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Comparative assessment of liver tissue:from microstructural and mesoscale vascular architecture to macroscopic mechanics

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Acta Mechanica Sinica 2024年第7期40卷 195-205页

作者： Wei Kang Kaixin Sun Lizhen Wang Yubo Fan key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China School of Engineering Medicine Beihang UniversityBeijing 100083China

Accurately characterizing the liver's mechanical properties is of paramount importance for disease diagnosis,treatment,surgical prosthetic modeling,and impact injury ***,due to its inherent biological soft tissue nature,the characterization of mechanical behavior varies across testing methods and sample *** this study,we employed transmission electron microscope and Micro CT to observe the morphology of the marginal and center of rat livers and conducted macroscopic mechanical tests to characterize their elasticity and *** results revealed that the central region displayed higher metabolic levels,elongated mitochondria,and an abundance of rough endoplasmic reticulum at the *** the mesoscale,larger diameter portal veins were mainly distributed in the central region,while smaller diameter arteries were predominantly located at the *** the macroscale,under a strain rate of 0.0167 s^(-1),no significant differences were observed in the elastic properties between the two ***,as the strain rate increased up to 0.167 s^(-1),the central region displayed higher porosity,resulting in reduced liquid loss,increased hardness,and higher viscosity compared to the ***,the liver demonstrated overall heterogeneity,with isotropic models suitable for the peripheral region,while more intricate models may be required to capture the complexity of the central region with its intricate vasculature.

关键词： Liver Mechanical properties Micro and macro tests

Biophysical cues involved in the stem cell niche for stemness maintenance

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Medicine in Novel Technology and Devices 2024年第2期22卷 80-89页

作者： Chiyu Li Lisha Zheng Yubo Fan key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

The characteristics of stem cells are self-renewal ability and differentiation *** properties are defined as stemness,offering them application in tissue repair and regeneration based on stem cells with great ***,stem cells undergo functional deterioration and gradually lose stemness with long-term *** evidence implies that the regulation of stemness is primarily orchestrated by the niche,which comprises the connection between stem cells and niche cells,extracellular matrix(ECM)proteins,and secreted ***,physical signals are being acknowledged as paramount regulators of cellular behavior,governing stem cell stemness,tissue development,and *** review outlines current approaches for stemness maintenance and the important biophysical cues involved in the stem *** first encompass the latest discoveries regarding the sources and transduction pathways of these biophysical ***,the specific biophysical factors for regulating stemness have been ***,we summarize existing challenges and prospect future research in this field.

关键词： Stemness Stem cell Biophysical Niche

Current research progress on cell membrane decorated macroscopic biomaterials

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Medicine in Novel Technology and Devices 2024年第1期21卷 23-30页

作者： Lingbing Yang Linhao Li Yubo Fan key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China

The cell membranes,derived from natural sources,possesses unique physicochemical properties of phospholipid bilayers and biological functionalities of membrane *** makes it an ideal biomimetic coating to enhance the in vivo circulation and retention time of micro/nanodrug carriers,provide targeted drug delivery effects,and neutralize bacterial ***,recent studies have successfully coated various types of cell membranes onto the surfaces of macroscopic materials,such as electrospun fiber scaffolds and decellularized matrices,to promote tissue repair,modulate host responses to foreign materials,and alleviate *** review comprehensively summarizes the latest research progress in the modification of macroscopic biomaterials with cell *** insights provided aim to serve as a valuable reference for the preparation of cell membrane biomimetic coatings and their applications in the field of tissue repair.

关键词： Cell membrane coating Macroscopic biomaterials Tissue repair Foreign body reactions

Multi-objective structural optimization and degradation model of magnesium alloy ureteral stent

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Medicine in Novel Technology and Devices 2024年第2期22卷 19-28页

作者： Lin Zhu Qiao Li Yuanming Gao Lizhen Wang Yubo Fan key laboratory for biomechanics and mechanobiology of ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering Medicine Beihang UniversityBeijing100191China

