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Analysis of the Constituents in Rat Serum after Oral Administration of Fufang Zhenzhu Tiaozhi Capsule by UPLC-Q-TOF-MS/MS

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Analysis of the Constituents in Rat Serum after Oral Adminis...

Clinical Characteristics and Outcomes of Type 2 Diabetes Patients Infected with COVID-19: A Retrospective Study

2013年广东省药师周大会

作者： Xunlong Zhong Jiao Guo LaiyouWang Duosheng Luo Weijian Bei Yuanyuan Chen Kangqi Yan Junhui Peng key unit of modulating liverto treat hyperlipemia satcm(StateAdministration of Traditional Chinese Medicine) Level 3 laboratory of Lipid Metabolism SATCMInstitute of Chinese Medical Science of Guangdong Pharmaceutical University Guangzhou University of Chinese Medicine

A rapid and sensitive UPLC/Q-TOF-MS method has been established for analysis of the constituents in rat serum after oral administration of Fufang Zhenzhu TiaoZhi(FTZ) capsule,an effective compound prescription for treating hyperlipidemia in *** UPLC/MS information of samples was obtained first in FTZ preparation and FTZ-treated rat *** spectra were acquired in both negative and positive ion modes.36 constituents in rat serum after oral administration of FTZ were detected,including the alkaloids,ginsenosides,pentacyclic triterpenes and their *** chemicals were identified based on the retention time and mass spectrometry data with those of authentic standards or comparison of the literatures reports.27 prototype components originated from FTZ and 9 were the metabolites of the constituents from *** results shed a light on the potential active constituents of the complextraditional Chinese medicinal formula.

关键词： UPLC/Q-TOF-MS Serum Pharmacology Metabolite Fufang Zhenzhu Tiaozhi Capsule

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Engineering 2020年第10期6卷 1321-1330页

作者： Yingyu Chen Jiankun Chen Xiao Gong Xianglu Rong Dewei Ye Yinghua Jin Zhongde Zhang Jiqiang Li Jiao Guo The First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou 510080China Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine&key Laboratory of Glucolipid Metabolic Disorder Ministry of Education of the People's Republic of China&Key Unit of Modulating Liver to Treat Hyperlipemia SATCM&Guangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China The Second Clinical College Guangzhou University of Chinese MedicineGuangzhou 510120China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510120China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510006China

据报道,糖尿病及其相关的代谢性疾病是新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者的主要合并症。这项临床研究旨在调查有或没有合并糖尿病的COVID-19患者的临床特征、影像学和实验室检查、并发症、治疗方法以及临床结局... 详细信息

据报道,糖尿病及其相关的代谢性疾病是新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者的主要合并症。这项临床研究旨在调查有或没有合并糖尿病的COVID-19患者的临床特征、影像学和实验室检查、并发症、治疗方法以及临床结局。这项回顾性研究纳入2020年1月12日至3月25日208例经实验室确认的COVID-19的住院患者(≥45岁)。分析病历信息包括临床特征、影像学和实验室检查、并发症、治疗和临床结果。其中,96名(46.2%)患者患有2型糖尿病。在COVID-19合并2型糖尿病患者中,高血压(58.3%vs.31.2%)、冠心病(17.1%vs.8.0%)和慢性肾脏病(6.2%vs.0%)的共存率明显高于没有2型糖尿病的COVID-19患者。COVID-19合并2型糖尿病患者的CT胸部扫描异常频率和程度显著增加,包括毛玻璃样混浊(85.6%vs.64.9%,P<0.001)和双侧斑片状阴影(76.7%vs.37.8%,P<0.001)。此外,患有糖尿病的COVID-19患者的血糖水平[7.23 mmol·L^-1(IQR:5.80~9.29)vs.5.46 mmol·L^-1(IQR:5.00-6.46)]、血液中低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)[2.21 mmol·L^-1(IQR:1.67~2.76)vs.1.75 mmol·L^-1(IQR:1.27~2.01)]和收缩压[130 mmHg(IQR:120~142)vs.122 mmHg(IQR:110~137),P<0.001]显著高于没有糖尿病的患者(P<0.001)。2型糖尿病和其他代谢性疾病共存于COVID-19患者中,这可能会增加发病率并加重COVID-19的病情。血糖和脂质代谢的最佳管理是确保更好的临床结果的关键。对于患有糖尿病及其他基础和慢性代谢性疾病的COVID-19患者,应提高临床警惕性。

