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Nanoparticles for the treatment of spinal cord injury

Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS key laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

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Recent advances in biocompatible supramolecular assemblies for biomolecular detection and delivery

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Chinese Chemical Letters 2013年第5期24卷 351-358页

作者： Lei Wang Li-Li Li Horse L.Ma Hao Wang CAS key laboratory for biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology(NCNST)

Inspired by sophisticated biological structures and their physiological processes, supramolecular chemistry has been developed for understanding and mimicking the behaviors of natural species. Through spontaneous self-assembly of functional building blocks, we are able to control the structures and regulate the functions of resulting supramolecular assemblies. Up to now, numerous functional supramolecular assemblies have been constructed and successfully employed as molecular devices, machines and biological diagnostic platforms. This review will focus on molecular structures of functional molecular building blocks and their assembled superstructures for biological detection and delivery.

关键词： Supramolecular Assembly biological detection Drug delivery

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“Smart”nanomaterials for cancer therapy

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Science China Chemistry 2010年第11期53卷 2241-2249页

作者： LE GUYADER Laurent Chinese Academy of Sciences key laboratory for biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

Recent development in nanotechnology has provided new tools for cancer therapy and *** of their small size,nanoscale devices readily interact with biomolecules both on the cell surface and inside the ***,such as fullerenes and their derivatives,are effective in terms of interactions with the immune system and have great potential as anticancer ***,other nanomaterials are able to load active drugs to cancer cells by selectively using the unique tumor environment,such as their enhanced permeability,retention effect and the specific acidic *** and multiplexed nanoparticles,as the next generation of nanoparticles,are now being extensively investigated and are promising tools to achieve personalized and tailored cancer treatments.

关键词： nanotechnology nanomaterials nanocarrier cancer therapy drug delivery passive target active target

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The new face of iron oxide nanoparticles: the bullets targeting tumor microenvironment for cancer therapy

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Science Bulletin 2016年第23期61卷 1788-1790页

作者： Jinxia Li Feng Zhao Chunying Chen CAS key laboratory for Biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences CAS key laboratory for Biomedical effects of nanomaterials and nanosafety National Center for Nanoscience and Technology

Ferumoxytol, an iron replacement product in clinic practices, is an agent of superparamagnetic iron oxide nanoparticles coated with polyglucose sorbitol carboxymethylether. It is approved for the intravenous therapy o... 详细信息

关键词：铁纳米粒子肿瘤治疗氧化微环境子弹缺铁性贫血临床实践替代产品

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Smart Supramolecular Nanosystems for Bioimaging and Drug Delivery

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Chinese Journal of Chemistry 2015年第1期33卷 59-70页

作者： Peipei Yang Lei Wang Hao Wang CAS key laboratory for biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China

The application of smart supramolecular nanosystems in biomedicine increases rapidly and offers promising prospects for disease diagnostics and *** nanosystems such as liposomes,micelles,or-ganic nanoaggregates and metallic nanostructures *** been widely explored as diagnostic/therapeutic ***,we review the recent advances in supramolecular nanosystems with different builtin reporters,e.g.,fluorescent,magnetic and photoacoustic signals for *** addition,the substantial progress of supramolecular nanosystems as drug delivery carriers for cancer therapy,including chemotherapy,photothermal and photodynamic therapies is also summarized.

关键词： supramolecular chemistry nanosystems bioimaging drug delivery

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Organs on microfluidic chips:a mini review

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Science China Chemistry 2014年第3期57卷 356-364页

作者： JIANG Bo ZHENG WenFu ZHANG Wei JIANG XingYu CAS key laboratory for biological effects of nanomaterials and nanosafety National Center for Nanoscience and Technology Graduate School of the Chinese Academy of Sciences

Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell *** the identified key aspects,including tissue-tissue interfaces,spatiotemporal chemical gradients,and dynamic mechanical forces,of living organs into the microfluidic system,"organs-on-chips"display an unprecedented application potential in a lot of biological fields such as fundamental physiological and pathophysiological research,drug efficacy and toxicity testing,and clinical ***,we review the recent development of organs-on-chips and briefly discuss their future challenges.