Background:Mg alloys have attractive properties,including biocompatibility,biodegradability,and ideal mechanical ***,Mg alloys are regarded as one of the promising candidates for manufacturing ureteral *** study proposed a multi-objective optimization method based on the Kriging surrogate model,NSGA-III,and finite element analysis to improve the degradation performance of Mg alloy ureteral ***:The finite element model for the degradation of Mg alloy ureteral stents has been established to compare the degradation performance of the stents under different *** hypercube sampling was adopted to generate train sample points in the design ***,the Kriging surrogate model was constructed between strut parameters and stent degradation *** NSGA-III was utilized to determine the optimal solution in the global design ***:The optimized stent achieved 5.52degradation uniformity(M),10degradation time(DT),and 4work time(FT).The errors between the Kriging surrogate model and the finite element calculation results were less than 6%.Conclusion:The optimized stent achieved better degradation *** degradation behavior of stents was dependent on the design *** multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.

关键词： Mg alloys ureteral stent Kriging surrogate model NSGA-III Multi-objective optimization Degradation model

Simulation Analysis of Deformation Control for Magnetic Soft Medical Robots

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： Jingxi Wang Baoyu Liu Edmond Q.Wu Jin Ma Ping Li key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of Aerospace Medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

Functional near-infrared spectroscopy in non-invasive neuromodulation

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Neural Regeneration Research 2024年第7期19卷 1517-1522页

作者： Congcong Huo Gongcheng Xu Hui Xie Tiandi Chen Guangjian Shao Jue Wang Wenhao Li Daifa Wang Zengyong Li Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Beijing key laboratory of Rehabilitation Technical Aids for Old-Age Disability National Research Center for Rehabilitation Technical AidsBeijingChina School of Mechatronic Engineering and Automation Foshan UniversityFoshanGuangdong ProvinceChina School of Rehabilitation Engineering Beijing College of Social AdministrationBeijingChina key laboratory of Neuro-functional Information and Rehabilitation Engineering of the ministry of Civil Affairs BeijingChina

Non-invasive cerebral neuromodulation technologies are essential for the reorganization of cerebral neural networks,which have been widely applied in the field of central neurological diseases,such as stroke,Parkinson’s disease,and mental *** significant advances have been made in neuromodulation technologies,the identification of optimal neurostimulation paramete rs including the co rtical target,duration,and inhibition or excitation pattern is still limited due to the lack of guidance for neural *** r,the neural mechanism unde rlying neuromodulation for improved behavioral performance remains poorly ***,advancements in neuroimaging have provided insight into neuromodulation *** near-infrared spectroscopy,as a novel non-invasive optical brain imaging method,can detect brain activity by measuring cerebral hemodynamics with the advantages of portability,high motion tole rance,and anti-electromagnetic *** functional near-infra red spectroscopy with neuromodulation technologies offe rs an opportunity to monitor the cortical response,provide realtime feedbac k,and establish a closed-loop strategy integrating evaluation,feedbac k,and intervention for neurostimulation,which provides a theoretical basis for development of individualized precise neuro *** aimed to summarize the advantages of functional near-infra red spectroscopy and provide an ove rview of the current research on functional near-infrared spectroscopy in transcranial magnetic stimulation,transcranial electrical stimulation,neurofeedback,and braincomputer ***,the future perspectives and directions for the application of functional near-infrared spectroscopy in neuromodulation are *** conclusion,functional near-infrared spectroscopy combined with neuromodulation may promote the optimization of central pellral reorganization to achieve better functional recovery form central nervous system

关键词： brain-computer interface cerebral neural networks functional near-infrared spectroscopy neural circuit neurofeedback neurological diseases neuromodulation non-invasive brain stimulation transcranial electrical stimulation transcranial electrical stimulation

Fully automatic AI segmentation of oral surgery-related tissues based on cone beam computed tomography images

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International Journal of Oral Science 2024年第3期16卷 413-424页

作者： Yu Liu Rui Xie Lifeng Wang Hongpeng Liu Chen Liu Yimin Zhao Shizhu Bai Wenyong Liu Beijing Yakebot Technology Co. Ltd.BeijingChina School of Mechanical Engineering and Automation Beihang UniversityBeijingChina State key laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDigital CenterSchool of StomatologyThe Fourth Military Medical UniversityXi’anChina key laboratory of biomechanics and mechanobiology of the ministry of education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

