检索结果-南通市图书馆

Are tuberculosis Patients Managed According to the National Guidelines in Lagos State Nigeria?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

international Journal of Clinical Medicine 2016年第1期7卷 16-24页

作者： Olusola Adedeji Adejumo Olusoji James Daniel Mustapha Gidado Andrew Folarin Otesanya Esther Ngozi Adejumo Ebunoluwa O. Jaiyesimi Oluwatoyin Esther idowu Olumuyiwa O. Odusanya Department of Community Health and Primary Health care Lagos State University Teaching Hospital Ikeja Lagos Nigeria Department of Community Medicine and Primary care Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria kncv tuberculosis foundation/tb care i project Abuja Nigeria Medical Services Department Central Bank of Nigeria Lagos Nigeria Department of Medical Laboratory Science Babcock University Ilisan-Remo Nigeria Department of Community Health and Primary Health care College of Medicine Lagos Lagos State University Lagos Nigeria

Setting: Private and public tuberculosis (tb) treatment centers in Lagos State, Nigeria. Objective: To compare adherence of private and public providers of directly observed treatment short course (DOTS) in the Lagos State tb control program, Nigeria (LStbLCP) with the national tb guidelines. Design: A retrospective review of treatment cards of tb patients managed within the first and second quarter of 2012 in 34 DOTS facilities {23 public, 7 private for profit (PFP), and 4 private not for profit (PNFP)} involved in the private public mix of the LStbLCP. Results: Of the 1896 treatment cards reviewed, 1524 (80.4%), 132 (7.0%) and 240 (12.6%) were from public, PFP and PNFP DOTS facilities, respectively. About 19%, 25% and none of the patients managed at the public, PNFP, and PFP DOTS facilities were treated in full adherence with the national guidelines respectively. A significantly higher proportion of adults and sputum smear positive tb patients were treated in full adherence with the national guidelines (p iated with full adherence with the national guidelines. Conclusion: There is a need to reorient health care providers in public and private health facilities in Lagos State Nigeria to ensure full adherence with the national tb guidelines.

关键词： Adherence National Guidelines Health Workers DOTS Facilities

Diagnostic performance and problem analysis of commercial tuberculosis antibody detection kits in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Military Medical Research 2018年第3期5卷 242-250页

作者： Xue-Juan Bai You-Rong Yang Jian-Qin Liang Hui-Ru An Jie Wang Yan-Bo Ling Zhong-Yuan Wang Xue-Qiong Wu Army tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Institute of Tuberculosis Research 309 Hospital of Chinese PLA tuberculosis Department No.2.institute of tuberculosis Research 309 hospital of Chinese PLA tuberculosis Department No.1.institute of tuberculosis Research 309 hospital of Chinese PLA tuberculosis Department No.3 Institute of Tuberculosis Research 309 Hospital of Chinese PLA

Background: The diagnosis of bacterium-negative pulmonary tuberculosis(tb) and extra-pulmonary tb is challenging clinically. The detection of the anti-tb antibody has an important, auxiliary, clinical diagnostic value. Therefore, tb antibody detection kits should be screened and evaluated, and the reagents with the highest sensitivity and specificity should be chosen and used ***: The diagnostic performance of 7 commercially available tb antibody detection kits(kits A, B, C, D, E, F and G) based on the gold immunoassay detection of immunoglobulin(ig) G or igM antibodies were simultaneously evaluated and compared in 62 tb cases and 56 non-tb cases in a laboratory. A retrospective analysis including 2549 cases was carried out to assess the clinical diagnosis values of bacteriological examinations and tb antibody tests(kits B and H used in the clinic).Results: The sensitivities of tb antibody kits A, B, C, D, E, F and G in the sera from 62 tb patients were 50.0%, 83.9%, 38.7%, 9.7%, 48.4%, 69.4% and 79.0%, respectively; the sensitivities in the sera from 24 smear-negative tb patients were 29.2%, 79.2%, 29.2%, 12.5%, 29.2%, 54.2% and 79.2%, respectively; the specificities in the sera from 56 nontb patients were 73.2%, 25.0%, 85.7%, 96.4%, 78.6%, 78.6% and 50.0%, respectively. Of the 2549 clinically diagnosed cases, there were 1752 pulmonary tb cases, 505 extra-pulmonary tb cases, 87 old pulmonary tb cases and 205 non-tb cases. The positive results for smear, culture, tb antibody kit B and kit H in pulmonary tb cases were 39.8%(543/1365), 48.6%(372/765), 45.8%(802/1752) and 25.2%(442/1752), respectively; the results in extra-pulmonary tb cases were 3.4%(6/178), 5.8%(4/69), 35.4%(179/505), and 11.3%(57/505), respectively; the results in old pulmonary tb cases were 0%(0/64), 0%(0/30), 32.2%(28/87), and 9.2%(8/87), respectively; and the results in non-tb cases were 0%(0/121), 0%(0/56), 21.5%(44/205), and 2.4%(5/205), respectively. Of 624 smear-positive and/or

