Bcl-2),sequestosome 1(p62),cleavedcaspase-1,cleaved-interleukin(IL)-1βand receptor-interacting protein kinase(RIP)1 in hepatocytes,while it did not significantly affect *** addition,MD significantly increased the protein expression of liver kinase B1(LKB1),p-AMPK,and Unc-51-like kinase 1(ULK1)without significant effect on p-target of ***,the use of CQ increased the protein expression of NOD-like receptor thermal protein domain associated protein 3(NLRP3),cleaved-caspase-1,and cleaved-IL-1βinhibited by MD;the use of CC significantly decreased the protein expression of MD-induced LC3Ⅱand increased the protein expression of MD-suppressed p62;then the use of NAC decreased the MD-induced p-AMPK protein *** MD promoted autophagy and apoptosis,but inhibited pyroptosis and ne

关键词： Autophagy Methionine Primary hepatocytes Pyroptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soybeanβ-conglycinin and glycinin reduced growth performance and the intestinal immune defense and altered microbiome in juvenile pearl gentian groupers Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂

引用

animal nutrition 2022年第2期9卷 193-203页

作者： Yuanfa He Jinfang Liang Xiaohui Dong Hongyu Liu Qihui Yang Shuang Zhang Shuyan Chi Beiping Tan laboratory of Aquatic animal nutrition and feed Fisheries CollegeGuangdong Ocean UniversityZhanjiang 524088China Aquatic animals Precision nutrition and High-Efficiency feed Engineering Research Center of Guangdong province Zhanjiang 524088China key laboratory of Aquatic Livestock and Poultry Feed Science and Technology in South ChinaMinistry of AgricultureZhanjiang 524088China

The utilization efficiency of soy protein is affected by its 2 anti-nutritional substancesdthe antigens bconglycinin and *** study investigated their effects on the growth performance,intestinal immune defense,andmicrobiome in juvenile pearl gentian groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂).Three isonitrogenous and isolipidic diets were formulated containing fishmeal supplemented with 70 g/kgβ-conglycinin or 100 g/kg glycinin,or no supplementation(control).Each experimental diet was fed to quadruplicate groups with 30 fish in each tank for 8 *** inclusion of eitherβ-conglycinin or glycinin significantly reduced weight gain and specific growth rates,and cell proliferation of the distal *** evaluation of the intestine tract revealed the inflammation signs,characterized by reducing of plica height and width as well as the number of the goblet cells,and widening of the lamina *** group fed theβ-conglycinin diet had reduced lysozyme activity,contents of immunoglobulin M and complements 3 and *** activities of caspase-3 and-9 were observed in the group fed the bconglycinin diet compared to the other 2 *** the intestinal microbiota,the relative abundances of the potentially pathogenic genera Photobacterium and Vibrio were significantly higher in the glycinin group than those in ***,the existence of soybean antigens(β-conglycinin or glycinin)could damage the structural integrity of the intestine,reduce immune defense,reshape the intestinal microbiome and,ultimately,impair growth in fish.

关键词： β-Conglycinin Glycinin Pearl gentian groupers Immune response Intestinal microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Co-fermented defatted rice bran alters gut microbiota and improves growth performance,antioxidant capacity,immune status and intestinal permeability of finishing pigs

引用

animal nutrition 2022年第4期11卷 413-424页

作者： Weifa Su Zipeng Jiang Cheng Wang Yu Zhang Tao Gong Fengqin Wang Mingliang Jin Yizhen Wang Zeqing Lu key laboratory of Molecular animal nutrition Ministry of EducationZhejiang University866 Yuhang Tang RoadHangzhouZhejiang 310058China key laboratory of animal nutrition and feed Ministry of AgricultureZhejiang University866 Yuhang Tang RoadHangzhouZhejiang 310058China National Engineering laboratory of Biological feed Safety and Pollution Prevention and Control Zhejiang University866 Yuhang Tang RoadHangzhouZhejiang 310058China key laboratory of animal nutrition and feed science of Zhejiang province Zhejiang University866 Yuhang Tang RoadHangzhouZhejiang 310058China College of animal science Institute of Feed ScienceZhejiang University866 Yuhang Tang RoadHangzhouZhejiang 310058China