关键词： microfluidics organ chip cell

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Nanotechnology in the programmed cell therapy:nowhere to escape of cancer

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Science Bulletin 2016年第1期61卷 45-47页

作者： Jinxia Li Yuliang Zhao CAS key laboratory for Biomedical effects of nanomaterials and nanosafety Institute of High Energy Physics Chinese Academy of Sciences CAS key laboratory for Biomedical effects of nanomaterials and nanosafety National Center for Nanosciences and Technology

For lymphomas,the transport of chemotherapeutic drugs usually meets physical barriers to the lymph nodes where disseminated tumor cells frequently *** new findings show that autologous T cells as live vectors combined with nanotechnology-based drug delivery can provide a novel opportunity for the improved chemotherapy toward lymphomas.

关键词：纳米技术细胞疗法程序性癌症化疗药物肿瘤细胞淋巴瘤淋巴结

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Polymers with tertiary amine groups for drug delivery and bioimaging

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Science China Chemistry 2016年第8期59卷 991-1002页

作者： Yu-Juan Gao Zeng-Ying Qiao Hao Wang CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Techr ology Beijing 100190 China

Over the past decade, biopolymers have gained great interests especially in biomedicine due to their physical properties and/or chemical structures changes in response to external stimuli in a certain time fiarne or at a specific location. Among them, poly（β-amino ester）s, methacrylate-based block copolymers and polypeptide with tertiary amine groups have been extensively studied and exhibit pH sensitive properties due to the protonation of tertiary amine groups. The pH values in normal organs, tissues, and subcellular compartments are always different from those in pathological tissues. These interesting properties allow their applications in a variety of fields ranging from diagnosis and therapeutics of diseases. Here, we review the recent progress of poly（β-amino ester）s, methacrylate-based block copolymers and polypeptide with tertiary amine groups and their applications in drug delivery and bioimaging.

关键词： biopolymers tertiary amine groups pH-responsive drug delivery bioimaging

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Analytical methods for nano-bio interface interactions

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Science China Chemistry 2016年第11期59卷 1467-1478页

作者： Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie CAS key laboratory for Biomedical effects of nanomaterials and nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology

Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

关键词： engineered nanomaterial nano-bio interface nano-bio interaction analytical methods protein corona synchrotron radiation

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Synthesis, Crystal Structure and Hydrogenation Catalysis of a CF_3-BINAP(O)-Rh-COD Complex

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Chinese Journal of Structural Chemistry 2012年第11期31卷 1669-1675页

作者：杨红芬卢伟刘蕾刘宇吴海臣 key laboratory for Biomedical effects of nanomaterials & nanosafety Institute of High Energy Physics Chinese Academy of Sciences

The complex [（CF3-BINAP（O））Rh（COD）][ClO4]·Et2O （2, CFa-BINAP（O） = 2- {bis[3,5-bis（trifluoromethyl）phenyl]phosphino } -2 ＇- {bis [3,5-bis（trifluoromethyl）phenyl]phosphinyl } -1,1、-binaphthyl, COD = 1,5-cyclooctadiene） was obtained directly from the reaction of CF3- BINAP（O） ligand with [Rh（COD）][C104]. Complex 2 has been characterized by single-crystal X-ray diffraction. The crystal adopts space group P21/n with a = 19.0727（4）, b = 15.6275（4）, c = 22.3039（6） A, fl = 112.3570（10）°, V= 6148.2（3） A3, Z = 4, Dc = 1.693 g/cm3, F（000） = 3144, μ（MoKa） = 0.500 mm-1, the final R = 0.0947 and wR = 0.2501. Structural studies reveal that Rh（I） is coordinated by one oxygen and one phosphorus in the same ligand. Asymmetric hydrogenation of acetami- docinnamic acid with compound 2 was also evaluated.

关键词： BINAP(O) ligand rhodium complex crystal structure asymmetric hydrogenation

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