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Design of a high sensitivity and wide range angular rate sensor based on exceptional surface

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Chinese Physics B 2024年第8期33卷 277-286页

作者：丁鑫圣刘文耀王师贤陶煜周彦汝白禹刘来邢恩博唐军刘俊 State key laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China Shanxi province key laboratory of Quantum Sensing and precision Measurement North University of ChinaTaiyuan 030051China

It is found that when the parity–time symmetry phenomenon is introduced into the resonant optical gyro system and it works near the exceptional point,the sensitivity can in theory be significantly amplified at low angular ***,in fact,the exceptional point is easily disturbed by external environmental variables,which means that it depends on harsh experimental environment and strong control ability,so it is difficult to move towards practical ***,we propose a new angular rate sensor structure based on exceptional surface,which has the advantages of high sensitivity and high *** system consists of two fiber-optic ring resonators and two optical loop mirrors,and one of the resonators contains a variable ratio coupler and a variable optical *** theoretically analyze the system response,and the effects of phase and coupling ratio on the system ***,compared with the conventional resonant gyro,the sensitivity of this exceptional surface angular rate sensor can be improved by about 300 times at low *** addition,by changing the loss coefficient in the ring resonator,we can achieve a wide range of 600 rad/*** scheme provides a new approach for the development of ultra-high sensitivity and wide range angular rate sensors in the future.

关键词： exceptional surface exceptional points ring resonator angular rate sensing rotational direction recognition wide operating range

Optimal Design of the Modular Joint drive Train for Enhancing Cobot Load Capacity and Dynamic Performance

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 26-40页

作者： Peng Li Zhenguo Nie Zihao Li Xinjun Liu Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China State key laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Beijing key Lab of precision/Ultra-precision Manufacturing Equipments and control Tsinghua UniversityBeijing 100084China

Automation advancements prompts the extensive integration of collaborative robot(cobot)across a range of *** to the commonly used design approach of increasing the payload-to-weight ratio of cobot to enhance load capacity,equal attention should be paid to the dynamic response characteristics of cobot during the design process to make the cobot more *** this paper,a new method for designing the drive train parameters of cobot is ***,based on the analysis of factors influencing the load capacity and dynamic response characteristics,design criteria for both aspects are established for cobot with all optimization design criteria normalized within the design ***,with the cobot in the horizontal pose,the motor design scheme is discretized and it takes the joint motor diameter and gearbox speed ratio as optimization design ***,all the discrete values of the optimization objectives are obtained through the enumeration method and the Pareto front is used to select the optimal solution through multi-objective *** on the cobot design method proposed in this paper,a six-axis cobot is designed and compared with the commercial *** result shows that the load capacity of the designed cobot in this paper reaches 8.4 kg,surpassing the 5 kg load capacity commercial cobot which is used as a *** minimum resonance frequency of the joints is 42.70 Hz.

关键词： Multi-objective optimization Modular joint drive train design Load capacity Dynamic response performance

Spatial light modulation for femtosecond laser manufacturing:Current developments and challenges

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Science China(Technological Sciences) 2024年第1期67卷 60-72页

作者： ZANG Xue LIU ZiTing XU YiShi WANG Yi WANG Qing LI ZhenZe WANG Lei State key laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China State key laboratory of precision Measurement and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Since the invention of lasers,spatial-light-modulated laser processing has become a powerful tool for various *** enables multidimensional and dynamic modulation of the laser beam,which significantly improves the processing efficiency,accuracy,and flexibility,and presents wider prospects over traditional mechanical technologies for machining three-dimensional,hard,brittle,or transparent *** this review,we introduce:(1)The role of spatial light modulation technology in the development of femtosecond laser manufacturing;(2)the structured light generated by spatial light modulation and its generation methods;and(3)representative applications of spatial-light-modulated femtosecond laser manufacturing,including aberration correction,parallel processing,focal field engineering,and polarization ***,we summarize the present challenges in the field and possible future research.

关键词： femtosecond laser manufacturing spatial light modulation structured light aberration correction parallel processing focal field engineering polarization control

Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023

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China CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao Wang Xiaoqing Liu Bing Zhu Hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili Cui Baicheng Xia Naiying Mao National key laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina precision Medicine Research Center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial Center for Disease control and Prevention Zhengzhou CityHenan ProvinceChina laboratory of Viral Diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina jiangxi Provincial Center for Disease control and Prevention Nanchang CityGansu ProvinceChina Virus laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Institute for Immunization and Prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia Autonomous Region Comprehensive Center for Disease control and Prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture Center for Disease control and Prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12,866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in *** median age of HPIVs-infected patients was 3 ***2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)*** peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak *** peaks of HPIV1 were observed in 2021 following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

Effects of hydroxyproline supplementation in low fish meal diets on collagen synthesis, myofiber development and muscular texture of juvenile Pacific white shrimp(Litopenaeus vannamei)