Based on preparation of co-fermented defatted rice bran(DFRB)using Bacillus subtilis,Saccharomyces cerevisiae,Lactobacillus plantarum and phytase,the present study aimed to evaluate the effects of cofermented DFRB on growth performance,antioxidant capacity,immune status,gut microbiota and permeability in finishing *** finishing pigs(85.30±0.97 kg)were randomly assigned to 3treatments(3 replicates/treatment)with a basal diet(Ctrl),a basal diet supplemented with 10% unfermented DFRB(UFR),and a basal diet supplemented with 10% fermented DFRB(FR)for 30 *** revealed that the diet supplemented with FR notably(Pfeed ratio(G:F)and the digestibility of crude protein,amino acids and dietary fiber of finishing pigs compared with ***,FR supplementation significantly(P<0.05)increased total antioxidant capacity,the activities of superoxide dismutase and catalase,and decreased the content of malonaldehyde in ***,FR remarkably(P<0.05)increased serum levels of Ig G,antiinflammatory cytokines(IL-22 and IL-23)and reduced pro-inflammatory cytokines(TNF-α,IL-1β and INF-γ).The decrease of serum diamine oxidase activity and serum D-lactate content in the FR group(P<0.05)suggested an improvement in intestinal *** of FR also elevated the content of acetate and butyrate in feces(P<0.05).Moreover,FR enhanced gut microbial richness and the abundance of fiber-degrading bacteria such as Clostridium butyricum and Lactobacillus *** analyses indicated dietary fiber in FR was associated with improvements in immune status,intestinal permeability and the level of butyrate-producing microbe ***,which was also verified by the in vitro fermentation *** findings provided an experimental and theoretical basis for the application of fermented DFRB in finishing pigs.

关键词： Co-fermented defatted rice bran Finishing pig Growth performance Gut microbiota Gut permeability Immune status

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cloning Sequencing and Bioinformatics Analysis of GRX2 and TRX2 from Puerpiao chicken and Tengchongxue chicken

引用

animal Husbandry and feed science 2014年第3期6卷 91-96,117页

作者： Fang Fang Zhang Chunyong Li Yanxuan Li Meiquan An Qingcong Chen Kelin Guo Rongfu key laboratory of animal nutrition and feed in yunnan province Yunnan Agricultural University

[ Objective ] The study was to explore whether glutaredoxin （GRX2） and thioredoxin （TRX2） genes vary between Puerpiao chicken and Tengchongxue chicken in yunnan province. [ Methods ] Using Sanhuang chicken as the control, the GRX2 and TRX2 genes were cloned from skirt tissues of Puerp/ao chicken and Tengchongxue chicken and then subjected to bioinformatics analysis. [ Results ] The sequencing results of both the GRX2 and TRX2 genes were completely consistent among Puerp/ao chicken, Tengchongxue chicken and Sanhuang chicken. And the sequences of GRX2 and TRX2 genes share a 100% homology with the results accessed in GenBank, and no any mutation was observed. [ Conclusion] The result provides scientific basis for investigating the antioxidant capacity of different chickens and utilizing elite local chicken resources.

关键词： GRX2 TRX2 Local chicken Cloning Bioinformatics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Xylooligosaccharide attenuates lipopolysaccharide-induced intestinal injury in piglets via suppressing inflammation and modulating cecal microbial communities

引用

animal nutrition 2021年第3期7卷 609-620页

作者： Xiuying Wang Kan Xiao Cheng Yu Longmei Wang Tianzeng Liang Huiling Zhu Xiao Xu Yulan Liu Hubei key laboratory of animal nutrition and feed science Hubei Collaborative Innovation Center for Animal Nutrition and Feed SafetyWuhan Polytechnic UniversityWuhan430023China College of Life sciences South-Central University for NationalitiesWuhan430023China

