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Chinese Medical Journal 2010年第5期123卷 581-584页

作者： HOU Jing-bo LIU Hui-min MA Li-jia YANG Shuang MENG Ling-bo HAN Zhi-gang ZHANG Shuo YU Bo Department of Cardiology Second Affiliated Hospital of Harbin Medical University key laboratories of education ministry for myocardial ischemia mechanism and treatment Harbin Heilongjiang 150086 China

Background Late stent malapposition was frequently observed after DES implantation, which has been associated with the occurrence of late stent thrombosis due to poor neointimal coverage. This study was designed to evaluate the frequency of late stent malapposition at least 1 year after different DESs implantation by optical coherence tomography （OCT）. Methods Angiographic and OCT examinations were given to 68 patients who had received total 126 various DESs implantation for at least 1 year to detect late stent malapposition. Malapposed strut distance （MSD）, malapposed strut area （MSA）, reference lumen area （RLA） and reference stent area （RSA） were checked with off-line OCT analysis. Results Totally 26 Cypher Select stents, 15 Taxus Liberte stents, 51 Partner stents and 34 Firebird I stents were examined. Among 68 patients who underwent DES implantation, 7 patients （10.3%） had late malapposition. Average RSA, MSA and MSD were （7.9=6？..8） mm2,（2.0＋1.6） mm2 and （590_＋_270） pm respectively. According to the MSA/RSA ratio 4 patients had slight malapposition, 2 patients had moderate malapposition and 1 patient had severe malapposition. Conclusions Late stent malapposition is detected frequently after implantation of DES, but if this predisposes to late stent thrombosis and requires any specific therapy needs to be further elucidated.

关键词： drug-eluting stent late stent malapposition very late stent thrombosis optical coherence tomography

Left bundle branch area pacing combined with implantable cardioverter-defibrillator treatment for heart failure after myocardial infarction

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Journal of Geriatric Cardiology 2024年第5期21卷 577-582页

作者： Bing-Chen GUO Jian XU Yan-Zong LIU Guo-Qing DU Bo YU Shu-Feng LI Wen-Juan DU Department of Cardiology the 2nd Affiliated Hospital of Harbin Medical UniversityHarbinChina The key Laboratory of myocardial ischemia Chinese Ministry of EducationHarbinChina Department of Ultrasonography Guangdong Provincial People's HospitalGuangzhouGuangdongChina

Left bundle branch area pacing(LBBAP)has emerged as a new physiological pacing *** studies have confirmed the feasibility and efficacy of LBBAP for cardiac resynchronization therapy(CRT)in heart failure(HF)patients with left bundle branch block(LBBB)and a narrower QRS duration(QRSd)to have a higher percentage of super responders,and lower pacing thresholds than biventricular pacing(BiVP).

关键词： pacing branch bundle

Preparation and evaluation of nano-hydroxyapatite/poly(styrene-divinylbenzene) porous microsphere for aspirin carrier

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Science China Chemistry 2012年第6期55卷 1134-1139页

作者： LI Sen WANG Kuan CHANG Kue-Chieh Alan ZONG Ming WANG Jing CAO YongGang BAI YuHua WEI TaiMing ZHANG ZhiRen School of Pharmacy Daqing Campus Harbin Medical University Daqing 163319 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 China Departments of Pharmacy and Cardiology The 2nd Affiliated Hospital of Harbin Medical University Key Laboratories of Ministry of Education for Myocardial lschemia Mechanism and Treatment Harbin Medical University Harbin 150086 China

A novel vehicle for the delivery of aspirin （ASA） was prepared from porous nano-hydroxyapafite/poly（styrene-divinylbenzene） [nano-HAP/P（St-DVB）] composite microspheres by grafting nano-HAP [Ca10（PO4）6（OH）2] onto porous P（St-DVB） micro- spheres. Four types of porous composite microspheres were prepared, each with different nano-HAP contents. The ASA-loaded composite microspheres prepared with 10% and 15% nano-HAP （mass ratio） exhibited excellent buoyancy with relatively short instantaneous floating time （within l0 min） and a long sustained floating time （12 h） in simulated gastric juice. They also offered good sustained release of ASA （up to 8 h）. Furthermore, these composite microspheres displayed good buff- ering capacity that prevented the buildup of acidity caused by hydrolysis of ASA, keeping the pH of gastric juice within the normal range （pH 0.9 to 1.5）. The results showed that porous nano-HAP/P（St-DVB） composite microspheres prepared with 10% and 15% nano-HAP could be used as a novel drug carrier for ASA, providing a sustained release dose without leading to stomach irritation, a side effect that is often associated with ASA medication.

