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Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic

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World Journal of Gastroenterology 2012年第32期18卷 4412-4418页

作者： Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí Second Department of Medicine Gastroenterology Charles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic Centre for Health Equity Studies Karolinska InstituteStockholm University17177 StockholmSweden First Faculty of Medicine Institute of General PracticeCharles University12108 PrahaCzech Republic institute of Clinical Biochemistry and Diagnostics Charles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic

AIM:To study possible decrease in prevalence of Helicobacter pylori(***) infection in the Czech Republic within a 10-year ***:A total of 22 centres entered the *** catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general *** infection was investigated by means of a 13 C-urea breath *** samples in duplicates were analysed using isotope ratio mass *** cut-off point was *** and demographic characteristics were based on data from self-completed ***:The overall prevalence of *** infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or *** was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).*** infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of *** infection was 39.8%(252/633,P < 0.001).The highest prevalence of *** infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of *** infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of *** infection was statistically significantly higher among married(35.4%,246/694,P < 0.001),divorced(36.8%,49/133,P < 0.001) and widowed study subjects(40.2%,45/112,P < 0.001),both in minimally and fully adjusted *** was no significant difference in the prevalence of *** infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).Ther

关键词： Epidemiology Helicobacter pylori Czech Republic 13 C-urea breath test Decline of prevalence

Networks in motion - from ion channels to behaviour

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Networks in motion - from ion channels to behaviour

Dementia studies in Chinese populations

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Sten Grillner Nobel institute for Neurophysiology Department of NeuroscienceStockholm Brain InstituteKarolinska InstitutetSE-171 77 Stockholm

＜正＞In all vertebrates from primates including man to fish and lamprey,the basic neuronal organization controlling patterns of motor behaviour such as locomotion,breathing,and posture are organized in a similar or identical *** networks form a motor infrastructure used to initiate all the movements that each species can *** networks in turn can be selected through subpopulations of cells in the basal ganglia,which play an important role for the selection of motor *** networks generating the locomotor movements are located in the spinal *** are responsible for the sequential activation of the different limb muscle in each locomotor *** activity level is controlled by locomotor command centres in the brainstem,conserved throughout the vertebrate *** elucidate the intrinsic function of these pattern generating networks and command systems we have developed the lamprey nervous system as an experimental *** now understand the cellular bases of the brainstem spinal cord networks generating goal- directed locomotion and control of body *** detailed synaptic interaction has been identified,as well as the network contribution of subtypes of ion channels.A major tool has been biologically realistic large scale computing.

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Neuroscience Bulletin 2014年第2期30卷 207-216页

作者： Jin-Jing Pei Maria Stella T. Giron Jianping Jia Hui-Xin Wang Department of Neurology Xuan Wu Hospital Capital Medical University Beijing 100053 China KI-Alzheimer's Disease Research Center Department of Neurobiology Care Sciences and Society Karolinska InstitutetNovum 141 86 Stockholm Sweden Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet and StockholmUniversity G~vlegatan 16 113 30 Stockholm Sweden

Variations in the prevalence of dementia in different ethnic groups have been reported worldwide, and a number of reviews have provided a picture of epidemiological studies in dementia research. However, little is known about epidemiological studies in Chinese populations. In this review, we searched PubMed and the Web of Science for original research articles published in English up to July 2013 on the prevalence, incidence, risk factors, and prognosis of dementia in Chinese populations worldwide. Except for the prevalence, we included only population-based follow-up studies. We identified 25 studies in elderly Chinese residents in China's Mainland, Hong Kong, Taiwan, and Singapore, and found a higher prevalence of dementia in China's Mainland than in the other locations, which may be due to that the studies from China's Mainland are more recent than those from other locations. A notable increase in incidence was observed when dementia cases were diagnosed using 10/66 diagnostic criteria compared to other criteria. Studies on risk factors for dementia were limited and mostly from China's Mainland. Age, gender, education, smoking, and alcohol consumption were related to the risk of dementia in Chinese populations. Only two prognostic studies were identified, and age, gender, and residential area were related to the prognosis of dementia. In conclusion, the prevalence, incidence, and risk factors for dementia found in Chinese populations were comparable to other ethnic groups, but no conclusive results on prognosis were found. The differences in prevalence and incidence were influenced by the diagnostic criteria and the time of study. Longitudinal population-based studies on the incidence, risk factors, and prognosis of dementia in Chinese populations are required.