关键词：新冠病毒肺炎冠状病毒糖尿病临床特征合并症

维普期刊数据库

Polygonatum Sibiricum Saponin-Lactic acid bacteria combination attenuate hyperglycemia in T2DM mice by modulating amino acid metabolism

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Food Science and Human Wellness 2024年

作者： Jiayuan Luo Mingjie Jia Shuang Liang Yangyang Chai Yihong Bao Shilong Jiang key Laboratory of Forest Food Resources Utilization of Heilongjiang Province Colleage of Life Science， Northeast Forestry University Heilongjiang Feihe Dairy Industry

Some researches have shown that the combination of plant extracts and probiotics may be a better way to treat type 2 diabetes mellitus (T2DM) than a single intervention. However， there are still relatively few relevant reports in this aspect. Therefore， this study aims to investigate whether the treatment of polygonatum sibiricum saponin (PSS) and lactic acid bacteria (LAB) combination can better manage T2DM. And the anti-diabetes mechanism of the combination was studied from the perspectives of glucose metabolism， microbiome and metabolome. The results showed that PSS+LAB could better improve FBG level， insulin sensitivity， lipid metabolism disorder， and liver function. Protein analysis showed that PSS+LAB treatment significantly increased the expression of p-PI3K/PI3K， p-AKT/AKT， GLUT2， IRS2， and GSK-3β in the liver of T2DM mice， while inhibiting the expression of FOXO1. This combination positively regulated the composition and abundance of the gut microbiota. Metabolomic analysis showed that the combination treatment exhibited more changes in gut microbiota metabolites compared to PSS treatment alone. The alteration of gut microbiota by LAB+PSS led to significant changes in alanine， aspartate and glucose metabolism pathways. This study may provide a theoretical basis for the combined application of plant extracts and probiotics for the management of T2DM.

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Radix Paeoniae Alba attenuates Radix Bupleuri-induced hepatotoxicity by modulating gut microbiota to alleviate the inhibition of saikosaponins on glutathione synthetase

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Journal of Pharmaceutical Analysis 2023年第6期13卷 640-659页

作者： Congcong Chen Wenxia Gong Junshen Tian Xiaoxia Gao Xuemei Qin Guanhua Du Yuzhi Zhou Modern Research Center for Traditional Chinese Medicine The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan030006China key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province Shanxi UniversityTaiyuan030006China Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Radix Bupleuri(RB)is commonly used to treat depression,but it can also lead to hepatotoxicity after longterm *** many anti-depression prescriptions,RB is often used in combination with Radix Paeoniae Alba(RPA)as an herb ***,whether RPA can alleviate RB-induced hepatotoxicity remain *** this work,the results confirmed that RB had a dose-dependent antidepressant effect,but the optimal antidepressant dose caused ***,RPA effectively reversed RB-induced ***,the mechanism of RB-induced hepatotoxicity was *** results showed that saikosaponin A and saikosaponin D could inhibit GSH synthase(GSS)activity in the liver,and further cause liver injury through oxidative stress and nuclear factor kappa B(NF-kB)/NOD-like receptor thermal protein domain associated protein 3(NLRP3)***,the mechanisms by which RPA attenuates RBinduced hepatotoxicity were *** results demonstrated that RPA increased the abundance of intestinal bacteria with glycosidase activity,thereby promoting the conversion of saikosaponins to saikogenins in *** from saikosaponin A and saikosaponin D,which are directly combined with GSS as an inhibitor,their deglycosylation conversion products saikogenin F and saikogenin G exhibited no GSS binding *** on this,RPA can alleviate the inhibitory effect of saikosaponins on GSS activity to reshape the liver redox balance and further reverse the RB-induced liver inflammatory response by the NFkB/NLRP3 *** conclusion,the present study suggests that promoting the conversion of saikosaponins by modulating gut microbiota to attenuate the inhibition of GSS is the potential mechanism by which RPA prevents RB-induced hepatotoxicity.

