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Journal of Environmental Sciences 2025年第3期149卷 88-98页

作者： Shi-Ya Peng Ya-Di Yang Rong Tian Naihao Lu jiangxi key laboratory of Green Chemistry College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China

A key characteristic to be elucidated,to address the harmful health risks of environmental perfluorinated alkyl substances(PFAS),is their binding modes to serum albumin,the most abundant protein in *** oxide-dimer acid(GenX or HFPO-DA)is a new industrial replacement for the widespread linear long-chain ***,the detailed interaction of new-generation short-chain PFAS with albumin is still ***,the binding characteristics of bovine serum albumin(BSA)to GenX were explored at the molecular and cellular *** found that this branched short-chain GenX could bind to BSA with affinity lower than that of legacy linear long-chain perfluorooctanoic acid(PFOA).Site marker competitive study and molecular docking simulation revealed that GenX interacted with subdomain IIIA to form BSA-GenX *** with its weaker affinity to albumin protein,the cytotoxicity of branched short-chain GenX was less susceptible to BSA binding compared with that of the linear long-chain *** contrast to the significant effects of strong BSA-PFOA interaction,the weak affinity of BSA-GenX binding did not influence the structure of protein and the cytotoxicity of *** detailed characterization and direct comparisons of serum albumin interaction with new generation short-chain GenX will provide a better understanding for the toxicological properties of this new alternative.

关键词： GenX Protein binding Albumin Cytotoxicity Risk assessment

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina key laboratory of Anesthesiology of jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Construction of the porcine genome mobile element variations and investigation of its role in population diversity and gene expression

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Journal of Animal Science and Biotechnology 2025年第1期16卷 59-75页

作者： Jianchao Hu Lu Gui Zhongzi Wu Lusheng Huang National key laboratory for Swine Genetic Improvement and Germplasm Innovation Ministry of Science and Technology of ChinaJiangxi Agricultural UniversityNanchangPeople’s Republic of China

Background Mobile element variants(MEVs)have a significant and complex impact on genomic diversity and phe-notypic ***,the quantity,distribution,and relationship with gene expression and complex traits of MEVs in the pig genome remain poorly *** We constructed the most comprehensive porcine MEV library based on high-depth whole genome sequencing(WGS)data from 747 pigs across 59 breeds *** database identified a total of 147,993 poly-morphic MEVs,including 121,099 short interspersed nuclear elements(SINEs),26,053 long interspersed nuclear elements(LINEs),802 long terminal repeats(LTRs),and 39 other transposons,among which 54%are newly *** found that MEVs are unevenly distributed across the genome and are strongly influenced by negative selec-tion ***,we identified 514,530,and 584 candidate MEVs associated with population differentiation,domestication,and breed formation,*** example,a significantly differentiated MEV is located in the ATRX intron between Asian and European pigs,whereas ATRX is also differentially expressed between Asian and European pigs in muscle *** addition,we identified 4,169 expressed MEVs(eMEVs)significantly associated with gene expression and 6,914 splicing MEVs(sMEVs)associated with gene splicing based on RNA-seq data from 266 porcine liver *** eMEVs and sMEVs explain 6.24%and 9.47%,respectively,of the observed cis-heritability and high-light the important role of MEVs in the regulation of gene ***,we provide a high-quality SNP–MEV reference haplotype panel to impute MEV genotypes from genome-wide ***,we identified a candidate MEV significantly associated with total teat number,demonstrating the functionality of this reference *** The present investigation demonstrated the importance of MEVs in pigs in terms of population diversity,gene expression and phenotypic traits,which may provide useful resources and theoretic

关键词： Gene expression Genetic diversity Mobile element variants Pig SNP–MEV reference panel

Airborne fungal communities are more susceptible to anthropogenic activities than bacteria

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Journal of Environmental Sciences 2025年第3期149卷 564-573页

作者： Yuanyuan Pan Zhiwei Zuo Xueyun Huang Renguo Zhu School of Water Resources&Environmental Engineering East China University of TechnologyNanchang 330013China jiangxi Province key laboratory of the Causes and Control of Atmospheric Pollution East China University of TechnologyNanchang 330013China

