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Microsystems & Nanoengineering 2022年第3期8卷 129-140页

作者： Xuanqi Chen Hao Wan Rui Guo Xinpeng Wang Yang Wang Caicai Jiao Kang Sun Liang Hu School of Biological Science and Medical engineering Being Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Biosensor National Special Laboratory Key Laboratory for Bipmedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China Department of biomedical engineering School of MedicineTsinghua UniversityBeijing China

Integrated electrochemical sensing plaforms in wearable devices have great prospects in biomedical ***,traditional electrochemical platforms are generally fabricated on airtight printed circuit boards,which lack sufficient flexibility,air permeability,and *** metals at room temperature with excellent mobility and electrical conductivity show high promise in flexible *** paper presents a miniaturized liquid metal-based flexible electrochemical detection system on fabric,which is intrinsically flexible,air-permeable,and conformable to the *** advantage of the excellent fluidity and electrical connectivity of liquid metal,a double-layer circuit is fabricated that significantly miniaturizes the size of the whole *** linear response,time stability,and repeatability of this system are verifed by resistance,stability,image characterization,and potassium ferricyanide ***,glucose in sweat can be detected at the millimolar level using this sensing system,which demonstrates its great potential for wearable and portable detection in biomedical fields,such as health monitoring and point-of-care testing.

关键词： wear electrochemical system

Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions

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Cell Research 2007年第1期17卷 62-72页

作者： Betty Ying Zhou Prashant Mali USA. Whitehead institute for biomedical Research CambridgeMA 02142USAThe Institute for Cell EngineeringDepartment of Gynecology & Obstetricsthe Johns Hopkins University School of MedicineBaltimoreMD Program of Biomedical Engineeringthe Johns Hopkins UniversiOSchool of MedicineBaltimoreMD 21205USA

We previously showed that Wnt3a could stimulate human embryonic stem (hES) cell proliferation and affect cell *** the absence of feeder cell-derived factors,hES cells cultured under a feeder-free condition survivedand proliferated *** recombinant Wnt3a in the absence of feeder cell derived-factors stimulated hES cellproliferation but also *** the present study,we further extended our analysis to other Wnt ligands such asWntl and *** Wntl displayed a similar effect on hES cells as Wnt3a,Wnt5a had little effect in this ***3a and Wntl enhanced proliferation of undifferentiated hES cells when feeder-derived self-renewal factors andbFGF are also *** explore the possibility to promote the proliferation of undifferentiated hES cells by activatingthe Wnt signaling,we overexpressed Wnt3a or Wntl gene in immortalized human adult fibroblast (HAFi) cells that aresuperior in supporting long-term growth of undifferentiated hES cells than primary mouse embryonic *** with or without a Wnt transgene can be propagated ***-expression of the Wnt3a gene significantlyenhanced the ability of HAFi feeder cells to support the undifferentiated growth of 3 different hES cell lines we ***-expression of three commonly-used drug selection genes in Wnt3a-overpressing HAFi cells further enabled us toselect rare hES clones after stable transfection or *** immortalized engineered feeder cells (W3R) thatco-express growth-promoting genes such as Wnt3a and three drug selection genes should empower us to efficiently makegenetic modified hES cell lines for basic and translational research.

关键词： WNT human embryonic stem cells stem cell renewal stem cell differentiation transgene

Direct ink writing of polycaprolactone/polyethylene oxide based 3D constructs

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Progress in Natural Science:Materials International 2021年第2期31卷 180-191页

作者： Bin Zhang Se Hun Chung Susan Barker Duncan Craig Roger J.Narayan Jie Huang Department of Mechanical engineering University College London Medway School of Pharmacy Universities of Greenwich and Kent School of Pharmacy University College London joint Department of biomedical engineering University of North Carolina and North Carolina State University