关键词： tuberculosis tuberculosis antibody test Smear Culture

Multichannel Financing Reduces Economic Burden and improves the Medical Security Level for tuberculosis Patients

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

China CDC weekly 2020年第12期2卷 194-197页

作者： Fei Huang Ni Wang You Li Hui Zhang Yanli Yuan Xiaomeng Wang Xiaolin Wang Shitong Huan Lixia Wang Mingting Chen Yanlin Zhao National Center for tuberculosis Control and Prevention China Center for Disease Control and PreventionBeijingChina Jilin Provincial Center for tuberculosis Control and Prevention ChangchunJilinChina Zhejiang Provincial Center for tuberculosis Control and Prevention HangzhouZhejiangChina Ningxia Hui Autonomous Region tuberculosis Dispensary YinchuanNingxia Hui Autonomous RegionChina Bill&Melinda Gates foundation Beijing officeBeijingChina

tuberculosis(tb)is one of the main infectious diseases to simultaneously cause poverty and be caused by *** the economic burden of tb patients in China is essential to improving patient compliance and reducing the impact of the tb *** accordance with the national reform of the medical and health system and the current status of the country’s tb prevention and treatment service system,representatives of the government proposed the concept of a multichannel financing mechanism.

关键词： prevention tuberculosis diseases

Evaluation of iFiT3 and ORM1 as Biomarkers for Discriminating Active tuberculosis from Latent infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2022年第6期42卷 1201-1212页

作者： Bing-fen YANG Fei ZHAi Shan YU Hong-juan AN Zhi-hong CAO Yan-hua LiU Ruo WANG Xiao-xing CHENG tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentInstitute of Senior Department of Tuberculosisthe Eighth Medical Center of Chinese PLA General HospitalBeijing100091China Fourth Division Senior Department of Tuberculosisthe Eighth Medical Center of PLA General HospitalBeijing100091China Department of tuberculosis Prevention and Control Senior Department of Tuberculosisthe Eighth Medical Center of PLA General HospitalBeijing100091China

Objective Current commercially available immunological tests cannot be used for discriminating active tuberculosis(tb)from latent tb *** evaluate the value of biomarker candidates in the diagnosis of active tb,this study aimed to identify differentially expressed genes in peripheral blood mononuclear cells(PBMCs)between patients with active tb and individuals with latent tb infection by transcriptome *** The differentially expressed genes in unstimulated PBMCs and in Mycobacterium tuberculosis(Mtb)antigen-stimulated PBMCs from patients with active tb and individuals with latent tb infection were identified by transcriptome *** candidate genes were evaluated in cohorts consisting of 110 patients with tb,30 individuals with latent tb infections,and 50 healthy controls by quantitative real-time *** operating characteristic(ROC)curve analysis was performed to calculate the diagnostic value of the biomarker *** Among the differentially expressed genes in PBMCs without Mtb antigen stimulation,interferon-induced protein with tetratricopeptide repeats 3(iFiT3)had the highest area under curve(AUC)value(0.918,95%Ci:0.852-0.984,Pin discriminating patients with active tb from individuals with latent tb infection,with a sensitivity of 91.86%and a specificity of 84.00%.in Mtb antigen-stimulated PBMCs,orosomucoid 1(ORM1)had a high AUC value(0.833,95%Ci:0.752-0.915,Pith a sensitivity of 81.94%and a specificity of 70.00%.Conclusion iFiT3 and ORM1 might be potential biomarkers for discriminating active tb from latent tb infection.

关键词： tuberculosis biomarker latent tuberculosis infection interferon-induced protein with tetratricopeptide repeats 3 orosomucoid 1

Mesenchymal-epithelial Transition Factor Regulates Monocyte Function during Mycobacterial infection via indoleamine 2,3-dioxygenase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2022年第2期42卷 407-416页

作者： Bing-fen YANG Fei ZHAi Hong-juan AN Jing JiANG Zhi-hong CAO Yan-hua LiU Jin-wen SU Ruo WANG Xiao-xing CHENG tuberculosis Prevention and Control Key Laboratory Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and TreatmentSenior Department of Tuberculosisthe Eighth Medical Center of Chinese PLA General HospitalBeijing100091China