Airborne microorganisms(AM)have significant environmental and health *** studies have been conducted to investigate the factors influencing the composition and diversity of ***,the knowledge of AM with anthropogenic activities has not reach a *** this study,we took advantage of the dramatic decline of outdoor anthropogenic activities resulting from COVID-19 lockdown to reveal their *** collected airborne particulate matter before and during the lockdown period in two *** results showed that it was fungal diversity and communities but not bacteria obviously different between pre-lockdownand lockdown samples,suggesting that airborne fungiwere more susceptible to anthropogenic activities than ***,after the implementation of lockdown,the co-occurrence networks of both bacterial and fungal community became more complex,whichmight be due to the variation of microbial ***,Mantel test and correlation analysis showed that air pollutants also partly contributed to microbial *** fungal community was more affected by air pollutants than bacterial ***,some human pathogens like Nigrospora and Arthrinium were negatively correlated with air ***,our study highlighted the more impacts of anthropogenic activities on airborne fungal community than bacterial community and advanced the understanding of associations between anthropogenic activities and AM.

关键词： COVID-19 lockdown Anthropogenic activities Airborne microorganisms Response Air pollutants

Optimization of transverse unidirectional scattering by morphology modification of irregular V-shaped silicon nanoantennas

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Optoelectronics Letters 2025年第3期21卷 129-135页

作者： ZENG Ming ZHAO Feng WANG Xianghui School of Electrical and Information Engineering Tianjin University Institute of Modern Optics Tianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyNankai University

A scheme based on irregular V-shaped silicon nanoantennas is proposed to optimize transverse unidirectional scattering under plane wave irradiation. Traditional methods of designing regular shapes offer fewer parameters and higher search efficiency. However, due to the limitations of regular shapes, it is challenging to meet high-precision design requirements. Irregular shape design allows for a broader range of adjustments, but the complexity of shape parameters leads to lower search efficiency and a higher likelihood of converging to local optima.

关键词： A

Valence electron matching law for MXene-based single-atom catalysts

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Journal of Energy Chemistry 2025年第2期101卷 641-650页

作者： Pei Song Yuhang Zhou Zishan Luo Hang Zhang Xi Sun Sen Lu Zepeng Jia Hong Cui Weizhi Tian Rong Feng Lingxia Jin Hongkuan Yuan School of Mechanical Engineering Shaanxi University of Technology Shaanxi key laboratory of Industrial Automation Shaanxi University of Technology Shaanxi key laboratory of Catalysis College of Chemical & Environment Science Shaanxi University of Technology School of Physical Science and technology Southwest University

Single-atom catalysts（SACs） have attracted considerable interest in the fields of energy and environmental science due to their adjustable catalytic *** this study,we investigated the matching of valence electron numbers between single atoms and adsorbed intermediates（O,N,C,and H） in MXene-anchored SACs（M-Ti2C/M-Ti2CO2）.The density functional theory results demonstrated that the sum of the valence electron number（VM） of the interface-doped metal and the valence electron number（VA） of the adsorbed intermediates in M-Ti2C followed the 10-valence electron matching ***,based on the 10-valence electron matching law,we deduced that the sum of the valence electron number（k） and VMfor the molecular adsorption intermediate interactions in M-Ti2CO2adhered to the 11-valence electron matching *** repulsion between the interface electrons in M-Ti2CO2and H2O weakened the adsorption of intermediates,Furthermore,we applied the 11-valence electron matching law to guide the design of catalysts for nitrogen reduction reaction,specifically for N2→ NNH conversion,in the *** sure independence screening and sparsifying operator algorithm was used to fit a simple three-dimensional descriptor of the adsorbate（R2up to 0.970） for catalyst *** study introduced a valence electron matching principle between doped metals（single atoms） and adsorbed intermediates（atomic and molecular） for MXene-based catalysts,providing new insights into the design of high-performance SACs.