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Animal Nutrition 2024年第2期17卷 428-437页

作者： Menglin Shi Haoming Li Tianyu Chen Bocheng Huang Xiaoyue Li Xiaohui Dong Shuyan Chi Qihui Yang Hongyu Liu Junming Deng Beiping Tan Shuang Zhang Shiwei Xie laboratory of Aquatic Nutrition and Feed College of Fisheries Guangdong Ocean University Aquatic Animals precision Nutrition and High-Efficiency Feed Engineering Research Centre of Guangdong province key laboratory of Aquatic Livestock and Poultry Feed Science and Technology in South China Ministry of Agriculture Guangdong Provincial key Lab of Aquatic Animals Disease control and Healthy Culture

This experiment aimed to evaluate the impact of dietary hydroxyproline(Hyp) supplementation on the muscle quality of juvenile Pacific white shrimp(Litopenaeus vannamei) fed a low fishmeal diet. Six formulated diets included one high fishmeal(HF; 25% fishmeal content) and five low fishmeal diets(10%fishmeal content) with 0%, 0.2%, 0.4%, 0.6% and 0.8% Hyp(LF0, LF2, LF4, LF6 and LF8, respectively). Each diet was assigned to four replicates, and 40 shrimp(0.32 ± 0.00 g) per replicate were fed four times a day for 8 weeks. Dietary Hyp supplementation had little effects on growth performance, but increased the contents of Hyp, prolyl 4-hydroxylases(P4Hs), and collagen. The meat yield, springiness, hardness,chewiness, and cohesiveness of muscle were the highest in the LF4 group among the low fishmeal groups(P < 0.05). Cooking loss and freezing loss of muscle were the lowest in the LF4 group(P < 0.05). Dietary supplementation with 0.4% Hyp increased the myofiber density and decreased the myofiber diameter of muscle(P < 0.05). Supplementation of Hyp in the diet up-regulated the mRNA expression of smyhc5,smyhc15, col1a1, col1a2, igf-1f, tgf-β and tor and down-regulated the mRNA expression of smyhc1, smyhc2,smyhc6a(P < 0.05). Supplementation of Hyp in the diet up-regulated the protein expression of P-4E-BP1,P-AKT, AKT and P-AKT/AKT(P < 0.05). These results suggested that the addition of 0.4% Hyp to low fishmeal diets improved the muscle quality of L. vannamei.

关键词： Hydroxyproline Collagen Muscle quality Litopenaeus vannamei

Enhanced high-temperature mechanical properties of laser-arc hybrid additive manufacturing of Al-Zn-Mg-Cu alloy via microstructure control

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Journal of Materials Science & Technology 2024年第2期169卷 220-234页

作者： Dehua Liu Dongjiang Wu Yunsong Wang Zhuo Chen Changrong Ge Qingyu Zhao Fangyong Niu Guangyi Ma State key laboratory of High-performance precision Manufacturing Dalian University of TechnologyDalian 116024China

Recently,rapid and cost-effective additive manufacturing solutions for lightweight aluminum alloys with excellent high-temperature mechanical properties have been increasingly in *** this study,we combined laser-arc hybrid additive manufacturing with solution and artificial aging treatments to achieve Al-Zn-Mg-Cu alloy with favorable high-temperature strength via microstructure *** pores became the major defect in the as-deposited and heat-treated *** continuous distribution of eutectics with hard-brittle characteristics at the grain boundaries was destructed following heat ***-densityηprecipitates were uniformly dispersed in the heat-treated Al-Zn-Mg-Cu alloy,whereas appeared coarsened and dissolved at 473 K,owing to the rapid diffusion of Zn and *** average 0.2%yield strength(318±16 MPa)and ultimate tensile strength(362±20 MPa)at 473 K af-ter heat treatment were enhanced by approximately 58%and 51%,respectively,compared to those of the as-deposited *** addition,theηprecipitates contributed to lattice distortions and strain fields,which prevented dislocation motion and increased slip deformation resistance at high *** as-deposited specimen exhibited intergranular fracture at 473 K,with cracks preferring to propagate along the aggregated ***,crack propagation proceeded in the sections with more pores in the heat-treated *** approach may provide a valid option for achieving alu-minum alloys with excellent high-temperature mechanical properties.

关键词： Laser-arc hybrid additive manufacturing Al-Zn-Mg-Cu alloy High-temperature strength Heat treatment,Microstructure evolution

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3170-3172页

作者： Xuan He Jingyou Yu Jiajing Jiang Jinyuan Liu Qi Qi Dan Liu Weimin Li Department of Pulmonary and Critical Care Medicine Precision Medicine Key Laboratory of Sichuan ProvinceState Key Laboratory of Respiratory Health and MultimorbidityWest China HospitalSichuan UniversityChengduSichuanChina Guangzhou National laboratory Bio-lslandGuangzhouGuangdongChina Sichuan Center for Disease control and Prevention ChengduSichuanChina

Dear Editor,Due to the ongoing evolution of SARS-CoV-2 and waning immunity following COVID-19 vaccination,breakthrough infections have become common *** exposure to viral antigens during different COVID-19 waves and vaccination contribute to the unique"hybrid immunity"-immune protection conferred by the combined vaccination and natural infection in individuals.

