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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal key laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina key laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,Pmanagement of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

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Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen Jiafu Ji Xiaofang Xing key laboratory of Carcinogenesis and Translational Research (ministry of education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University key laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State key laboratory of Holistic Integrative management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State key laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Effects of natural forest conversion and plantation tree species composition on soil macrofauna communities in Northeast China mountains

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Journal of forestry Research 2023年第5期34卷 1475-1489页

作者： Shuangjiao Ma Qingcheng Wang Yong Zhang Limei Yan Donghai Cui Liqing Xu key laboratory for sustainable forest ecosystem management−ministry of education School of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China

As primary and secondary forests are being replaced by plantations across the globe,the soil macrofauna community structure is also affected,but little is known about the impact of mixed culture plantations compared with monocultures on the soil *** determine the impact of forest conversion on soil macrofauna,we surveyed the soil macrofauna in two broad-leaved and three coniferous monoculture stands and four coniferous-broadleaved mixed stands,and in adjacent reserved secondary stands as a *** macro fauna community composition was significant affected by forest type,season and their interaction(Pforest *** negative effects of the conifer monoculture on soil macro fauna were not present in the mixed stands with broad-leaved *** conversion impacted soil properties;soil moisture,NO_(3)^(-),and pH were significant drivers of soil macrofauna community *** impact of forest conversion on soil macrofauna was closely dependent on tree species composition and *** macro fauna community structure in the broadleaved and the mixed stands were relatively similar to that in the natural forest,and thus recommended for forest conversion in the study area.

关键词： forest conversion Plantation forest Tree species composition Soil macrofauna Diversity Functional group

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Imidazolium-based ionic polymers for fast and efficient anion-exchange driven capture of Cr2O72-

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Science China Chemistry 2025年

作者： Yishou Wang Xiaonan Yuan Xingxing Gou Xiatian Song Xiaogang Wang Ling Guo Yanfeng Liu Chengfang Qiao Chunsheng Zhou Yingfeng Han Shaanxi key laboratory of Comprehensive Utilization of Tailings Resources Shaanxi Engineering Research Center for Mineral Resources Clean & Efficient Conversion and New Materials College of Chemical Engineering and Modern Materials Shangluo University key laboratory of Synthetic and Natural Functional Molecule Chemistry of the ministry of education Xi'an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials Science Northwest University

The pervasive issue of chromium（VI） contamination,particularly in dichromate (Cr2O2-7),resulting from unchecked industrial growth and inadequate waste management,remains a pressing concern that demands immediate and dedicated ***,we present two novel imidazolium-based ionic polymers （ImIPs）.The ImIPs boast a highly cationic structure rich in bromide（Br-） ions and exhibit remarkable porosity,facilitating the easy exchange of these ions for chromate (Cr2O2-7) through anion *** unique combination leads to exceptional performance,including a high adsorption capacity （423 mg/g）,rapid adsorption rate (75 mg g-1min-1),and a broad operational pH range （2–12）.Moreover,our material demonstrates remarkable reusability,maintaining its efficacy even after 10 cycles without significant loss of *** mechanistic studies underscore the role of ion-exchange chemistry in effectively removing dichromate by the presented ImIPs,providing strong evidence for their suitability as a robust solution to address the ongoing challenges in water *** findings represent a crucial step in developing advanced materials for tackling chromium（VI） pollution.

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Quantifying fire severity:a brief review and recommendations for improvement

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ecosystem Health and Sustainability 2021年第1期7卷 342-353页

作者： Dongdong Han Xueying Di Guang Yang Long Sun Yuetai Weng School of forestry Northeast Forestry UniversityKey Laboratory of Sustainable Forest Ecosystem ManagementMinistry of EducationHarbinHeilongjiangChina

Introduction:Quantifying fire severity is an important aspect of studying the response mechanism of terrestrial ecosystems to wildfire,and it is of great significance to fire *** this paper we comprehensively introduce and compare the classification and quantification methods for fire severity;we discuss the development and application status of various methods,and we elucidate their existing ***:1)According to features of the burned area,fire severity can be classified as light,moderate,and heavy.2)Using composite burn index(CBI)to quantify and record the fire severity.3)In quantifying fire severity with vegetation change,there are certain limitations and theoretical problems to be solved.4)Remote sensing could very well be an important means of measuring fire severity in the future,but there are still many problems that need to be solved before the remote sensing index can become a global fire severity *** and Conclusion:Only by clarifying the relationship between fire behavior,fire severity,time related variables and the pre-and post-fire ecosystem can the existing models be perfected or new,better fire severity measurement models be proposed for broad applications.