Objective Mycobacterium tuberculosis(Mtb),the causative agent of tuberculosis(tb),causes an estimated 1.6 million human deaths annually,but the pathogenesis of tb remains *** plays a critical role in the onset and outcome of *** study aimed to uncover the roles of innate and adaptive immunity in *** The gene expression profiles generated by RNA sequencing from human peripheral blood mononuclear cells(PBMCs)stimulated with or without Mtb strain H37Rv antigens were analyzed.A total of 973 differentially expressed mRNAs were *** The differentially expressed genes were enriched in innate immunity signaling *** mesenchymal-epithelial transition factor(MET)gene was significantly upregulated in CD14^(+)monocytes.A MET inhibitor improved the uptake of the BCG strain by monocytes and macrophages as well as inhibited the expression of indoleamine 2,3-dioxygenase(iDO).The expression of iDO was increased in PBMCs stimulated with Mtb antigens,and the iDO inhibitor promoted the expression of CD40,CD83,and *** Our results might provide clues regarding the immunomodulatory mechanisms used by Mtb to evade the host defense system.

关键词： monocytes mycobacteria mesenchymal-epithelial transition factor indoleamine 2,3-dioxygenase

Effectiveness of the integrated tb Surveillance System--China,2018-2019

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China CDC weekly 2020年第12期2卷 190-193页

作者： Ni Wang Tao Li Xin Du You Li Miaomiao Sun Shitong Huan Hui Zhang Lixia Wang Mingting Chen Fei Huang Yanlin Zhao National Center for tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina PATH Beijing officeBeijingChina Bill&Melinda Gates foundation Beijing officeBeijingChina

What is already known about this topic?China’s national health information system provides important support and means for deepening the country’s medical and health reform,for improving relevant delivery services,for enhancing the level of scientific management of health,and for promoting the goal of basic medical and health services for everyone in *** is added by this report?To further the construction of the national health information system,the National Center for tuberculosis Control and Prevention of China CDC,started a pilot project for a new tuberculosis(tb)integrated health(iHealth)surveillance system,which was integrated with regional health information *** goal was to explore automatic data exchange between hospitals and disease control facilities to reduce the workload of *** are the implications for public health practice?This pilot proved that data sharing and automatic exchanges between different information systems can be achieved through a unified surveillance dataset,which could provide a reference point for the construction of surveillance systems for other infectious diseases or for the entire public health information system.

关键词： services deepening everyone

Risk Factors for Multidrug-Resistant tuberculosis and Characteristics of Cases: A Case-Control Study of Patients Attending ALERT General Hospital in Addis Ababa, Ethiopia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Respiratory Diseases 2019年第1期9卷 1-17页

作者： Ezra Shimeles Fikre Enquselassie Melaku Tilahun Alemayehu Mekonnen Getachew Wondimagegn Tsegaye Hailu Abraham Aseffa Armauer Hanson Research institute Addis Ababa Ethiopia School of Public Health College of Health Sciences Addis Ababa University Black Lion Hospital Addis Ababa Ethiopia Ethiopian Public Health Association Addis Ababa Ethiopia kncv tuberculosis foundation Addis Ababa Ethiopia

Background:tuberculosis remains a major public-health problem in the world, despite several efforts to improve case identification and treatment. Particularly multidrug-resistant tuberculosis is becoming a major threat to tuberculosis control programs in Ethiopia which seriously threatens the control and prevention efforts and is associated with both high death rates and treatment costs. Methods: A case-control study was conducted to assess risk factors and characteristics of MDR-tb cases at ALERT Hospital, Addis Ababa, Ethiopia, where cases were 167 MDR-tb patients, while controls were newly diagnosed and bacteriologically confirmed pulmonary tb cases of similar number, who were matched by sex and age of 5-years interval. Results: The socio-demographic characteristics of the participants indicated that majority (53.3%) were males and 46.7% females;a little over half of cases (55.1%) were in the age group 26 - 45 years, whereas 46.7% of controls were in this age group. According to the multivariable logistic regression analysis, previous history of hospital admission was the only factor that was identified as predictor which increased risk to develop MDR-tb by almost twenty times (AOR = 19.5;95% Ci: 9.17 - 41.62) and P-value of ied factor such as being unemployed, family size, having member of household member with tb, and history of visiting hospital in past 12 months etc., didn’t show any statistically significant association. Conclusion: The study identified previous history of hospital admission as independent predictors for the occurrence of MDR-tb, while other studied variables didn’t show any strong association. The findings added to the pool of knowledge emphasizing the need for instituting strong infection control practice at health care facilities to prevent nosocomial transmission of MDR-tb.

