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Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

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Chinese Chemical Letters 2013年第8期24卷 673-676页

作者： Yin-Bo Chen Ji-Ling Li Xu-Sheng Shao Xiao-Yong Xu Zhong Li Shanghai key lab of Chemistry biology School of PharmacyEast China University of Science and Technology

A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was *** target compounds were characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and *** preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/*** difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.

关键词： Anthranilic diamides Benzyl sulfide Synthesis Insecticidal activity

FgHAT2 is involved in regulating vegetative growth, conidiation, DNA damage repair, DON production and virulence in Fusarium graminearum

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Journal of Integrative Agriculture 2020年第7期19卷 1813-1824页

作者： LU Wu-yun YANG Nan XU Zhe DAI Han TANG Shuai WANG Zheng-yi State key laboratory of Rice biology&Ministry of Agriculture key lab of Molecular biology of Crop Pathogens and Insects Institute of BiotechnologyZhejiang UniversityHangzhou 310029P.R.China

Histone lysine acetylation is catalyzed by acetyltransferases(HATs), which is important in regulating gene expression and physiological function in eukaryotic cells. HATs can be classified into two main types: A-and B-type HATs. Recently, in Fusarium graminearum, it has been reported that A-type HATs are involved in hyphal development, conidiation, sexual reproduction and virulence. However, the biological roles of B-type HATs are unknown. Here we report the identification and characterization of two B-type HATs(FgHat1 and FgHat2) in F. graminearum. Targeted deletion of FgHAT1 did not result in any detectable phenotypes. However, ΔFghat2 mutants were severely defective in vegetative growth, conidia production and morphogenesis, deoxynivalenol(DON) biosynthesis and virulence. Interestingly, deletion of Fg HAT2 resulted in significantly increased sensitivity to the DNA-damaging agent methyl methanesulfonate(MMS). Furthermore, double deletion mutants(ΔFghat1ΔFghat2) displayed similar phenotypes to the ΔFghat2 mutants. Taken together, we conclude that FgHat2 but not FgHat1 plays essential roles in regulating morphogenesis, DNA damage repair, DON production and virulence in F. graminearum.

关键词： Fusarium graminearum acetyltransferases FgHA T2 pathogenicity

Imidazolium-based ionic polymers for fast and efficient anion-exchange driven capture of Cr2O72-

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Science China Chemistry 2025年

作者： Yishou Wang Xiaonan Yuan Xingxing Gou Xiatian Song Xiaogang Wang Ling Guo Yanfeng Liu Chengfang Qiao Chunsheng Zhou Yingfeng Han Shaanxi key laboratory of Comprehensive Utilization of Tailings Resources Shaanxi Engineering Research Center for Mineral Resources Clean & Efficient Conversion and New Materials College of Chemical Engineering and Modern Materials Shangluo University key laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education Xi'an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials Science Northwest University

The pervasive issue of chromium（VI） contamination,particularly in dichromate (Cr2O2-7),resulting from unchecked industrial growth and inadequate waste management,remains a pressing concern that demands immediate and dedicated ***,we present two novel imidazolium-based ionic polymers （ImIPs）.The ImIPs boast a highly cationic structure rich in bromide（Br-） ions and exhibit remarkable porosity,facilitating the easy exchange of these ions for chromate (Cr2O2-7) through anion *** unique combination leads to exceptional performance,including a high adsorption capacity （423 mg/g）,rapid adsorption rate (75 mg g-1min-1),and a broad operational pH range （2–12）.Moreover,our material demonstrates remarkable reusability,maintaining its efficacy even after 10 cycles without significant loss of *** mechanistic studies underscore the role of ion-exchange chemistry in effectively removing dichromate by the presented ImIPs,providing strong evidence for their suitability as a robust solution to address the ongoing challenges in water *** findings represent a crucial step in developing advanced materials for tackling chromium（VI） pollution.

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CAN Catalyzed Preparation of β-Enamino Ketones from Amines and Acetylacetone

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Chinese Chemical Letters 2006年第12期17卷 1566-1568页

作者： Zheng DUAN Ting LI Xue Jie XUAN Yang Jie WU Department of Chemistry The Key Lab of Chemical Biology and Organic Chemistry of Henan Province The Key and Open Lab of Applied Chemistry of Henan Universities Zhengzhou University Zhengzhou 450052

A variety of β-enamino ketones were synthesized in high to excellent yields by reacting acetylacetone with amines in the presence of a catalytic amount of cerium（IV） ammonium nitrate （CAN） under ultrasonic irradi... 详细信息

关键词： CAN catalyzed β-enamino ketone ultrasound.

有机高温余辉材料:一个正在不断发展的重要研究领域（英文）

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Science China Materials 2025年

作者：王家强李振李倩倩 Hubei key lab on Organic and Polymeric Opto-Electronic Materials Department of ChemistryWuhan University TaiKang Center for Life and Medical Sciences Wuhan University

具有大范围温度响应或耐高温性能的有机余辉材料在多个领域展现出广泛的应用前景.对高温余辉材料进行系统研究,对抑制有机发光材料的热猝灭、提升余辉性能至关重要,而且能拓展分子聚集态调控策略,加深分子聚集态发光机制探索.根据有机...

