Morphologic characteristics of late stent malapposition after drug-eluting stents implantation by optical coherence tomography follow-up

作     者：HOU Jing-bo LIU Hui-min MA Li-jia YANG Shuang MENG Ling-bo HAN Zhi-gang ZHANG Shuo YU Bo 

作者机构：Department of Cardiology Second Affiliated Hospital of Harbin Medical University Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment Harbin Heilongjiang 150086 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2010年第123卷第5期

页      面：581-584页

核心收录：

学科分类：0821[工学-纺织科学与工程] 08[工学] 09[农学] 0902[农学-园艺学] 082104[工学-服装设计与工程] 090202[农学-蔬菜学] 

主　　题：drug-eluting stent late stent malapposition very late stent thrombosis optical coherence tomography 

摘      要：Background Late stent malapposition was frequently observed after DES implantation, which has been associated with the occurrence of late stent thrombosis due to poor neointimal coverage. This study was designed to evaluate the frequency of late stent malapposition at least 1 year after different DESs implantation by optical coherence tomography （OCT）. Methods Angiographic and OCT examinations were given to 68 patients who had received total 126 various DESs implantation for at least 1 year to detect late stent malapposition. Malapposed strut distance （MSD）, malapposed strut area （MSA）, reference lumen area （RLA） and reference stent area （RSA） were checked with off-line OCT analysis. Results Totally 26 Cypher Select stents, 15 Taxus Liberte stents, 51 Partner stents and 34 Firebird I stents were examined. Among 68 patients who underwent DES implantation, 7 patients （10.3%） had late malapposition. Average RSA, MSA and MSD were （7.9=6？..8） mm2,（2.0＋1.6） mm2 and （590_＋_270） pm respectively. According to the MSA/RSA ratio 4 patients had slight malapposition, 2 patients had moderate malapposition and 1 patient had severe malapposition. Conclusions Late stent malapposition is detected frequently after implantation of DES, but if this predisposes to late stent thrombosis and requires any specific therapy needs to be further elucidated.