关键词： Mycobacterium tuberculosis Multidrug-Resistant tuberculosis Risk Factors Characteristics

Use of anti-tuberculosis drugs among newly diagnosed pulmonary tuberculosis inpatients in China: a retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

infectious Diseases of Poverty 2016年第1期5卷 9-14页

作者： Fei Huang Hui Zhang Qing Lv Kaori DSato Yan Qu Shitong Huan Jun Cheng Fei Zhao Lixia Wang National Center for tb control and prevention No 155 Changbai RoadChangping DistrictBeijing 102206China Duke Global Health institute DurhamNCUSA Bill&Melinda Gates foundation Beijing officeBeijingChina

Background:China’s national tuberculosis control program(NTP)provides free,first-line anti-tuberculosis(tb)drugs to pulmonary tb *** treatment regimen follows the World Health Organization’s(WHO)*** objective of this paper is to evaluate the current status of anti-tb drug use for newly diagnosed pulmonary tb inpatients treated in prefecture-and county-level designated ***:Three prefecture-level hospitals and nine county-level hospitals were selected for the *** newly diagnosed pulmonary tb inpatient medical records from 2012 were reviewed and doubly examined by two national senior *** rational use of anti-tb drugs was evaluated based on criteria in line with WHO’s ***:Of the 2,060 total treatment regimens for tb,53.1%were found to be rational(1093/2060).The percentages in prefecture-level and county-level hospitals were 50.3%(761/1513)and 60.7%(332/547),*** difference between the two levels of hospitals was statistically significant(Chi-square value=17.44,Pional treatment regimens for first-time hospitalizations and for two or more hospitalizations were 59.5%(983/1653)and 27.0%(110/407),respectively,with a statistically significant difference(Chi-square value=138.00,Pine drugs(SLD)was 54.9%(1131/2060).The percentages for prefecture-level and county-level hospitals were 50.6%(766/1513)and 66.7%(365/547),respectively.A statistically significant difference was found(Chi-square value=42.06,Pinpatients hospitalized once and inpatients hospitalized twice or more was 58.4%(966/1653)and 40.5%(165/407),respectively,with a statistically significant difference(Chi-square value=42.26,Pions:Half of inpatients might be treated with irrational regimens,and the use of SLD was more appropriately dispensed in city-level hospitals than in county-level *** and guidelines for health personnel,

关键词： tuberculosis inpatient Drug Regimen Rationality

Barriers to the Acceptance of tuberculosis Preventive Treatment:A Multicenter Cross-sectional Study in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第11期37卷 1303-1309页

作者： Jingjuan Ren &Fei Huang Haifeng Chen Huimin Zhang Jianwei Sun Ahui Zhao Zuhui Xu Liqin Liu Huizhong Wu Lanjun Fang Chengguo Wu Qingya Wang Wenqian Zhang Xinhua Sun Xiaoping Liu Jizheng Yuan Bohan Chen Ni Wang Yanlin Zhao National Key Laboratory of intelligent Tracking and Forecasting for infectious Diseases Chinese Center for Disease Control and PreventionBeijing 102206China National Center for tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Hebei Province Center for Disease Prevention and Control Hebei 050021China institute of tuberculosis Control and Prevention Henan Center for Disease Control and PreventionHenan 450016China Hunan institute for tuberculosis Control(Hunan Chest Hospital) Hunan 410006China Center for tuberculosis Control of Guangdong Province Guangdong 510630China Chongqing institute for tuberculosis Prevention and Control Chongqing 404100China Tianjin Center for tuberculosis Control Tianjin 300041China Chinese foundation for Prevention of STD and AiDS Beijing 100069China National Key Laboratory of intelligent Tracking and Forecasting for infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Objective We aimed to understand the willingness and barriers to the acceptance of tuberculosis(tb)preventive treatment(TPT)among people with latent tb infection(Ltbi)in *** A multicenter cross-sectional study was conducted from May 18,2023 to December 31,2023 across 10 counties in *** to a national technical guide,we included healthcare workers,students,teachers,and others occupations aged 15-65 years as our research *** Overall,17.0%(183/1,077)of participants accepted *** were statistically significant differences in the acceptance rate of TPT among different sexes,ages,educational levels,and occupations(Pin barriers to TPT acceptance were misconceptions that it had uncertain effects on prevention(57.8%,517/894),and concerns about side effects(32.7%,292/894).Conclusion An enhanced and comprehensive understanding of Ltbi and TPT among people with Ltbi is vital to further expand TPT in ***,targeted policies need to be developed to address barriers faced by different groups of people.

关键词： Latent tuberculosis infection tuberculosis preventive treatment Acceptance Healthcare workers Students Teachers