关键词： Radix Bupleuri Radix Paeoniae Alba Hepatotoxicity Gut microbiota Saikosaponins Combination mechanisms

Herbal formula BaWeiBaiDuSan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice

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Acta Pharmaceutica Sinica B 2023年第8期13卷 1164-1179页

作者： Xiaoqing Fan Chutian Mai Ling Zuo Jumin Huang Chun Xie Zebo Jiang Runze Li Xiaojun Yao Xingxing Fan Qibiao Wu Peiyu Yan Liang Liu Jianxin Chen Ying Xie Elaine Lai-Han Leung Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyTaipaMacao 999078China Beijing University of Chinese Medicine Beijing 100029China Cancer Center Faculty of Health Science、MOE Frontiers Science Center for Precision OncologyUniversity of MacaoMacao 999078China Guangdong Provincial key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China State key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou 510120China

Sepsis-induced liver injury(SILI)is an important cause of septicemia ***(BWBDS)was extracted from a formula of Panax ginseng ***,Lilium brownie *** ex Miellez *** Baker,Polygonatum sibiricum *** Redoute,Lonicera japonica Thunb.,Hippophae rhamnoides Linn.,Amygdalus Communis Vas,Platycodon grandiflorus(Jacq.)***.,and Cortex ***,we investigated whether the BWBDS treatment could reverse SILI by the mechanism of modulating gut *** protected mice against SILI,which was associated with promoting macrophage anti-inflammatory activity and enhancing intestinal *** selectively promoted the growth of Lactobacillus johnsonii(***)in cecal ligation and puncture treated *** microbiota transplantation treatment indicated that gut bacteria correlated with sepsis and was required for BWBDS anti-sepsis ***,*** significantly reduced SILI by promoting macrophage anti-inflammatory activity,increasing interleukin-10+M2 macrophage production and enhancing intestinal ***,heat inactivation ***(***)treatment promoted macrophage anti-inflammatory activity and alleviated *** findings revealed BWBDS and gut microbiota *** as novel prebiotic and probiotic that may be used to treat *** potential underlying mechanism was at least in part,via ***-dependent immune regulation and interleukin-10+M2 macrophage production.

关键词： BaWeiBaiDuSan Sepsis-induced liver injury Network pharmacology 16S PacBio SMRT sequencing Lactobacillus johnsonii Macrophages Interleukin-10

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Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease

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World Journal of Gastroenterology 2015年第4期21卷 1099-1107页

作者： Long-Xin Qiu Tong Chen School of Life Sciences Longyan University key Laboratory of Preventive Veterinary Medicine and Biotechnology of Fujian Province

Fatty liver disease(FLD) is a growing public health problem worldwide. There is an urgent requirement for alternative and natural medicine to treat this disease. As phytochemicals, isoflavones have attracted considerable attention for the prevention of FLD. Numerous studies have revealed that isoflavones protect against FLD through various pathways which modulate fatty acid β-oxidation, lipid synthesis, and oxidative stress. Recently, the aldose reductase(AR)/polyol pathwayhas been reported to be involved in the development of FLD by modulating hepatic fructose production, peroxisome proliferator-activated receptor(PPAR)α activity, cytochrome P450(CYP)2E1 expression, and gut bacterial endotoxin-induced cytokine release. It has been reported that some isoflavones are potent AR inhibitors. Here, we review the anti-FLD actions of isoflavones and the proposed mechanism whereby isoflavones protect against FLD, with regard to the AR/polyol pathway. We propose that isoflavones block the AR/polyol pathway and in turn reduce fructose production and subsequent fat accumulation in the liver in diabetic or high-glucose-diet mice. In addition, in rodents with alcoholic liver disease or nonalcoholic fatty liver disease/nonalcoholic steatohepatitis, inhibition of AR by isoflavones may improve PPARα-mediated fatty acid oxidation, reduce hepatic steatosis, and attenuate CYP2E1-mediated oxidative stress or AR/gut bacterial endotoxin-mediated cytokine overproduction, to alleviate progression of FLD.

关键词： Isoflavones Fatty liver disease Aldose reductase F