There has been increasing interest over recent years in the application of three-dimensional(3 D) printing technologies in the biomedical field. One such method is Direct Ink Writing(DIW); this approach has the potential advantage of allowing room-temperature deposition of materials, presented as an ink, to build complex architectures. DIW offers the ability to process biomaterials containing temperature-sensitive components. Due to the fabrication principles of DIW, there are specific rheological requirements that the ink must exhibit for the 3 D construction. For this reason, hydrogel-based liquid feed stocks have been the focal point of ink development. As a consequence, studies based on inks comprising hydrophobic biomaterials, which are insoluble in water and hence unsuited to the hydrogel approach, have been *** this study, we investigate novel inks that utilize polycaprolactone(PCL), a hydrophobic polymer, as the primary constituent by dissolving the polymer in solvent systems based on dichloromethane(DCM) and acetone(ACE). Moreover, polyethylene oxide(PEO) was incorporated into the PCL systems in order to extend the range of hydrophilicity of the systems. The rheological properties of the inks were investigated as a function of polymer composition and solvent system. Woodpile constructs of PCL and PCL/PEO were fabricated using DIW method and were assessed by a series of material characterisation. The type of solvent system had a noticeable impact on the ink rheology, which ultimately affected the surface properties. The incorporation of PEO particularly enhanced the roughness and wettability of the constructs. Our results support the use of DIW as a new means to process hydrophobic polymers for biomedical applications.

关键词： Direct ink writing Polycaprolactone Polyethylene oxide Ink rheology Material characterisation 3D construct

An exploration of frictional and vibrational behaviors of textured deep groove ball bearing in the vicinity of requisite minimum load

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Friction 2021年第6期9卷 1749-1765页

作者： K.E.Ch.VIDYASAGAR R.K.PANDEY Dinesh KALYANASUNDARAM Center for biomedical engineering Indian Institute of Technology DelhiNew Delhi 110016India Department of biomedical engineering College of EngineeringOsmania UniversityTelangana 500007India Department of Mechanical engineering Indian Institute of Technology DelhiNew Delhi 110016India Department of biomedical engineering Indian Institute of Technology DelhiNew Delhi 110016India

In case of lightly loaded radial ball bearings,failure mechanisms other than fatigue such as smearing of raceways due to increased frictional torque and vibrations often ***,attempts have been made herein for reducing the frictional torque and minimizing the vibrations of a radial deep groove ball bearing employing surface textures at the inner *** pulsed laser was used to create texture(involving micro-dimples having different dimple area density)on the inner race of test *** an in-house developed test rig,frictional torque and vibrational parameters were measured at different speeds and light loads(*** vicinity of 0.01C,where C is dynamic load capacity of radial ball bearing).Significant reduction in frictional torque and overall vibrations were found in the presence of micro-dimples on inner race at light loads irrespective of operating *** without satisfying the minimum load needed criteria for the satisfactory operation,substantial reduction in smearing marks was found on the races of textured ball bearings in comparison to conventional cases.

关键词： ball bearing textured inner race grease lubricated frictional torque vibration

Martensitic transformation and magnetic properties of Ti-doped NiCoMnSn shape memory alloy

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Rare Metals 2014年第5期33卷 511-515页

作者： Feng Chen Yun-Xiang Tong Bing Tian Li Li Yu-Feng Zheng Center for biomedical Materials and engineering Harbin Engineering University Department of Materials Science and engineering College of Engineering Peking University

Martensitic transformation, microstructure, and magnetic properties of Ti-doped Ni43-xTixCo7Mn43Sn7（at%）（x = 0, 0.5, 1.0, 2.0, and 4.0） shape memory alloys were investigated. The results show that transformation temperatures of Ni43Co7Mn43Sn7 can be efficiently adjusted by the substitution of Ti for Ni. For example, the martensitic transformation starting temperature（Ms） is reduced by about 278 K with 4 at% addition of Ti. Room temperature microstructure evolves from single tetragonal martensite for the Ti-free alloy to dual phases（tetragonal martensite ＋ second phase） with 0.5 at%, 1.0 at%, and2.0 at% addition of Ti to dual phases（cubic austenite ＋ second phase） for 4.0 at% Ti-doped alloy. The mechanical properties can be obviously improved by adding an appropriate amount of Ti. A noteworthy point is that magnetic-field-induced reverse transformation is observed in Ni39Ti4Co7Mn43Sn7 alloy.