关键词： porous nano-hydroxyapatite microsphere carrier aspirin

Ferroptosis:From Basic Research to Clinical Therapeutics in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 207-218页

作者： Ziyue Huang Haoming Xia Yunfu Cui Judy Wai Ping Yam Yi Xu Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina key Laboratory of myocardial ischemia Harbin Medical UniversityMinistry of EducationHarbinHeilongjiangChina

Hepatocellular carcinoma(HCC)is one of the most common and highly heterogeneous malignancies *** the rapid development of multidisciplinary treatment and personalized precision medicine strategies,the overall survival of HCC patients remains *** limited survival benefit may be attributed to difficulty in early diagnosis,the high recurrence rate and high tumor ***,a novel mode of cell death driven by iron-dependent lipid peroxidation,has been implicated in the development and therapeutic response of various tumors,including *** this review,we discuss the regulatory network of ferroptosis,describe the crosstalk between ferroptosis and HCCrelated signaling pathways,and elucidate the potential role of ferroptosis in various treatment modalities for HCC,such as systemic therapy,radiotherapy,immunotherapy,interventional therapy and nanotherapy,and applications in the diagnosis and prognosis of HCC,to provide a theoretical basis for the diagnosis and treatment of HCC to effectively improve the survival of HCC patients.

关键词： Hepatocellular carcinoma Ferroptosis Sorafenib Cancer therapy Molecular targets

Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and treatment

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Journal of Clinical and Translational Hepatology 2022年第3期10卷 496-508页

作者： Hang Wang Liang Yu Peng Huang Yongxu Zhou Wangyang Zheng Nanfeng Meng Risheng He Yi Xu Tey Sze Keong Yunfu Cui Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina The key Laboratory of myocardial ischemia Harbin Medical UniversityMinistry of EducationHarbinHeilongjiangChina Department of Pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Hepatocellular carcinoma(HCC)has become a challenging disease *** are still limitations in the diagnosis and treatment of HCC,and its high metastatic capacity and high recurrence rate are the main reasons for its poor *** ability of extracellular vesicles(EVs)to transfer functionally-active substances and their widespread presence in almost all body fluids suggest their unprecedented potential in the study of various *** unique physicochemical properties of EVs determine their potential as antitumor vaccines and drug *** the last decade,the study of EVs in HCC has evolved from a single hot topic to a system with considerable *** paper summarizes the role of EVs,especially exosomes,in the occurrence,metastasis and tumor immunity of HCC,reviews their applications in tumor diagnosis,prognosis and treatment,describes the pros and cons of these studies,and looks forward towards the future research directions of EVs in HCC.

关键词： Extracellular vesicles Exosome Hepatocellular carcinoma Tumor formation and progression

Cu^(Ⅱ)-loaded polydopaminecoatingswith in situ nitric oxidegenerationfunctionforimproved hemocompatibility

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Regenerative Biomaterials 2020年第2期7卷 153-160页

作者： Lei Zhou Xin Li Kebing Wang Fangyu Shen Lu Zhang Peichuang Li Tengda Shang Jin Wang Nan Huang key laboratories of Advanced Technology for Materials of education ministry School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031China

NO is the earliest discovered gas signal molecule which is produced by normal healthy endothelial cells,and it has many functions,such as maintaining cardiovascular homeostasis,regulating vasodilation,inhibiting intimal hyperplasia and preventing atherosclerosis in the blood *** NO release is often observed in the pathological environment,for instance *** was discovered that NO could be released from the human endogenous NO donor by many compounds,and these methods can be used for the treatment of certain diseases in the blood *** this work,a series of copper-loaded polydopamine(PDA)coatings were produced through self-polymerization time for 24,48 and 72 *** chemical composition and structure,coating thickness and hydrophilicity of the different copper-loaded PDA coatings surfaces were characterized by phenol hydroxyl quantitative,X-ray photoelectron spectroscopy,ellipsometry atomic force microscopy and water contact *** results indicate that the thickness and the surface phenolic hydroxyl density of the PDA coatings increased with the polymerization *** copperloaded coating has glutathione peroxidase-like activity,and it has the capability of catalyzing NO releasing from *** surface of the coating showed desirable hemocompatibility,the adhesion and activation of platelets were inhibited on the copper-loaded *** the same time,the formation of the thrombosis was also *** copper-loaded PDA coatings could provide a promising platform for the development of blood contact materials.