具有大范围温度响应或耐高温性能的有机余辉材料在多个领域展现出广泛的应用前景.对高温余辉材料进行系统研究,对抑制有机发光材料的热猝灭、提升余辉性能至关重要,而且能拓展分子聚集态调控策略,加深分子聚集态发光机制探索.根据有机高温余辉的产生机制,可将材料分为高温磷光材料,高温热激活延迟荧光余辉材料,以及热释光材料.本文对其进行了简要的综述,总结了构筑有机高温余辉材料以及提升其性能的有效策略,展望了此类材料的发展前景.

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Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China Life Sciences 2025年

作者： Cong Zhou Tingting Gong Shuhang Li Li Jin Shaohua Fan State key laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are crucial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we construct an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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Problems, challenges and future of plant disease management: from an ecological point of view

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Journal of Integrative Agriculture 2016年第4期15卷 705-715页

作者： HE Dun-chun ZHAN Jia-sui XIE Lian-hui Fujian key lab of Plant Virology Institute of Plant Virology Fujian Agriculture and Forestry University key lab for Biopesticide and Chemical biology Ministry of EducationFujian Agriculture and Forestry University

Plant disease management faces ever-growing challenges due to：（i） increasing demands for total, safe and diverse foods to support the booming global population and its improving living standards; （ii） reducing production potential in agriculture due to competition for land in fertile areas and exhaustion of marginal arable lands; （iii） deteriorating ecology of agro-ecosystems and depletion of natural resources; and （iv） increased risk of disease epidemics resulting from agricultural intensification and monocultures. Future plant disease management should aim to strengthen food security for a stable society while simultaneously safeguarding the health of associated ecosystems and reducing dependency on natural resources. To achieve these multiple functionalities, sustainable plant disease management should place emphases on rational adaptation of resistance, avoidance, elimination and remediation strategies individually and collectively, guided by traits of specific host-pathogen associations using evolutionary ecology principles to create environmental （biotic and abiotic） conditions favorable for host growth and development while adverse to pathogen reproduction and evolution.

关键词： disease resistance avoidance elimination and remediation ecological plant disease management evolutionaryprinciple food security plant disease economy

The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of histone acetylation

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Frontiers of Agricultural Science and Engineering 2016年第4期3卷 357-362页

作者： Shixin ZHANG Shaohua WU Weimin TIAN key laboratory of biology and Genetic Resources of rubber Tree Ministry of Agriculture State key laboratory Incubation Base for Cultivation and Physiology of Tropical Crops Rubber Research InstituteChinese Academy of Tropical Agricultural Sciences

The secondary laticifer, a specific tissue in the secondary phloem of rubber tree, is differentiated from the vascular cambia. The number of the secondary laticifer in the trunk bark of rubber tree is positively correlated with rubber yield. Although jasmonates have been demonstrated to be crucial in the regulation of secondary laticifer differentiation, the mechanism for the jasmonate-induced secondary laticifer differentiation remains to be *** using an experimental morphological technique, the present study revealed that trichostatin A(TSA), an inhibitor of histone deacetylation, could induce the secondary laticifer differentiation in a concentrationdependent manner. The results suggest that histone acetylation is essential for the secondary laticifer differentiation in rubber tree.

关键词： Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia

A growth-regulating factor 7(GRF7)-mediated gene regulatory network promotes leaf growth and expansion in sugarcane

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The Crop Journal 2024年第2期12卷 422-431页

作者： Qiaoyu Wang Yihan Li Dadong Lin Xiaoxi Feng Yongjun Wang Tianyou Wang Hongyan Ding Jisen Zhang State key lab for Conservation and Utilization of Subtropical AgroBiological Resources and Guangxi key lab for Saccharum biology Guangxi UniversityNanning 530005GuangxiChina Center for Genomics and Biotechnology/Fujian Provincial key laboratory of Haixia Applied Plant Systems biology/key laboratory of Saccharum biology and Genetic Breeding/National Engineering Research Center for Saccharum Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Knowledge of the function of growth-regulating factors(GRFs)in sugarcane(Saccharum officinarum and ***)growth and development could assist breeders in selecting desirable plant ***,limited information about GRFs is available in Saccharum due to their *** this study,22 GRFs were identified in the two species and their conserved domains,gene structures,chromosome location,and synteny were ***7 expression varied among tissues and responded to diurnal ***7-YFP was localized preferentially in the nucleus and appears to act as a transcriptional ***7 positively regulated the size and length of rice leaves,possibly by regulating cell size and plant *** seven potential transcription factors binding to the SsGRF7 promoter in ***,four showed positive expression patterns,and two showed negative expression patterns relative to SsGRF7.

关键词： Expression analysis Growth-regulating factor Leaf development Sugarcane Transcription factors