关键词： immunity vaccination infection

Improved observation of colonized roots reveals the regulation of arbuscule development and senescence by drought stress in the arbuscular mycorrhizae of citrus

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Horticultural Plant Journal 2024年第2期10卷 425-436页

作者： Xilong Yin Wei Zhang Zengwei Feng Guangda Feng Honghui Zhu Qing Yao College of Horticulture South China Agricultural UniversityKey Laboratory of Biology and Genetic Improvement of Horticultural Crops(South China)Ministry of Agriculture and Rural AffairsGuangdong Province Key Laboratory of Microbial Signals and Disease ControlGuangzhouGuangdong 510642China key laboratory of Agricultural Microbiomics and precision Application Ministry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationKey Laboratory of Agricultural MicrobiomicsState Key Laboratory of Applied Microbiology Southern ChinaGuangdong Microbial Culture Collection Center(GDMCC)Institute of MicrobiologyGuangdong Academy of SciencesGuangzhouGuangdong 510070China

Citrus is the typical mycorrhizal fruit tree species establishing symbiosis with arbuscular mycorrhizal (AM) fungi. However, arbuscule development and senescence in colonized citrus roots, especially in response to drought stress, remain unclear, which is mainly due to the difficulty in clearing and staining lignified roots with the conventional method. Here, we improved the observation of colonized roots of citrus plants with the sectioning method, which enabled the clear observation of AM fungal structures. Furthermore, we investigated the effects of one week of drought stress on arbuscule development and senescence with the sectioning method. Microscopy observations indicated that drought stress significantly decreased mycorrhizal colonization (F%and M%) although it did not affect plant growth performance. Fluorescence probes (WGA 488 and/or Nile red) revealed that drought stress inhibited arbuscule development by increasing the percentage of arbuscules at the early stage and decreasing the percentages of arbuscules at the midterm and mature stages. Meanwhile, drought stress accelerated arbuscule senescence, which was characterized by the increased accumulation of neutral lipids. Overall, the sectioning method developed in this study enables the in-depth investigation of arbuscule status, and drought stress can inhibit arbuscule development but accelerate arbuscule senescence in the colonized roots of citrus plants. This study paves the way to elaborately dissecting the arbuscule dynamics in the roots of fruit tree species in response to diverse abiotic stresses.

关键词： Arbuscular mycorrhizae Citrus Drought stress Arbuscule development Arbuscule senescence Fruit tree species

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunitβin human cancer

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 144-181页

作者： Yao Rong Song-Hua Liu Ming-Zheng Tang Zhi-Hang Wu Guo-Rong Ma Xiao-Feng Li Hui Cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina key laboratory of Molecular Diagnostics and precision Medicine for Surgical Oncology in Gansu province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC key laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND The pyruvate dehydrogenase E1 subunitβ(PDHB)gene which regulates energy metabolism is located in ***,few studies have elucidated the role and mechanism of PDHB in different *** To comprehensive pan-cancer analysis of PDHB was performed based on bioinformatics approaches to explore its tumor diagnostic and prognostic value and tumor immune relevance in *** vitro experiments were performed to examine the biological regulation of PDHB in liver *** Pan-cancer data related to PDHB were obtained from the Cancer Genome Atlas(TCGA)*** of the gene expression profiles of PDHB was based on TCGA and Genotype Tissue Expression Dataset *** regression analysis and Kaplan-Meier methods were used to assess the correlation between PDHB expression and survival prognosis in cancer *** correlation between PDHB and receiver operating characteristic diagnostic curve,clinicopathological staging,somatic mutation,tumor mutation burden(TMB),microsatellite instability(MSI),DNA methylation,and drug susceptibility in pan-cancer was also *** algorithms were used to analyze the correlation between PDHB and immune cell infiltration and tumor chemotaxis environment,as well as the co-expression analysis of PDHB and immune checkpoint(ICP)*** expression and functional phenotype of PDHB in single tumor cells were studied by single-cell sequencing,and the functional enrichment analysis of PDHB-related genes was *** study also validated the level of mRNA or protein expression of PDHB in several ***,in vitro experiments verified the regulatory effect of PDHB on the proliferation,migration,and invasion of liver *** PDHB was significantly and differently expressed in most *** was significantly associated with prognosis in patients with a wide range of cancers,including kidney renal clear cell carcinoma,kidney renal papillary cell carcinoma,breast invasive carcinom

关键词： Cuprotosis Pyruvate dehydrogenase E1 subunitβ Pan-cancer Prognosis Liver cancer