关键词： dementia epidemiology risk factors prognosis prevalence incidence

Pain and fatigue in adult patients with rheumatoid arthritis: Association with body awareness, demographic, disease-related, emotional and psychosocial factors

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Open Journal of Nursing 2013年第2期3卷 293-300页

作者： Helena Loof Unn-Britt Johansson Elisabet Welin Henriksson Staffan Lindblad Fredrik Saboonchi Sophiahemmet University StockholmSweden karolinska institutet Department of Clinical SciencesDanderyd HospitalDivision of MedicineStockholmSweden karolinska institutet Division of NursingDepartment of Neurobiology and Rheumatology UnitKarolinska HospitalStockholmSweden karolinska institutet Department of Learning InformaticsManagement and EthicsStockholmSweden karolinska institutet Department of NeuroscienceDivision of Insurance MedicineStockholmSweden University of Stockholm Stress Research InstituteStockholmSweden Red Cross University College StockholmSweden

Background: Patients and clinicians report pain and fatigue as key outcome measures in rheumatoid arthritis. Fatigue and pain are a major concern to patients. Aim: The objective of this study was to examine fatigue and pain in adult patients with rheumatoid arthritis (RA) and to investigate the association between pain and fatigue with body awareness, demographic, disease-related, emotional and psychosocial factors. Method: Data were collected from a sample of patients with RA (n = 120) recruited from a Rheumatology clinic in a large university hospital in Stockholm, Sweden. Eligible for inclusion were patients between 20 -80 years of age and with a confirmed diagnosis of RA. Fatigue was measured using the Multidimensional Assessment of Fatigue (MAF) scale, while the Visual Analogue Scale (VAS) was used to assess components of pain. A multiple stepwise regression analysis was performed to evaluate factors related to fatigue and pain. In the first step a univariate analysis of variance (ANOVA) was used for all relevant independent factors. In the next step backwards stepwise regression was applied. Result: Fatigue was significantly associated with the Disease Activity Score 28-joints (DAS 28) (p = 0.049), the Body Awareness Questionnaire (BAQ) (p = 0.006), the Positive Affect (PA) scale (p = 0.008) and no smoking (p = 0.021). Pain was significantly associated with the EuroQol EQ-5D (p = 0.008) and the DAS 28 (p = 0.001). The adjusted R-square was 28.6% for fatigue and 50.0% for pain. Conclusion: This study clearly demonstrates that fatigue and pain in patients with RA appear to be associated with disease-related factors. Furthermore, fatigue was related to body awareness and emotional factors, and pain was related to health related quality of life.

关键词： Pain Fatigue Emotional Psychosocial Rheumatoid Arthritis

Seminal HPV detection:a pilot study comparing the preservation effectiveness and cost between a methanol-based solution and cryopreservation with liquid nitrogen

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Asian Journal of Andrology 2022年第5期24卷 560-561页

作者： Jynfiaf Francis Cecilia Kärrberg Jonas Hermansson Magnus Lindh Sofia Ganidou Ann Thurin-Kjellberg Kersti Lundin Randa Akouri Panagiotis Tsiartas Department of Reproductive Medicine Sahlgrenska University HospitalGothenburg 41345Sweden Department of Obstetrics and Gynecology Institute of Clinical SciencesSahlgrenska AcademyGothenburg UniversityGothenburg 40530Sweden Department of Research and Development Angered HospitalAngered 42465Sweden Department of Clinical Microbiology Sahlgrenska University HospitalGothenburg 41346Sweden Department of OncologyPathology Karolinska InstituteStockholm 17177Sweden

Dear Editor,Human papillomavirus(HPV)is the most common sexually transmitted virus worldwide,and high-risk HPV infection is the most important risk factor for cervical cancer.1 However,few conclusive data are available on the prevalence of the male HPV infection and its health *** has been found that the prevalence of seminal HPV infection is higher in men with unexplained infertility,ranging between 10%and 35%compared with the general population(range:2%to 11%).2–4 In three recent systematic reviews,it was seen that HPV sperm infection may be associated with impaired sperm function that could lead to male infertility.2,4,5 HPV sperm infection with high-risk HPV among infertile men was shown to be associated with lower progressive sperm motility and higher DNA fragmentation index.6 Moreover,a high rate of pregnancy loss has been found among couples with HPV sperm infection after in vitro fertilization(IVF).7 In the majority of the studies performed to assess seminal HPV infection.