Xylooligosaccharide(XOS)has been considered to be an effective prebiotic,but its exact mechanisms remain *** research was conducted to evaluate the effects of XOS on pig intestinal bacterial community and mucosal barrier using a lipopolysaccharide(LPS)-caused gut damage ***-four weaned pigs were assigned to 4 treatments in a 2×2 factorial design involving diet(with or without XOS)and immunological challenge(saline or LPS).After 21 d of feeding 0%or 0.02%commercial XOS product,piglets were treated with saline or *** that,blood,small intestinal mucosa and cecal digesta were *** XOS enhanced intestinal mucosal integrity demonstrated by higher villus height,villus height-to-crypt depth ratio,disaccharidase activities and claudin-1 protein expression and lower crypt *** also caused down-regulation of the gene expression of toll-like receptor 4 and nucleotide-binding oligomerization domain protein signaling,accompanied with decreased pro-inflammatory cytokines and cyclooxygenase 2 contents or mRNA expression and increased heat shock protein 70 mRNA and protein ***,increased Bacteroidetes and decreased Firmicutes relative abundance were observed in the piglets fed with *** the genus level,XOS enriched the relative abundance of beneficial bacteria,e.g.,Faecalibacterium,Lactobacillus,and ***,XOS enhanced short chain fatty acids contents and inhibited histone *** correlation analysis of the combined datasets implied some potential connections between the intestinal microbiota and pro-inflammatory cytokines or cecal *** results suggest that XOS inhibits inflam-matory response and beneficially modifies microbes and metabolites of the hindgut to protect the in-testine from inflammation-related injury.

关键词： Xylooligosaccharide Piglet Lipopolysaccharide Inflammation Intestinal microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dietary supplementation with 2-hydroxy-4-methyl(thio)butanoic acid and DL-methionine improves productive performance,egg quality and redox status of commercial laying ducks

引用

animal nutrition 2023年第3期14卷 101-110页

作者： Yanan Zhang Zhiwei Zhuang Tahir Mahmood Yves Mercier Yongyan Jin Xuebing Huang Kaichao Li Shuang Wang Weiguang Xia Shenglin Wang Miao Yu Wei Chen Chuntian Zheng Institute of animal science Guangdong Academy of Agricultural SciencesKey Laboratory of Animal Nutrition and Feed Science(South China)of Ministry of AgricultureState Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and Nutrition510640GuangzhouChina Institute of Life science and Engineering Foshan University528200FoshanChina Adisseo France S.A.S.Centre of Excellence and Research in nutrition CommentryFrance

This experiment aimed to study the effects of supplemental methionine sources,2-hydroxy-4 methyl(thio)butanoic acid(HMTBa)and DL-Methionine(DL-Met),on productive performance,egg quality,and redox status of laying ducks.A total of 792 healthy 25-wk-old Longyan laying ducks with similar body weights were randomly allotted to 11 treatment *** treatment group had 6 replicates of 12 *** trial lasted for 16 *** were fed a basal deficient diet(Met:0.24%;Met+Cys:0.51%)or supplemented with DL-Met or HMTBa at 0.05%,0.12%,0.19%,0.26%,and 0.33%of diet,*** with the basal diet,supplementation with either DL-Met or HMTBa increased the average egg weight,egg mass,and decreased feed to egg ratio during the whole trial period(P<0.05).Albumen weight and its ratio to total egg weight were increased,but yolk and shell ratio,albumen height,Haugh unit and shell breaking strength were decreased(P<0.05).Dietary DL-Met or HMTBa supplementation increased taurine,methionine,leucine,tryptophan and arginine content,and decreased serine and lysine content in plasma(P<0.05).The redox status of laying ducks was improved by enhancing the glutathione peroxidase and catalase activities,glutathione content and its ratio relative to glutathione(oxidized)content and decreasing malondialdehyde content and increasing mRNA expression of superoxide dismutase-1,glutathione peroxidase-1,hemeoxygenase-1 and nuclear factor-like 2 in liver and ileum with the supplementation of DL-Met or HMTBa(P<0.05).Liver health status measured by average area proportion lipid droplet was improved with supplementation of DL-Met or HMTBa(P<0.05).Villus height and villus height to crypt depth ratio in the ileum and the ileal gene expression of tight junction protein and occludin were increased with DL-Met or HMTBa supplementation(P<0.05).Taken together,these results suggested that the efficacy of dietary supplementation of HMTBa was similar to DL-Met,and it ranged from 98%to 100%for productive