关键词： nitric oxide polydopamine coating copper ion hemocompatibility

Anti-Hypertensive Action of Fenofibrate via UCP2 Upregulation Mediated by PPAR Activation in Baroreflex Afferent Pathway

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Neuroscience Bulletin 2019年第1期35卷 15-24页

作者： Jian Guan Miao Zhao Chao He Xue Li Ying Li Jie Sun Wei Wang Ya-Li Cui Qing Zhang Bai-Yan Li Guo-Fen Qiao Department of Pharmacology(State-Province key laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Medicine ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China

Fenofibrate, an agonist for peroxisome proliferator-activated receptor alpha(PPAR-a), lowers blood pressure, but whether this action is mediated via baroreflex afferents has not been elucidated. In this study, the distribution of PPAR-a and PPAR-c was assessed in the nodose ganglion(NG) and the nucleus of the solitary tract(NTS). Hypertension induced by drinking high fructose(HFD) was reduced, along with complete restoration of impaired baroreceptor sensitivity, by chronic treatment with fenofibrate. The molecular data also showed that both PPAR-a and PPAR-c were dramatically up-regulated in the NG and NTS of the HFD group. Expression of the downstream signaling molecule of PPAR-a, the mitochondrial uncoupling protein 2(UCP2), was up-regulated in the baroreflex afferent pathway under similar experimental conditions, along with amelioration of reduced superoxide dismutase activity and increased superoxide in HFD *** results suggest that chronic treatment with fenofibrate plays a crucial role in the neural control of blood pressure by improving baroreflex afferent function due at least partially to PPAR-mediated up-regulation of UCP2 expression and reduction of oxidative stress.

关键词： Fenofibrate Peroxisome proliferator-activated receptor Mitochondrial uncoupling protein Baroreflex afferent function Blood pressure regulation

Relationship between Leucite Content and Compressive Strength of K_2O-Al_2O_3-SiO_2 System Dental Glass Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2009年第1期24卷 72-74页

作者：张飚钱法汤 key Laboratory of Oral Biomedical Engineering of ministry of education Wuhan University

Relationship between leucite content and compressive strength of K2O-Al2O3-SiO2 sys-tem dental glass ceramics were investigated. 10 groups of feedstock powder with different composi-tions were treated according to the same thermal treatment system of leucite micro-crystallization reported in some primary studies. The products of each group were analyzed by X-ray diffractometer, polaring microscope and scanning electronic microscope （SEM）, and then the compressive strength was tested by a material testing machine. A direct proportion was found between leucite content and the compressive strength when leucite content was less than 50 vol%, and compressive strength de-creased with the increasing of leucite micro-crystals when leucite content was more than 50vol%, The leucite content has a notable influence on the compressive strength of K2O-Al2O3-SiO2 system dental glass ceramics.

关键词： leucite content compressive strength glass ceramics

LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

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Science China(Life Sciences) 2024年第8期67卷 1601-1619页

作者： Hua Yang Lina Xuan Shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei Jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

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Frontiers of Medicine 2024年第3期18卷 499-515页

作者： Han Wu Weitao Jiang Ping Pang Wei Si Xue Kong Xinyue Zhang Yuting Xiong Chunlei Wang Feng Zhang Jinglun Song Yang Yang Linghua Zeng Kuiwu Liu Yingqiong Jia Zhuo Wang Jiaming Ju Hongtao Diao Yu Bian Baofeng Yang Department of Pharmacology(National key Laboratory of Frigid Zone Cardiovascular Diseases the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart *** N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the occurrence and development of many *** investigating the biological function of the m^(6)A reader YTHDF1 in cardiac fibrosis,adeno-associated virus 9 was used to knock down or overexpress the YTHDF1 gene in mouse hearts,and MI surgery in vivo and transforming growth factor-β(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosis *** results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosis,whereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricular pathological remodeling and fibrotic ***,zinc finger BED-type containing 6 mediated the transcriptional function of the YTHDF1 gene ***1 augmented AXL translation and activated the TGF-β-Smad2/3 signaling pathway,thereby aggravating the occurrence and development of cardiac dysfunction and myocardial ***,our data indicated that YTHDF1 was involved in activation,proliferation,and migration to participate in cardiac fibrosis in *** results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis.

关键词： cardiac fibrosis YTHDF1 AXL ZBED6 heart failure