关键词： Fire severity composite burn index remote sensing index fire behavior ecosystem response fire intensity

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The sex peptide receptor in the Asian gypsy moth,Lymantria dispar,is involved in development and stress resistance

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Journal of Integrative Agriculture 2021年第11期20卷 2976-2985页

作者： DU Hui SUN Li-li LIU Peng CAO Chuan-wang key laboratory of sustainable forest ecosystem management of ministry of education School of ForestryNortheast Forestry UniversityHarbin 150040P.R.Chin

The G protein-coupled receptor(GPCR)regulates downstream genes by binding to a heterotrimeric G ***,the function of sex peptide receptor(SPR)in lepidopteran species is mostly *** the physiological functions of SPR in insects is essential for exploring new insecticidal *** the present study,the functions of an SPR in Lymantria dispar(Asian gypsy moth;LdSPR)were *** expression of LdSPR was the highest in the 6 th instar larval stage,and there was a large difference in expression between male and female *** LdSPR gene silencing,*** larvae showed increased sensitivity to high temperature,starvation,and oxidative stress,indicating that LdSPR enhances stress *** results enrich our knowledge of the function of the insect SPRs,which will lead to a better understanding of other insect GPCR family members and the identification of new targets for the development of environmentally friendly pesticides.

关键词： Lymantria dispar sex peptide receptor RNAi physiological function stress resistance

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Intra-and inter-species variations in carbon content of 14 major tree species in Northeast China

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Journal of forestry Research 2021年第6期32卷 2545-2556页

作者： Faris Rafi Almay Widagdo Fengri Li Longfei Xie Lihu Dong key laboratory of sustainable forest ecosystem management-ministry of education School of ForestryNortheast Forestry UniversityHarbinHeilongjiang150040People’s Republic of China

Reducing greenhouse gas emissions is one of the major challenges in combating global ***,including in the form of carbon dioxide(CO_(2)),is considered an essential greenhouse gas under human control to demonstrate success in emission ***,many carbon stock quantifications in forest ecosystems still rely on the estimated 50%carbon content instead of more precise species-,tissue-and site-specific ***,this study aimed to thoroughly measure and analyze the carbon content and variability using the 14 major tree species in Northeast *** 600 trees were destructively sampled from three different major mountainous regions(i.e.,the Changbai,Daxing’an,and Xiaoxing’an mountains),and the carbon contents of each species were precisely measured to the sub-tissue *** contents varied significantly between species,with foliage carbon mostly found to be the highest,while root carbon contents were the *** carbon contents can be ranked as:Ulmus laciniata(43.4%)forest Inventory.

关键词： Carbon concentration Carbon sequestration Hardwoods Conifers Temperate forest

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Developing Weibull-based diameter distributions for the major coniferous species in Heilongjiang Province,China

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Journal of forestry Research 2023年第6期34卷 1803-1815页

作者： Qila Sa Xingji Jin Timo Pukkala Fengri Li key laboratory of sustainable forest ecosystem management Ministry of EducationNortheast Forestry UniversityHarbin 150040People’s Republic of China University of Eastern Finland 80101 JoensuuFinland

Diameter distribution models play an important role in forest inventories,growth prediction,and *** Weibull probability density function is widely used in *** a number of methods have been proposed to predict or recover the Weibull distribution,their applicability and predictive performance for the major tree species of China remain to be *** in sample plots of three even-aged coniferous species(Larix olgensis,Pinus sylvestris and Pinus koraiensis)were measured both in un-thinned and thinned stands to develop parameter prediction models for the Weibull probability density *** least squares(OLS)and maximum likelihood regression(MLER),as well as cumulative distribution function regression(CDFR)were used,and their performance *** results show that MLER and CDFR were better than OLS in predicting diameter distributions of tree *** produced the best results in terms of fitting *** on the error statistics calculated for different age groups,CDFR was considered the most suitable method for developing prediction models for Weibull parameters in coniferous plantations.

关键词： Parameter prediction Maximum likelihood regression Cumulative distribution function regression

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Diurnal variation models for fine fuel moisture content in boreal forests in China

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Journal of forestry Research 2021年第3期32卷 1177-1187页

作者： Ran Zhang Haiqing Hu Zhilin Qu Tongxin Hu key laboratory of sustainable forest ecosystem management-ministry of education Northeast Forestry UniversityHarbin 150040China College of Science Northeast Forestry UniversityHarbin 150040China

Studying diurnal variation in the moisture content of fine forest fuel(FFMC)is key to understanding forest fire *** study established models for predicting the diurnal mean,maximum,and minimum FFMC in a boreal forest in China using the relationship between FFMC and meteorological variables.A spline interpolation function is proposed for describing diurnal variations in *** 1 day with a 1 h field measurement data testing,the results indicate that the accuracy of the sunny slope model was 100%and 84%when the absolute error wasforest fire danger prediction in boreal forest ecosystems in China.

关键词： forest fuel forest fire Moisture content Prediction model Diurnal variation

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