关键词： impaired methanol HPV

MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction

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Protein & Cell 2016年第12期7卷 916-920页

作者： Han Feng Sheng Wang Ling Guo Avinash S. Punekar Rudolf Ladenstein Da-Cheng Wang Wei Liu National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Key Laboratory of Molecular Biophysics of the Ministry of Educa- tion College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China institute of Immunology The Third Military Medical University Chongqing 400038 China Department of Biosciences and Nutrition Karolinska Institutet NOVUM 14183 Huddinge Sweden

Dear Editor, Heat shock factors （HSFs） constitute a transcription factor family playing regulatory roles in maintaining cellular protein homeostasis or mediating cell differentiation and develop- ment （Akerfelt et al., 2010, Bjork and Sistonen 2010, Westerheide et al., 2012）. Some human diseases such as cancer and neurodegeneration are often linked with mal- function of HSFs （Dai et al., 2007, Neef et al., 2011, Scherz- Shouval et al., 2014）. The human HSF family consists four members： HSF1-4, which exhibit tissue-specific expression profiles and possess unique but overlapping functions. HSF1 is the major regulator of the heat shock response.

关键词： Minor Groove Major Groove Significant Conformational Change Sumo Modification Attenuation Phase

Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis

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World Journal of Gastroenterology 2016年第17期22卷 4389-4396页

作者： Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer Department of Pediatrics Tampere University Hospital 33521 Tampere Finland Department of Pediatrics and Adolescent Medicine Clemenshospital 48153 Munster Germany karolinska University Hospital Astrid Lindgren Children's Hospital 17176 Solna Sweden Department of Pediatrics Karolinska University Hospital Huddinge 14186 Stockholm Sweden Department of Pediatrics Hvidovre Hospital 2650 Hvidovre Denmark

AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative ***: The ADAPT study was a prospective, open-label, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index (PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn® granulocyte, monocyte/macrophage adsorptive (GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as (Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement (PUCAI decrease of 20 ® GMA apheresis treatment was effective in ped

关键词： Granulocyte-monocyte apheresis Pediatric Ulcerative colitis Inflammatory bowel disease Therapy Steroids Clinical trial

Surgical trauma and postoperative nutrition:A longitudinal study of muscle protein metabolism

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中华临床营养杂志 1994年第4期12卷 47-48页

作者： Erik Vinnars Professor Department of Anaesthesiology and the Metabolic Research Laboratory Karolinska InstituteSt Gorans Hospia alS-112 81 StockholmSwedenDepartment of Anaesthesiology and the Metabolic Research LaboratoryKarolinska InstituteSt Gorans Hospia alS-112 81 StockholmSweden

A catabolic state develops following surgical *** weight loss and muscle wasting,whichleads to an increased loss of nitrogen in the urineThere is a decrease in muscle protein synthesis and anincreased translocation of amino acids from muscle tothe splanchnic *** results in an impoverish-ment of muscle free amino *** GLN,andeventually impairment of muscle function which can-not be counteracted by conventional ***,TPN supplemented with GLN improves nitrogen bal-

关键词： nutrition longitudinal metabolism trauma impairment translocation postoperative wasting supplemented 口凹

New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond

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World Journal of Gastroenterology 2017年第36期23卷 6593-6627页

作者： Emanuele Sinagra Gaetano Cristian Morreale Ghazaleh Mohammadian Giorgio Fusco Valentina Guarnotta Giovanni Tomasello Francesco Cappello Francesca Rossi Georgios Amvrosiadis Dario Raimondo Gastroenterology and Endoscopy Unit Fondazione Istituto Giuseppe GiglioContrada Pietra Pollastra Pisciotto Euro-Mediterranean institute of Science and Technology Department of Experimental Biomedicine and Clinical Neuroscience Section of Human AnatomyUniversity of Palermo Unit of Gastroenterology Ospedali Riuniti Villa Sofia-Vincenzo Cervello Department of Medicine Division of Gastroenterology and HepatologyKarolinska InstitutetKarolinska University Hospital Unit of Internal Medicine Ospedali Riuniti Villa Sofia-Vincenzo Cervello Section of Cardio-Respiratory and Endocrine-Metabolic Diseases Biomedical Department of Internal and Specialist MedicineUniversity of Palermo

Irritable bowel syndrome(IBS)is a chronic,recurring,and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain,distention,and changes in bowel *** there are several drugs for IBS,effective and approved treatments for one or more of the symptoms for various IBS subtypes are *** understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism,neurohormonal regulation,immune dysfunction,the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of *** regards to therapies for restoring intestinal permeability,multiple studies with prebiotics and probiotics are ongoing,even if to date their efficacy has been *** parallel,much progress has been made in targeting low-grade inflammation,especially through the introduction of drugs such as mesalazine and rifaximin,even if a better knowledge of the mechanisms underlying the low-grade inflammation in IBS may allow the design of clinical trials that test the efficacy and safety of such *** literature review aims to summarize the findings related to new and investigational therapeutic agents for IBS,most recently developed in preclinical as well as Phase 1 and Phase 2clinical studies.

关键词： Therapy Low grade inflammation Motility Secretion Irritable bowel syndrome Immunoendocrine axis