Accurate segmentation of oral surgery-related tissues from cone beam computed tomography(CBCT)images can significantly accelerate treatment planning and improve surgical *** this paper,we propose a fully automated tissue segmentation system for dental implant ***,we propose an image preprocessing method based on data distribution histograms,which can adaptively process CBCT images with different *** on this,we use the bone segmentation network to obtain the segmentation results of alveolar bone,teeth,and maxillary *** use the tooth and mandibular regions as the ROI regions of tooth segmentation and mandibular nerve tube segmentation to achieve the corresponding *** tooth segmentation results can obtain the order information of the *** corresponding experimental results show that our method can achieve higher segmentation accuracy and efficiency compared to existing *** average Dice scores on the tooth,alveolar bone,maxillary sinus,and mandibular canal segmentation tasks were 96.5%,95.4%,93.6%,and 94.8%,*** results demonstrate that it can accelerate the development of digital dentistry.

关键词： surgery CBCT beam

Bioinspiration review of Aquatic Unmanned Aerial Vehicle(AquaUAV)

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Biomimetic Intelligence & Robotics 2024年第2期4卷 1-11页

作者： Xinyang Wang Jjiawei Zhao Xuan Pei Tianmiao Wang Taogang Hou Xingbang Yang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China Department of Bioengineering Imperial College LondonLondon SW72AZUK School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Biological Science and Medical Engineering Bejing Advanced Innovation Centre for Biomedical EngineeringKey Laboratory for Biomechanics and Mechanobiology of Ministry of EducationBeihang UniversityBeijing 100191China

The performance of Aquatic Unmanned Aerial Vehicle(AquaUAV)has always been limited so far and far from practical applications,due to insufficient propulsion,large-resistance structure ***-aquatic amphibians in nature may facilitate the development of AquaUAV since their excellent amphibious locomotion capabilities evolved under long-term natural *** article will take four typical aerial-aquatic amphibians as representatives,i.e.,gannet,cormorant,flying fish and flying *** summarized the multi-mode locomotion process of common aerial-aquatic amphibians and the evolutionary trade-offs they have made to adapt to amphibious *** four typical propulsion mechanisms were investigated,which may further inspire the propulsion design of the *** their morphological models could guide the layout ***,we reviewed the state of art in AquaUAV to validate the potential value of our bioinspiration,and discussed the futureprospects.

关键词： Aerial-aquatic amphibians Multi-mode locomotion trade-offs Propulsion mechanism Morphological design

Polar-coordinate line-projection light-curing continuous 3D printing for tubular structures

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International Journal of Extreme Manufacturing 2024年第4期6卷 247-260页

作者： Huiyuan Wang Siqin Liu Xincheng Yin Mingming Huang Yanzhe Fu Xun Chen Chao Wang Jingyong Sun Xin Yan Jianmin Han Jiping Yang Zhijian Wang Lizhen Wang Yubo Fan Jiebo Li key laboratory of biomechanics and mechanobiology(Beihang University) Ministry of EducationInstitute of Medical PhotonicsBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191People's Republic of China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191People's Republic of China Peking University School and Hospital of Stomatology Beijing 100081People's Republic of China School of Materials Science and Engineering Beihang UniversityBeijing 100191People's Republic of China

3D printing techniques offer an effective method in fabricating complex radially multi-material ***,it is challenging for complex and delicate radially multi-material model geometries without supporting structures,such as tissue vessels and tubular graft,among *** this work,we tackle these challenges by developing a polar digital light processing technique which uses a rod as the printing *** 3D model fabrication is accomplished through line *** rotation and translation of the rod are synchronized to project and illuminate the photosensitive material *** controlling the distance between the rod and the printing window,we achieved the printing of tubular structures with a minimum wall thickness as thin as 50 *** controlling the width of fine slits at the printing window,we achieved the printing of structures with a minimum feature size of 10 *** process accomplished the fabrication of thin-walled tubular graft structure with a thickness of only 100 micrometers and lengths of several centimeters within a timeframe of just 100 ***,it enables the printing of axial multi-material structures,thereby achieving adjustable mechanical *** method is conducive to rapid customization of tubular grafts and the manufacturing of tubular components in fields such as dentistry,aerospace,and more.

关键词： 3D printing polar coordinate line projection light-curing tubular structure radially multi-material structures