关键词： DL-Methionine 2-Hydroxy-4 methyl(thio)butanoic acid Productive performance Efficacy Laying duck

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fecal scores and microbial metabolites in weaned piglets fed different protein sources and levels

引用

animal nutrition 2018年第1期4卷 31-36页

作者： Xiaolu Wen Li Wang Chuntian Zheng Xuefen Yang Xianyong Ma Yunpeng Wu Zhuang Chen Zongyong Jiang key laboratory of animal nutrition and feed science in South China Ministry of AgricultureState Key Laboratory of Livestock and Poultry BreedingGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Key Laboratory of Animal Breeding and NutritionInstitute of Animal ScienceGuangdong Academy of Agricultural Sciences Agro-Biological Gene Research Center Guangdong Academy of Agricultural Sciences

This experiment studied the effects of dietary protein sources and levels on the gut health of piglets,p H value,and concentrations of microbial metabolites(ammonia-N,volatile fatty acids [VFA],and polyamines) in the distal colonic and proximal colonic digesta of piglets weaned at 21 d of age.A total of 150 early-weaned piglets were allotted randomly to 5 diets: 1) control diet(CT; 17% CP),2) CT formulated with more soy protein concentrate(SPC19; 19% CP),3) more fish meal(FM19; 19% CP),4) CT formulated with more soy protein concentrate(SPC23; 23% CP),and 5) more fish meal(FM23; 23%CP).Results showed high protein level increased fecal score(P 0.05).The p H value and ammonia-N concentration of digesta in the proximal and distal colon of FM23 were significantly higher(P 0.05).Histamine and spermidine concentrations of FM23 were higher than those of other treatments(P < 0.05).Propionic acid and butyric acid concentrations in the distal colon were higher of FM23 than of FM19(P < 0.05); putrescine,histamine and spermidine were higher of FM23 than of LP and FM19(P < 0.05).It was concluded that high dietary CP content increased microbial metabolites(ammonia-N,histamine,putrescine) in colonic digesta and aggravated piglets' diarrhea.

关键词： Piglet Protein level Protein source Microbial metabolites Diarrhea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Convergent genomic signatures of high-altitude adaptation among domestic mammals

引用

National science Review 2020年第6期7卷 952-963页

作者： Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang State key laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of Life science University ofChinese Academy of Sciences Center for Excellence in animal Evolution and Genetics Chinese Academy of Sciences key laboratory of animal Models and Human Disease Mechanisms of the Chinese Academy of sciences &yunnan province KunmingInstitute of Zoology Chinese Academy of Sciences Kunming College of Life science University of Chinese Academy of Sciences Institute of animal science Chinese Academy of Agricultural Sciences key laboratory of animalnutrition and feed science of yunnan province Yunnan Agricultural University CAS key laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Departmentof Pathology the Second Xiangya Hospital Central South University key laboratory of animal Models and Human Disease Mechanisms of the Chinese Academy of sciences &yunnan province Kunming Institute of Zoology Chinese Academy of Sciences State key laboratoryfor Conservation and Utilization of Bio-resource Yunnan University State key laboratory of Genetic Resources and Evolution Kunming Instituteof Zoology Chinese Academy of Sciences key laboratory of animal nutrition and feed science of yunnan province Yunnan Agricultural University Departmentof animal science Faculty of Agriculture Shahid Bahonar University of Kerman State key laboratory of Genetic Resources and Evolution Kunming Institute of Zoology ChineseAcademy of Sciences Department of laboratory Medicine and Pathobiology University of Toronto Kunming College of Life science University ofChinese Academy o fSciences CAS key laboratory ofComputational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Kunming College of Lifescience University of Chinese Academy of Sciences State key laboratory for Conservation and U

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep,goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10 orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

关键词： high altitude Tibetan Plateau genome convergent evolution domestic animals

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：