Significant decrease in prevalence ofHelicobacter pylori in the Czech Republic

作     者：Jan Bure Marcela Kopáová Ilona Koupil Bohumil Seifert Miluka kodová Fendrichová Jana pirková Viktor Voíek Stanislav Rejchrt TomáDouda Norbert Král Ilja Tachecí 

作者机构：Second Department of Medicine GastroenterologyCharles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic Centre for Health Equity StudiesKarolinska InstituteStockholm University17177 StockholmSweden First Faculty of MedicineInstitute of General PracticeCharles University12108 PrahaCzech Republic Institute of Clinical Biochemistry and DiagnosticsCharles University in PrahaFaculty of Medicine at Hradec KrálovéUniversity Teaching Hospital50005 Hradec KrálovéCzech Republic 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第32期

页      面：4412-4418页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Research Project PRVOUK P37-08 from Faculty of Medicine at Hradec Králové Charles University in Praha Czech Republic 

主　　题：Epidemiology Helicobacter pylori Czech Republic 13 C urea breath test Decline of prevalence 

摘      要：AIM:To study possible decrease in prevalence of Helicobacter pylori(***) infection in the Czech Republic within a 10-year ***:A total of 22 centres entered the *** catchment areas of these centres covered cities and towns with more than 20 000 inhabitants,smaller towns(≤ 20 000 inhabitants) with surrounding villages and rural areas,and were spread over the whole country,corresponding well to the geographical distribution of the Czech population.A total of 1 837 subjects(aged 5-98 years) took part in the study,randomly selected out of 38 147 people from the general *** infection was investigated by means of a 13 C-urea breath *** samples in duplicates were analysed using isotope ratio mass *** cut-off point was *** and demographic characteristics were based on data from self-completed ***:The overall prevalence of *** infection was 23.5%(430/1826),and 4.8%(20/420) in children aged 15 or *** was no statistically significant difference in prevalence between males(24.3%;208/857) and females(22.9%,222/969,P = 0.494).*** infection was strongly associated with higher age,among subjects aged 55+ years,prevalence of *** infection was 39.8%(252/633,P 0.001).The highest prevalence of *** infection was found among persons aged 55-64 years(43.9%,97/221) and 75+ years(37.9%,58/153).Among study subjects aged 15+ years,prevalence of *** infection was significantly increased in those with lowest education(odds risk 3.19,95% CI 1.87-5.47).Compared to never married(14.1%),the prevalence of *** infection was statistically significantly higher among married(35.4%,246/694,P 0.001),divorced(36.8%,49/133,P 0.001) and widowed study subjects(40.2%,45/112,P 0.001),both in minimally and fully adjusted *** was no significant difference in the prevalence of *** infection between married and widowed subjects(35.4%,246/694 vs 40.2%,45/112,P = 0.389).Ther