关键词： Density functional theory Nitrogen reduction reaction Sure independence screening and sparsifying operator Valence electron matching law

Interface compatibility between sulfide solid electrolytes and Ni-rich oxide cathode materials:Factors,modification,perspectives

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Journal of Energy Chemistry 2025年第2期101卷 233-262页

作者： Tianwen Yang Haijuan Pei Haijian Lv Shijie Lu Qi Liu Daobin Mu Beijing key laboratory of Environmental Science and Engineering School of Materials Science an Engineering Beijing Institute of Technology State key laboratory of Space Power-Sources technology Shanghai Institute of Space Power-Sources

All-solid-state batteries(ASSBs) assembled with sulfide solid electrolytes(SSEs) and nickel(Ni)-rich oxide cathode materials are expected to achieve high energy density and safety,representing potential candidates for the next-generation energy storage ***,interfacial issues between SSEs and Nirich oxide cathode materials,attributed to space charge layer,interfacial side reactions,and mechanical contact failure,significantly restrict the performances of *** interface degradation is closely related to the components of the composite cathode and the process of electrode *** on the influencing factors of interface compatibility between SSEs and Ni-rich oxide cathode,this article systematically discusses how cathode active materials(CAMs),electrolytes,conductive additives,binders,and electrode fabrication impact the interface *** addition,the strategies for the compatibility modification are ***,the challenges and prospects of intensive research on the degradation and modification of the SSE/Ni-rich cathode material interface are *** review is intended to inspire the development of high-energy-density and high-safety all-solid-state batteries.

关键词： All–solid–state batteries Influencing factors Interface compatibility Ni–rich oxide cathode Sulfide solid electrolyte

A new multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth

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Chinese Journal of Aeronautics 2025年第1期38卷 568-585页

作者： Xinghui HAN Yanhui WANG Lin HUA Wuhao ZHUANG Fangyan ZHENG Wei FENG Hubei key laboratory of Advanced technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Longzhong laboratory Xiangyang 441000China

Spiral bevel gears are critical transmission components,and are widely used in the aerospace *** paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel ***,the multi-DOF envelope forming principle of spiral bevel gears is ***,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement ***,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel ***,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their ***,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming *** simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.

关键词： Multi-DOF envelope forming Spiral bevel gear Back taper tooth Metal flow Process design

MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO Yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN key laboratory of Optoelectronics technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology key laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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Genomic selection for meat quality traits based on VIS/NIR spectral information

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Journal of Integrative Agriculture 2025年第1期24卷 235-245页

作者： Xi Tang Lei Xie Min Yan Longyun Li Tianxiong Yao Siyi Liu Wenwu Xu Shijun Xiao Nengshui Ding Zhiyan Zhang Lusheng Huang State key laboratory for Pig Genetic Improvement and Production technology Jiangxi Agricultural UniversityNanchang 330045China

The principle of genomic selection(GS) entails estimating breeding values(BVs) by summing all the SNP polygenic effects. The visible/near-infrared spectroscopy(VIS/NIRS) wavelength and abundance values can directly reflect the concentrations of chemical substances, and the measurement of meat traits by VIS/NIRS is similar to the processing of genomic selection data by summing all ‘polygenic effects' associated with spectral feature peaks. Therefore, it is meaningful to investigate the incorporation of VIS/NIRS information into GS models to establish an efficient and low-cost breeding model. In this study, we measured 6 meat quality traits in 359Duroc×Landrace×Yorkshire pigs from Guangxi Zhuang Autonomous Region, China, and genotyped them with high-density SNP chips. According to the completeness of the information for the target population, we proposed 4breeding strategies applied to different scenarios: Ⅰ, only spectral and genotypic data exist for the target population;Ⅱ, only spectral data exist for the target population;Ⅲ, only spectral and genotypic data but with different prediction processes exist for the target population;and Ⅳ, only spectral and phenotypic data exist for the target *** 4 scenarios were used to evaluate the genomic estimated breeding value(GEBV) accuracy by increasing the VIS/NIR spectral information. In the results of the 5-fold cross-validation, the genetic algorithm showed remarkable potential for preselection of feature wavelengths. The breeding efficiency of Strategies Ⅱ, Ⅲ, and Ⅳ was superior to that of traditional GS for most traits, and the GEBV prediction accuracy was improved by 32.2, 40.8 and 15.5%, respectively on average. Among them, the prediction accuracy of Strategy Ⅱ for fat(%) even improved by 50.7% compared to traditional GS. The GEBV prediction accuracy of Strategy Ⅰ was nearly identical to that of traditional GS, and the fluctuation range was less than 7%. Moreover, the breeding cost of the 4 strategies was lo

关键词： VIS/NIR genomic selection GEBV machine learning pig meat quality