关键词： NiCoMnSn Shape memory alloy Martensitic transformation Magnetic property

Optimized Implementation of the FDK Algorithm on One Digital Signal Processor

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Tsinghua Science and Technology 2010年第1期15卷 108-113页

作者：梁文轩张辉胡广书 Department of biomedical engineering Tsinghua University

This paper presents an optimized implementation of the FDK algorithm on a single fixed-point TMS320C6455 digital signal processor （DSP）. Software pipelining and proper configuration of the data transfer enables a 2563 volume to be reconstructed in about 42 seconds from 360 projections with very good accuracy. This implementation reveals the potential of modern high-performance DSPs in accelerating image reconstruction, especially when cost and power consumption are emphasized.

关键词： computed tomography digital signal processor (DSP) high performance computing software pipelining

A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

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Computer Modeling in engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu Zhou Xiaobing Chen Salman A.AlQahtani Hongrong Chen Bo Yang Siyu Lu Wenfeng Zheng Department of Computer Science and engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrical and Computer engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation

The dependences of osteocyte network on bone compartment, age, and disease

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Bone Research 2015年第2期3卷 72-82页

作者： Xiaohan Lai Christopher Price Shannon Modla William R Thompson Jeffrey Caplan Catherine B Kirn-Safran Liyun Wang Department of Mechanical engineering University of Delaware biomedical engineering program University of Delaware DBI Bioimaging Center University of Delaware Department of Physical Therapy Indiana University Department of Biological Sciences University of Delaware

Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system （LCS） buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compa~ tments, at different ages, and in two disease conditions with altered mechanosensing （perlecan deficiency and diabetes）. LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae （similar to the ＂nodes＂ in a computer network）, and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi （similar to the ＂bandwidth＂ of individual links in a computer network）. Age, in the range of our study （15-32 weeks）, affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation.

关键词： The dependences of osteocyte network on bone compartment age and disease bone

Rapid odor perception in rat olfactory bulb by microelectrode array

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 1015-1023页

作者： Jun ZHOU Qi DONG Liu-jing ZHUANG Rong LI Ping WANG Biosensor National Special Lab Key Lab for Biomedical Engineering of Ministry of EducationDepartment of Biomedical EngineeringZhejiang UniversityHangzhou 310027China

Responses of 302 mitral/tufted (M/T) cells in the olfactory bulb were recorded from 42 anesthetized freely breathing rats using a 16-channel microwire electrode *** vapors of four pure chemicals,anisole,carvone,citral and isoamyl acetate were *** aligning spike trains to the initial phase of the inhalation after odor onset,the responses of M/T cells showed transient temporal features including excitatory and inhibitory *** odor-evoked patterns indicated that mammals recognize odors within a short respiration cycle after odor *** to the small amount of information received from a single cell,we pooled results from all responsive M/T cells to study the ensemble *** firing rates of the cell ensembles were computed over 100 ms bins and population vectors were *** high dimension vectors were condensed into three dimensions for visualization using principal component *** trajectories of both excitatory and inhibitory cell ensembles displayed strong dynamics during odor *** distances among cluster centers were enlarged compared to those of the resting ***,we presumed that pictures of odor information sent to higher brain regions were depicted and odor discrimination was completed within the first breathing cycle.

关键词： Rapid odor perception Mitral/tufted cell Multielectrode array Odor trajectory

Towards skin polarization characterization using polarimetric technique

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 602-608页

作者： Pejhman GHASSEMI Mohammad Hossein MIRANBAYGI biomedical engineering Group Department of Electrical and Computer EngineeringTarbiat Modares University

Measurement of optical properties of skin is an expanding and growing field of *** studies have shown that the biological tissue,especially skin,changes the polarization state of the incident *** this property will enable the study of abnormalities and diseases that alter not only the light intensity but also its polarization *** this paper we report an experimental study for measuring changes of polarization state of the light scattered from a phantom similar to a sample model of scattering *** the notation of Stokes vector for the polarized light and Mueller matrix for the sample with its polarization properties,we have shown that some elements of the matrix were particularly sensitive to the changes of the polarization-altering physical properties of the scatterers within the phantom.

关键词： Polarization Skin Phantom Scattering polarimetry Mueller matrix Stokes vector